iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Oga-088797

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAQR03070609

Gene Name

WSB2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOGAG00000008202.2	ENSOGAT00000008203.2	ENSOGAP00000007339.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.00e-31	107.6	154	187
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	6.80e-15	54.7	359	406
UBD/Beta-Prp	4.30e-44	150.9	127	363

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf..sd.tllvsGsdDgtikvWDlr 31
           gH+d v++l+f  s+  +lvs+s+D+t+++WDl 
   Q: 154  GHQDVVRDLSFtpSGsLILVSASRDKTLRIWDLN 187
           8***********6556779*************85 PP

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 1    lsklwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyed 51
           ++++w++++   SL+hLCR+a r++l+++++    +LP+Pk++k++L y++
   Q: 359  HVQFWTAPRVLSSLKHLCRKALRSFLTTYQV---LALPIPKKMKEFLTYRT 406
           689****************************...***************86 PP

UBD/Beta-Prp

   S: 24   llatgsrdgtikvwdvttgkl.lrslsgheaevtavkfspdgk.ilvtgseDrtikvwdls.tgkcvhtlkghedsvlslsfspsgdkl 109
           +latg  dg ik+w+v+t  l l  lsgh++ v++++f p+g+ ilv++s+D+t+++wdl+  gk++++l+gh + v+++s+sp+ + l
   Q: 127  ILATGLNDGQIKIWEVQTVGLlLLNLSGHQDVVRDLSFTPSGSlILVSASRDKTLRIWDLNkHGKQIQVLSGHLQWVYCCSISPDCSML 215
           699*************99666599*******************9****************9789********************99*** PP
   S: 110  vsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtl...........tgghtdsvysls 187
            s+   + + +w +++++ ++  l+gh+++v +  ++pd+ llv++s+D+ v +Wd  tg+ lr l           +  h +s +s+ 
   Q: 216  CSAAGEKSVFLWSMRSYTLIR-KLEGHQSSVVSCDFSPDSALLVTASYDTNVIMWDPYTGERLRSLhhtqvdpamddSDVHISSLRSVC 303
           *********************.********************************************99999999888777888888888 PP
   S: 188  fdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriW 249
           f+++g +l+++++d+ +++w l+ ++   +  +  +n ++  f+p++  +++g+ Dg +++W
   Q: 304  FSPEGLYLATVADDRLLRIWALELKT--PIAFAPMTNGLCCTFFPHGGVIATGTRDGHVQFW 363
           **********************9885..7899****************************** PP

Organism

Otolemur garnettii

Protein Sequence
(Fasta)

MLSPAPEEPL LLAELKPGRP HQFDWKSSCE TWSVAFSPDG SWFAWSQGHC IVKLIPWPLE 60
EQFIPKGFEA KSRGSKNETK GRGSPKEKTL DCGQIVWGLA FSPWPSPPSR KLWARHPPQV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCTATCTC CTGCTCCAGA GGAACCTCTG CTGCTGGCTG AACTCAAGCC TGGGCGCCCC 60
CACCAGTTTG ATTGGAAGTC GAGCTGTGAA ACCTGGAGTG TCGCCTTCTC CCCAGATGGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR003143--Cyt_cd1_C
IPR020472--G-protein_beta_WD-40_rep
IPR001496--SOCS_box
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50225--SOCS
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF07525--SOCS_box
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00253--SOCS
SM00969--SOCS_box
SM00320--WD40

Gene Ontology

GO:0005622--C:intracellular
GO:0035556--P:intracellular signal transduction
GO:0016567--P:protein ubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002221	Ailuropoda melanoleuca	97.30	0.00e+00	810.00
IUUC-Apl-004107	Anas platyrhynchos	68.59	1.00e-129	456.00
IUUC-Aca-004354	Anolis carolinensis	73.20	5.00e-167	580.00
IUUC-Bta-012627	Bos taurus	98.28	0.00e+00	769.00
IUUC-Cja-018897	Callithrix jacchus	97.18	0.00e+00	773.00
IUUC-Cfa-020122	Canis familiaris	97.54	0.00e+00	811.00
IUUC-Cpo-022540	Cavia porcellus	97.05	0.00e+00	781.00
IUUC-Csa-023719	Chlorocebus sabaeus	98.71	0.00e+00	786.00
IUUC-Cho-024367	Choloepus hoffmanni	96.99	7.00e-170	589.00
IUUC-Dno-029021	Dasypus novemcinctus	97.79	0.00e+00	785.00
IUUC-Dor-030321	Dipodomys ordii	97.17	0.00e+00	777.00
IUUC-Ete-032955	Echinops telfairi	96.75	0.00e+00	771.00
IUUC-Eca-033485	Equus caballus	97.96	0.00e+00	761.00
IUUC-Fca-035389	Felis catus	97.69	0.00e+00	781.00
IUUC-Fal-037184	Ficedula albicollis	83.80	2.00e-141	494.00
IUUC-Gga-041014	Gallus gallus	76.80	5.00e-177	613.00
IUUC-Ggo-045585	Gorilla gorilla	98.98	0.00e+00	796.00
IUUC-Hsa-046344	Homo sapiens	99.02	0.00e+00	795.00
IUUC-Itr-049085	Ictidomys tridecemlineatus	97.44	0.00e+00	782.00
IUUC-Lch-050131	Latimeria chalumnae	69.34	4.00e-166	577.00
IUUC-Loc-052807	Lepisosteus oculatus	54.61	1.00e-115	409.00
IUUC-Laf-053528	Loxodonta africana	97.79	0.00e+00	766.00
IUUC-Mcc-055665	Macaca mulatta	99.02	0.00e+00	795.00
IUUC-Meu-056054	Macropus eugenii	87.66	0.00e+00	692.00
IUUC-Mga-059326	Meleagris gallopavo	77.25	0.00e+00	629.00
IUUC-Mmr-060815	Microcebus murinus	96.56	0.00e+00	778.00
IUUC-Mdo-062000	Monodelphis domestica	90.59	0.00e+00	741.00
IUUC-Mmu-063927	Mus musculus	95.64	0.00e+00	771.00
IUUC-Mpu-065726	Mustela putorius furo	95.90	0.00e+00	767.00
IUUC-Mlu-067527	Myotis lucifugus	96.21	1.00e-116	411.00
IUUC-Nle-069680	Nomascus leucogenys	98.47	0.00e+00	787.00
IUUC-Opr-070356	Ochotona princeps	97.25	0.00e+00	793.00
IUUC-Oan-073647	Ornithorhynchus anatinus	83.64	4.00e-135	474.00
IUUC-Ocu-073973	Oryctolagus cuniculus	96.81	0.00e+00	775.00
IUUC-Oar-089187	Ovis aries	98.21	0.00e+00	769.00
IUUC-Ptr-091317	Pan troglodytes	98.98	0.00e+00	794.00
IUUC-Pan-092694	Papio anubis	90.93	0.00e+00	677.00
IUUC-Psi-093392	Pelodiscus sinensis	79.70	0.00e+00	640.00
IUUC-Pab-098145	Pongo abelii	98.71	0.00e+00	786.00
IUUC-Pca-100454	Procavia capensis	88.25	0.00e+00	711.00
IUUC-Pva-102986	Pteropus vampyrus	89.50	0.00e+00	719.00
IUUC-Rno-104931	Rattus norvegicus	94.34	0.00e+00	758.00
IUUC-Sha-106476	Sarcophilus harrisii	91.54	0.00e+00	740.00
IUUC-Ssc-115643	Sus scrofa	98.20	0.00e+00	781.00
IUUC-Tgu-117522	Taeniopygia guttata	64.37	3.00e-137	481.00
IUUC-Tsy-119301	Tarsius syrichta	99.00	0.00e+00	809.00
IUUC-Ttr-128683	Tursiops truncatus	98.20	0.00e+00	781.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence