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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063178
UUCD1 version UUC-MuM-00197
Ensembl Protein ID ENSMUSP00000045792.9
UniProt Accession Q8C2S5; Q14CG1; Q3TAK6; Q3TWC9; Q3UC66; Q80XI5; Q8BGF5; Q8BNL3; Q8C3Q8; FBXL5_MOUSE
Genbank Protein ID BAC26698.1; BAC30964.1; BAC38698.1; BAC39366.1; BAC40126.1; BAE29748.1; BAE35337.1; BAE42662.1; AAH47214.1; AAI13799.1
Protein Name F-box/LRR-repeat protein 5; F-box and leucine-rich repeat protein 5
Genbank Nucleotide ID AK029957; AK041497; AK082931; AK085100; AK088067; AK150664; AK159744; AK171783; BC047214; BC113798
Gene Name Fbxl5
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000039753.16 ENSMUST00000119523.7 ENSMUSP00000113557.1
ENSMUSG00000039753.16 ENSMUST00000141902.7 ENSMUSP00000120338.1
ENSMUSG00000039753.16 ENSMUST00000196483.4 ENSMUSP00000143703.1
ENSMUSG00000039753.16 ENSMUST00000047857.15 ENSMUSP00000045792.9
ENSMUSG00000039753.16 ENSMUST00000114047.9 ENSMUSP00000109681.3
ENSMUSG00000039753.16 ENSMUST00000124610.5 ENSMUSP00000116720.2
ENSMUSG00000039753.16 ENSMUST00000087465.10 ENSMUSP00000084733.4
ENSMUSG00000039753.16 ENSMUST00000121736.5 ENSMUSP00000112444.1
ENSMUSG00000039753.16 ENSMUST00000199055.1 ENSMUSP00000142582.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitecircBasemicroRNATRANSFAC
RepTarmiRNAMapRAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 adaptor/Cullin RING/SCF/F-box 93.63 0.00e+00 1284.00 IUUC-Hsa-047001
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description


     Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. Upon high iron and oxygen level, it specifically recognizes and binds IREB2/IRP2, promoting its ubiquitination and degradation by the proteasome. Promotes ubiquitination and subsequent degradation of DCTN1/p150-glued (By similarity).
 Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. Upon high iron and oxygen level, it specifically recognizes and binds IREB2/IRP2, promoting its ubiquitination and degradation by the proteasome. Promotes ubiquitination and subsequent degradation of DCTN1/p150-glued (By similarity).
Protein Sequence
(Fasta)
MAPFPDEVDV FTAPHWRMKQ LVGRYCDKLS KTNFSNNNDF RALLQSLYAT FKEFKMHEQI 60
ENEYIIGLLQ QRSQTIYNVH SDNKLSEMLS LFEKGLKNVK NEYEQLNYAK QLKERLEAFT 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063178|E3,F-box|Mus musculus
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Nucleotide Sequence
(Fasta)
AGCAGGTGGT TATTCTCCCA GAACAGTGAC TGATGAGAAA CAACCAGGAG TTAAAATACG 60
AAATAAAATG GAAGCACCTT GACTGCAGTG TCGTCGAGGT AAGTCAGCAG CCGTTCCTCA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063178|E3,F-box|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0408--Iron
KW-0433--Leucine-rich repeat
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
Interpro

IPR001810--F-box_dom
IPR012312--Haemerythrin-like
IPR032675--L_dom-like
IPR001611--Leu-rich_rpt
IPR006553--Leu-rich_rpt_Cys-con_subtyp
PROSITE

PS50181--FBOX
Pfam

PF12937--F-box-like
PF01814--Hemerythrin
PF13516--LRR_6
SMART

SM00256--FBOX
SM00367--LRR_CC
Gene Ontology

GO:0048471--C:perinuclear region of cytoplasm
GO:0019005--C:SCF ubiquitin ligase complex
GO:0005506--F:iron ion binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0055072--P:iron ion homeostasis
GO:1903364--P:positive regulation of cellular protein catabolic process
GO:0016567--P:protein ubiquitination
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
KEGG mmu:242960
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002319 Ailuropoda melanoleuca 92.97 0.00e+00 1177.00
IUUC-Apl-003755 Anas platyrhynchos 79.22 0.00e+00 997.00
IUUC-Aca-004798 Anolis carolinensis 76.45 0.00e+00 1042.00
IUUC-Ame-011091 Astyanax mexicanus 59.72 0.00e+00 774.00
IUUC-Bta-013204 Bos taurus 90.99 0.00e+00 1180.00
IUUC-Cja-019594 Callithrix jacchus 91.86 0.00e+00 1013.00
IUUC-Cfa-020965 Canis familiaris 93.05 0.00e+00 1222.00
IUUC-Cpo-021308 Cavia porcellus 92.62 0.00e+00 1239.00
IUUC-Csa-023865 Chlorocebus sabaeus 93.34 0.00e+00 1293.00
IUUC-Cho-024778 Choloepus hoffmanni 82.08 3.00e-163 568.00
IUUC-Dre-027628 Danio rerio 54.57 7.00e-178 617.00
IUUC-Dno-029899 Dasypus novemcinctus 91.40 0.00e+00 1259.00
IUUC-Dor-031105 Dipodomys ordii 81.16 0.00e+00 1067.00
IUUC-Ete-032314 Echinops telfairi 85.82 0.00e+00 1074.00
IUUC-Eca-033797 Equus caballus 91.82 0.00e+00 1127.00
IUUC-Eeu-034811 Erinaceus europaeus 83.27 0.00e+00 877.00
IUUC-Fca-036516 Felis catus 91.87 0.00e+00 1156.00
IUUC-Fal-036824 Ficedula albicollis 77.39 0.00e+00 932.00
IUUC-Gga-040271 Gallus gallus 79.48 0.00e+00 1059.00
IUUC-Gac-041399 Gasterosteus aculeatus 63.16 0.00e+00 805.00
IUUC-Ggo-044415 Gorilla gorilla 93.34 0.00e+00 1294.00
IUUC-Hsa-047001 Homo sapiens 93.63 0.00e+00 1312.00
IUUC-Itr-048356 Ictidomys tridecemlineatus 92.74 0.00e+00 1051.00
IUUC-Lch-049897 Latimeria chalumnae 65.62 0.00e+00 836.00
IUUC-Loc-052162 Lepisosteus oculatus 66.04 0.00e+00 862.00
IUUC-Laf-054031 Loxodonta africana 91.75 0.00e+00 1238.00
IUUC-Mcc-054680 Macaca mulatta 93.34 0.00e+00 1294.00
IUUC-Meu-056199 Macropus eugenii 80.69 4.00e-104 372.00
IUUC-Mga-059675 Meleagris gallopavo 79.25 0.00e+00 1016.00
IUUC-Mmr-061694 Microcebus murinus 93.20 0.00e+00 1284.00
IUUC-Mdo-062900 Monodelphis domestica 87.99 0.00e+00 1204.00
IUUC-Mpu-066584 Mustela putorius furo 93.04 0.00e+00 1231.00
IUUC-Mlu-067859 Myotis lucifugus 91.86 0.00e+00 1166.00
IUUC-Nle-069172 Nomascus leucogenys 93.63 0.00e+00 1269.00
IUUC-Opr-070992 Ochotona princeps 88.59 0.00e+00 997.00
IUUC-Ont-072577 Oreochromis niloticus 62.43 0.00e+00 806.00
IUUC-Oan-072870 Ornithorhynchus anatinus 83.45 0.00e+00 895.00
IUUC-Ocu-074849 Oryctolagus cuniculus 90.45 0.00e+00 1231.00
IUUC-Oni-082377 Oryza nivara 25.63 3.00e-04 42.70
IUUC-Ola-087146 Oryzias latipes 60.79 0.00e+00 788.00
IUUC-Oga-088307 Otolemur garnettii 92.64 0.00e+00 1209.00
IUUC-Oar-090192 Ovis aries 88.87 0.00e+00 1191.00
IUUC-Ptr-091049 Pan troglodytes 93.63 0.00e+00 1298.00
IUUC-Pan-091995 Papio anubis 93.49 0.00e+00 1297.00
IUUC-Psi-093154 Pelodiscus sinensis 79.12 0.00e+00 985.00
IUUC-Pma-094334 Petromyzon marinus 47.36 6.00e-142 498.00
IUUC-Pfo-096154 Poecilia formosa 62.06 0.00e+00 782.00
IUUC-Pab-098264 Pongo abelii 93.37 0.00e+00 1238.00
IUUC-Pca-100884 Procavia capensis 70.72 0.00e+00 914.00
IUUC-Pva-102114 Pteropus vampyrus 92.05 0.00e+00 1253.00
IUUC-Rno-105392 Rattus norvegicus 96.96 0.00e+00 1328.00
IUUC-Sha-106508 Sarcophilus harrisii 85.05 0.00e+00 1152.00
IUUC-Sar-113107 Sorex araneus 88.17 0.00e+00 825.00
IUUC-Ssc-115489 Sus scrofa 92.62 0.00e+00 1217.00
IUUC-Tgu-116734 Taeniopygia guttata 78.04 0.00e+00 1012.00
IUUC-Tru-117632 Takifugu rubripes 61.90 0.00e+00 791.00
IUUC-Tsy-119400 Tarsius syrichta 91.70 0.00e+00 1197.00
IUUC-Tni-120602 Tetraodon nigroviridis 60.85 0.00e+00 807.00
IUUC-Tbe-127833 Tupaia belangeri 90.41 0.00e+00 630.00
IUUC-Ttr-129289 Tursiops truncatus 91.03 0.00e+00 722.00
IUUC-Vpa-130253 Vicugna pacos 95.30 0.00e+00 640.00
Created Date 25-Jun-2017

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