iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ocu-073973

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAGW02063899

Gene Name

WSB2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOCUG00000010382.3	ENSOCUT00000021634.2	ENSOCUP00000022207.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	7.10e-15	54.7	358	405
E3 adaptor/Cullin RING/DCX/DWD	1.00e-32	110.8	153	186
UBD/Beta-Prp	4.60e-46	157.4	127	362

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 1    lsklwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyed 51
           ++++w++++   SL+hLCR+a r++l+++++    +LP+Pk++k++L y++
   Q: 358  HVQFWTAPRVLSSLKHLCRKALRSFLTTYQV---LALPIPKKMKEFLTYRT 405
           689****************************...***************86 PP

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf..sd.tllvsGsdDgtikvWDlr 31
           gH+d v++l+f  s+  +lvs+s+D+t+++WDl 
   Q: 153  GHQDVVRDLSFtpSGsLILVSASRDKTLRIWDLN 186
           8***********6556779*************85 PP

UBD/Beta-Prp

   S: 24   llatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgk.ilvtgseDrtikvwdls.tgkcvhtlkghedsvlslsfspsgdklv 110
           +latg  dg ik+w+v+tg ll  lsgh++ v++++f p+g+ ilv++s+D+t+++wdl+  gk++++l+gh + v+++s+sp+ + l 
   Q: 127  ILATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSlILVSASRDKTLRIWDLNkHGKQIQVLSGHLQWVYCCSISPDCSMLC 215
           699***************************************9****************9789********************99**** PP
   S: 111  sGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtl...........tgghtdsvyslsf 188
           s+   + + +w +++++ ++  l+gh+++v +  ++pd+ llv++s+D+ v +Wd  tg+ lr l           +  h +s +s+ f
   Q: 216  SAAGEKSVFLWSMRSYTLIR-KLEGHQSSVVSCDFSPDSALLVTASYDTSVIMWDPYTGERLRSLrhaqldpamddSDVHMSSLRSVCF 303
           ********************.********************************************99999988888667888888888* PP
   S: 189  dsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriW 249
           +++g +l+++++d+ +++w l+ +    +  +  +n ++  f+p++  +++g+ Dg +++W
   Q: 304  SPEGLYLATVADDRLLRIWALELK--APIAFAPMTNGLCCTFFPHGGVIATGTRDGHVQFW 362
           *********************877..6899******************************* PP

Organism

Oryctolagus cuniculus

Protein Sequence
(Fasta)

MLSPAPEEPL LLAELKPGRP HQFDWKSSCE TWSVAFSPDG SWFAWSQGHC IVKLIPWPLE 60
EHFIPKGFEA KSRSSKNDPK GRGSPKEKTL DCGQIVWGLA FSPWPSPPSR KLWARHHPQG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCTCTCTC CCGCCCCAGA GGAACCACTG CTGCTGGCCG AACTCAAGCC CGGGCGCCCC 60
CACCAATTCG ATTGGAAGTC GAGCTGTGAA ACCTGGAGTG TCGCCTTCTC CCCCGATGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR027295--Quinoprotein_ADH-like_fam
IPR001496--SOCS_box
IPR023294--Tachylectin2
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50225--SOCS
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF07525--SOCS_box
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00253--SOCS
SM00969--SOCS_box
SM00320--WD40

