iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Xma-133445

Ensembl Protein ID

ENSXMAP00000018576.1

UniProt Accession

M4AVT1; M4AVT1_XIPMA

Genbank Protein ID

ENSXMAP00000018576

Protein Name

Apoptotic protease-activating factor 1

Genbank Nucleotide ID

AGAJ01029470

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXMAG00000018504.1	ENSXMAT00000018604.1	ENSXMAP00000018576.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.30e-54	179.8	661	699
UBD/Beta-Prp	5.50e-91	304.9	974	1236

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllks 38
           H ++v c+af +d +ll+++s D ++kvW++ +g+ll++
   Q: 661  HDEEVLCCAFsPDdHLLATCSSDRKVKVWNIQQGKLLRT 699
           999********88799******************99875 PP

UBD/Beta-Prp

   S: 16   vkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsf 102
            ++ ++ s ++ g ++g ++v  + +gkll++l gh+++v  ++f ++g++l+t+seD ti+vw  ++g+c  +l+gh+++v++ s+
   Q: 974  TCMCRNPSAVVLGQENGNVQVLALPSGKLLATLLGHTKTVLHCQFCQNGQTLITSSEDTTIRVWKWKSGECK-VLQGHKEQVRCFSL 1059
           4445588999*************************************************************6.699********998 PP
   S: 103  sp...sgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvysl 186
                ++++l+s s d t++vwd+e+g++l+   + h+g++ + +v+pd +l+++ s+D+t +lW+ ++ +++ tl+g h+d v+s 
   Q: 1060 LSdsaNDSRLLSWSFDGTVKVWDIESGEKLQ-DIKAHQGAILSCHVSPDRCLFATTSADKTTKLWSCESWQCVFTLRG-HQDCVRSC 1144
           8877799************************.667799999999999*9****************************9.******** PP
   S: 187  sfdsngkelvsgsldgtvklwdlqtgecvrtlnght.........dnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhn 264
            f+ ++k+l++g+++g +++w+++ g+ ++ +   +          +v++++fspn+  lvs++  g i+ Wd+  g+ l+t+  + 
   Q: 1145 RFSWDSKRLATGDDNGEIRIWSVKDGSLLKVCSQESkdatdsvhgGWVTDLHFSPNNSVLVSTG--GYIKWWDVARGESLQTFYPTG 1229
           ************************888766666655566677777*******************..****************97666 PP
   S: 265  ssvisva 271
           s + ++ 
   Q: 1230 SALKKIH 1236
           5555554 PP

Organism

Xiphophorus maculatus

Functional Description
(View)

Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.

Protein Sequence
(Fasta)

MALQERTRRS LLRLRHQLEQ DIKPQDLMDH MISDGVITVD EEEKVRIKPT RKDQAAALIE 60
LLLRKDDRSF ISFYNALVKE TYYDLAKPLY QDLPGVSFNG RKGSFDSSET SVQIMLSEGG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCGGAAGCTT GAATCTCTTA TTGGGCGTGT GTTATGTCGA AAGAGAAATA AATAAGAATT 60
TTGTGGCTTG AGGATATCTT GAAAACGCGA CATAACTTTG AGGACTATCT TTCAACAGAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0053--Apoptosis
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR017251--Apaf-1
IPR001315--CARD
IPR011029--DEATH-like_dom
IPR020472--G-protein_beta_WD-40_rep
IPR002182--NB-ARC
IPR027417--P-loop_NTPase
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS50209--CARD
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00619--CARD
PF00931--NB-ARC
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00114--CARD
SM00320--WD40

Gene Ontology

GO:0043293--C:apoptosome
GO:0043531--F:ADP binding
GO:0005524--F:ATP binding
GO:0097190--P:apoptotic signaling pathway
GO:0042981--P:regulation of apoptotic process

KEGG

xma:102220895

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001432	Ailuropoda melanoleuca	54.68	0.00e+00	1370.00
IUUC-Apl-004201	Anas platyrhynchos	54.14	0.00e+00	1370.00
IUUC-Aca-004638	Anolis carolinensis	53.90	0.00e+00	1386.00
IUUC-Ame-011062	Astyanax mexicanus	69.21	0.00e+00	1744.00
IUUC-Bta-012865	Bos taurus	54.74	0.00e+00	1389.00
IUUC-Cja-018815	Callithrix jacchus	50.88	0.00e+00	1230.00
IUUC-Cfa-020222	Canis familiaris	51.54	0.00e+00	1264.00
IUUC-Cpo-021524	Cavia porcellus	54.82	0.00e+00	1393.00
IUUC-Csa-023861	Chlorocebus sabaeus	54.90	0.00e+00	1386.00
IUUC-Cho-024484	Choloepus hoffmanni	46.26	0.00e+00	682.00
IUUC-Dre-028006	Danio rerio	66.30	0.00e+00	1613.00
IUUC-Dno-029591	Dasypus novemcinctus	55.46	0.00e+00	1403.00
IUUC-Dor-030237	Dipodomys ordii	44.76	1.00e-169	591.00
IUUC-Ete-032620	Echinops telfairi	51.04	0.00e+00	640.00
IUUC-Eca-033569	Equus caballus	54.74	0.00e+00	1382.00
IUUC-Eeu-035354	Erinaceus europaeus	41.48	6.00e-98	352.00
IUUC-Fca-036337	Felis catus	54.37	0.00e+00	1385.00
IUUC-Fal-037077	Ficedula albicollis	53.49	0.00e+00	1353.00
IUUC-Gmo-039687	Gadus morhua	63.11	0.00e+00	1177.00
IUUC-Gga-040299	Gallus gallus	53.13	0.00e+00	1370.00
IUUC-Gac-041762	Gasterosteus aculeatus	73.56	0.00e+00	1838.00
IUUC-Ggo-045563	Gorilla gorilla	55.14	0.00e+00	1396.00
IUUC-Hsa-046771	Homo sapiens	55.06	0.00e+00	1393.00
IUUC-Lch-050200	Latimeria chalumnae	56.88	0.00e+00	1408.00
IUUC-Loc-052090	Lepisosteus oculatus	64.54	0.00e+00	1618.00
IUUC-Laf-053861	Loxodonta africana	55.05	0.00e+00	1386.00
IUUC-Mcc-055543	Macaca mulatta	54.98	0.00e+00	1388.00
IUUC-Meu-056688	Macropus eugenii	56.43	0.00e+00	1389.00
IUUC-Mga-059243	Meleagris gallopavo	53.49	0.00e+00	1369.00
IUUC-Mmr-061134	Microcebus murinus	52.22	0.00e+00	1192.00
IUUC-Mdo-062913	Monodelphis domestica	55.95	0.00e+00	1391.00
IUUC-Mmu-063811	Mus musculus	55.30	0.00e+00	1399.00
IUUC-Mpu-066780	Mustela putorius furo	54.69	0.00e+00	1372.00
IUUC-Mlu-067276	Myotis lucifugus	54.70	0.00e+00	1380.00
IUUC-Nle-069129	Nomascus leucogenys	54.82	0.00e+00	1384.00
IUUC-Opr-071007	Ochotona princeps	42.20	0.00e+00	654.00
IUUC-Ont-071348	Oreochromis niloticus	81.03	0.00e+00	2083.00
IUUC-Oan-072717	Ornithorhynchus anatinus	55.42	0.00e+00	1423.00
IUUC-Ocu-074286	Oryctolagus cuniculus	55.36	0.00e+00	1205.00
IUUC-Ola-086895	Oryzias latipes	68.42	0.00e+00	1692.00
IUUC-Oga-088678	Otolemur garnettii	55.86	0.00e+00	1402.00
IUUC-Oar-089359	Ovis aries	55.14	0.00e+00	1390.00
IUUC-Ptr-091062	Pan troglodytes	55.14	0.00e+00	1395.00
IUUC-Pan-092528	Papio anubis	57.94	0.00e+00	848.00
IUUC-Psi-093430	Pelodiscus sinensis	55.93	0.00e+00	1398.00
IUUC-Pma-094690	Petromyzon marinus	40.21	9.00e-153	534.00
IUUC-Pfo-097204	Poecilia formosa	95.24	0.00e+00	2458.00
IUUC-Pab-097690	Pongo abelii	55.06	0.00e+00	1392.00
IUUC-Pca-100778	Procavia capensis	42.99	0.00e+00	690.00
IUUC-Pva-102870	Pteropus vampyrus	53.43	0.00e+00	1258.00
IUUC-Rno-104889	Rattus norvegicus	55.06	0.00e+00	1377.00
IUUC-Sha-107465	Sarcophilus harrisii	55.01	0.00e+00	1389.00
IUUC-Sar-113268	Sorex araneus	51.69	9.00e-107	382.00
IUUC-Ssc-115654	Sus scrofa	54.98	0.00e+00	1396.00
IUUC-Tgu-117302	Taeniopygia guttata	53.54	0.00e+00	1365.00
IUUC-Tru-118363	Takifugu rubripes	79.08	0.00e+00	2023.00
IUUC-Tsy-119007	Tarsius syrichta	52.73	0.00e+00	1323.00
IUUC-Tni-120910	Tetraodon nigroviridis	77.42	0.00e+00	1952.00
IUUC-Tbe-127413	Tupaia belangeri	45.46	0.00e+00	808.00
IUUC-Ttr-129213	Tursiops truncatus	51.04	0.00e+00	1247.00
IUUC-Vpa-130146	Vicugna pacos	51.12	0.00e+00	955.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence