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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046103
Ensembl Protein ID ENSP00000479193.1
UniProt Accession Q9P203; A8K5V7; Q69Z05; Q7Z308; Q86TS0; Q9HAA4; Q9NVM0; BTBD7_HUMAN
Genbank Protein ID BAA96049.2; BAA91730.1; BAB13946.1; BAF84111.1; AAH47071.1; CAH10736.1; CAD66569.1
Protein Name BTB/POZ domain-containing protein 7
Genbank Nucleotide ID AB040958; AK001510; AK021953; AK291422; AL122023; AL049394; BX248762
Gene Name BTBD7; KIAA1525
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000277222.4 ENST00000620259.2 ENSP00000478856.2
ENSG00000277222.4 ENST00000613725.4 ENSP00000479193.1
ENSG00000277222.4 ENST00000627779.2 ENSP00000486274.1
ENSG00000277222.4 ENST00000628944.1 ENSP00000486038.1
ENSG00000277222.4 ENST00000613511.3 ENSP00000481899.1
ENSG00000277222.4 ENST00000625801.1 ENSP00000486521.1
Annotation
Cancer Mutation
TCGACOSMICCGAPIntOGen
mRNA Expression
TCGAICGCCOSMICTHPA
HPM
DNA & RNA Element
UTRdbcircRNADbCircNetRepTar
SomamiRmiRcodeRAID2
Protein-protein Interaction
Mentha
Disease-associated Variation
GWASdb
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDUniProtmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB 1.80e-19 71.5 142 208
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_Other: BTB
   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikd..vqpevfrallkFlYtgkld 66
           +Dv l+ +++ f++h+++Laa++++F+ l+++  e +  +  ++i+   ++   f+all++lYtg++ 
   Q: 142  TDVDLIFQETCFPVHRAILAARCPFFKTLLSSSPEYGA-EIIMDINTagIDMPMFSALLHYLYTGEFG 208
           79****************************99888876.7888888346****************975 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Acts as a mediator of epithelial dynamics and organ branching by promoting cleft progression. Induced following accumulation of fibronectin in forming clefts, leading to local expression of the cell-scattering SNAIL2 and suppression of E-cadherin levels, thereby altering cell morphology and reducing cell-cell adhesion. This stimulates cell separation at the base of forming clefts by local, dynamic intercellular gap formation and promotes cleft progression (By similarity).
 Acts as a mediator of epithelial dynamics and organ branching by promoting cleft progression. Induced following accumulation of fibronectin in forming clefts, leading to local expression of the cell-scattering SNAIL2 and suppression of E-cadherin levels, thereby altering cell morphology and reducing cell-cell adhesion. This stimulates cell separation at the base of forming clefts by local, dynamic intercellular gap formation and promotes cleft progression (By similarity).
Protein Sequence
(Fasta)
MGANASNYPH SCSPRVGGNS QAQQTFIGTS SYSQQGYGCE SKLYSLDHGH EKPQDKKKRT 60
SGLATLKKKF IKRRKSNRSA DHAKQMRELL SGWDVRDVNA LVEEYEGTSA LKELSLQASL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046103|E3,BTB_Other|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGCCGGCTCC GCAGCGCCGC GCAGGCGCCC CAGGGCCACG CCGAACCGAG CCCCTCCTGC 60
TCCGTCTAGG AGTCAAAATG GCGGCGAGGG GAACCTGGAG CAGTCCCGGA GCCTGAGCCA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046103|E3,BTB_Other|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0449--Lipoprotein
KW-0519--Myristate
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
Interpro

IPR011705--BACK
IPR000210--BTB/POZ_dom
IPR011333--SKP1/BTB/POZ
PROSITE

PS50097--BTB
Pfam

PF07707--BACK
PF00651--BTB
SMART

SM00875--BACK
SM00225--BTB
Gene Ontology

GO:0005634--C:nucleus
GO:0007275--P:multicellular organism development
GO:0060693--P:regulation of branching involved in salivary gland morphogenesis
KEGG hsa:55727
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001669 Ailuropoda melanoleuca 95.41 0.00e+00 2080.00
IUUC-Apl-004146 Anas platyrhynchos 89.31 0.00e+00 2027.00
IUUC-Aca-004531 Anolis carolinensis 86.04 0.00e+00 1859.00
IUUC-Ame-011888 Astyanax mexicanus 66.38 0.00e+00 1349.00
IUUC-Bta-012739 Bos taurus 95.32 0.00e+00 2115.00
IUUC-Cja-019090 Callithrix jacchus 96.91 0.00e+00 2170.00
IUUC-Cfa-021272 Canis familiaris 95.76 0.00e+00 2090.00
IUUC-Cpo-021381 Cavia porcellus 91.53 0.00e+00 2065.00
IUUC-Csa-023734 Chlorocebus sabaeus 98.02 0.00e+00 2079.00
IUUC-Cho-024830 Choloepus hoffmanni 80.06 1.00e-152 534.00
IUUC-Dre-027552 Danio rerio 66.95 0.00e+00 1403.00
IUUC-Dno-028927 Dasypus novemcinctus 94.79 0.00e+00 2118.00
IUUC-Dor-030455 Dipodomys ordii 88.55 0.00e+00 1144.00
IUUC-Dme-031575 Drosophila melanogaster 46.09 9.00e-156 544.00
IUUC-Ete-032546 Echinops telfairi 82.60 0.00e+00 1712.00
IUUC-Eca-033548 Equus caballus 94.09 0.00e+00 2042.00
IUUC-Fca-036539 Felis catus 95.85 0.00e+00 2113.00
IUUC-Fal-037224 Ficedula albicollis 85.98 0.00e+00 2001.00
IUUC-Gmo-039413 Gadus morhua 81.38 0.00e+00 653.00
IUUC-Gga-040778 Gallus gallus 94.07 0.00e+00 741.00
IUUC-Gac-041839 Gasterosteus aculeatus 65.01 0.00e+00 1402.00
IUUC-Ggo-045450 Gorilla gorilla 99.65 0.00e+00 2185.00
IUUC-Itr-048595 Ictidomys tridecemlineatus 99.22 0.00e+00 809.00
IUUC-Lch-050622 Latimeria chalumnae 81.63 0.00e+00 1814.00
IUUC-Loc-052889 Lepisosteus oculatus 74.57 0.00e+00 1581.00
IUUC-Laf-053392 Loxodonta africana 94.52 0.00e+00 2084.00
IUUC-Mcc-055838 Macaca mulatta 98.15 0.00e+00 2133.00
IUUC-Meu-056638 Macropus eugenii 79.44 0.00e+00 1517.00
IUUC-Mtr-058684 Medicago truncatula 30.43 2.00e-05 43.90
IUUC-Mga-059339 Meleagris gallopavo 88.26 0.00e+00 2007.00
IUUC-Mmr-061046 Microcebus murinus 96.47 0.00e+00 2137.00
IUUC-Mdo-062182 Monodelphis domestica 93.02 0.00e+00 1615.00
IUUC-Mmu-064311 Mus musculus 93.12 0.00e+00 1964.00
IUUC-Mpu-066893 Mustela putorius furo 95.14 0.00e+00 2108.00
IUUC-Mlu-067087 Myotis lucifugus 95.32 0.00e+00 2082.00
IUUC-Nle-069780 Nomascus leucogenys 98.68 0.00e+00 2134.00
IUUC-Opr-070487 Ochotona princeps 88.61 0.00e+00 1029.00
IUUC-Ont-071582 Oreochromis niloticus 65.75 0.00e+00 1408.00
IUUC-Oan-072900 Ornithorhynchus anatinus 89.41 0.00e+00 1947.00
IUUC-Ocu-073746 Oryctolagus cuniculus 94.42 0.00e+00 1765.00
IUUC-Ola-086582 Oryzias latipes 64.77 0.00e+00 1390.00
IUUC-Oga-088013 Otolemur garnettii 95.94 0.00e+00 2106.00
IUUC-Oar-089234 Ovis aries 94.17 0.00e+00 2071.00
IUUC-Ptr-091490 Pan troglodytes 99.56 0.00e+00 2171.00
IUUC-Pan-092592 Papio anubis 98.15 0.00e+00 2133.00
IUUC-Psi-093163 Pelodiscus sinensis 89.23 0.00e+00 1942.00
IUUC-Pma-094133 Petromyzon marinus 55.01 3.00e-85 308.00
IUUC-Pfo-096674 Poecilia formosa 64.80 0.00e+00 1393.00
IUUC-Pab-098305 Pongo abelii 98.59 0.00e+00 2174.00
IUUC-Pva-102998 Pteropus vampyrus 94.79 0.00e+00 2131.00
IUUC-Rno-105445 Rattus norvegicus 94.35 0.00e+00 2011.00
IUUC-Sha-106737 Sarcophilus harrisii 90.64 0.00e+00 1950.00
IUUC-Sar-113474 Sorex araneus 97.77 0.00e+00 1192.00
IUUC-Ssc-116111 Sus scrofa 95.58 0.00e+00 2125.00
IUUC-Tgu-117204 Taeniopygia guttata 88.60 0.00e+00 1996.00
IUUC-Tru-118753 Takifugu rubripes 65.35 0.00e+00 1402.00
IUUC-Tsy-119632 Tarsius syrichta 94.36 0.00e+00 2057.00
IUUC-Tni-120088 Tetraodon nigroviridis 65.22 0.00e+00 1396.00
IUUC-Tbe-127435 Tupaia belangeri 96.27 0.00e+00 1352.00
IUUC-Ttr-128912 Tursiops truncatus 89.93 0.00e+00 1938.00
IUUC-Vpa-130654 Vicugna pacos 99.00 0.00e+00 1367.00
IUUC-Xtr-132530 Xenopus tropicalis 83.05 0.00e+00 1880.00
Created Date 25-Jun-2017

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