Gene Ontology

GO:0005622--C:intracellular
GO:0035556--P:intracellular signal transduction
GO:0016567--P:protein ubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002221	Ailuropoda melanoleuca	96.55	0.00e+00	805.00
IUUC-Apl-004107	Anas platyrhynchos	69.03	1.00e-131	462.00
IUUC-Aca-004354	Anolis carolinensis	73.63	3.00e-169	587.00
IUUC-Bta-012627	Bos taurus	97.04	0.00e+00	762.00
IUUC-Cja-018897	Callithrix jacchus	95.63	0.00e+00	765.00
IUUC-Cfa-020122	Canis familiaris	96.80	0.00e+00	805.00
IUUC-Cpo-022540	Cavia porcellus	97.78	0.00e+00	788.00
IUUC-Csa-023719	Chlorocebus sabaeus	96.91	0.00e+00	777.00
IUUC-Cho-024367	Choloepus hoffmanni	97.32	1.00e-171	595.00
IUUC-Dno-029021	Dasypus novemcinctus	97.78	0.00e+00	788.00
IUUC-Dor-030321	Dipodomys ordii	97.68	0.00e+00	780.00
IUUC-Ete-032955	Echinops telfairi	96.99	0.00e+00	775.00
IUUC-Eca-033485	Equus caballus	97.44	0.00e+00	755.00
IUUC-Fca-035389	Felis catus	97.43	0.00e+00	782.00
IUUC-Fal-037184	Ficedula albicollis	84.81	1.00e-143	501.00
IUUC-Gga-041014	Gallus gallus	77.26	6.00e-178	616.00
IUUC-Ggo-045585	Gorilla gorilla	97.19	0.00e+00	785.00
IUUC-Hsa-046344	Homo sapiens	97.29	0.00e+00	785.00
IUUC-Itr-049085	Ictidomys tridecemlineatus	97.69	0.00e+00	784.00
IUUC-Lch-050131	Latimeria chalumnae	69.76	3.00e-168	584.00
IUUC-Loc-052807	Lepisosteus oculatus	51.40	5.00e-117	414.00
IUUC-Laf-053528	Loxodonta africana	97.54	0.00e+00	768.00
IUUC-Mcc-055665	Macaca mulatta	97.29	0.00e+00	785.00
IUUC-Meu-056054	Macropus eugenii	88.38	0.00e+00	698.00
IUUC-Mga-059326	Meleagris gallopavo	78.00	0.00e+00	632.00
IUUC-Mmr-060815	Microcebus murinus	95.57	0.00e+00	774.00
IUUC-Mdo-062000	Monodelphis domestica	91.32	0.00e+00	752.00
IUUC-Mmu-063927	Mus musculus	97.17	0.00e+00	783.00
IUUC-Mpu-065726	Mustela putorius furo	95.12	0.00e+00	762.00
IUUC-Mlu-067527	Myotis lucifugus	97.62	1.00e-119	422.00
IUUC-Nle-069680	Nomascus leucogenys	96.68	0.00e+00	777.00
IUUC-Opr-070356	Ochotona princeps	98.50	0.00e+00	806.00
IUUC-Oan-073647	Ornithorhynchus anatinus	83.94	1.00e-135	476.00
IUUC-Oga-088797	Otolemur garnettii	96.81	0.00e+00	775.00
IUUC-Oar-089187	Ovis aries	96.93	0.00e+00	761.00
IUUC-Ptr-091317	Pan troglodytes	97.19	0.00e+00	785.00
IUUC-Pan-092694	Papio anubis	89.35	0.00e+00	669.00
IUUC-Psi-093392	Pelodiscus sinensis	80.40	0.00e+00	645.00
IUUC-Pab-098145	Pongo abelii	96.91	0.00e+00	776.00
IUUC-Pca-100454	Procavia capensis	87.97	0.00e+00	711.00
IUUC-Pva-102986	Pteropus vampyrus	88.97	0.00e+00	716.00
IUUC-Rno-104931	Rattus norvegicus	95.36	0.00e+00	764.00
IUUC-Sha-106476	Sarcophilus harrisii	92.52	0.00e+00	749.00
IUUC-Ssc-115643	Sus scrofa	97.42	0.00e+00	776.00
IUUC-Tgu-117522	Taeniopygia guttata	63.16	4.00e-135	474.00
IUUC-Tsy-119301	Tarsius syrichta	97.24	0.00e+00	798.00
IUUC-Ttr-128683	Tursiops truncatus	97.42	0.00e+00	778.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence