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Tag Content
UUCD2 ID IUUC-Aml-001308
UUCD1 version UUC-AiM-00931
Ensembl Protein ID ENSAMEP00000019333.1
UniProt Accession G1MIZ8; G1MIZ8_AILME
Genbank Protein ID ENSAMEP00000019333
Protein Name Uncharacterized protein
Genbank Nucleotide ID ACTA01064176
Gene Name AREL1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSAMEG00000018293.1 ENSAMET00000020100.1 ENSAMEP00000019333.1
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/HECT 4.50e-102 342.0 485 822
Active Site
Position(s) Description Evidence
790 Glycyl thioester intermediate {ECO:0000256|PROSITE-ProRule:PRU00104}
Domain Profile

   E3 activity/HECT
   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglf.lysendketlqpnpdsglknpehlklFeflGrllgkalqdg..... 85
           sd++k++ev f++Ee+ld+gG+ re+++l++k+l++++++lf ++s+n+++ ++pnp++  +   +lk++ef+Grl+gk+l+++     
   Q: 485  SDWSKNFEVVFQDEEALDWGGPRREWFELICKALFDTTNQLFtRFSDNNQALVHPNPNRPAH--LRLKMYEFAGRLVGKCLYESslgga 571
           7999**************************************888999***********975..9******************999999 PP
   S: 86   ..rlldlplsksfyklllgkklsledleevdpelyks.lkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNke 171
             +l+++++++sf+ +++g +++++ +e+ dpe+yks + +i++n   d++e++l ++ ++ +++ +  k++eL++gG+++pVtn+Nk 
   Q: 572  ykQLVRARFTRSFLAQIIGLRMHYKYFETDDPEFYKSkVCFILNN---DMSEMELVFAEEKYNKSGQLDKVVELMTGGAQTPVTNANKI 657
           99***********************************99****99...9****9****9999999************************ PP
   S: 172  eYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkket.kykggytedspaiqwFwevleefsse 259
            Y +l+++yrl +++ke+ve+f +G+ne++p++ll++F+e+elell+cG+ +i+v+d+k+++    g ++ ++++++wFw v++++++e
   Q: 658  FYLNLLAQYRLASQVKEEVEHFLKGLNELVPENLLAIFDENELELLMCGTGDISVSDFKAHAvVVGGSWHFREKVMRWFWTVVSSLTQE 746
           **************************************************************555788999****************** PP
   S: 260  erkafLqFvTgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kgFel 335
           e +++LqF+Tgss+lP+gGfa+l p++ +i    +++ lP+++TCfn+L+LP+Y+s+e+++++L++Ai+e+ +gF++
   Q: 747  ELARLLQFTTGSSQLPPGGFAALCPSFQIIAA-PTHSTLPTAHTCFNQLCLPTYDSYEEVHRMLQLAISEGcEGFGM 822
           ************************99555555.**************************************9***97 PP
   
Organism Ailuropoda melanoleuca
Protein Sequence
(Fasta)
YFFIIGGITV SVVAFFFTIK FLFELAARVV SFLQNEDRER RGDRTIYDYV RGNYLDPRSC 60
KVSWDWKDPY EVGHSMAFRV HLFYKNGQPF PAHRPVGLRV HISHVELAVE IPVTQEVLQE 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Aml-001308|E3,HECT|Ailuropoda melanoleuca
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TACTTCTTTA TTTATTTATT TTAAGATTTT ATTTATTTAT TTGAGAGAGA GAGAGAGAGT 60
GCACGCACAA GCAAGCACAA GCAGAGGAAG AGGGAGAAGC AGGCTCCATC CTCTCCCTGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Aml-001308|E3,HECT|Ailuropoda melanoleuca
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR017868--Filamin/ABP280_repeat-like
IPR000569--HECT_dom
IPR013783--Ig-like_fold
IPR014756--Ig_E-set
PROSITE

PS50194--FILAMIN_REPEAT
PS50237--HECT
Pfam

PF00630--Filamin
PF00632--HECT
SMART

SM00119--HECTc
Gene Ontology

GO:0005829--C:cytosol
GO:0004842--F:ubiquitin-protein transferase activity
GO:0043066--P:negative regulation of apoptotic process
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Apl-004071 Anas platyrhynchos 91.67 0.00e+00 1477.00
IUUC-Aca-005218 Anolis carolinensis 91.74 0.00e+00 1503.00
IUUC-Ame-011871 Astyanax mexicanus 79.81 0.00e+00 1373.00
IUUC-Bta-012978 Bos taurus 97.81 0.00e+00 1620.00
IUUC-Cja-019081 Callithrix jacchus 97.81 0.00e+00 1622.00
IUUC-Cfa-020736 Canis familiaris 96.59 0.00e+00 1541.00
IUUC-Cpo-021581 Cavia porcellus 97.45 0.00e+00 1613.00
IUUC-Csa-024189 Chlorocebus sabaeus 95.61 0.00e+00 897.00
IUUC-Cho-024751 Choloepus hoffmanni 96.35 0.00e+00 1553.00
IUUC-Cin-025773 Ciona intestinalis 42.49 2.00e-148 519.00
IUUC-Csv-026090 Ciona savignyi 40.44 1.00e-172 600.00
IUUC-Dre-027788 Danio rerio 80.66 0.00e+00 1380.00
IUUC-Dno-030022 Dasypus novemcinctus 97.57 0.00e+00 1614.00
IUUC-Dme-031577 Drosophila melanogaster 47.85 0.00e+00 730.00
IUUC-Ete-032402 Echinops telfairi 95.85 0.00e+00 1544.00
IUUC-Eca-033908 Equus caballus 98.91 0.00e+00 1637.00
IUUC-Eeu-034869 Erinaceus europaeus 98.27 0.00e+00 926.00
IUUC-Fca-036023 Felis catus 98.91 0.00e+00 1637.00
IUUC-Fal-037477 Ficedula albicollis 92.09 0.00e+00 1534.00
IUUC-Gmo-039197 Gadus morhua 80.78 0.00e+00 1357.00
IUUC-Gga-040704 Gallus gallus 92.09 0.00e+00 1526.00
IUUC-Gac-041511 Gasterosteus aculeatus 79.44 0.00e+00 1363.00
IUUC-Ggo-044527 Gorilla gorilla 94.41 0.00e+00 1550.00
IUUC-Hsa-046082 Homo sapiens 97.93 0.00e+00 1625.00
IUUC-Itr-048168 Ictidomys tridecemlineatus 98.05 0.00e+00 1626.00
IUUC-Lch-049772 Latimeria chalumnae 77.49 0.00e+00 1253.00
IUUC-Loc-052541 Lepisosteus oculatus 81.53 0.00e+00 1394.00
IUUC-Laf-053852 Loxodonta africana 97.57 0.00e+00 1612.00
IUUC-Mcc-054759 Macaca mulatta 96.30 0.00e+00 814.00
IUUC-Meu-056247 Macropus eugenii 78.15 0.00e+00 840.00
IUUC-Mga-060161 Meleagris gallopavo 91.25 0.00e+00 1507.00
IUUC-Mmr-061447 Microcebus murinus 97.93 0.00e+00 1622.00
IUUC-Mdo-062110 Monodelphis domestica 94.77 0.00e+00 1542.00
IUUC-Mmu-064349 Mus musculus 96.72 0.00e+00 1609.00
IUUC-Mpu-065824 Mustela putorius furo 99.03 0.00e+00 1640.00
IUUC-Mlu-067729 Myotis lucifugus 98.18 0.00e+00 1618.00
IUUC-Nle-069721 Nomascus leucogenys 97.45 0.00e+00 1613.00
IUUC-Opr-070189 Ochotona princeps 97.55 0.00e+00 1605.00
IUUC-Ont-072122 Oreochromis niloticus 81.02 0.00e+00 1359.00
IUUC-Oan-072700 Ornithorhynchus anatinus 84.56 0.00e+00 1228.00
IUUC-Ocu-074057 Oryctolagus cuniculus 97.69 0.00e+00 1618.00
IUUC-Ola-087492 Oryzias latipes 79.93 0.00e+00 1363.00
IUUC-Oga-088084 Otolemur garnettii 98.05 0.00e+00 1619.00
IUUC-Oar-090354 Ovis aries 97.91 0.00e+00 1598.00
IUUC-Ptr-091456 Pan troglodytes 97.69 0.00e+00 1620.00
IUUC-Pan-092596 Papio anubis 96.48 0.00e+00 1593.00
IUUC-Psi-092942 Pelodiscus sinensis 92.58 0.00e+00 1531.00
IUUC-Pma-094662 Petromyzon marinus 60.95 0.00e+00 757.00
IUUC-Pfo-096838 Poecilia formosa 80.78 0.00e+00 1341.00
IUUC-Pab-097849 Pongo abelii 97.45 0.00e+00 1617.00
IUUC-Pca-100498 Procavia capensis 95.58 0.00e+00 917.00
IUUC-Pva-102599 Pteropus vampyrus 98.30 0.00e+00 1629.00
IUUC-Rno-105776 Rattus norvegicus 97.08 0.00e+00 1612.00
IUUC-Sha-106699 Sarcophilus harrisii 95.01 0.00e+00 1548.00
IUUC-Sar-113621 Sorex araneus 96.56 0.00e+00 1582.00
IUUC-Ssc-115742 Sus scrofa 98.42 0.00e+00 1628.00
IUUC-Tgu-116490 Taeniopygia guttata 91.61 0.00e+00 1531.00
IUUC-Tru-117679 Takifugu rubripes 80.05 0.00e+00 1350.00
IUUC-Tsy-119607 Tarsius syrichta 94.22 0.00e+00 1123.00
IUUC-Tni-120376 Tetraodon nigroviridis 76.51 0.00e+00 1270.00
IUUC-Tbe-127348 Tupaia belangeri 67.34 6.00e-180 623.00
IUUC-Ttr-128786 Tursiops truncatus 94.89 0.00e+00 1556.00
IUUC-Vpa-130180 Vicugna pacos 98.05 0.00e+00 1302.00
IUUC-Xtr-132631 Xenopus tropicalis 67.35 0.00e+00 1129.00
Created Date 25-Jun-2017

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