iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mga-059239

UUCD1 version

UUC-MeG-00119

Ensembl Protein ID

ENSMGAP00000002012.2

UniProt Accession

G1MU46; G1MU46_MELGA

Protein Name

Uncharacterized protein

Gene Name

CBL

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMGAG00000002406.2	ENSMGAT00000002684.2	ENSMGAP00000002012.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	6.10e-08	32.8	361	400

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iC e  kd +++ pCgH+++++Cl +w    + +s  + CP Cr
   Q: 361  CKICAENDKD-VKIEPCGHLMCTSCLTAW----Q-ESEGQGCPFCR 400
           99********.******************....5.555555****8 PP

Organism

Meleagris gallopavo

Protein Sequence
(Fasta)

XKKGPGGLIG LMKDAFQPHH HHLGPHQPGA VDKKMVEKCW KLMDKVVRLC QNPKLALKNS 60
PPYILDLLPD TYQHLRTILS RYEGKMETLG ENEYFRVFME NLMKKTKQTI SLFKEGKERM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

NNGAAGAAGG GCCCCGGGGG GCTGATCGGG CTGATGAAGG ACGCCTTCCA GCCGCATCAC 60
CACCACCTCG GGCCGCATCA GCCCGGCGCC GTGGATAAAA AGATGGTGGA GAAGTGCTGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR024162--Adaptor_Cbl
IPR014741--Adaptor_Cbl_EF_hand-like
IPR003153--Adaptor_Cbl_N_hlx
IPR014742--Adaptor_Cbl_SH2-like
IPR024159--Cbl_PTB
IPR011992--EF-hand-dom_pair
IPR000980--SH2
IPR015940--UBA
IPR009060--UBA-like
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS51506--CBL_PTB
PS50030--UBA
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF02262--Cbl_N
PF02761--Cbl_N2
PF02762--Cbl_N3
PF00627--UBA

SMART

SM00184--RING
SM00165--UBA

Gene Ontology

GO:0005829--C:cytosol
GO:0016600--C:flotillin complex
GO:0005634--C:nucleus
GO:0005509--F:calcium ion binding
GO:0004871--F:signal transducer activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007166--P:cell surface receptor signaling pathway
GO:0043066--P:negative regulation of apoptotic process
GO:0042059--P:negative regulation of epidermal growth factor receptor signaling pathway
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0048260--P:positive regulation of receptor-mediated endocytosis
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002357	Ailuropoda melanoleuca	84.09	0.00e+00	1357.00
IUUC-Apl-004041	Anas platyrhynchos	96.73	0.00e+00	1573.00
IUUC-Aca-004899	Anolis carolinensis	85.37	0.00e+00	1342.00
IUUC-Ame-010746	Astyanax mexicanus	62.47	0.00e+00	654.00
IUUC-Bta-012759	Bos taurus	83.89	0.00e+00	1400.00
IUUC-Cel-018674	Caenorhabditis elegans	54.90	2.00e-133	468.00
IUUC-Cja-019207	Callithrix jacchus	82.78	0.00e+00	1392.00
IUUC-Cfa-020897	Canis familiaris	83.71	0.00e+00	1380.00
IUUC-Cpo-021453	Cavia porcellus	83.12	0.00e+00	1387.00
IUUC-Csa-023136	Chlorocebus sabaeus	82.96	0.00e+00	1383.00
IUUC-Cho-024282	Choloepus hoffmanni	74.69	0.00e+00	1143.00
IUUC-Cin-025574	Ciona intestinalis	70.81	8.00e-179	619.00
IUUC-Csv-025938	Ciona savignyi	69.37	8.00e-173	599.00
IUUC-Dre-027644	Danio rerio	71.55	0.00e+00	1072.00
IUUC-Dno-030025	Dasypus novemcinctus	83.72	0.00e+00	1365.00
IUUC-Dme-032213	Drosophila melanogaster	74.23	0.00e+00	644.00
IUUC-Ete-033118	Echinops telfairi	68.18	0.00e+00	697.00
IUUC-Eca-033900	Equus caballus	84.97	0.00e+00	1389.00
IUUC-Eeu-035142	Erinaceus europaeus	80.41	0.00e+00	891.00
IUUC-Fca-035455	Felis catus	83.30	0.00e+00	1385.00
IUUC-Fal-037182	Ficedula albicollis	98.96	0.00e+00	928.00
IUUC-Gmo-038698	Gadus morhua	88.49	0.00e+00	881.00
IUUC-Gga-040438	Gallus gallus	98.42	0.00e+00	1641.00
IUUC-Gac-042166	Gasterosteus aculeatus	73.49	0.00e+00	908.00
IUUC-Ggo-045618	Gorilla gorilla	83.50	0.00e+00	1399.00
IUUC-Hsa-046177	Homo sapiens	82.94	0.00e+00	1386.00
IUUC-Itr-048795	Ictidomys tridecemlineatus	89.05	0.00e+00	934.00
IUUC-Lch-050095	Latimeria chalumnae	84.70	0.00e+00	1041.00
IUUC-Loc-052570	Lepisosteus oculatus	73.51	0.00e+00	1142.00
IUUC-Laf-054008	Loxodonta africana	83.11	0.00e+00	1395.00
IUUC-Mcc-054676	Macaca mulatta	82.85	0.00e+00	1380.00
IUUC-Mmr-060907	Microcebus murinus	81.74	0.00e+00	1380.00
IUUC-Mdo-062595	Monodelphis domestica	86.67	0.00e+00	1384.00
IUUC-Mmu-063725	Mus musculus	83.52	0.00e+00	1444.00
IUUC-Mpu-066771	Mustela putorius furo	83.46	0.00e+00	1389.00
IUUC-Mlu-067206	Myotis lucifugus	71.71	0.00e+00	1022.00
IUUC-Nle-069285	Nomascus leucogenys	81.09	0.00e+00	1306.00
IUUC-Opr-071026	Ochotona princeps	83.10	0.00e+00	1355.00
IUUC-Ont-071954	Oreochromis niloticus	71.81	0.00e+00	1083.00
IUUC-Ocu-074657	Oryctolagus cuniculus	84.09	0.00e+00	1341.00
IUUC-Ola-087165	Oryzias latipes	68.80	0.00e+00	1077.00
IUUC-Oga-088198	Otolemur garnettii	74.70	0.00e+00	1221.00
IUUC-Oar-090258	Ovis aries	84.25	0.00e+00	1344.00
IUUC-Ptr-090710	Pan troglodytes	82.94	0.00e+00	1386.00
IUUC-Pan-092785	Papio anubis	82.96	0.00e+00	1383.00
IUUC-Psi-093431	Pelodiscus sinensis	82.78	0.00e+00	778.00
IUUC-Pma-094249	Petromyzon marinus	75.94	2.00e-125	441.00
IUUC-Pfo-096990	Poecilia formosa	90.51	0.00e+00	830.00
IUUC-Pab-098526	Pongo abelii	82.92	0.00e+00	1387.00
IUUC-Pva-102352	Pteropus vampyrus	95.37	0.00e+00	880.00
IUUC-Rno-105876	Rattus norvegicus	82.87	0.00e+00	1417.00
IUUC-Sha-107588	Sarcophilus harrisii	84.66	0.00e+00	1212.00
IUUC-Sar-112959	Sorex araneus	81.50	0.00e+00	1334.00
IUUC-Ssc-115261	Sus scrofa	84.15	0.00e+00	1408.00
IUUC-Tgu-116580	Taeniopygia guttata	90.68	0.00e+00	1455.00
IUUC-Tru-118731	Takifugu rubripes	70.01	0.00e+00	1070.00
IUUC-Tsy-118982	Tarsius syrichta	73.40	0.00e+00	889.00
IUUC-Tni-120725	Tetraodon nigroviridis	69.73	0.00e+00	1066.00
IUUC-Tbe-128018	Tupaia belangeri	90.21	0.00e+00	1090.00
IUUC-Ttr-128927	Tursiops truncatus	84.00	0.00e+00	1434.00
IUUC-Vpa-130369	Vicugna pacos	83.63	0.00e+00	1302.00
IUUC-Xtr-132474	Xenopus tropicalis	75.30	0.00e+00	1195.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence