iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	miRNAMap	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	18650381; 20921134; 26151332

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	5.50e-06	27.9	18	57
ULD/UDP/UFD/RAWUL	2.70e-30	105.8	131	224

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C +C   f d + +  C H f+++C+ ++        ++ +CP+C+
   Q: 18   CVLCGGYFIDATTIIECLHSFCKTCIVRY------LETSKYCPICD 57
           ********99999****************......**********5 PP

ULD/UDP/UFD/RAWUL

   S: 1    islsLeplesnkakddsk........lkkkylrcsarltVkhlkkflaeklklsssyevdllcedevLednetLeeikyifiwkkegpL 81
           isls+e++++++ +++ +        ++k+ylrc+a++tV+hl+kfl++k+++++++++d+++e+e+L+d++tL++i+yi++w+++gpL
   Q: 131  ISLSIEFFDQSRLDRKVNkekpkeevNDKRYLRCPAAMTVMHLRKFLRSKMDIPNTFQIDVMYEEEPLKDYYTLMDIAYIYTWRRNGPL 219
           78999999999999977789999999*************************************************************** PP
   S: 82   vLqYr 86
           +L+Yr
   Q: 220  PLKYR 224
           ****9 PP

Organism

Mus musculus

Functional Description
(View)

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2 (By similarity).

Protein Sequence
(Fasta)

MHRTTRIKIT ELNPHLMCVL CGGYFIDATT IIECLHSFCK TCIVRYLETS KYCPICDVQV 60
HKTRPLLNIR SDKTLQDIVY KLVPGLFKNE MKRRRDFYAA HPSADAANGS NEDRGEVADE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATAATCGTAG TATTAAAGGC AGAGATCGGG AGAGACAATG GGGAGGTTGG CGAGGGAGCC 60
CCGCGCAGGC TTAGCAACAC CTCCCGGCCC CGCAGAATAA TACGGCTCGG CCCCTCTGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0656--Proto-oncogene
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR032443--RAWUL
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF16207--RAWUL

SMART

SM00184--RING

Gene Ontology

GO:0005737--C:cytoplasm
GO:0000792--C:heterochromatin
GO:0016604--C:nuclear body
GO:0005634--C:nucleus
GO:0031519--C:PcG protein complex
GO:0000151--C:ubiquitin ligase complex
GO:0003682--F:chromatin binding
GO:1990841--F:promoter-specific chromatin binding
GO:0000978--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0043565--F:sequence-specific DNA binding
GO:0097027--F:ubiquitin-protein transferase activator activity
GO:0008270--F:zinc ion binding
GO:0007420--P:brain development
GO:0009987--P:cellular process
GO:0071549--P:cellular response to dexamethasone stimulus
GO:0071347--P:cellular response to interleukin-1
GO:0006306--P:DNA methylation
GO:0048706--P:embryonic skeletal system development
GO:0048704--P:embryonic skeletal system morphogenesis
GO:0061484--P:hematopoietic stem cell homeostasis
GO:0016573--P:histone acetylation
GO:0016574--P:histone ubiquitination
GO:0006959--P:humoral immune response
GO:0001701--P:in utero embryonic development
GO:2001234--P:negative regulation of apoptotic signaling pathway
GO:0045814--P:negative regulation of gene expression, epigenetic
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0030890--P:positive regulation of B cell proliferation
GO:0033092--P:positive regulation of immature T cell proliferation in thymus
GO:0051443--P:positive regulation of ubiquitin-protein transferase activity
GO:2000011--P:regulation of adaxial/abaxial pattern formation
GO:0021903--P:rostrocaudal neural tube patterning
GO:0001501--P:skeletal system development
GO:0048103--P:somatic stem cell division
GO:0006351--P:transcription, DNA-templated

KEGG

mmu:12151

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000603	Aegilops tauschii	37.21	6.00e-12	65.50
IUUC-Aml-001498	Ailuropoda melanoleuca	97.24	8.00e-168	582.00
IUUC-Apl-004208	Anas platyrhynchos	92.01	8.00e-133	466.00
IUUC-Aca-004661	Anolis carolinensis	81.29	4.00e-137	480.00
IUUC-Ath-007649	Arabidopsis thaliana	42.50	3.00e-12	66.60
IUUC-Ame-010610	Astyanax mexicanus	73.48	1.00e-138	485.00
IUUC-Bta-012606	Bos taurus	96.01	5.00e-166	576.00
IUUC-Cja-019482	Callithrix jacchus	97.45	3.00e-176	610.00
IUUC-Cfa-020482	Canis familiaris	97.24	8.00e-168	582.00
IUUC-Cpo-022061	Cavia porcellus	97.45	2.00e-176	611.00
IUUC-Csa-024102	Chlorocebus sabaeus	97.13	5.00e-177	613.00
IUUC-Cho-025081	Choloepus hoffmanni	79.52	6.00e-108	383.00
IUUC-Cin-025612	Ciona intestinalis	48.83	5.00e-52	197.00
IUUC-Dre-027929	Danio rerio	80.25	2.00e-143	501.00
IUUC-Dno-029797	Dasypus novemcinctus	95.54	1.00e-180	625.00
IUUC-Dor-030256	Dipodomys ordii	97.76	3.00e-168	583.00
IUUC-Dme-031904	Drosophila melanogaster	45.58	2.00e-53	205.00
IUUC-Ete-033148	Echinops telfairi	64.83	1.00e-82	299.00
IUUC-Eca-033318	Equus caballus	96.63	1.00e-166	578.00
IUUC-Eeu-034547	Erinaceus europaeus	83.76	5.00e-145	506.00
IUUC-Fca-035866	Felis catus	96.93	1.00e-167	582.00
IUUC-Fal-036660	Ficedula albicollis	92.94	4.00e-158	550.00
IUUC-Gmo-039341	Gadus morhua	82.95	3.00e-125	441.00
IUUC-Gga-040611	Gallus gallus	92.68	6.00e-163	566.00
IUUC-Gac-041888	Gasterosteus aculeatus	72.49	3.00e-128	451.00
IUUC-Gma-042798	Glycine max	39.02	6.00e-12	65.50
IUUC-Ggo-045027	Gorilla gorilla	97.13	7.00e-176	609.00
IUUC-Hsa-045665	Homo sapiens	97.13	7.00e-177	613.00
IUUC-Itr-049045	Ictidomys tridecemlineatus	96.79	1.00e-175	608.00
IUUC-Lch-049714	Latimeria chalumnae	85.28	4.00e-162	563.00
IUUC-Loc-052161	Lepisosteus oculatus	82.26	5.00e-144	503.00
IUUC-Laf-054108	Loxodonta africana	94.97	4.00e-173	600.00
IUUC-Mcc-055562	Macaca mulatta	97.13	8.00e-177	613.00
IUUC-Meu-056709	Macropus eugenii	95.09	2.00e-168	584.00
IUUC-Mtr-058158	Medicago truncatula	43.42	4.00e-10	57.40
IUUC-Mga-060104	Meleagris gallopavo	89.56	3.00e-117	414.00
IUUC-Mmr-061191	Microcebus murinus	97.13	6.00e-177	613.00
IUUC-Mdo-062711	Monodelphis domestica	91.01	2.00e-149	521.00
IUUC-Mpu-066466	Mustela putorius furo	96.63	2.00e-166	578.00
IUUC-Mlu-067622	Myotis lucifugus	97.13	8.00e-176	609.00
IUUC-Nle-069253	Nomascus leucogenys	97.13	8.00e-177	613.00
IUUC-Opr-070511	Ochotona princeps	97.13	1.00e-174	605.00
IUUC-Ont-072177	Oreochromis niloticus	84.50	3.00e-130	457.00
IUUC-Oan-073336	Ornithorhynchus anatinus	94.79	2.00e-166	578.00
IUUC-Ocu-074113	Oryctolagus cuniculus	95.86	1.00e-166	578.00
IUUC-Oni-082398	Oryza nivara	42.25	1.00e-11	65.10
IUUC-Ola-087057	Oryzias latipes	84.71	8.00e-123	433.00
IUUC-Oga-088346	Otolemur garnettii	97.13	7.00e-176	609.00
IUUC-Oar-089843	Ovis aries	96.01	5.00e-166	576.00
IUUC-Ptr-090486	Pan troglodytes	97.13	7.00e-176	609.00
IUUC-Pan-092667	Papio anubis	97.72	9.00e-156	543.00
IUUC-Psi-093469	Pelodiscus sinensis	93.56	1.00e-168	585.00
IUUC-Pma-094481	Petromyzon marinus	73.11	2.00e-89	321.00
IUUC-Ppa-095526	Physcomitrella patens	41.38	1.00e-09	58.50
IUUC-Pfo-097156	Poecilia formosa	70.42	2.00e-132	465.00
IUUC-Pab-097670	Pongo abelii	97.13	7.00e-176	609.00
IUUC-Pop-099100	Populus trichocarpa	37.65	2.00e-12	67.40
IUUC-Pva-102800	Pteropus vampyrus	97.13	7.00e-176	609.00
IUUC-Rno-105128	Rattus norvegicus	95.83	7.00e-173	599.00
IUUC-Sha-106747	Sarcophilus harrisii	94.48	1.00e-159	555.00
IUUC-Sar-113416	Sorex araneus	96.82	7.00e-175	605.00
IUUC-Ssc-115864	Sus scrofa	97.45	4.00e-176	610.00
IUUC-Tgu-116851	Taeniopygia guttata	92.01	1.00e-133	469.00
IUUC-Tru-117698	Takifugu rubripes	85.37	5.00e-126	443.00
IUUC-Tsy-119590	Tarsius syrichta	97.13	9.00e-176	608.00
IUUC-Tni-120170	Tetraodon nigroviridis	84.11	4.00e-129	454.00
IUUC-Tae-123760	Triticum aestivum	37.21	6.00e-12	65.90
IUUC-Tur-126396	Triticum urartu	37.21	6.00e-12	65.50
IUUC-Tbe-127790	Tupaia belangeri	96.82	2.00e-175	608.00
IUUC-Ttr-129316	Tursiops truncatus	96.32	3.00e-175	607.00
IUUC-Vpa-130669	Vicugna pacos	96.63	8.00e-167	579.00
IUUC-Xtr-131912	Xenopus tropicalis	85.02	4.00e-145	507.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence