iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oga-089128

Ensembl Protein ID

ENSOGAP00000001286.2

UniProt Accession

H0WIL7; H0WIL7_OTOGA

Genbank Protein ID

ENSOGAP00000001286

Protein Name

Ubiquitin-related modifier 1

Genbank Nucleotide ID

AAQR03035948

Gene Name

URM1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOGAG00000001445.2	ENSOGAT00000001445.2	ENSOGAP00000001286.2

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
ULD/UDP/UBQ/UBQ_Other	43.43	2.00e-17	81.30	IUUC-Sce-106366

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Otolemur garnettii

Functional Description
(View)

Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.

Protein Sequence
(Fasta)

MAAPLSVEVE FGGGAELLFD GVKKHQVTLP GQEEPWDIRN LLVWIKKNLL KERPELFIQG 60
DSVRPGILVL INDADWELLG ELDYQLQDQD TILFISTLHG G 101

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Nucleotide Sequence
(Fasta)

ATGGCAGCGC CCTTGTCAGT GGAGGTGGAA TTCGGGTGAG TTACAGAGCT GGGGCGCCGT 60
AGGGATGAAT TGAAGTCGTC AGTCCCGGAA CTCCCTTACC TCTCTCGGGG CCTAACACGG 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-1185--Reference proteome
KW-0819--tRNA processing
KW-0833--Ubl conjugation pathway

Interpro

IPR012675--Beta-grasp_dom
IPR016155--Mopterin_synth/thiamin_S_b
IPR015221--Urm1

Pfam

PF09138--Urm1

Gene Ontology

GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0016783--F:sulfurtransferase activity
GO:0032447--P:protein urmylation
GO:0034227--P:tRNA thio-modification
GO:0002098--P:tRNA wobble uridine modification

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002254	Ailuropoda melanoleuca	96.04	2.00e-53	199.00
IUUC-Atr-003089	Amborella trichopoda	58.59	2.00e-30	123.00
IUUC-Apl-003382	Anas platyrhynchos	87.91	3.00e-43	165.00
IUUC-Aca-004981	Anolis carolinensis	82.18	1.00e-47	180.00
IUUC-Aly-005517	Arabidopsis lyrata	55.43	6.00e-28	114.00
IUUC-Ath-006718	Arabidopsis thaliana	55.95	2.00e-24	103.00
IUUC-Ago-007917	Ashbya gossypii	42.42	4.00e-20	89.00
IUUC-Acl-008054	Aspergillus clavatus	68.00	3.00e-15	72.80
IUUC-Afl-008704	Aspergillus flavus	56.18	9.00e-21	90.90
IUUC-Aor-009890	Aspergillus oryzae	58.42	2.00e-25	107.00
IUUC-Bta-012448	Bos taurus	96.04	4.00e-53	198.00
IUUC-Bci-013865	Botrytis cinerea	47.52	1.00e-21	94.40
IUUC-Bdi-014980	Brachypodium distachyon	62.34	2.00e-24	103.00
IUUC-Bol-016055	Brassica oleracea	55.00	5.00e-24	102.00
IUUC-Bra-016845	Brassica rapa	55.00	5.00e-24	102.00
IUUC-Cel-018485	Caenorhabditis elegans	35.92	3.00e-12	62.80
IUUC-Cja-019587	Callithrix jacchus	98.02	1.00e-53	200.00
IUUC-Cfa-020653	Canis familiaris	97.03	3.00e-53	199.00
IUUC-Cpo-021622	Cavia porcellus	98.02	1.00e-53	200.00
IUUC-Cre-023015	Chlamydomonas reinhardtii	52.04	1.00e-25	107.00
IUUC-Csa-023756	Chlorocebus sabaeus	98.73	5.00e-41	159.00
IUUC-Cgl-026518	Colletotrichum gloeosporioides	46.53	4.00e-21	92.80
IUUC-Cne-026953	Cryptococcus neoformans	57.28	7.00e-28	115.00
IUUC-Cme-027314	Cyanidioschyzon merolae	43.75	2.00e-18	82.80
IUUC-Dre-027884	Danio rerio	77.23	2.00e-44	169.00
IUUC-Dno-029262	Dasypus novemcinctus	93.83	1.00e-39	155.00
IUUC-Dor-030601	Dipodomys ordii	65.35	7.00e-28	114.00
IUUC-Dme-031893	Drosophila melanogaster	62.75	3.00e-32	129.00
IUUC-Ete-032773	Echinops telfairi	90.10	5.00e-48	181.00
IUUC-Eca-034187	Equus caballus	99.01	7.00e-54	201.00
IUUC-Eeu-034808	Erinaceus europaeus	94.06	3.00e-52	195.00
IUUC-Fca-036107	Felis catus	97.03	2.00e-53	199.00
IUUC-Fal-036607	Ficedula albicollis	86.81	7.00e-43	164.00
IUUC-Fox-037698	Fusarium oxysporum	48.08	3.00e-23	99.80
IUUC-Gmo-039492	Gadus morhua	75.25	1.00e-43	167.00
IUUC-Ggr-039965	Gaeumannomyces graminis	49.04	1.00e-20	92.00
IUUC-Gga-041268	Gallus gallus	87.13	7.00e-49	184.00
IUUC-Gac-042111	Gasterosteus aculeatus	79.21	2.00e-46	176.00
IUUC-Gma-043240	Glycine max	52.38	5.00e-23	98.60
IUUC-Ggo-045176	Gorilla gorilla	96.20	3.00e-32	130.00
IUUC-Hsa-046077	Homo sapiens	95.05	7.00e-45	171.00
IUUC-Itr-048111	Ictidomys tridecemlineatus	95.51	4.00e-38	148.00
IUUC-Kpa-049157	Komagataella pastoris	49.49	3.00e-20	89.40
IUUC-Lch-049889	Latimeria chalumnae	78.22	2.00e-45	172.00
IUUC-Lpe-050783	Leersia perrieri	56.63	4.00e-23	99.00
IUUC-Loc-052400	Lepisosteus oculatus	78.22	5.00e-45	171.00
IUUC-Lma-053259	Leptosphaeria maculans	46.53	7.00e-21	92.00
IUUC-Laf-053596	Loxodonta africana	95.15	8.00e-52	194.00
IUUC-Mcc-054845	Macaca mulatta	90.82	3.00e-47	179.00
IUUC-Meu-055968	Macropus eugenii	93.07	2.00e-51	192.00
IUUC-Mor-057126	Magnaporthe oryzae	45.19	3.00e-19	87.00
IUUC-Mpo-057311	Magnaporthe poae	50.50	8.00e-22	95.90
IUUC-Mtr-058266	Medicago truncatula	50.00	1.00e-22	97.40
IUUC-Mla-058847	Melampsora laricipopulina	39.81	4.00e-12	63.20
IUUC-Mga-059468	Meleagris gallopavo	87.91	2.00e-43	166.00
IUUC-Mvi-060235	Microbotryum violaceum	36.42	3.00e-19	87.40
IUUC-Mdo-061948	Monodelphis domestica	91.09	5.00e-51	191.00
IUUC-Mmu-063946	Mus musculus	96.04	2.00e-52	196.00
IUUC-Mac-064812	Musa acuminata	58.33	1.00e-24	104.00
IUUC-Mpu-066763	Mustela putorius furo	97.03	3.00e-52	196.00
IUUC-Mlu-066970	Myotis lucifugus	100.00	3.00e-41	158.00
IUUC-Ncr-068824	Neurospora crassa	45.54	1.00e-19	88.20
IUUC-Nle-069849	Nomascus leucogenys	97.47	2.00e-40	157.00
IUUC-Opr-070227	Ochotona princeps	98.02	1.00e-53	200.00
IUUC-Ont-072530	Oreochromis niloticus	80.20	3.00e-46	176.00
IUUC-Oan-073191	Ornithorhynchus anatinus	82.47	4.00e-42	162.00
IUUC-Ocu-074460	Oryctolagus cuniculus	97.96	2.00e-51	192.00
IUUC-Oba-075499	Oryza barthii	65.62	1.00e-22	99.00
IUUC-Obr-076896	Oryza brachyantha	56.25	5.00e-22	97.80
IUUC-Ogl-077834	Oryza glaberrima	65.62	3.00e-23	99.80
IUUC-Ogu-078622	Oryza glumaepatula	65.62	3.00e-23	99.80
IUUC-Oin-079358	Oryza indica	65.62	9.00e-23	99.80
IUUC-Olo-081035	Oryza longistaminata	50.49	8.00e-24	102.00
IUUC-Oni-082425	Oryza nivara	65.62	3.00e-23	99.80
IUUC-Opu-083461	Oryza punctata	65.08	2.00e-22	98.20
IUUC-Oru-084875	Oryza rufipogon	59.15	3.00e-21	92.40
IUUC-Oar-089896	Ovis aries	96.04	4.00e-53	198.00
IUUC-Ptr-091618	Pan troglodytes	96.20	3.00e-32	130.00
IUUC-Pan-092238	Papio anubis	98.73	5.00e-41	159.00
IUUC-Psi-093879	Pelodiscus sinensis	85.15	6.00e-48	181.00
IUUC-Pma-094484	Petromyzon marinus	81.19	5.00e-36	142.00
IUUC-Ppa-095801	Physcomitrella patens	56.79	2.00e-22	96.70
IUUC-Pfo-097192	Poecilia formosa	81.19	3.00e-46	176.00
IUUC-Pab-098203	Pongo abelii	94.06	2.00e-44	169.00
IUUC-Pop-099614	Populus trichocarpa	55.95	4.00e-24	102.00
IUUC-Pca-100507	Procavia capensis	98.73	5.00e-41	158.00
IUUC-Ppe-101174	Prunus persica	54.55	9.00e-29	117.00
IUUC-Pva-102735	Pteropus vampyrus	96.04	8.00e-50	187.00
IUUC-Pgr-103510	Puccinia graminis	38.83	5.00e-12	62.80
IUUC-Ptt-103918	Puccinia triticina	34.95	3.00e-10	56.60
IUUC-Pte-104173	Pyrenophora teres	48.54	4.00e-23	99.40
IUUC-Pyt-104806	Pyrenophora triticirepentis	48.54	4.00e-23	99.40
IUUC-Rno-105820	Rattus norvegicus	97.03	7.00e-53	197.00
IUUC-Sce-106366	Saccharomyces cerevisiae	43.43	7.00e-18	81.30
IUUC-Sja-107727	Schizosaccharomyces japonicus	40.62	3.00e-16	76.60
IUUC-Spo-108074	Schizosaccharomyces pombe	38.78	2.00e-09	53.90
IUUC-Smo-108944	Selaginella moellendorffii	59.55	4.00e-26	108.00
IUUC-Sit-110277	Setaria italica	55.95	5.00e-24	102.00
IUUC-Sly-111505	Solanum lycopersicum	53.57	3.00e-24	102.00
IUUC-Stu-112076	Solanum tuberosum	54.76	1.00e-24	104.00
IUUC-Sbi-114274	Sorghum bicolor	57.14	6.00e-24	102.00
IUUC-Sre-114953	Sporisorium reilianum	58.82	2.00e-27	113.00
IUUC-Ssc-115418	Sus scrofa	97.03	3.00e-53	199.00
IUUC-Tgu-117311	Taeniopygia guttata	86.81	9.00e-43	164.00
IUUC-Tru-118598	Takifugu rubripes	82.02	1.00e-40	156.00
IUUC-Tni-120109	Tetraodon nigroviridis	77.45	5.00e-43	165.00
IUUC-Tca-120942	Theobroma cacao	54.22	3.00e-23	99.40
IUUC-Tre-122099	Trichoderma reesei	48.94	5.00e-16	75.50
IUUC-Tvi-122285	Trichoderma virens	52.88	7.00e-21	92.00
IUUC-Tae-125193	Triticum aestivum	56.63	2.00e-23	100.00
IUUC-Tur-126677	Triticum urartu	49.47	6.00e-21	92.00
IUUC-Tme-127120	Tuber melanosporum	50.00	1.00e-24	104.00
IUUC-Tbe-128050	Tupaia belangeri	70.30	1.00e-33	134.00
IUUC-Ttr-129019	Tursiops truncatus	95.05	3.00e-50	189.00
IUUC-Uma-129483	Ustilago maydis	56.86	3.00e-25	106.00
IUUC-Vda-129690	Verticillium dahliae	41.96	8.00e-17	78.60
IUUC-Vvi-131174	Vitis vinifera	57.83	1.00e-24	103.00
IUUC-Xma-133862	Xiphophorus maculatus	81.19	3.00e-46	176.00
IUUC-Yli-134398	Yarrowia lipolytica	47.47	1.00e-19	87.40
IUUC-Zma-134964	Zea mays	58.54	8.00e-23	97.80

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence