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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063550
Ensembl Protein ID ENSMUSP00000138320.1
UniProt Accession Q91X43; O08635; O35146; Q8C7I2; SH319_MOUSE
Genbank Protein ID BAA19686.2; AAH12633.1; AAH31117.1; AAB82091.1; BAC34114.1
Protein Name SH3 domain-containing protein 19; Kryn
Genbank Nucleotide ID D89677; AC133508; BC031117; AF003234; AK050185
Gene Name Sh3d19
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000028082.13 ENSMUST00000182666.7 ENSMUSP00000138320.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarRAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
UniProt
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 4.90e-59 197.3 732 786
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 4    ekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekl 62
           +kv++lyd+ ++n+deL++k+Gdv++ +  e  d  W++g  el g+ G+fP+n+v+ l
   Q: 732  RKVKALYDFLGENEDELSFKAGDVITEL--EPIDDAWMRG--ELMGRAGMFPKNYVQFL 786
           68************************99..8999******..9*************866 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     May play a role in regulating A disintegrin and metalloproteases (ADAMs) in the signaling of EGFR-ligand shedding. May be involved in suppression of Ras-induced cellular transformation and Ras-mediated activation of ELK1. Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity).
 May play a role in regulating A disintegrin and metalloproteases (ADAMs) in the signaling of EGFR-ligand shedding. May be involved in suppression of Ras-induced cellular transformation and Ras-mediated activation of ELK1. Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity).
Protein Sequence
(Fasta)
MNIMNTEQSQ NTIVSRIKAF EGQTNTEIPG LPKKPEIIPR TIPPKPAVSS GKPLVAPKPA 60
ANRASGEWDT WAENRLKVTS REGLTPYSSP QEAGITPVTK PELPKKPTPG LTRSVNHETS 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063550|UBD,SH3|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGGGAAGGGA ACCGGACGGG AAGCGAGCTG CCGAGGAGCT GCAGGCCGCC GGTGCGTGCC 60
CAGAAGGCGG GGAGCTCGGC CCAGCCCGCG CCCCAGCTCC GCGCTGCAGG TGGAGCCCTC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063550|UBD,SH3|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0728--SH3 domain
Interpro

IPR011511--SH3_2
IPR001452--SH3_domain
IPR028505--SH3D19
PROSITE

PS50002--SH3
Pfam

PF00018--SH3_1
PF07653--SH3_2
PF14604--SH3_9
PRINTS

PR00452--SH3DOMAIN
SMART

SM00326--SH3
Gene Ontology

GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0070064--F:proline-rich region binding
GO:0007010--P:cytoskeleton organization
GO:0051044--P:positive regulation of membrane protein ectodomain proteolysis
GO:0022604--P:regulation of cell morphogenesis
KEGG mmu:27059
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001834 Ailuropoda melanoleuca 78.45 0.00e+00 1152.00
IUUC-Apl-003344 Anas platyrhynchos 51.96 0.00e+00 728.00
IUUC-Aca-005221 Anolis carolinensis 53.59 0.00e+00 770.00
IUUC-Afu-008895 Aspergillus fumigatus 29.26 2.00e-16 81.60
IUUC-Ame-011778 Astyanax mexicanus 43.34 3.00e-75 276.00
IUUC-Bta-012502 Bos taurus 76.39 0.00e+00 1121.00
IUUC-Cel-018400 Caenorhabditis elegans 27.60 1.00e-26 114.00
IUUC-Cja-018838 Callithrix jacchus 76.84 0.00e+00 1199.00
IUUC-Cfa-020664 Canis familiaris 78.23 0.00e+00 1146.00
IUUC-Cpo-021287 Cavia porcellus 77.90 0.00e+00 1080.00
IUUC-Csa-024210 Chlorocebus sabaeus 77.72 0.00e+00 1198.00
IUUC-Cho-024868 Choloepus hoffmanni 75.25 0.00e+00 1051.00
IUUC-Cgl-026571 Colletotrichum gloeosporioides 27.54 8.00e-12 65.90
IUUC-Dre-027868 Danio rerio 39.62 6.00e-82 299.00
IUUC-Dno-029133 Dasypus novemcinctus 75.73 0.00e+00 1048.00
IUUC-Dor-030741 Dipodomys ordii 71.28 0.00e+00 948.00
IUUC-Ete-032584 Echinops telfairi 59.94 6.00e-88 318.00
IUUC-Eca-033653 Equus caballus 78.78 0.00e+00 1177.00
IUUC-Eeu-035309 Erinaceus europaeus 56.16 2.00e-153 536.00
IUUC-Fca-036080 Felis catus 77.08 0.00e+00 1165.00
IUUC-Fal-037649 Ficedula albicollis 54.74 0.00e+00 735.00
IUUC-Fso-038435 Fusarium solani 30.07 5.00e-13 70.10
IUUC-Gmo-038989 Gadus morhua 40.07 6.00e-61 229.00
IUUC-Ggr-039882 Gaeumannomyces graminis 24.83 3.00e-11 64.30
IUUC-Gga-040572 Gallus gallus 54.55 0.00e+00 719.00
IUUC-Gac-041335 Gasterosteus aculeatus 37.55 4.00e-76 280.00
IUUC-Ggo-044910 Gorilla gorilla 78.00 0.00e+00 1200.00
IUUC-Hsa-046590 Homo sapiens 75.70 0.00e+00 1153.00
IUUC-Itr-047880 Ictidomys tridecemlineatus 79.37 0.00e+00 1134.00
IUUC-Lch-050177 Latimeria chalumnae 55.59 5.00e-90 323.00
IUUC-Loc-051874 Lepisosteus oculatus 36.80 5.00e-116 412.00
IUUC-Laf-053588 Loxodonta africana 74.84 0.00e+00 1090.00
IUUC-Mcc-055832 Macaca mulatta 75.19 0.00e+00 1168.00
IUUC-Meu-056226 Macropus eugenii 58.13 0.00e+00 776.00
IUUC-Mga-059651 Meleagris gallopavo 54.29 0.00e+00 722.00
IUUC-Mmr-061243 Microcebus murinus 74.81 0.00e+00 1132.00
IUUC-Mdo-061881 Monodelphis domestica 62.25 0.00e+00 907.00
IUUC-Mpu-066280 Mustela putorius furo 75.85 0.00e+00 1124.00
IUUC-Mlu-067585 Myotis lucifugus 74.27 0.00e+00 1125.00
IUUC-Nfi-068448 Neosartorya fischeri 27.32 9.00e-17 82.40
IUUC-Ncr-068730 Neurospora crassa 25.47 2.00e-14 75.10
IUUC-Nle-069589 Nomascus leucogenys 75.57 0.00e+00 1162.00
IUUC-Opr-070223 Ochotona princeps 71.04 0.00e+00 850.00
IUUC-Ont-071560 Oreochromis niloticus 41.84 8.00e-70 258.00
IUUC-Oan-073575 Ornithorhynchus anatinus 65.01 2.00e-166 578.00
IUUC-Ocu-074487 Oryctolagus cuniculus 78.00 0.00e+00 1191.00
IUUC-Ola-086641 Oryzias latipes 37.86 1.00e-84 308.00
IUUC-Oga-088091 Otolemur garnettii 75.65 0.00e+00 942.00
IUUC-Oar-090100 Ovis aries 77.02 0.00e+00 1126.00
IUUC-Ptr-090777 Pan troglodytes 77.72 0.00e+00 1199.00
IUUC-Pan-092179 Papio anubis 78.11 0.00e+00 885.00
IUUC-Psi-093919 Pelodiscus sinensis 61.87 2.00e-148 518.00
IUUC-Pma-094188 Petromyzon marinus 39.92 5.00e-29 120.00
IUUC-Pno-095096 Phaeosphaeria nodorum 27.67 2.00e-14 74.70
IUUC-Pfo-097487 Poecilia formosa 36.69 1.00e-79 291.00
IUUC-Pab-098395 Pongo abelii 79.46 0.00e+00 909.00
IUUC-Pca-100188 Procavia capensis 65.10 8.00e-90 325.00
IUUC-Pva-102375 Pteropus vampyrus 62.56 0.00e+00 862.00
IUUC-Pte-104156 Pyrenophora teres 29.58 1.00e-13 72.40
IUUC-Pyt-104742 Pyrenophora triticirepentis 28.37 1.00e-13 72.00
IUUC-Rno-105575 Rattus norvegicus 92.02 0.00e+00 1343.00
IUUC-Sce-106337 Saccharomyces cerevisiae 49.23 2.00e-13 69.70
IUUC-Sha-107633 Sarcophilus harrisii 62.50 0.00e+00 892.00
IUUC-Sar-113090 Sorex araneus 71.52 1.00e-119 423.00
IUUC-Ssc-116331 Sus scrofa 75.25 0.00e+00 1081.00
IUUC-Tgu-117385 Taeniopygia guttata 53.58 0.00e+00 725.00
IUUC-Tru-117836 Takifugu rubripes 40.24 2.00e-67 250.00
IUUC-Tsy-119158 Tarsius syrichta 71.98 7.00e-63 235.00
IUUC-Tni-119957 Tetraodon nigroviridis 41.21 1.00e-70 261.00
IUUC-Tme-127196 Tuber melanosporum 27.86 6.00e-15 76.30
IUUC-Tbe-127514 Tupaia belangeri 67.69 0.00e+00 853.00
IUUC-Ttr-128684 Tursiops truncatus 73.57 0.00e+00 1052.00
IUUC-Vpa-130409 Vicugna pacos 80.41 0.00e+00 960.00
IUUC-Xtr-131817 Xenopus tropicalis 43.17 1.00e-139 491.00
IUUC-Xma-133529 Xiphophorus maculatus 38.96 1.00e-75 277.00
Created Date 25-Jun-2017

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