iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aml-001262

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ACTA01076121

Gene Name

TRAF6

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMEG00000013844.1	ENSAMET00000015201.1	ENSAMEP00000014595.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	5.10e-07	29.8	66	127

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 4    eeflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplteedlvPnltlrrli 65
           + + CpI l   r+ v +p+G+ + +++I k +++ g++cPv+++ l e++l P ++ +r i
   Q: 66   SKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHKCPVDNEILLENQLFPDNFAKREI 127
           5689*****************************999999*****************999977 PP

Organism

Ailuropoda melanoleuca

Protein Sequence
(Fasta)

MSLLNCENSC GSSQSESDCC AAMASSCSAA AKDDSVSGTA STGNLSSSFM EEIQGYDVEF 60
DPPLESKYEC PICLMALREA VQTPCGHRFC KACIIKSIRD AGHKCPVDNE ILLENQLFPD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAGTCTGC TAAACTGTGA AAACAGCTGT GGATCCAGCC AGTCTGAAAG TGACTGCTGT 60
GCCGCCATGG CCAGCTCCTG TAGCGCTGCA GCTAAAGATG ACAGTGTGAG TGGAACCGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR002083--MATH/TRAF_dom
IPR012227--TNF_rcpt--assoc_TRAF
IPR008974--TRAF-like
IPR027139--TRAF6
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
IPR001293--Znf_TRAF

PROSITE

PS50144--MATH
PS00518--ZF_RING_1
PS50089--ZF_RING_2
PS50145--ZF_TRAF

Pfam

PF02176--zf-TRAF

SMART

SM00061--MATH
SM00184--RING

Gene Ontology

GO:0035631--C:CD40 receptor complex
GO:0009898--C:cytoplasmic side of plasma membrane
GO:0005829--C:cytosol
GO:0005811--C:lipid particle
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0043234--C:protein complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0007250--P:activation of NF-kappaB-inducing kinase activity
GO:0019886--P:antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0045453--P:bone resorption
GO:0048468--P:cell development
GO:0071222--P:cellular response to lipopolysaccharide
GO:0007249--P:I-kappaB kinase/NF-kappaB signaling
GO:0070498--P:interleukin-1-mediated signaling pathway
GO:0043011--P:myeloid dendritic cell differentiation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0001843--P:neural tube closure
GO:0042475--P:odontogenesis of dentin-containing tooth
GO:0001503--P:ossification
GO:0030316--P:osteoclast differentiation
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045084--P:positive regulation of interleukin-12 biosynthetic process
GO:0032743--P:positive regulation of interleukin-2 production
GO:0045410--P:positive regulation of interleukin-6 biosynthetic process
GO:0043507--P:positive regulation of JUN kinase activity
GO:0031666--P:positive regulation of lipopolysaccharide-mediated signaling pathway
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0045672--P:positive regulation of osteoclast differentiation
GO:0002726--P:positive regulation of T cell cytokine production
GO:0042102--P:positive regulation of T cell proliferation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:2000679--P:positive regulation of transcription regulatory region DNA binding
GO:0051865--P:protein autoubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0042981--P:regulation of apoptotic process
GO:0051023--P:regulation of immunoglobulin secretion
GO:0050852--P:T cell receptor signaling pathway
GO:0042088--P:T-helper 1 type immune response

KEGG

aml:100483216

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-004062	Anas platyrhynchos	74.23	0.00e+00	825.00
IUUC-Aca-004636	Anolis carolinensis	72.34	0.00e+00	777.00
IUUC-Ame-011682	Astyanax mexicanus	56.05	4.00e-165	574.00
IUUC-Bta-012692	Bos taurus	92.24	0.00e+00	1004.00
IUUC-Bdi-014466	Brachypodium distachyon	29.82	4.00e-08	52.00
IUUC-Cja-019426	Callithrix jacchus	90.76	0.00e+00	971.00
IUUC-Cfa-020948	Canis familiaris	97.14	0.00e+00	914.00
IUUC-Cpo-021378	Cavia porcellus	91.71	0.00e+00	992.00
IUUC-Csa-024045	Chlorocebus sabaeus	91.31	0.00e+00	981.00
IUUC-Cho-024973	Choloepus hoffmanni	76.61	8.00e-102	363.00
IUUC-Csv-026300	Ciona savignyi	41.59	2.00e-45	175.00
IUUC-Dre-027557	Danio rerio	59.60	5.00e-174	604.00
IUUC-Dno-030032	Dasypus novemcinctus	90.49	9.00e-154	535.00
IUUC-Dor-030790	Dipodomys ordii	89.83	0.00e+00	969.00
IUUC-Dse-031478	Dothistroma septosporum	23.08	2.00e-10	61.20
IUUC-Dme-031921	Drosophila melanogaster	26.52	3.00e-40	159.00
IUUC-Ete-032952	Echinops telfairi	84.37	8.00e-170	590.00
IUUC-Eca-033924	Equus caballus	89.50	0.00e+00	910.00
IUUC-Eeu-034734	Erinaceus europaeus	83.95	0.00e+00	879.00
IUUC-Fca-036222	Felis catus	88.54	0.00e+00	900.00
IUUC-Fal-036834	Ficedula albicollis	75.74	0.00e+00	749.00
IUUC-Fox-037935	Fusarium oxysporum	29.77	2.00e-22	100.00
IUUC-Gmo-039061	Gadus morhua	61.79	2.00e-86	313.00
IUUC-Ggr-040084	Gaeumannomyces graminis	27.93	2.00e-11	64.30
IUUC-Gga-040599	Gallus gallus	75.23	0.00e+00	833.00
IUUC-Gac-041977	Gasterosteus aculeatus	56.05	2.00e-168	585.00
IUUC-Ggo-044508	Gorilla gorilla	85.45	0.00e+00	902.00
IUUC-Hsa-046349	Homo sapiens	91.31	0.00e+00	990.00
IUUC-Itr-047966	Ictidomys tridecemlineatus	90.02	0.00e+00	963.00
IUUC-Lch-049821	Latimeria chalumnae	67.92	0.00e+00	748.00
IUUC-Loc-051995	Lepisosteus oculatus	61.66	0.00e+00	642.00
IUUC-Laf-054115	Loxodonta africana	88.91	0.00e+00	984.00
IUUC-Mcc-055298	Macaca mulatta	91.31	0.00e+00	981.00
IUUC-Mor-057263	Magnaporthe oryzae	30.23	3.00e-17	83.60
IUUC-Mpo-057517	Magnaporthe poae	28.77	1.00e-13	71.20
IUUC-Mga-059340	Meleagris gallopavo	75.05	0.00e+00	830.00
IUUC-Mvi-060553	Microbotryum violaceum	27.68	2.00e-14	73.60
IUUC-Mmr-061063	Microcebus murinus	92.59	0.00e+00	985.00
IUUC-Mdo-062075	Monodelphis domestica	81.58	0.00e+00	896.00
IUUC-Mmu-063780	Mus musculus	87.06	0.00e+00	907.00
IUUC-Mpu-065748	Mustela putorius furo	97.22	0.00e+00	1024.00
IUUC-Mlu-067888	Myotis lucifugus	91.11	0.00e+00	981.00
IUUC-Ncr-068632	Neurospora crassa	27.50	4.00e-15	76.60
IUUC-Nle-069234	Nomascus leucogenys	91.31	0.00e+00	987.00
IUUC-Opr-070393	Ochotona princeps	96.24	4.00e-123	434.00
IUUC-Ont-072459	Oreochromis niloticus	57.50	1.00e-175	609.00
IUUC-Oan-073578	Ornithorhynchus anatinus	83.64	0.00e+00	924.00
IUUC-Ocu-074201	Oryctolagus cuniculus	92.61	0.00e+00	996.00
IUUC-Ola-087319	Oryzias latipes	63.83	6.00e-89	321.00
IUUC-Olu-087748	Ostreococcus lucimarinus	24.40	6.00e-11	61.60
IUUC-Oga-087936	Otolemur garnettii	90.39	0.00e+00	979.00
IUUC-Oar-089379	Ovis aries	92.05	0.00e+00	1012.00
IUUC-Ptr-090758	Pan troglodytes	91.68	0.00e+00	986.00
IUUC-Pan-092590	Papio anubis	91.50	0.00e+00	982.00
IUUC-Psi-093948	Pelodiscus sinensis	73.49	0.00e+00	818.00
IUUC-Pma-094434	Petromyzon marinus	44.80	4.00e-127	448.00
IUUC-Pfo-096912	Poecilia formosa	56.30	6.00e-169	587.00
IUUC-Pab-097651	Pongo abelii	91.68	0.00e+00	988.00
IUUC-Pca-100958	Procavia capensis	85.71	0.00e+00	705.00
IUUC-Pva-103247	Pteropus vampyrus	93.25	1.00e-130	459.00
IUUC-Rno-104994	Rattus norvegicus	85.40	0.00e+00	919.00
IUUC-Sha-106494	Sarcophilus harrisii	82.44	0.00e+00	907.00
IUUC-Sar-113375	Sorex araneus	87.64	0.00e+00	939.00
IUUC-Sre-115218	Sporisorium reilianum	25.97	9.00e-15	75.50
IUUC-Ssc-115417	Sus scrofa	92.80	0.00e+00	1016.00
IUUC-Tgu-117232	Taeniopygia guttata	75.18	0.00e+00	809.00
IUUC-Tru-118321	Takifugu rubripes	56.02	2.00e-167	582.00
IUUC-Tni-120475	Tetraodon nigroviridis	57.25	5.00e-166	577.00
IUUC-Tbe-127719	Tupaia belangeri	80.11	0.00e+00	831.00
IUUC-Ttr-129264	Tursiops truncatus	91.70	3.00e-127	448.00
IUUC-Uma-129620	Ustilago maydis	26.74	2.00e-17	84.70
IUUC-Vpa-130244	Vicugna pacos	90.91	3.00e-129	454.00
IUUC-Xtr-131948	Xenopus tropicalis	65.89	0.00e+00	733.00
IUUC-Xma-133132	Xiphophorus maculatus	56.98	5.00e-171	593.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence