iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mlu-067206

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAPE02055483

Gene Name

CBL

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMLUG00000006385.2	ENSMLUT00000006393.2	ENSMLUP00000005839.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	4.40e-07	30.4	317	356

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iC e  kd +++ pCgH+++++Cl  w    + +s  + CP Cr
   Q: 317  CKICAENDKD-VKIEPCGHLMCTSCLTSW----Q-ESEGQGCPFCR 356
           99********.******************....5.555555****8 PP

Organism

Myotis lucifugus

Protein Sequence
(Fasta)

QVVRLCQNPK LALKNSPPYI LDLLPDTYQH LRTVLSRYEG KMETLGENEY FRVFMENLMK 60
KTKQTISLFK EGKERMYEEN SQPRRNLTKL SLIFSHMLAE LKGIFPSGLF QGDAFRITKA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGGTGGTGC GGCTGTGTCA GAACCCAAAG CTGGCGCTAA AGAACAGCCC GCCTTACATC 60
CTAGACCTGC TGCCAGACAC CTACCAGCAC CTGCGCACTG TCCTGTCAAG ATATGAGGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR024162--Adaptor_Cbl
IPR014741--Adaptor_Cbl_EF_hand-like
IPR003153--Adaptor_Cbl_N_hlx
IPR014742--Adaptor_Cbl_SH2-like
IPR024159--Cbl_PTB
IPR011992--EF-hand-dom_pair
IPR000980--SH2
IPR015940--UBA
IPR009060--UBA-like
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS51506--CBL_PTB
PS50030--UBA
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF02262--Cbl_N
PF02761--Cbl_N2
PF02762--Cbl_N3
PF00627--UBA

SMART

SM00184--RING
SM00165--UBA

Gene Ontology

GO:0005829--C:cytosol
GO:0016600--C:flotillin complex
GO:0005634--C:nucleus
GO:0005509--F:calcium ion binding
GO:0004871--F:signal transducer activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007166--P:cell surface receptor signaling pathway
GO:0043066--P:negative regulation of apoptotic process
GO:0042059--P:negative regulation of epidermal growth factor receptor signaling pathway
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0048260--P:positive regulation of receptor-mediated endocytosis
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002357	Ailuropoda melanoleuca	79.08	0.00e+00	1151.00
IUUC-Apl-004041	Anas platyrhynchos	88.19	0.00e+00	1010.00
IUUC-Aca-004899	Anolis carolinensis	73.61	0.00e+00	1047.00
IUUC-Bta-012759	Bos taurus	79.91	0.00e+00	1176.00
IUUC-Cja-019207	Callithrix jacchus	78.36	0.00e+00	1162.00
IUUC-Cfa-020897	Canis familiaris	79.67	0.00e+00	1159.00
IUUC-Cpo-021453	Cavia porcellus	78.04	0.00e+00	1179.00
IUUC-Csa-023136	Chlorocebus sabaeus	78.66	0.00e+00	1163.00
IUUC-Cho-024282	Choloepus hoffmanni	77.86	0.00e+00	862.00
IUUC-Csv-025938	Ciona savignyi	69.47	9.00e-166	576.00
IUUC-Dre-027644	Danio rerio	89.31	0.00e+00	786.00
IUUC-Dno-030025	Dasypus novemcinctus	77.92	0.00e+00	1167.00
IUUC-Eca-033900	Equus caballus	79.39	0.00e+00	1188.00
IUUC-Eeu-035142	Erinaceus europaeus	82.30	0.00e+00	852.00
IUUC-Fca-035455	Felis catus	78.76	0.00e+00	1168.00
IUUC-Fal-037182	Ficedula albicollis	96.61	0.00e+00	857.00
IUUC-Gmo-038698	Gadus morhua	86.17	0.00e+00	798.00
IUUC-Gga-040438	Gallus gallus	87.86	0.00e+00	1002.00
IUUC-Gac-042166	Gasterosteus aculeatus	72.88	0.00e+00	808.00
IUUC-Ggo-045618	Gorilla gorilla	78.69	0.00e+00	1167.00
IUUC-Hsa-046177	Homo sapiens	78.69	0.00e+00	1162.00
IUUC-Itr-048795	Ictidomys tridecemlineatus	91.47	0.00e+00	900.00
IUUC-Lch-050095	Latimeria chalumnae	81.52	0.00e+00	911.00
IUUC-Loc-052570	Lepisosteus oculatus	65.45	0.00e+00	950.00
IUUC-Laf-054008	Loxodonta africana	78.53	0.00e+00	1173.00
IUUC-Mcc-054676	Macaca mulatta	78.55	0.00e+00	1160.00
IUUC-Mga-059239	Meleagris gallopavo	86.89	0.00e+00	999.00
IUUC-Mmr-060907	Microcebus murinus	75.12	0.00e+00	1114.00
IUUC-Mdo-062595	Monodelphis domestica	77.20	0.00e+00	1151.00
IUUC-Mmu-063725	Mus musculus	78.76	0.00e+00	1194.00
IUUC-Mpu-066771	Mustela putorius furo	78.55	0.00e+00	1164.00
IUUC-Nle-069285	Nomascus leucogenys	76.05	0.00e+00	1068.00
IUUC-Opr-071026	Ochotona princeps	78.15	0.00e+00	1176.00
IUUC-Ont-071954	Oreochromis niloticus	64.55	0.00e+00	926.00
IUUC-Ocu-074657	Oryctolagus cuniculus	79.32	0.00e+00	1151.00
IUUC-Ola-087165	Oryzias latipes	78.33	0.00e+00	848.00
IUUC-Oga-088198	Otolemur garnettii	74.01	0.00e+00	1119.00
IUUC-Oar-090258	Ovis aries	80.00	0.00e+00	1167.00
IUUC-Ptr-090710	Pan troglodytes	78.69	0.00e+00	1162.00
IUUC-Pan-092785	Papio anubis	78.66	0.00e+00	1162.00
IUUC-Ppa-095308	Physcomitrella patens	22.58	1.00e-06	47.00
IUUC-Pfo-096990	Poecilia formosa	71.47	0.00e+00	837.00
IUUC-Pab-098526	Pongo abelii	78.45	0.00e+00	1158.00
IUUC-Pva-102352	Pteropus vampyrus	97.82	0.00e+00	832.00
IUUC-Rno-105876	Rattus norvegicus	78.88	0.00e+00	1178.00
IUUC-Sha-107588	Sarcophilus harrisii	86.75	0.00e+00	923.00
IUUC-Sar-112959	Sorex araneus	76.06	0.00e+00	1118.00
IUUC-Ssc-115261	Sus scrofa	79.56	0.00e+00	1181.00
IUUC-Tgu-116580	Taeniopygia guttata	84.52	0.00e+00	964.00
IUUC-Tru-118731	Takifugu rubripes	73.53	0.00e+00	842.00
IUUC-Tni-120725	Tetraodon nigroviridis	71.47	0.00e+00	816.00
IUUC-Tbe-128018	Tupaia belangeri	92.17	0.00e+00	1049.00
IUUC-Ttr-128927	Tursiops truncatus	80.02	0.00e+00	1202.00
IUUC-Vpa-130369	Vicugna pacos	79.60	0.00e+00	1132.00
IUUC-Xtr-132474	Xenopus tropicalis	77.34	0.00e+00	892.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence