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Tag Content
UUCD2 ID IUUC-Dre-028639
UUCD1 version UUC-DaR-01448
Ensembl Protein ID ENSDARP00000014516.7
UniProt Accession A5PMR2; Q6NYK6; UBP33_DANRE
Genbank Protein ID CAN88027.1; AAH66557.1
Protein Name Ubiquitin carboxyl-terminal hydrolase 33; Deubiquitinating enzyme 33; Ubiquitin thioesterase 33; Ubiquitin-specific-processing protease 33
Genbank Nucleotide ID BX649634; BC066557
Gene Name usp33; ch211-284g18.1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSDARG00000016163.9 ENSDART00000018114.8 ENSDARP00000014516.7
ENSDARG00000016163.9 ENSDART00000133037.1 ENSDARP00000118654.1
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/USP 1.40e-112 377.1 156 669
Active Site
Position(s) Description Evidence
165 Nucleophile ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
628 Proton acceptor ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
Domain Profile

   DUB/USP
   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefsgye 88
           tGlkN+gNtCYmN++LQ+Lsn+p+l++++le     +    ++++k +l+ks+qkl++ lw k+++ +v p++l++ +k+++++f+gy+
   Q: 156  TGLKNIGNTCYMNAALQALSNCPPLTQFFLE-----CGGLVKTDKKPALCKSYQKLITDLWhKNRNAYVVPTNLFQGIKAVNPMFRGYS 239
           7******************************.....9999999******************999999********************** PP
   S: 89   qqDaqEflaflldqleeelkk........eknkpkeeeeeedkselsde........................................ 129
           qqD+qEfl++l+dql+eelk+        ++    +++ +ed+ ++sd+                                        
   Q: 240  QQDSQEFLRCLMDQLHEELKElipepedpNQAVAMDDSPDEDNHSQSDDfqscescgssdradnegprvpedineaemlmpeqnqnnrd 328
           *******************998877766544444444444444444444899999999999**************************** PP
   S: 130  ......................................................................................... 129
                                                                                                    
   Q: 329  wqkeknlinnlyragshgdldkdvdttsdsrpiissqgaikaqgrtsdseiqvsstvrpqsptgnegitsrlsssppkssawpnlssth 417
           ***************************************************************************************** PP
   S: 130  ........aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke......................... 185
                    + k ++k++s+is++F+g++ s+++cl+cd+vs++ e+f+d+slp+pgke+ +k+                         
   Q: 418  kkvpmftpTKTKRQRKYHSIISEVFDGTIVSSVQCLTCDRVSVTLENFQDISLPIPGKEDLAKLhssshqtalvkagscgeayapqgwi 506
           ********9999***********************************************99888************************* PP
   S: 186  ................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefple 258
                           +lqdcL++f++++el+g+n+y+cekckk+++ +k +k+++lPe+L++hLkRf  ++e ++++ki ++v+fple
   Q: 507  afvmeyikswfwgpvvTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQSLPEILCIHLKRF--RHELMFSTKIGTHVSFPLE 593
           ********************************************************************..9999*************** PP
   S: 259  .LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYkr 337
            L+++pf+++++++   +++Y+L++v++H+G++ssGHY+ay++ne ++ W++fdD++Vtev+e+ v++   ++aYvlfYk+
   Q: 594  gLEMQPFLAKDSSAL--TTTYDLLSVICHHGTASSGHYIAYCRNELNQlWYEFDDQSVTEVSESCVQN---AEAYVLFYKK 669
           **********88888..9**************************99999*******************...********98 PP
   
Organism Danio rerio
Functional Description
(View)

Functional Description


     Deubiquitinating enzyme involved in various processes such as centrosome duplication, cellular migration and beta-2 adrenergic receptor/ADRB2 recycling. Involved in regulation of centrosome duplication by mediating deubiquitination of ccp110 in S and G2/M phase, leading to stabilize ccp110 during the period which centrioles duplicate and elongate. Involved in cell migration via its interaction with intracellular domain of robo1, leading to regulate the Slit signaling. Plays a role in commissural axon guidance cross the ventral midline of the neural tube in a Slit-dependent manner, possibly by mediating the deubiquitination of robo1. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination of beta-arrestins (arrb1 and arrb2) and beta-2 adrenergic receptor (adrb2). Deubiquitinates dio2, thereby regulating thyroid hormone regulation. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).
 Deubiquitinating enzyme involved in various processes such as centrosome duplication, cellular migration and beta-2 adrenergic receptor/ADRB2 recycling. Involved in regulation of centrosome duplication by mediating deubiquitination of ccp110 in S and G2/M phase, leading to stabilize ccp110 during the period which centrioles duplicate and elongate. Involved in cell migration via its interaction with intracellular domain of robo1, leading to regulate the Slit signaling. Plays a role in commissural axon guidance cross the ventral midline of the neural tube in a Slit-dependent manner, possibly by mediating the deubiquitination of robo1. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination of beta-arrestins (arrb1 and arrb2) and beta-2 adrenergic receptor (adrb2). Deubiquitinates dio2, thereby regulating thyroid hormone regulation. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).
Protein Sequence
(Fasta)
MSGVSSNDCP HLECVGEITK EELIQKSHGQ CQDCKVGGPN LWACLENGCS YVGCGESHAD 60
HSTVHSQETR HNLTVNLTTL RVWCYACTKE VFLERKLGPH KQLPNAAKAV SPVQTPCQDL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Dre-028639|DUB,USP|Danio rerio
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATTCACTTTC ATTCACAACC GGAAGAAGCA GTTTGAATGT GTCATACCAT GTAGCTCCAG 60
TTTGAAGTTG AAGTGTCTGG TACCAAGCGT TGGAAAAACC ACTGTCTGCA AACCGAGGAA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Dre-028639|DUB,USP|Danio rerio
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0254--Endocytosis
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0677--Repeat
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP
PROSITE

PS51283--DUSP
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP
Pfam

PF06337--DUSP
PF00443--UCH
PF02148--zf-UBP
SMART

SM00695--DUSP
SM00290--ZnF_UBP
Gene Ontology

GO:0005813--C:centrosome
GO:0048471--C:perinuclear region of cytoplasm
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0007411--P:axon guidance
GO:0016477--P:cell migration
GO:0051298--P:centrosome duplication
GO:0006897--P:endocytosis
GO:0016579--P:protein deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0008277--P:regulation of G-protein coupled receptor protein signaling pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG dre:406508
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001742 Ailuropoda melanoleuca 69.91 0.00e+00 1284.00
IUUC-Apl-003987 Anas platyrhynchos 70.39 0.00e+00 1252.00
IUUC-Aca-004713 Anolis carolinensis 68.53 0.00e+00 1248.00
IUUC-Bta-013132 Bos taurus 70.31 0.00e+00 1289.00
IUUC-Cja-018811 Callithrix jacchus 70.41 0.00e+00 1295.00
IUUC-Cfa-021158 Canis familiaris 70.35 0.00e+00 1286.00
IUUC-Cpo-021910 Cavia porcellus 64.99 0.00e+00 1145.00
IUUC-Csa-023130 Chlorocebus sabaeus 70.52 0.00e+00 1291.00
IUUC-Cho-024383 Choloepus hoffmanni 51.81 2.00e-106 380.00
IUUC-Csv-025889 Ciona savignyi 42.77 6.00e-36 143.00
IUUC-Dno-029416 Dasypus novemcinctus 70.63 0.00e+00 1264.00
IUUC-Dme-031837 Drosophila melanogaster 48.33 8.00e-131 461.00
IUUC-Ete-032994 Echinops telfairi 55.95 1.00e-159 557.00
IUUC-Eca-034248 Equus caballus 70.66 0.00e+00 1293.00
IUUC-Eeu-035357 Erinaceus europaeus 54.96 0.00e+00 887.00
IUUC-Fca-036013 Felis catus 68.67 0.00e+00 1239.00
IUUC-Fal-037509 Ficedula albicollis 70.72 0.00e+00 1280.00
IUUC-Gmo-038944 Gadus morhua 78.20 0.00e+00 1383.00
IUUC-Gga-040647 Gallus gallus 70.80 0.00e+00 1259.00
IUUC-Gac-041752 Gasterosteus aculeatus 80.31 0.00e+00 1472.00
IUUC-Hsa-045694 Homo sapiens 70.19 0.00e+00 1280.00
IUUC-Itr-049041 Ictidomys tridecemlineatus 70.94 0.00e+00 1286.00
IUUC-Lch-050400 Latimeria chalumnae 67.98 0.00e+00 1224.00
IUUC-Loc-052616 Lepisosteus oculatus 77.23 0.00e+00 1430.00
IUUC-Laf-053493 Loxodonta africana 70.50 0.00e+00 1287.00
IUUC-Mcc-055542 Macaca mulatta 70.52 0.00e+00 1292.00
IUUC-Meu-056645 Macropus eugenii 61.95 0.00e+00 1066.00
IUUC-Mga-060019 Meleagris gallopavo 70.17 0.00e+00 1056.00
IUUC-Mmr-061241 Microcebus murinus 67.99 0.00e+00 1252.00
IUUC-Mmu-063786 Mus musculus 69.82 0.00e+00 1260.00
IUUC-Mlu-067732 Myotis lucifugus 70.02 0.00e+00 1283.00
IUUC-Nle-069528 Nomascus leucogenys 70.22 0.00e+00 1293.00
IUUC-Opr-070606 Ochotona princeps 66.70 0.00e+00 1147.00
IUUC-Ont-071495 Oreochromis niloticus 81.60 0.00e+00 1478.00
IUUC-Ocu-074457 Oryctolagus cuniculus 68.70 0.00e+00 1282.00
IUUC-Ola-086739 Oryzias latipes 79.57 0.00e+00 1491.00
IUUC-Oga-088720 Otolemur garnettii 69.90 0.00e+00 1304.00
IUUC-Oar-089921 Ovis aries 70.20 0.00e+00 1290.00
IUUC-Ptr-090526 Pan troglodytes 70.30 0.00e+00 1283.00
IUUC-Pan-092396 Papio anubis 70.39 0.00e+00 1285.00
IUUC-Psi-092971 Pelodiscus sinensis 70.74 0.00e+00 1315.00
IUUC-Pfo-097415 Poecilia formosa 79.25 0.00e+00 1442.00
IUUC-Pab-098740 Pongo abelii 70.63 0.00e+00 1306.00
IUUC-Pca-100598 Procavia capensis 67.51 0.00e+00 714.00
IUUC-Pva-102820 Pteropus vampyrus 67.24 0.00e+00 1063.00
IUUC-Rno-104894 Rattus norvegicus 69.64 0.00e+00 1261.00
IUUC-Sha-107244 Sarcophilus harrisii 66.19 0.00e+00 1166.00
IUUC-Sar-113665 Sorex araneus 68.98 0.00e+00 1284.00
IUUC-Ssc-115793 Sus scrofa 70.41 0.00e+00 1262.00
IUUC-Tgu-117487 Taeniopygia guttata 71.25 0.00e+00 1239.00
IUUC-Tru-117694 Takifugu rubripes 76.75 0.00e+00 1462.00
IUUC-Tsy-119598 Tarsius syrichta 62.01 0.00e+00 1058.00
IUUC-Tni-120189 Tetraodon nigroviridis 74.73 0.00e+00 1388.00
IUUC-Tbe-128125 Tupaia belangeri 72.67 3.00e-77 283.00
IUUC-Ttr-128269 Tursiops truncatus 69.38 0.00e+00 1215.00
IUUC-Vpa-130598 Vicugna pacos 68.83 0.00e+00 1251.00
IUUC-Xtr-132044 Xenopus tropicalis 69.40 0.00e+00 1233.00
Created Date 25-Jun-2017

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