iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Eca-033399

UUCD1 version

UUC-EqC-00669

Ensembl Protein ID

ENSECAP00000009221.1

UniProt Accession

F7AQE9; F7AQE9_HORSE

Protein Name

Uncharacterized protein

Gene Name

NLE1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000011072.1	ENSECAT00000011754.1	ENSECAP00000009221.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.10e-66	217.0	196	239
UBD/Beta-Prp	1.60e-79	267.3	105	302

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf......sd.tllvsGsdDgtikvWDlrtgvllk 37
           gH+ ++t+l++      ++ ++++s+s Dg+++vWD++ g++++
   Q: 196  GHSKWITGLSWeplhanPEcRYVASSSKDGSVRVWDTTAGRCER 239
           8***************9889**********************86 PP

UBD/Beta-Prp

   S: 44   llrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleet 132
           + +sl+gh+++v +v fsp+gk+l++gs D t++ wdlst ++  t +gh + vls+s+sp+g+kl+sG +   i +wd +tg+ +  t
   Q: 105  CTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCQGHRHWVLSISWSPDGKKLASGCKNGQILLWDPSTGKQVGRT 193
           5799************************************************************************************* PP
   S: 133  lsghdgvvncvvv.....hpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvr 216
           l+gh+++++++++     +p++++++s+s+D+ vr+Wd   g++ r ltg ht+sv++l +  +g  l s+s+d+t+k+w  + g   r
   Q: 194  LAGHSKWITGLSWeplhaNPECRYVASSSKDGSVRVWDTTAGRCERILTG-HTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCR 280
           **********9873332257889**************************9.************98.*********************** PP
   S: 217  tlnghtdnvksvrfspnderlvs 239
           tl+gh  +v+ +++s  d  l +
   Q: 281  TLQGHGHWVNTMALS-TDYALRT 302
           **************9.4444444 PP

Organism

Equus caballus

Protein Sequence
(Fasta)

MAAVADEAAA RDVQRLLVQF QDEGGQLLGS PFDVPVDITP DKLQLVCNAL LAQEDPLPLA 60
FYVHDAEIVS SLGKTLESQA VETEKVLDII YQPQAIFRVR AVTRCTSSLE GHSEAVISVA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCTTTCTCCT CCACGTGGGG CGCAGGATGG CGGCGGTGGC GGTGGGTGTG CTTAAGTGCG 60
GGCTGGCACG GCGGGGCGCT CGGGCCGGGG TCCCTGAGGC CGGCGGGCGG GGGAGACGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR001632--Gprotein_B
IPR012972--NLE
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08154--NLE
PF00400--WD40

PRINTS

PR00319--GPROTEINB
PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005730--C:nucleolus
GO:0005840--C:ribosome
GO:0061484--P:hematopoietic stem cell homeostasis
GO:0001826--P:inner cell mass cell differentiation
GO:0001822--P:kidney development
GO:2001268--P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:0045930--P:negative regulation of mitotic cell cycle
GO:0007219--P:Notch signaling pathway
GO:0090263--P:positive regulation of canonical Wnt signaling pathway
GO:0000027--P:ribosomal large subunit assembly
GO:0048705--P:skeletal system morphogenesis
GO:0001756--P:somitogenesis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000437	Aegilops tauschii	58.37	4.00e-169	587.00
IUUC-Aml-001793	Ailuropoda melanoleuca	98.10	0.00e+00	956.00
IUUC-Atr-002507	Amborella trichopoda	59.06	1.00e-168	586.00
IUUC-Apl-003964	Anas platyrhynchos	84.80	0.00e+00	814.00
IUUC-Aly-006396	Arabidopsis lyrata	54.68	7.00e-161	560.00
IUUC-Ath-007278	Arabidopsis thaliana	54.89	1.00e-160	559.00
IUUC-Ago-007951	Ashbya gossypii	47.43	5.00e-128	451.00
IUUC-Acl-008298	Aspergillus clavatus	46.67	4.00e-119	421.00
IUUC-Afl-008581	Aspergillus flavus	51.81	2.00e-108	385.00
IUUC-Afu-008906	Aspergillus fumigatus	45.66	5.00e-119	421.00
IUUC-Ani-009189	Aspergillus nidulans	44.02	2.00e-115	409.00
IUUC-Ang-009630	Aspergillus niger	47.06	5.00e-122	431.00
IUUC-Aor-010038	Aspergillus oryzae	47.00	2.00e-126	446.00
IUUC-Ate-010278	Aspergillus terreus	46.09	5.00e-121	427.00
IUUC-Ame-011890	Astyanax mexicanus	80.55	0.00e+00	823.00
IUUC-Bgr-012011	Blumeria graminis	47.83	1.00e-129	456.00
IUUC-Bta-012964	Bos taurus	97.26	0.00e+00	951.00
IUUC-Bci-013592	Botrytis cinerea	44.53	1.00e-119	422.00
IUUC-Bdi-015035	Brachypodium distachyon	58.46	2.00e-170	591.00
IUUC-Bol-015501	Brassica oleracea	55.56	8.00e-161	560.00
IUUC-Bra-017642	Brassica rapa	55.34	4.00e-160	557.00
IUUC-Cel-018430	Caenorhabditis elegans	58.15	2.00e-167	581.00
IUUC-Cja-019125	Callithrix jacchus	96.84	0.00e+00	947.00
IUUC-Cfa-021013	Canis familiaris	97.00	0.00e+00	865.00
IUUC-Cpo-021743	Cavia porcellus	96.41	0.00e+00	944.00
IUUC-Cre-022973	Chlamydomonas reinhardtii	47.56	2.00e-122	432.00
IUUC-Csa-024270	Chlorocebus sabaeus	97.68	0.00e+00	954.00
IUUC-Cin-025795	Ciona intestinalis	66.10	0.00e+00	686.00
IUUC-Csv-025953	Ciona savignyi	67.16	0.00e+00	686.00
IUUC-Cgl-026517	Colletotrichum gloeosporioides	51.46	4.00e-108	384.00
IUUC-Cne-026901	Cryptococcus neoformans	49.11	7.00e-139	487.00
IUUC-Cme-027281	Cyanidioschyzon merolae	47.89	8.00e-114	404.00
IUUC-Dre-028515	Danio rerio	78.22	0.00e+00	802.00
IUUC-Dno-029596	Dasypus novemcinctus	97.46	0.00e+00	949.00
IUUC-Dor-030494	Dipodomys ordii	97.03	0.00e+00	942.00
IUUC-Dse-031538	Dothistroma septosporum	47.62	4.00e-129	454.00
IUUC-Dme-031974	Drosophila melanogaster	59.17	8.00e-168	583.00
IUUC-Ete-032948	Echinops telfairi	97.13	2.00e-118	418.00
IUUC-Eeu-035013	Erinaceus europaeus	95.69	6.00e-117	414.00
IUUC-Fca-035860	Felis catus	97.26	0.00e+00	949.00
IUUC-Fal-037069	Ficedula albicollis	88.40	2.00e-132	464.00
IUUC-Fox-038059	Fusarium oxysporum	46.35	5.00e-125	441.00
IUUC-Fso-038445	Fusarium solani	46.56	2.00e-125	442.00
IUUC-Gmo-039319	Gadus morhua	76.17	0.00e+00	736.00
IUUC-Ggr-040095	Gaeumannomyces graminis	46.88	1.00e-121	429.00
IUUC-Gga-040303	Gallus gallus	86.40	9.00e-131	459.00
IUUC-Gac-042267	Gasterosteus aculeatus	78.69	0.00e+00	766.00
IUUC-Gma-043974	Glycine max	57.66	4.00e-170	590.00
IUUC-Ggo-044637	Gorilla gorilla	97.45	0.00e+00	943.00
IUUC-Hsa-046128	Homo sapiens	97.89	0.00e+00	956.00
IUUC-Hvu-047373	Hordeum vulgare	57.82	2.00e-168	585.00
IUUC-Itr-048070	Ictidomys tridecemlineatus	97.07	0.00e+00	951.00
IUUC-Kpa-049274	Komagataella pastoris	44.08	1.00e-125	443.00
IUUC-Lch-049907	Latimeria chalumnae	82.60	0.00e+00	825.00
IUUC-Lpe-050778	Leersia perrieri	53.65	2.00e-152	531.00
IUUC-Loc-051889	Lepisosteus oculatus	80.97	0.00e+00	827.00
IUUC-Lma-053041	Leptosphaeria maculans	49.07	5.00e-116	411.00
IUUC-Laf-053598	Loxodonta africana	97.89	0.00e+00	957.00
IUUC-Mcc-055660	Macaca mulatta	97.47	0.00e+00	952.00
IUUC-Meu-056197	Macropus eugenii	80.81	0.00e+00	781.00
IUUC-Mor-056949	Magnaporthe oryzae	45.96	1.00e-119	422.00
IUUC-Mpo-057571	Magnaporthe poae	44.75	2.00e-63	236.00
IUUC-Mtr-058530	Medicago truncatula	58.09	4.00e-166	577.00
IUUC-Mla-059133	Melampsora laricipopulina	46.08	3.00e-124	438.00
IUUC-Mga-059252	Meleagris gallopavo	84.66	0.00e+00	660.00
IUUC-Mvi-060522	Microbotryum violaceum	49.80	6.00e-136	477.00
IUUC-Mmr-061117	Microcebus murinus	96.63	0.00e+00	941.00
IUUC-Mdo-062892	Monodelphis domestica	90.27	0.00e+00	895.00
IUUC-Mmu-064108	Mus musculus	96.83	0.00e+00	919.00
IUUC-Mac-064430	Musa acuminata	59.53	3.00e-173	601.00
IUUC-Mpu-065882	Mustela putorius furo	97.46	0.00e+00	945.00
IUUC-Mlu-068123	Myotis lucifugus	97.89	0.00e+00	956.00
IUUC-Nfi-068484	Neosartorya fischeri	46.35	4.00e-119	421.00
IUUC-Ncr-068649	Neurospora crassa	43.54	4.00e-115	408.00
IUUC-Nle-069140	Nomascus leucogenys	97.66	0.00e+00	946.00
IUUC-Opr-070220	Ochotona princeps	89.38	0.00e+00	825.00
IUUC-Ont-072643	Oreochromis niloticus	80.21	0.00e+00	817.00
IUUC-Ocu-074007	Oryctolagus cuniculus	96.83	0.00e+00	918.00
IUUC-Oba-075904	Oryza barthii	58.89	1.00e-171	595.00
IUUC-Obr-076280	Oryza brachyantha	58.46	9.00e-171	592.00
IUUC-Ogl-077425	Oryza glaberrima	58.89	9.00e-172	596.00
IUUC-Ogu-078586	Oryza glumaepatula	58.89	1.00e-171	595.00
IUUC-Oin-079489	Oryza indica	56.75	1.00e-162	566.00
IUUC-Olo-080766	Oryza longistaminata	58.76	2.00e-171	595.00
IUUC-Ome-081905	Oryza meridionalis	58.89	8.00e-172	596.00
IUUC-Oni-083022	Oryza nivara	58.89	6.00e-172	597.00
IUUC-Opu-083615	Oryza punctata	58.89	9.00e-172	596.00
IUUC-Oru-085076	Oryza rufipogon	58.89	6.00e-172	597.00
IUUC-Osa-085744	Oryza sativa	59.10	3.00e-172	598.00
IUUC-Ola-087290	Oryzias latipes	78.32	0.00e+00	802.00
IUUC-Olu-087898	Ostreococcus lucimarinus	53.56	2.00e-144	505.00
IUUC-Oga-088980	Otolemur garnettii	96.60	0.00e+00	939.00
IUUC-Oar-089580	Ovis aries	97.56	0.00e+00	829.00
IUUC-Ptr-090845	Pan troglodytes	97.24	0.00e+00	939.00
IUUC-Pan-092836	Papio anubis	97.26	0.00e+00	952.00
IUUC-Psi-093965	Pelodiscus sinensis	84.21	7.00e-57	211.00
IUUC-Pno-095052	Phaeosphaeria nodorum	46.82	1.00e-121	429.00
IUUC-Ppa-095432	Physcomitrella patens	58.85	7.00e-171	593.00
IUUC-Pfo-096963	Poecilia formosa	72.00	0.00e+00	701.00
IUUC-Pab-097716	Pongo abelii	93.84	0.00e+00	899.00
IUUC-Pop-099224	Populus trichocarpa	58.94	1.00e-171	595.00
IUUC-Pca-100682	Procavia capensis	92.68	0.00e+00	677.00
IUUC-Ppe-101819	Prunus persica	58.64	3.00e-169	587.00
IUUC-Pva-102338	Pteropus vampyrus	98.60	0.00e+00	731.00
IUUC-Pgr-103583	Puccinia graminis	54.99	5.00e-132	464.00
IUUC-Ptt-103737	Puccinia triticina	44.80	3.00e-99	355.00
IUUC-Pte-104150	Pyrenophora teres	49.55	1.00e-120	426.00
IUUC-Pyt-104606	Pyrenophora triticirepentis	49.32	1.00e-120	426.00
IUUC-Rno-105987	Rattus norvegicus	96.40	0.00e+00	942.00
IUUC-Sce-106315	Saccharomyces cerevisiae	46.65	6.00e-129	454.00
IUUC-Sha-107273	Sarcophilus harrisii	90.70	0.00e+00	905.00
IUUC-Sja-107677	Schizosaccharomyces japonicus	46.33	7.00e-118	417.00
IUUC-Spo-108092	Schizosaccharomyces pombe	48.05	4.00e-122	431.00
IUUC-Ssl-108442	Sclerotinia sclerotiorum	44.49	7.00e-116	410.00
IUUC-Smo-108855	Selaginella moellendorffii	56.26	4.00e-164	571.00
IUUC-Sit-110329	Setaria italica	59.31	1.00e-171	596.00
IUUC-Sly-111830	Solanum lycopersicum	59.96	1.00e-174	606.00
IUUC-Stu-112603	Solanum tuberosum	59.96	1.00e-174	605.00
IUUC-Sar-113504	Sorex araneus	93.66	6.00e-75	274.00
IUUC-Sbi-114560	Sorghum bicolor	58.24	1.00e-168	585.00
IUUC-Sre-115133	Sporisorium reilianum	41.62	8.00e-124	437.00
IUUC-Ssc-115903	Sus scrofa	97.68	0.00e+00	952.00
IUUC-Tgu-116798	Taeniopygia guttata	85.41	0.00e+00	857.00
IUUC-Tru-118361	Takifugu rubripes	78.53	0.00e+00	803.00
IUUC-Tsy-118849	Tarsius syrichta	98.30	0.00e+00	949.00
IUUC-Tni-120094	Tetraodon nigroviridis	78.48	0.00e+00	802.00
IUUC-Tca-121634	Theobroma cacao	58.30	4.00e-168	584.00
IUUC-Tre-122051	Trichoderma reesei	46.25	2.00e-119	422.00
IUUC-Tvi-122322	Trichoderma virens	47.50	3.00e-123	435.00
IUUC-Tae-125822	Triticum aestivum	58.24	2.00e-169	588.00
IUUC-Tur-126766	Triticum urartu	52.00	6.00e-161	560.00
IUUC-Tme-127175	Tuber melanosporum	51.16	1.00e-131	463.00
IUUC-Tbe-127779	Tupaia belangeri	96.25	0.00e+00	837.00
IUUC-Ttr-128224	Tursiops truncatus	92.76	0.00e+00	818.00
IUUC-Uma-129537	Ustilago maydis	42.16	3.00e-125	442.00
IUUC-Vda-129927	Verticillium dahliae	45.61	1.00e-110	393.00
IUUC-Vpa-130658	Vicugna pacos	85.35	0.00e+00	803.00
IUUC-Vvi-131659	Vitis vinifera	58.64	6.00e-171	593.00
IUUC-Xtr-132918	Xenopus tropicalis	77.05	0.00e+00	789.00
IUUC-Xma-133700	Xiphophorus maculatus	80.42	0.00e+00	815.00
IUUC-Yli-134478	Yarrowia lipolytica	49.69	1.00e-138	486.00
IUUC-Zma-135835	Zea mays	55.78	1.00e-165	576.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence