iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Laf-053732

UUCD1 version

UUC-LoA-01091

Ensembl Protein ID

ENSLAFP00000022541.1

UniProt Accession

G3U3Y3; G3U3Y3_LOXAF

Protein Name

Ubiquitin carboxyl-terminal hydrolase 16; Deubiquitinating enzyme 16; Ubiquitin thioesterase 16; Ubiquitin-specific-processing protease 16

Gene Name

USP16

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000002380.3	ENSLAFT00000029036.1	ENSLAFP00000022541.1
ENSLAFG00000002380.3	ENSLAFT00000002380.3	ENSLAFP00000001992.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	9.30e-95	318.0	198	827

Active Site

Position(s)	Description	Evidence
207	Nucleophile	ECO:0000256\|HAMAP-Rule:MF_03062}
763	Proton acceptor	ECO:0000256\|HAMAP-Rule:MF_03062}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.............kkkeklneenp.........kepkgellkslqklfeelwkskkka 67
           +Gl+NlgNtC++N+v+Q Ls++p lrell+e                                  ep g+l+ +l ++++e++++kk+ 
   Q: 198  KGLSNLGNTCFFNAVMQNLSQTPVLRELLKEvkmsgtivkieppD---------LalteplevnLEPPGPLTLALSQFLNEMQETKKGI 277
           5******************************86666666654441.........04444455558899********************* PP
   S: 68   vsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlk 151
           v+p+el+++++k+a++f+gy+qqD+qE+l++lld+++ e +++ +k + +++++++++l++e     ++++kkk+ +s+++++F+g+l+
   Q: 278  VTPKELFSQVCKKAVRFKGYQQQDSQELLRYLLDGMRAEEHQRVSKGILKAFGNSTEKLDEElknkvKDYEKKKSIPSFVDRIFGGELT 366
           *************************************************************99999999999***************** PP
   S: 152  sqikclecdnvssreepfldlslpvpgkeetkke....................................................... 185
           s+i+c ec++vs  +e+fldlslpv ++++ kk+                                                       
   Q: 367  STIMCDECRTVSLVHESFLDLSLPVLDDQSGKKSindknlkktmegedkdseeekdndsyikerndissgtskhlqkkakkqakkqakn 455
           *****************************99999******************************************************* PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 456  qrrqqkiqgkvlllsgirtidnpednecdaevslqgelgvksshvseedvidkensvsqkdlngqekvienvtdsqnsteevdvenvhg 544
           ***************************************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 545  dnvlealassptectenlngiylkegsdgevdissgfknlnlnaalqpeeinieilndshtagtkiyevvnedpetafctlanreafnt 633
           ***************************************************************************************** PP
   S: 186  ...slqdcLesftkeeelegenkyycekckkkqe.................aekklklkklPevLilhLkRfsfseeqksrekinkkve 254
              s+++cL +ft++e+l+++nk+ ce c ++q                  a+k++ ++  P+vL+lhLkRf  ++++ + +kink+++
   Q: 634  yecSIEHCLYQFTRNEKLRDANKLLCEVCSRRQYngpkanikgerkhvytnAKKQMLISLAPPVLTLHLKRF--QQAGFNLRKINKHIK 720
           ******************************777788888888888888888*********************..9999*********** PP
   S: 255  fpleLdlspfctspeekqke...kkkYeLiavvvHsGslssGHYvayvkn........................ekgkWllfdDskVte 316
           fp+ Ldl+pfct ++++++e   ++ Y+L++vv HsG+++sGHY+ay+k                         +kg+W++++D++V++
   Q: 721  FPEILDLAPFCTLKCKNVAEentRVLYSLYGVVEHSGTMRSGHYTAYAKArtanshlsnlvlhgdipqdfemesTKGQWFHISDTHVQA 809
           *************9999887777999************************9999999999999999999999888999*********** PP
   S: 317  vkeeevleetgstaYvlfYkr 337
           v+ ++vl+   s+aY+lfY+r
   Q: 810  VPTTKVLS---SQAYLLFYER 827
           ********...********98 PP

Organism

Loxodonta africana

Functional Description
(View)

Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.

Protein Sequence
(Fasta)

MGKKRTKGKT VPIDDSSESL EPMCRHLRKG LEQSNLKKAL VNVEWNICQD CKTDNKVKDK 60
SEEEAEENPS VWLCLKCGHQ GCGRDSQEQH ALKHYLTPRS EPHCLVLNLD TWSVWCYMCD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGAAAGA AACGGACAAA GGGAAAAACT GTTCCAATTG ATGATTCTTC TGAATCTTTA 60
GGTATGTTTC ACTAATTAAA TATTTAATGT TTGTATCCCT AATGGATGTG TATATTTTAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0010--Activator
KW-0131--Cell cycle
KW-0132--Cell division
KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0498--Mitosis
KW-0539--Nucleus
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR030849--UBP16
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0005634--C:nucleus
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0003713--F:transcription coactivator activity
GO:0008270--F:zinc ion binding
GO:0051301--P:cell division
GO:0006974--P:cellular response to DNA damage stimulus
GO:0070537--P:histone H2A K63-linked deubiquitination
GO:0007067--P:mitotic nuclear division
GO:0035522--P:monoubiquitinated histone H2A deubiquitination
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0045901--P:positive regulation of translational elongation
GO:0051289--P:protein homotetramerization
GO:0051726--P:regulation of cell cycle
GO:0006351--P:transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000997	Aegilops tauschii	29.80	2.00e-29	124.00
IUUC-Aml-001931	Ailuropoda melanoleuca	86.97	0.00e+00	1365.00
IUUC-Atr-003015	Amborella trichopoda	31.30	8.00e-36	145.00
IUUC-Apl-004145	Anas platyrhynchos	60.24	0.00e+00	868.00
IUUC-Aca-004314	Anolis carolinensis	57.86	0.00e+00	877.00
IUUC-Ame-011659	Astyanax mexicanus	58.48	1.00e-67	251.00
IUUC-Bta-013362	Bos taurus	85.65	0.00e+00	1367.00
IUUC-Bdi-014465	Brachypodium distachyon	30.91	3.00e-28	120.00
IUUC-Bol-015941	Brassica oleracea	29.26	1.00e-31	132.00
IUUC-Bra-016751	Brassica rapa	28.61	1.00e-29	125.00
IUUC-Cja-019177	Callithrix jacchus	87.09	0.00e+00	1409.00
IUUC-Cfa-020051	Canis familiaris	86.85	0.00e+00	1381.00
IUUC-Cpo-021886	Cavia porcellus	79.00	0.00e+00	1263.00
IUUC-Csa-024103	Chlorocebus sabaeus	86.85	0.00e+00	1408.00
IUUC-Cho-024315	Choloepus hoffmanni	79.86	1.00e-132	467.00
IUUC-Cin-025775	Ciona intestinalis	49.65	9.00e-40	155.00
IUUC-Csv-026075	Ciona savignyi	50.95	2.00e-58	219.00
IUUC-Dre-028388	Danio rerio	45.38	0.00e+00	647.00
IUUC-Dno-029409	Dasypus novemcinctus	85.40	0.00e+00	1366.00
IUUC-Dor-030443	Dipodomys ordii	72.06	1.00e-176	613.00
IUUC-Ete-032807	Echinops telfairi	79.33	0.00e+00	637.00
IUUC-Eca-033479	Equus caballus	86.25	0.00e+00	1407.00
IUUC-Eeu-034835	Erinaceus europaeus	81.11	0.00e+00	636.00
IUUC-Fca-036320	Felis catus	87.58	0.00e+00	1422.00
IUUC-Fal-037029	Ficedula albicollis	57.99	0.00e+00	844.00
IUUC-Gmo-039480	Gadus morhua	50.86	2.00e-111	396.00
IUUC-Gga-040527	Gallus gallus	61.31	0.00e+00	886.00
IUUC-Gac-042343	Gasterosteus aculeatus	45.45	0.00e+00	631.00
IUUC-Gma-044402	Glycine max	29.31	5.00e-33	136.00
IUUC-Ggo-045598	Gorilla gorilla	86.37	0.00e+00	1396.00
IUUC-Hsa-046598	Homo sapiens	86.01	0.00e+00	1385.00
IUUC-Hvu-047146	Hordeum vulgare	28.88	6.00e-29	123.00
IUUC-Itr-047951	Ictidomys tridecemlineatus	86.13	0.00e+00	1390.00
IUUC-Lch-050536	Latimeria chalumnae	52.03	0.00e+00	755.00
IUUC-Lpe-050703	Leersia perrieri	28.83	1.00e-28	122.00
IUUC-Loc-051814	Lepisosteus oculatus	51.53	0.00e+00	710.00
IUUC-Mcc-054661	Macaca mulatta	87.21	0.00e+00	1410.00
IUUC-Meu-055967	Macropus eugenii	69.91	6.00e-146	511.00
IUUC-Mtr-057945	Medicago truncatula	31.52	3.00e-34	140.00
IUUC-Mga-059551	Meleagris gallopavo	61.66	0.00e+00	897.00
IUUC-Mvi-060391	Microbotryum violaceum	32.65	2.00e-19	91.30
IUUC-Mmr-061747	Microcebus murinus	86.90	0.00e+00	1383.00
IUUC-Mdo-062220	Monodelphis domestica	65.42	0.00e+00	990.00
IUUC-Mmu-063582	Mus musculus	78.10	0.00e+00	1215.00
IUUC-Mpu-066339	Mustela putorius furo	86.49	0.00e+00	1403.00
IUUC-Mlu-067511	Myotis lucifugus	81.54	0.00e+00	1290.00
IUUC-Nle-069252	Nomascus leucogenys	86.97	0.00e+00	1407.00
IUUC-Opr-070969	Ochotona princeps	82.53	0.00e+00	1281.00
IUUC-Ont-071786	Oreochromis niloticus	48.82	2.00e-112	400.00
IUUC-Ocu-074704	Oryctolagus cuniculus	86.31	0.00e+00	1365.00
IUUC-Oba-075094	Oryza barthii	30.91	3.00e-30	127.00
IUUC-Obr-076743	Oryza brachyantha	30.98	2.00e-30	127.00
IUUC-Ogl-077739	Oryza glaberrima	30.91	2.00e-30	127.00
IUUC-Ogu-078851	Oryza glumaepatula	30.91	3.00e-30	127.00
IUUC-Oin-079402	Oryza indica	30.91	3.00e-30	127.00
IUUC-Olo-080431	Oryza longistaminata	30.91	3.00e-30	127.00
IUUC-Ome-081580	Oryza meridionalis	30.91	3.00e-30	127.00
IUUC-Oni-082644	Oryza nivara	30.91	3.00e-30	127.00
IUUC-Opu-083452	Oryza punctata	30.06	9.00e-30	125.00
IUUC-Oru-084546	Oryza rufipogon	30.91	3.00e-30	127.00
IUUC-Osa-085858	Oryza sativa	30.91	3.00e-30	127.00
IUUC-Ola-086795	Oryzias latipes	48.54	1.00e-110	394.00
IUUC-Oga-088713	Otolemur garnettii	85.16	0.00e+00	1375.00
IUUC-Oar-089887	Ovis aries	86.25	0.00e+00	1377.00
IUUC-Ptr-091670	Pan troglodytes	86.49	0.00e+00	1399.00
IUUC-Pan-092293	Papio anubis	87.21	0.00e+00	1410.00
IUUC-Psi-093101	Pelodiscus sinensis	63.37	0.00e+00	912.00
IUUC-Ppa-095622	Physcomitrella patens	30.51	6.00e-35	143.00
IUUC-Pfo-097202	Poecilia formosa	48.07	6.00e-114	405.00
IUUC-Pab-098773	Pongo abelii	89.15	0.00e+00	1099.00
IUUC-Pop-099136	Populus trichocarpa	29.90	1.00e-39	158.00
IUUC-Pca-101069	Procavia capensis	75.12	0.00e+00	920.00
IUUC-Ppe-101794	Prunus persica	30.45	1.00e-35	145.00
IUUC-Pva-103092	Pteropus vampyrus	83.47	0.00e+00	655.00
IUUC-Rno-105237	Rattus norvegicus	77.86	0.00e+00	1215.00
IUUC-Sha-106889	Sarcophilus harrisii	70.67	0.00e+00	1063.00
IUUC-Spo-108149	Schizosaccharomyces pombe	35.71	1.00e-19	92.00
IUUC-Ssl-108648	Sclerotinia sclerotiorum	28.32	1.00e-11	65.10
IUUC-Sit-110283	Setaria italica	32.08	3.00e-30	127.00
IUUC-Sly-111487	Solanum lycopersicum	29.46	1.00e-37	152.00
IUUC-Stu-112820	Solanum tuberosum	28.61	2.00e-36	147.00
IUUC-Sar-113530	Sorex araneus	80.00	0.00e+00	1286.00
IUUC-Sbi-113785	Sorghum bicolor	38.71	1.00e-24	108.00
IUUC-Ssc-116091	Sus scrofa	86.40	0.00e+00	1366.00
IUUC-Tgu-117478	Taeniopygia guttata	57.59	0.00e+00	825.00
IUUC-Tru-118640	Takifugu rubripes	50.93	2.00e-114	406.00
IUUC-Tsy-119042	Tarsius syrichta	71.49	0.00e+00	875.00
IUUC-Tni-120015	Tetraodon nigroviridis	45.45	3.00e-177	615.00
IUUC-Tca-121701	Theobroma cacao	28.79	3.00e-37	150.00
IUUC-Tae-125785	Triticum aestivum	29.48	4.00e-27	117.00
IUUC-Tur-126788	Triticum urartu	29.18	7.00e-27	115.00
IUUC-Tbe-127309	Tupaia belangeri	73.64	0.00e+00	1089.00
IUUC-Ttr-128271	Tursiops truncatus	86.13	0.00e+00	1392.00
IUUC-Vpa-130674	Vicugna pacos	86.01	0.00e+00	1283.00
IUUC-Xtr-131869	Xenopus tropicalis	52.11	0.00e+00	799.00
IUUC-Xma-134195	Xiphophorus maculatus	47.85	1.00e-113	404.00
IUUC-Zma-135157	Zea mays	30.58	1.00e-26	115.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence