iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGALG00000037193.1	ENSGALT00000065224.1	ENSGALP00000047326.1
ENSGALG00000037193.1	ENSGALT00000057176.1	ENSGALP00000046221.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	4.50e-122	408.0	1276	1608

Active Site

Position(s)	Description	Evidence
1576	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
           + ++++l+++fvgEegld++G++ref++lls+el+np++glf+ys+nd++t+q++p s +  ++hl++F+f Gr+lg+al ++ lld
   Q: 1276 ELQRNKLYITFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFV-ENHLEWFRFSGRILGLALIHQYLLD 1361
           567899****************************************************985.6************************ PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
           ++++++fyk ll+ +++l+dle +d+e+++sl+++k+n   +i+++ ldltf+v+ee++g+++e+eLk+gG+n+ Vt++Nk+eY+++
   Q: 1362 AFFTRPFYKALLRLPCDLSDLEYLDEEFHQSLQWMKDN---NITDI-LDLTFTVNEEVFGQVTERELKSGGANTAVTEKNKKEYIER 1444
           ************************************99...9***9.**************************************** PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
           +v++r+++g+ +q+ea+ +Gf+ev++ +l+s+F+++elel+i G++eid++d++++t+y+ggy++ + +i+wFw ++e+f++e+r +
   Q: 1445 MVKWRVERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNTEYRGGYHDGHIVIRWFWAAVERFNNEQRLR 1531
           *************************************************************************************** PP
   S: 264  fLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           +LqFvTg+s++P +Gfa+l+     r+f+i+k+++ ++lP+++TCfn+L+LP+Y+s++ l+ekLl+A+eet+ F+l+
   Q: 1532 LLQFVTGTSSVPYEGFAALRgsngLRRFCIEKWGKITSLPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTFGLE 1608
           ************************999***********************************************985 PP

Organism

Gallus gallus

Protein Sequence
(Fasta)

MNCAQAGIVQ NLYQNRFLGL AAMASPSRNS QNRRRCKEPL RYSYNPDQFH NMDIRNNSHE 60
TVTIPRSTSD TDLVTSDSRS TLMVSSSYYS IGHSQDLVIY WDIKEEVDAG DWIGMYLIDE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTCCGTGCG CCCGGTACCC GGCGACAGGC GGCGGGGTGG GAGGAGGCTG GCGGGGAGGG 60
GGAGGAGGGA GCGCGGCGGC GTTGCAGCCG GTGCTGCCGG ACTATGGTGA GCTTTGGCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR032348--HECW_N
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF16562--HECW_N
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001636	Ailuropoda melanoleuca	81.51	0.00e+00	1676.00
IUUC-Apl-003299	Anas platyrhynchos	95.69	0.00e+00	2902.00
IUUC-Aca-005024	Anolis carolinensis	87.73	0.00e+00	2672.00
IUUC-Bta-012604	Bos taurus	78.20	0.00e+00	2353.00
IUUC-Cja-019880	Callithrix jacchus	73.68	0.00e+00	1979.00
IUUC-Cfa-021216	Canis familiaris	82.85	0.00e+00	1702.00
IUUC-Cpo-021466	Cavia porcellus	91.64	0.00e+00	1634.00
IUUC-Csa-023080	Chlorocebus sabaeus	80.23	0.00e+00	2384.00
IUUC-Dre-028750	Danio rerio	72.28	0.00e+00	1570.00
IUUC-Dno-030019	Dasypus novemcinctus	85.52	0.00e+00	1744.00
IUUC-Dor-031030	Dipodomys ordii	71.71	0.00e+00	1112.00
IUUC-Ete-032352	Echinops telfairi	92.53	0.00e+00	1247.00
IUUC-Eca-033948	Equus caballus	82.34	0.00e+00	1698.00
IUUC-Eeu-034474	Erinaceus europaeus	68.19	0.00e+00	817.00
IUUC-Fca-036148	Felis catus	84.44	0.00e+00	1716.00
IUUC-Fal-036957	Ficedula albicollis	95.26	0.00e+00	2915.00
IUUC-Gmo-038714	Gadus morhua	68.88	0.00e+00	1021.00
IUUC-Gac-041366	Gasterosteus aculeatus	70.55	0.00e+00	1436.00
IUUC-Ggo-045442	Gorilla gorilla	68.94	0.00e+00	1774.00
IUUC-Hsa-045730	Homo sapiens	79.91	0.00e+00	2383.00
IUUC-Itr-048439	Ictidomys tridecemlineatus	86.25	0.00e+00	1766.00
IUUC-Lch-050185	Latimeria chalumnae	73.79	0.00e+00	2056.00
IUUC-Loc-052744	Lepisosteus oculatus	76.19	0.00e+00	2280.00
IUUC-Mcc-055487	Macaca mulatta	79.98	0.00e+00	2393.00
IUUC-Meu-056751	Macropus eugenii	91.60	0.00e+00	729.00
IUUC-Mga-059545	Meleagris gallopavo	98.06	0.00e+00	3018.00
IUUC-Mmr-061078	Microcebus murinus	83.10	0.00e+00	1656.00
IUUC-Mdo-062176	Monodelphis domestica	83.65	0.00e+00	1699.00
IUUC-Mmu-063513	Mus musculus	77.19	0.00e+00	2309.00
IUUC-Mpu-065786	Mustela putorius furo	84.53	0.00e+00	1739.00
IUUC-Mlu-067780	Myotis lucifugus	77.69	0.00e+00	1531.00
IUUC-Nle-069213	Nomascus leucogenys	79.79	0.00e+00	2356.00
IUUC-Opr-070208	Ochotona princeps	93.44	0.00e+00	1446.00
IUUC-Ont-072132	Oreochromis niloticus	70.90	0.00e+00	1434.00
IUUC-Oan-072807	Ornithorhynchus anatinus	87.38	0.00e+00	1757.00
IUUC-Ocu-074745	Oryctolagus cuniculus	84.23	0.00e+00	1713.00
IUUC-Ola-086981	Oryzias latipes	73.24	0.00e+00	1491.00
IUUC-Oga-087965	Otolemur garnettii	85.77	0.00e+00	1693.00
IUUC-Oar-089749	Ovis aries	82.16	0.00e+00	1699.00
IUUC-Ptr-091243	Pan troglodytes	79.81	0.00e+00	2378.00
IUUC-Pan-092201	Papio anubis	79.77	0.00e+00	2383.00
IUUC-Psi-093511	Pelodiscus sinensis	87.19	0.00e+00	2617.00
IUUC-Pfo-097001	Poecilia formosa	71.97	0.00e+00	1463.00
IUUC-Pab-098728	Pongo abelii	76.85	0.00e+00	2270.00
IUUC-Pca-100129	Procavia capensis	77.41	0.00e+00	1201.00
IUUC-Pva-102250	Pteropus vampyrus	71.62	0.00e+00	1704.00
IUUC-Rno-105031	Rattus norvegicus	78.41	0.00e+00	2331.00
IUUC-Tgu-117515	Taeniopygia guttata	94.46	0.00e+00	2895.00
IUUC-Tru-117914	Takifugu rubripes	76.44	0.00e+00	1389.00
IUUC-Tsy-119379	Tarsius syrichta	77.65	0.00e+00	780.00
IUUC-Tni-120178	Tetraodon nigroviridis	76.37	0.00e+00	1402.00
IUUC-Tbe-127762	Tupaia belangeri	79.61	0.00e+00	1596.00
IUUC-Ttr-128806	Tursiops truncatus	86.60	0.00e+00	1628.00
IUUC-Xtr-132903	Xenopus tropicalis	78.03	0.00e+00	1950.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence