iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Eca-034231

UUCD1 version

UUC-EqC-00638

Ensembl Protein ID

ENSECAP00000004466.1

UniProt Accession

F7A921; F7A921_HORSE

Protein Name

Uncharacterized protein

Gene Name

WDR61

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000005595.1	ENSECAT00000006322.1	ENSECAP00000004466.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.40e-39	132.5	188	220
UBD/Beta-Prp	7.20e-65	219.2	12	303

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlr 31
           gH+ ++++l f +d  llv++sdDg ik++Dl+
   Q: 188  GHAMPIRSLTFsPDsQLLVTASDDGYIKIYDLS 220
           79999*******999****************85 PP

UBD/Beta-Prp

   S: 6    kghhksvitcvkf....spdksllatgsrdgtikvwdvttgkl..lrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvh 88
           +++h++ i +v++    +++++ ++tgs d+ +kvw+++++ l   +sl+gh+ +v +v++s++ ++ +++s D++i++wdl++gk++ 
   Q: 12   EQAHDDAIWSVAWgtnkKENSETVVTGSLDDLVKVWKWRDERLdlQWSLEGHQLGVVSVDISHTLPVAASSSLDAHIRLWDLENGKQIK 100
           567788888899998888999********************99999******************************************* PP
   S: 89   tlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltg 177
           ++ +   ++++l+fsp++++l++G+h+  ++++ +e+g++ +  l+ + +++ +++++pdg++l+sG+ D++++++d++tgkll+tl+g
   Q: 101  SIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEY-SLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEG 188
           ******************************************.*********************************************9 PP
   S: 178  ghtdsvyslsfdsngkelvsgsldgtvklwdlq....tgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlql 262
            h  +++sl+f+++++ lv++s+dg++k++dl+    +g+  + ++++++n            ++  ssD+s+++Wd+ ++++++t+  
   Q: 189  -HAMPIRSLTFSPDSQLLVTASDDGYIKIYDLSelslAGTRAEHQRAQSENCFLTL----MFPFLNSSSDKSVKVWDVGTRTCVHTFFD 272
           .********************************55555555555555555544333....556777788******************** PP
   S: 263  hnssvisvavlsfgdnvlvlgsedskvniwkl 294
           h+++v+ v++ + +++++v++++d++++i+++
   Q: 273  HQDQVWGVKY-NGNGSKIVSVGDDQEIHIYDC 303
           **********.999****************97 PP

Organism

Equus caballus

Protein Sequence
(Fasta)

MTNQYSILFK QEQAHDDAIW SVAWGTNKKE NSETVVTGSL DDLVKVWKWR DERLDLQWSL 60
EGHQLGVVSV DISHTLPVAA SSSLDAHIRL WDLENGKQIK SIDAGPVDAW TLAFSPDSQY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCCTCAGTG AAACCCTTTG TTGTTTCCAC AGAGCTGTCT GGCCTTTAGC CCTTCATCCT 60
TGGTTAAAGA AATGACCAAC CAGGTAAGGC CTGTGGCAAG GGGAGCACAT CAGTTGGTCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0016593--C:Cdc73/Paf1 complex
GO:0005829--C:cytosol
GO:0055087--C:Ski complex
GO:0035327--C:transcriptionally active chromatin
GO:0080182--P:histone H3-K4 trimethylation
GO:0045638--P:negative regulation of myeloid cell differentiation
GO:0051571--P:positive regulation of histone H3-K4 methylation
GO:2001162--P:positive regulation of histone H3-K79 methylation
GO:0032968--P:positive regulation of transcription elongation from RNA polymerase II promoter

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000774	Aegilops tauschii	31.07	4.00e-43	168.00
IUUC-Aml-002245	Ailuropoda melanoleuca	90.82	5.00e-153	533.00
IUUC-Atr-003142	Amborella trichopoda	43.71	4.00e-33	134.00
IUUC-Apl-003179	Anas platyrhynchos	82.95	1.00e-141	495.00
IUUC-Aca-004880	Anolis carolinensis	81.64	4.00e-148	516.00
IUUC-Aly-005956	Arabidopsis lyrata	34.28	6.00e-50	191.00
IUUC-Ath-007230	Arabidopsis thaliana	33.96	7.00e-46	177.00
IUUC-Acl-008297	Aspergillus clavatus	27.08	8.00e-22	97.80
IUUC-Ame-011511	Astyanax mexicanus	77.20	1.00e-135	475.00
IUUC-Bgr-012189	Blumeria graminis	28.92	7.00e-26	110.00
IUUC-Bta-012936	Bos taurus	91.15	2.00e-153	534.00
IUUC-Bdi-015020	Brachypodium distachyon	34.48	2.00e-42	165.00
IUUC-Bol-016345	Brassica oleracea	34.91	4.00e-51	194.00
IUUC-Bra-017323	Brassica rapa	34.91	3.00e-51	195.00
IUUC-Cja-019961	Callithrix jacchus	91.48	2.00e-153	535.00
IUUC-Cfa-020862	Canis familiaris	90.49	3.00e-152	530.00
IUUC-Cpo-021356	Cavia porcellus	91.06	1.00e-150	525.00
IUUC-Cre-022602	Chlamydomonas reinhardtii	37.95	8.00e-55	206.00
IUUC-Csa-024067	Chlorocebus sabaeus	91.15	6.00e-153	533.00
IUUC-Cho-024421	Choloepus hoffmanni	71.72	2.00e-66	244.00
IUUC-Cin-025261	Ciona intestinalis	60.33	3.00e-111	394.00
IUUC-Dre-027706	Danio rerio	63.34	2.00e-108	385.00
IUUC-Dno-029084	Dasypus novemcinctus	91.21	1.00e-152	531.00
IUUC-Dor-030353	Dipodomys ordii	82.61	4.00e-129	453.00
IUUC-Dme-031836	Drosophila melanogaster	48.00	2.00e-81	295.00
IUUC-Ete-032261	Echinops telfairi	87.87	5.00e-146	509.00
IUUC-Eeu-034828	Erinaceus europaeus	89.69	5.00e-142	496.00
IUUC-Fca-036569	Felis catus	91.15	6.00e-153	532.00
IUUC-Fal-037469	Ficedula albicollis	84.92	1.00e-145	508.00
IUUC-Fox-038047	Fusarium oxysporum	31.65	6.00e-26	111.00
IUUC-Gmo-039579	Gadus morhua	77.05	1.00e-133	469.00
IUUC-Gga-040808	Gallus gallus	85.27	8.00e-139	486.00
IUUC-Gac-042100	Gasterosteus aculeatus	77.38	3.00e-134	471.00
IUUC-Gma-044408	Glycine max	38.29	3.00e-54	205.00
IUUC-Ggo-045227	Gorilla gorilla	91.48	2.00e-153	535.00
IUUC-Hsa-045839	Homo sapiens	91.48	2.00e-153	535.00
IUUC-Hvu-047591	Hordeum vulgare	34.81	2.00e-45	176.00
IUUC-Itr-048741	Ictidomys tridecemlineatus	91.80	4.00e-154	536.00
IUUC-Lch-049549	Latimeria chalumnae	77.05	2.00e-136	478.00
IUUC-Lpe-050746	Leersia perrieri	36.33	7.00e-44	170.00
IUUC-Loc-052540	Lepisosteus oculatus	79.67	3.00e-134	471.00
IUUC-Laf-053907	Loxodonta africana	91.80	4.00e-154	536.00
IUUC-Mcc-055828	Macaca mulatta	85.54	3.00e-149	521.00
IUUC-Meu-056075	Macropus eugenii	85.10	4.00e-120	423.00
IUUC-Mor-056971	Magnaporthe oryzae	30.57	6.00e-24	104.00
IUUC-Mtr-057728	Medicago truncatula	37.03	1.00e-50	193.00
IUUC-Mga-059872	Meleagris gallopavo	85.25	4.00e-146	510.00
IUUC-Mvi-060564	Microbotryum violaceum	32.21	3.00e-31	129.00
IUUC-Mmr-060985	Microcebus murinus	88.82	1.00e-145	508.00
IUUC-Mdo-062758	Monodelphis domestica	82.89	2.00e-144	504.00
IUUC-Mmu-063580	Mus musculus	89.51	3.00e-151	527.00
IUUC-Mac-064880	Musa acuminata	38.78	1.00e-54	206.00
IUUC-Mpu-066577	Mustela putorius furo	90.16	2.00e-151	527.00
IUUC-Nle-069573	Nomascus leucogenys	91.48	2.00e-153	535.00
IUUC-Opr-070216	Ochotona princeps	90.37	5.00e-150	523.00
IUUC-Ont-071981	Oreochromis niloticus	78.36	2.00e-136	478.00
IUUC-Oan-073223	Ornithorhynchus anatinus	88.46	6.00e-92	329.00
IUUC-Ocu-074199	Oryctolagus cuniculus	84.87	3.00e-140	490.00
IUUC-Oba-075255	Oryza barthii	37.31	2.00e-37	148.00
IUUC-Obr-076168	Oryza brachyantha	42.86	2.00e-31	129.00
IUUC-Ogl-077777	Oryza glaberrima	36.13	1.00e-44	173.00
IUUC-Ogu-078780	Oryza glumaepatula	36.13	1.00e-44	173.00
IUUC-Oin-079228	Oryza indica	36.45	4.00e-47	181.00
IUUC-Ome-081421	Oryza meridionalis	36.45	1.00e-43	170.00
IUUC-Oni-082997	Oryza nivara	36.45	4.00e-47	181.00
IUUC-Opu-083931	Oryza punctata	36.22	2.00e-44	172.00
IUUC-Oru-084645	Oryza rufipogon	36.13	1.00e-44	173.00
IUUC-Osa-085842	Oryza sativa	36.45	4.00e-47	181.00
IUUC-Ola-086696	Oryzias latipes	77.38	2.00e-131	461.00
IUUC-Olu-087643	Ostreococcus lucimarinus	35.32	3.00e-36	144.00
IUUC-Oga-088272	Otolemur garnettii	89.80	3.00e-150	524.00
IUUC-Oar-089416	Ovis aries	91.15	2.00e-153	534.00
IUUC-Ptr-090944	Pan troglodytes	91.48	2.00e-153	535.00
IUUC-Pan-091861	Papio anubis	91.48	2.00e-153	535.00
IUUC-Psi-093750	Pelodiscus sinensis	86.23	2.00e-146	511.00
IUUC-Pma-094608	Petromyzon marinus	73.23	2.00e-121	428.00
IUUC-Pno-094832	Phaeosphaeria nodorum	30.57	3.00e-23	102.00
IUUC-Ppa-095737	Physcomitrella patens	37.11	4.00e-52	197.00
IUUC-Pfo-096479	Poecilia formosa	79.02	5.00e-131	460.00
IUUC-Pab-098179	Pongo abelii	91.48	2.00e-153	535.00
IUUC-Pop-099532	Populus trichocarpa	36.64	2.00e-50	192.00
IUUC-Pca-100664	Procavia capensis	67.75	3.00e-89	321.00
IUUC-Ppe-102056	Prunus persica	37.34	2.00e-53	202.00
IUUC-Pva-102859	Pteropus vampyrus	91.15	8.00e-153	532.00
IUUC-Pte-104236	Pyrenophora teres	32.97	4.00e-22	98.60
IUUC-Rno-105826	Rattus norvegicus	89.18	2.00e-150	525.00
IUUC-Sha-106660	Sarcophilus harrisii	84.39	1.00e-138	485.00
IUUC-Sja-107800	Schizosaccharomyces japonicus	30.19	2.00e-31	129.00
IUUC-Spo-108244	Schizosaccharomyces pombe	29.39	2.00e-31	129.00
IUUC-Smo-109234	Selaginella moellendorffii	39.46	4.00e-55	207.00
IUUC-Sit-110048	Setaria italica	34.36	4.00e-36	145.00
IUUC-Sly-111618	Solanum lycopersicum	34.94	9.00e-46	177.00
IUUC-Stu-112543	Solanum tuberosum	34.94	6.00e-49	187.00
IUUC-Sar-113743	Sorex araneus	78.03	9.00e-132	462.00
IUUC-Sbi-114309	Sorghum bicolor	36.43	1.00e-37	149.00
IUUC-Ssc-115560	Sus scrofa	85.90	4.00e-140	490.00
IUUC-Tgu-117300	Taeniopygia guttata	85.25	3.00e-146	510.00
IUUC-Tru-117933	Takifugu rubripes	77.70	1.00e-135	475.00
IUUC-Tsy-119574	Tarsius syrichta	81.31	3.00e-130	457.00
IUUC-Tni-120191	Tetraodon nigroviridis	77.64	4.00e-98	350.00
IUUC-Tca-120983	Theobroma cacao	36.89	3.00e-52	198.00
IUUC-Tae-122888	Triticum aestivum	33.12	3.00e-45	175.00
IUUC-Tur-126711	Triticum urartu	33.23	4.00e-44	171.00
IUUC-Tme-127066	Tuber melanosporum	31.23	8.00e-30	124.00
IUUC-Tbe-127802	Tupaia belangeri	91.15	6.00e-153	532.00
IUUC-Ttr-128861	Tursiops truncatus	98.11	3.00e-57	215.00
IUUC-Vpa-130618	Vicugna pacos	91.34	9.00e-121	425.00
IUUC-Vvi-130981	Vitis vinifera	37.50	2.00e-50	192.00
IUUC-Xtr-132460	Xenopus tropicalis	79.34	2.00e-132	464.00
IUUC-Xma-134154	Xiphophorus maculatus	79.02	4.00e-131	460.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence