iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Eca-034393

UUCD1 version

UUC-EqC-00733

Ensembl Protein ID

ENSECAP00000016260.1

UniProt Accession

F7BPW3; F7BPW3_HORSE

Protein Name

Uncharacterized protein

Gene Name

KLHL40

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000018580.1	ENSECAT00000019833.1	ENSECAP00000016260.1
ENSECAG00000018580.1	ENSECAT00000019910.1	ENSECAP00000016326.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB	5.90e-15	55.6	34	97
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box	1.10e-06	27.9	130	160

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB

   S: 2    DvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklden 68
           D+++ vg++ef++h++vLaa+S++F+a fl e e     ++  +++v+p+v+ ++l++lYt+++ ++
   Q: 34   DCVVRVGEREFPCHRLVLAACSPYFRARFLAEPERA---GELRLEEVSPDVVAQVLHYLYTSEIALD 97
           9****************************9988864...699999*****************99876 PP

E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box

   S: 1    leNclgilrfAdlydcpdLkdaaldfilkhF 31
           l+Ncl+++r++ l+dc +L+ aa+dfi+  F
   Q: 130  LSNCLAVFRLGLLLDCARLAVAARDFICARF 160
           69**************************999 PP

Organism

Equus caballus

Protein Sequence
(Fasta)

MPLGLEQAEE QRLYQQTLLQ DGLKDMLDHG KFLDCVVRVG EREFPCHRLV LAACSPYFRA 60
RFLAEPERAG ELRLEEVSPD VVAQVLHYLY TSEIALDEAS VQDLFAAAHR FQIPSIFTIC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCGAGAGGAG GCCCCTGGCA CCGTCGCTGC ACCCTAGGCC ACCCGCCATG CCGCTGGGCT 60
TGGAGCAGGC AGAGGAGCAG CGCCTGTACC AGCAGACGCT CCTGCAGGAC GGGCTCAAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0880--Kelch repeat
KW-1185--Reference proteome
KW-0677--Repeat

Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR030607--KLHL40
IPR011333--SKP1/BTB/POZ

PROSITE

PS50097--BTB

Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1

SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch

Gene Ontology

GO:0031672--C:A band
GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0031674--C:I band
GO:0032435--P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0031397--P:negative regulation of protein ubiquitination
GO:0016567--P:protein ubiquitination
GO:0048741--P:skeletal muscle fiber development

KEGG

ecb:100067358

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001792	Ailuropoda melanoleuca	90.12	0.00e+00	1007.00
IUUC-Apl-003748	Anas platyrhynchos	70.52	0.00e+00	842.00
IUUC-Aca-005275	Anolis carolinensis	63.85	0.00e+00	761.00
IUUC-Acl-008133	Aspergillus clavatus	33.87	2.00e-04	41.20
IUUC-Ame-011294	Astyanax mexicanus	55.78	0.00e+00	685.00
IUUC-Bta-012801	Bos taurus	92.63	0.00e+00	1086.00
IUUC-Cja-019795	Callithrix jacchus	90.27	0.00e+00	1011.00
IUUC-Cfa-021245	Canis familiaris	90.58	0.00e+00	771.00
IUUC-Cpo-022436	Cavia porcellus	88.57	0.00e+00	1064.00
IUUC-Csa-023105	Chlorocebus sabaeus	93.61	0.00e+00	1063.00
IUUC-Dre-028603	Danio rerio	57.31	0.00e+00	706.00
IUUC-Dno-030015	Dasypus novemcinctus	77.16	2.00e-177	615.00
IUUC-Fca-035823	Felis catus	80.26	0.00e+00	916.00
IUUC-Fal-037632	Ficedula albicollis	70.85	0.00e+00	818.00
IUUC-Gmo-039697	Gadus morhua	56.35	0.00e+00	695.00
IUUC-Gga-040525	Gallus gallus	70.69	0.00e+00	842.00
IUUC-Gac-042421	Gasterosteus aculeatus	59.03	0.00e+00	723.00
IUUC-Ggo-045596	Gorilla gorilla	93.61	0.00e+00	1061.00
IUUC-Hsa-046235	Homo sapiens	93.61	0.00e+00	1061.00
IUUC-Itr-048612	Ictidomys tridecemlineatus	92.11	0.00e+00	1083.00
IUUC-Lch-050123	Latimeria chalumnae	65.31	0.00e+00	820.00
IUUC-Loc-051824	Lepisosteus oculatus	62.75	0.00e+00	790.00
IUUC-Laf-053485	Loxodonta africana	87.62	0.00e+00	698.00
IUUC-Mcc-054909	Macaca mulatta	93.61	0.00e+00	1061.00
IUUC-Meu-055972	Macropus eugenii	75.33	0.00e+00	933.00
IUUC-Mga-059451	Meleagris gallopavo	70.69	0.00e+00	846.00
IUUC-Mmr-060736	Microcebus murinus	93.45	0.00e+00	1080.00
IUUC-Mdo-062563	Monodelphis domestica	76.84	0.00e+00	737.00
IUUC-Mmu-063549	Mus musculus	90.25	0.00e+00	1066.00
IUUC-Mpu-066262	Mustela putorius furo	92.29	0.00e+00	1086.00
IUUC-Mlu-067210	Myotis lucifugus	92.28	0.00e+00	1078.00
IUUC-Nle-069300	Nomascus leucogenys	92.24	0.00e+00	758.00
IUUC-Opr-070384	Ochotona princeps	87.77	0.00e+00	969.00
IUUC-Ont-071273	Oreochromis niloticus	58.96	0.00e+00	706.00
IUUC-Ocu-074499	Oryctolagus cuniculus	91.67	0.00e+00	1060.00
IUUC-Ola-087175	Oryzias latipes	58.19	0.00e+00	694.00
IUUC-Oga-088855	Otolemur garnettii	92.94	0.00e+00	1070.00
IUUC-Oar-089342	Ovis aries	79.06	0.00e+00	850.00
IUUC-Ptr-091028	Pan troglodytes	92.47	0.00e+00	759.00
IUUC-Pan-091827	Papio anubis	93.95	0.00e+00	1063.00
IUUC-Psi-092998	Pelodiscus sinensis	71.36	0.00e+00	853.00
IUUC-Pma-094586	Petromyzon marinus	64.56	6.00e-96	343.00
IUUC-Pfo-096216	Poecilia formosa	57.29	0.00e+00	717.00
IUUC-Pab-097656	Pongo abelii	91.75	0.00e+00	661.00
IUUC-Pva-102331	Pteropus vampyrus	94.80	0.00e+00	964.00
IUUC-Pte-104085	Pyrenophora teres	35.29	7.00e-05	41.20
IUUC-Pyt-104655	Pyrenophora triticirepentis	35.29	7.00e-05	41.60
IUUC-Rno-105613	Rattus norvegicus	88.93	0.00e+00	986.00
IUUC-Sha-107091	Sarcophilus harrisii	76.64	0.00e+00	950.00
IUUC-Sar-112941	Sorex araneus	87.36	0.00e+00	763.00
IUUC-Ssc-116276	Sus scrofa	92.96	0.00e+00	1090.00
IUUC-Tgu-116494	Taeniopygia guttata	70.85	0.00e+00	850.00
IUUC-Tru-118614	Takifugu rubripes	58.46	0.00e+00	718.00
IUUC-Tsy-119499	Tarsius syrichta	87.63	0.00e+00	627.00
IUUC-Tni-119776	Tetraodon nigroviridis	58.63	0.00e+00	717.00
IUUC-Tbe-127806	Tupaia belangeri	83.03	0.00e+00	964.00
IUUC-Ttr-128813	Tursiops truncatus	91.61	0.00e+00	1077.00
IUUC-Vpa-130127	Vicugna pacos	92.23	0.00e+00	665.00
IUUC-Xtr-132942	Xenopus tropicalis	66.67	0.00e+00	818.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence