iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

mRNA Expression
GEO	FFGED
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
CPLM	dbPAF	dbPTM	UniProt
BioGRID
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/USP	USP	17190603

Classification

Family	E-value	Score	Start	End
DUB/USP	2.60e-50	169.9	230	495

Active Site

Position(s)	Description	Evidence
118	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
447	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 143  sdlFqgqlksqikclecdnvs..sreepfldlslpvpgkeetkkeslqdcL.esftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfse 241
           s+ F++q+k++ik  + dn    +++e+  +l+++++g ++   + l + L e++ k+  l+g+n +y+ +           k+++lP++L+++  Rf +++
   Q: 230  SEDFRIQFKTTIKDTANDNDItvKENESDSKLQCHISGTTNFMRNGLLEGLnEKIEKRSDLTGANSIYSVEK----------KISRLPKFLTVQYVRFFWKR 321
           567999*******8888887645777888999999*****9999999999988999999***9998776654..........49****************** PP
   S: 242  eqksrekinkkvefpleLdlspfcts.................peekqke.................................................... 274
           ++++++ki +kv fp +Ld++ ++t                  +     e                                                    
   Q: 322  STNKKSKILRKVVFPFQLDVADMLTPeyaaekvkvrdelrkveK-----Eknekereikrrkfdpsssenvmtpreqyetqvalnesekdqwleeykkhfpp 418
           *********************99999555555555555555551.....05555566677777777777777777777777777788888888888888888 PP
   S: 275  ........kkkYeLiavvvHsG.slssGHYvayvkn..ekgkWllfdDskVtevkeeevleetg....staYvlfYk 336
                   ++ Y+Li+v+ H+G +++sGHY a++++  +++kW++f+D+kV++v++e++++  g    ++a +l+Yk
   Q: 419  nlekgenpSCVYNLIGVITHQGaNSESGHYQAFIRDelDENKWYKFNDDKVSVVEKEKIESLAGggesDSALILMYK 495
           88888888****************************666888*******************888************8 PP

Organism

Saccharomyces cerevisiae

Functional Description
(View)

Predominant proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Has proteasome-inhibitory activity and delays the degradation of ubiquitinated proteins to provide a time window allowing gradual deubiquitination of the substrate. Stabilizes the association of HUL5 with proteasomes and works in opposition to polyubiquitin elongation activity of HUL5.

Protein Sequence
(Fasta)

MSGETFEFNI RHSGKVYPIT LSTDATSADL KSKAEELTQV PSARQKYMVK GGLSGEESIK 60
IYPLIKPGST VMLLGTPDAN LISKPAKKNN FIEDLAPEQQ VQQFAQLPVG FKNMGNTCYL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAGCGGAG AAACGTTTGA GTTCAATATT AGACATTCTG GTAAAGTTTA CCCAATAACA 60
CTTTCCACTG ATGCTACTTC AGCAGATTTG AAAAGCAAAG CAGAGGAATT GACCCAAGTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001394--Peptidase_C19_UCH
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

SMART

SM00213--UBQ

Gene Ontology

GO:0000502--C:proteasome complex
GO:0005838--C:proteasome regulatory particle
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:1901799--P:negative regulation of proteasomal protein catabolic process
GO:0016579--P:protein deubiquitination
GO:0032434--P:regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

sce:YFR010W

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000893	Aegilops tauschii	28.05	2.00e-21	95.10
IUUC-Aml-002053	Ailuropoda melanoleuca	32.40	2.00e-59	221.00
IUUC-Atr-002725	Amborella trichopoda	33.00	1.00e-57	215.00
IUUC-Apl-004031	Anas platyrhynchos	32.23	9.00e-59	219.00
IUUC-Aca-004361	Anolis carolinensis	32.94	1.00e-61	228.00
IUUC-Aly-006078	Arabidopsis lyrata	33.40	5.00e-62	229.00
IUUC-Ath-007623	Arabidopsis thaliana	33.26	1.00e-61	228.00
IUUC-Ago-007796	Ashbya gossypii	58.70	6.00e-174	601.00
IUUC-Acl-008258	Aspergillus clavatus	35.84	1.00e-58	218.00
IUUC-Afl-008732	Aspergillus flavus	34.99	4.00e-81	293.00
IUUC-Afu-008755	Aspergillus fumigatus	34.50	2.00e-79	288.00
IUUC-Ani-009148	Aspergillus nidulans	35.05	6.00e-78	282.00
IUUC-Ang-009878	Aspergillus niger	34.68	8.00e-78	282.00
IUUC-Aor-010239	Aspergillus oryzae	34.99	4.00e-81	293.00
IUUC-Ate-010243	Aspergillus terreus	34.59	3.00e-77	280.00
IUUC-Ame-011327	Astyanax mexicanus	50.00	8.00e-15	72.80
IUUC-Bgr-012231	Blumeria graminis	33.33	4.00e-78	283.00
IUUC-Bta-012553	Bos taurus	33.00	6.00e-60	223.00
IUUC-Bci-013606	Botrytis cinerea	34.45	9.00e-84	302.00
IUUC-Bdi-014567	Brachypodium distachyon	33.94	1.00e-68	251.00
IUUC-Bol-015565	Brassica oleracea	33.89	4.00e-66	243.00
IUUC-Bra-017297	Brassica rapa	33.82	5.00e-66	243.00
IUUC-Cel-018140	Caenorhabditis elegans	29.03	1.00e-50	191.00
IUUC-Cja-019516	Callithrix jacchus	32.02	3.00e-62	230.00
IUUC-Cfa-020808	Canis familiaris	32.80	1.00e-59	221.00
IUUC-Cpo-021688	Cavia porcellus	32.34	3.00e-59	220.00
IUUC-Cre-022663	Chlamydomonas reinhardtii	26.90	5.00e-41	159.00
IUUC-Csa-023429	Chlorocebus sabaeus	32.21	5.00e-59	219.00
IUUC-Cho-024347	Choloepus hoffmanni	32.21	7.00e-59	219.00
IUUC-Cin-025198	Ciona intestinalis	29.56	3.00e-44	170.00
IUUC-Csv-026007	Ciona savignyi	29.43	5.00e-47	179.00
IUUC-Cgl-026757	Colletotrichum gloeosporioides	33.27	1.00e-70	258.00
IUUC-Cne-026963	Cryptococcus neoformans	32.43	1.00e-65	242.00
IUUC-Cme-027240	Cyanidioschyzon merolae	30.19	3.00e-40	157.00
IUUC-Dre-027647	Danio rerio	33.40	5.00e-63	233.00
IUUC-Dno-029967	Dasypus novemcinctus	32.21	1.00e-58	218.00
IUUC-Dor-030886	Dipodomys ordii	30.40	7.00e-45	172.00
IUUC-Dse-031466	Dothistroma septosporum	32.70	3.00e-53	200.00
IUUC-Dme-032079	Drosophila melanogaster	30.45	1.00e-55	208.00
IUUC-Ete-032351	Echinops telfairi	32.43	1.00e-58	218.00
IUUC-Eca-033461	Equus caballus	32.80	2.00e-63	234.00
IUUC-Eeu-035220	Erinaceus europaeus	29.51	5.00e-28	117.00
IUUC-Fca-036210	Felis catus	33.00	7.00e-60	222.00
IUUC-Fal-037528	Ficedula albicollis	32.73	3.00e-58	217.00
IUUC-Fox-037805	Fusarium oxysporum	33.88	7.00e-61	226.00
IUUC-Fso-038177	Fusarium solani	36.63	2.00e-86	310.00
IUUC-Gmo-038953	Gadus morhua	32.40	5.00e-54	203.00
IUUC-Ggr-039972	Gaeumannomyces graminis	31.71	1.00e-71	261.00
IUUC-Gga-040462	Gallus gallus	31.85	5.00e-57	213.00
IUUC-Gac-041312	Gasterosteus aculeatus	33.01	3.00e-62	230.00
IUUC-Gma-043255	Glycine max	34.56	7.00e-66	242.00
IUUC-Ggo-045458	Gorilla gorilla	30.88	5.00e-29	120.00
IUUC-Hsa-045706	Homo sapiens	32.41	2.00e-59	221.00
IUUC-Hvu-047821	Hordeum vulgare	35.22	2.00e-29	120.00
IUUC-Itr-048654	Ictidomys tridecemlineatus	32.21	8.00e-64	235.00
IUUC-Lch-050464	Latimeria chalumnae	33.33	2.00e-60	224.00
IUUC-Lpe-051419	Leersia perrieri	32.67	4.00e-63	233.00
IUUC-Loc-052732	Lepisosteus oculatus	32.87	3.00e-62	230.00
IUUC-Lma-053177	Leptosphaeria maculans	33.79	1.00e-55	208.00
IUUC-Laf-053822	Loxodonta africana	32.80	6.00e-59	219.00
IUUC-Mcc-055893	Macaca mulatta	32.41	2.00e-59	221.00
IUUC-Meu-056307	Macropus eugenii	30.68	4.00e-54	203.00
IUUC-Mor-057171	Magnaporthe oryzae	34.42	8.00e-80	289.00
IUUC-Mpo-057415	Magnaporthe poae	32.97	6.00e-76	276.00
IUUC-Mtr-057901	Medicago truncatula	34.75	2.00e-66	244.00
IUUC-Mla-058897	Melampsora laricipopulina	33.63	8.00e-46	176.00
IUUC-Mga-060016	Meleagris gallopavo	31.98	9.00e-59	219.00
IUUC-Mvi-060562	Microbotryum violaceum	31.50	7.00e-45	172.00
IUUC-Mmr-060624	Microcebus murinus	33.07	1.00e-64	238.00
IUUC-Mdo-061809	Monodelphis domestica	32.56	2.00e-60	224.00
IUUC-Mmu-063869	Mus musculus	33.13	1.00e-59	222.00
IUUC-Mac-064876	Musa acuminata	31.33	1.00e-54	205.00
IUUC-Mpu-066480	Mustela putorius furo	33.00	4.00e-60	223.00
IUUC-Mlu-067866	Myotis lucifugus	32.80	2.00e-60	224.00
IUUC-Nfi-068393	Neosartorya fischeri	34.68	1.00e-78	285.00
IUUC-Ncr-068815	Neurospora crassa	36.30	2.00e-81	294.00
IUUC-Nle-070121	Nomascus leucogenys	36.41	2.00e-28	117.00
IUUC-Opr-070712	Ochotona princeps	29.61	2.00e-32	131.00
IUUC-Ont-071544	Oreochromis niloticus	32.82	2.00e-53	201.00
IUUC-Oan-073635	Ornithorhynchus anatinus	31.40	7.00e-48	182.00
IUUC-Ocu-074926	Oryctolagus cuniculus	32.47	8.00e-60	222.00
IUUC-Oba-075633	Oryza barthii	32.39	4.00e-64	236.00
IUUC-Obr-076423	Oryza brachyantha	37.02	2.00e-54	204.00
IUUC-Ogl-077913	Oryza glaberrima	33.40	2.00e-67	247.00
IUUC-Ogu-078435	Oryza glumaepatula	32.39	4.00e-64	236.00
IUUC-Oin-080072	Oryza indica	32.39	5.00e-64	236.00
IUUC-Olo-080535	Oryza longistaminata	31.10	1.00e-56	211.00
IUUC-Ome-081309	Oryza meridionalis	32.39	4.00e-64	236.00
IUUC-Oni-083113	Oryza nivara	32.39	4.00e-64	236.00
IUUC-Opu-083168	Oryza punctata	32.39	1.00e-62	231.00
IUUC-Oru-084253	Oryza rufipogon	32.39	4.00e-64	236.00
IUUC-Osa-085554	Oryza sativa	34.00	8.00e-68	249.00
IUUC-Ola-086998	Oryzias latipes	33.01	3.00e-61	227.00
IUUC-Olu-087818	Ostreococcus lucimarinus	28.57	1.00e-50	192.00
IUUC-Oga-088571	Otolemur garnettii	33.13	5.00e-59	219.00
IUUC-Oar-089526	Ovis aries	33.00	7.00e-60	222.00
IUUC-Ptr-091433	Pan troglodytes	32.41	2.00e-59	221.00
IUUC-Pan-091966	Papio anubis	32.21	5.00e-59	219.00
IUUC-Psi-093458	Pelodiscus sinensis	32.99	8.00e-62	229.00
IUUC-Pma-094343	Petromyzon marinus	30.85	6.00e-29	119.00
IUUC-Pno-095109	Phaeosphaeria nodorum	33.22	2.00e-72	264.00
IUUC-Ppa-095756	Physcomitrella patens	33.40	2.00e-64	237.00
IUUC-Pfo-096514	Poecilia formosa	33.59	5.00e-56	209.00
IUUC-Pab-098477	Pongo abelii	29.90	5.00e-40	156.00
IUUC-Pop-099221	Populus trichocarpa	34.21	4.00e-64	236.00
IUUC-Pca-100791	Procavia capensis	28.48	2.00e-36	144.00
IUUC-Ppe-101812	Prunus persica	33.05	1.00e-61	228.00
IUUC-Pva-102462	Pteropus vampyrus	32.15	4.00e-52	196.00
IUUC-Pgr-103623	Puccinia graminis	34.59	3.00e-48	184.00
IUUC-Ptt-103767	Puccinia triticina	35.46	2.00e-47	181.00
IUUC-Pte-104109	Pyrenophora teres	31.87	2.00e-71	261.00
IUUC-Pyt-104766	Pyrenophora triticirepentis	32.13	5.00e-53	200.00
IUUC-Rno-105351	Rattus norvegicus	32.54	6.00e-59	219.00
IUUC-Sha-107491	Sarcophilus harrisii	32.43	5.00e-60	223.00
IUUC-Sja-107769	Schizosaccharomyces japonicus	37.22	2.00e-80	290.00
IUUC-Spo-108174	Schizosaccharomyces pombe	39.52	4.00e-78	283.00
IUUC-Ssl-108659	Sclerotinia sclerotiorum	35.62	2.00e-62	231.00
IUUC-Smo-108805	Selaginella moellendorffii	31.40	6.00e-62	229.00
IUUC-Sit-110361	Setaria italica	32.93	4.00e-67	246.00
IUUC-Sly-110965	Solanum lycopersicum	33.33	6.00e-63	233.00
IUUC-Sar-113355	Sorex araneus	32.59	4.00e-39	153.00
IUUC-Sbi-114778	Sorghum bicolor	33.74	1.00e-66	245.00
IUUC-Sre-115011	Sporisorium reilianum	32.97	4.00e-49	187.00
IUUC-Ssc-116273	Sus scrofa	33.00	2.00e-58	218.00
IUUC-Tgu-117063	Taeniopygia guttata	32.73	3.00e-58	217.00
IUUC-Tru-118381	Takifugu rubripes	31.85	2.00e-54	204.00
IUUC-Tsy-119076	Tarsius syrichta	34.20	2.00e-25	107.00
IUUC-Tni-119941	Tetraodon nigroviridis	32.36	6.00e-54	202.00
IUUC-Tca-121246	Theobroma cacao	34.30	4.00e-64	236.00
IUUC-Tre-121969	Trichoderma reesei	35.23	7.00e-59	219.00
IUUC-Tvi-122543	Trichoderma virens	34.84	1.00e-79	288.00
IUUC-Tae-125744	Triticum aestivum	34.82	2.00e-70	257.00
IUUC-Tur-126128	Triticum urartu	27.54	4.00e-21	94.00
IUUC-Tbe-128030	Tupaia belangeri	30.02	1.00e-44	171.00
IUUC-Ttr-128701	Tursiops truncatus	31.61	1.00e-47	181.00
IUUC-Uma-129657	Ustilago maydis	33.89	2.00e-50	191.00
IUUC-Vda-129723	Verticillium dahliae	34.04	2.00e-79	288.00
IUUC-Vvi-131037	Vitis vinifera	33.33	5.00e-64	236.00
IUUC-Xtr-132235	Xenopus tropicalis	31.94	3.00e-61	227.00
IUUC-Xma-133840	Xiphophorus maculatus	33.59	1.00e-62	232.00
IUUC-Yli-134453	Yarrowia lipolytica	38.51	1.00e-84	305.00
IUUC-Zma-135791	Zea mays	36.06	1.00e-49	188.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence