iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ocu-074477

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAGW02063922

Gene Name

FBXW8

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOCUG00000014685.3	ENSOCUT00000024914.2	ENSOCUP00000017473.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.10e-13	50.9	366	396
UBD/Beta-Prp	4.50e-42	144.3	100	399

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    HtdsvtclafsdtllvsGsdDgtikvWDlrt 32
           H+ +v++++ +d+ +vsG+  g + vWD+r 
   Q: 366  HQLGVSAVQMDDWKIVSGGEEGLVSVWDYRM 396
           7778999999669***************875 PP

UBD/Beta-Prp

   S: 8    hhksvitcvkfspdksllatgsrdgtikvwdvttgkl.....lrslsgheae....vtavkfspdgkilvtgseDrtikvwdlstgkcv 87
            +++v+++v+   ++ ++++g+++g ++vwd++t+++      ++++++e++    v+ v+++++  + v + eD+++++wdl+tg + 
   Q: 100  VPDAVLCDVHS--HDGVVVAGYTSGDVRVWDTRTWDYvapflESEFEEDEPGmqpyVSFVRINSS--LAVAAYEDGFLNIWDLRTGRYP 184
           57889997777..9***********************6666544555555559999*********..9********************9 PP
   S: 88   htlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdg.nllvsGslDrtvrlWdlktgkllrtl 175
           ++  +h++++ +l++s++g +++++s+  +i+++  e+g++  +t+ + +++v ++++ pd+ +  v+ ++ + + ++ lk ++  rtl
   Q: 185  IHRFEHDARIQALALSRKGATVATASAFGVIMLYPNEEGYWQMATEFEVQKLVDYLEIVPDTgRFPVAIAAAGDL-VYLLKAEDSARTL 272
           99999*********************************************************9999999999998.5************ PP
   S: 176  tgghtdsvyslsfdsng.....kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfs.pnderlvsgssDgsiriWdlrsgdllk 258
                ++v++l+++ n+     k+l ++ + +++ +++l++++c+ +l +    +++v++  +   ++vsg++D+ +ri+dlr++++  
   Q: 273  HYVYGQPVTCLDVSANQvafgvKSLGWVYEGNKILVYSLEAERCLSKLGNALGDFTCVNLRdSPPSLMVSGNMDRRVRIHDLRTDKIAL 361
           999********************************************************996788999********************* PP
   S: 259  tlqlhnssvisvavlsfgdnvlvlgsedskvniwklkknep 299
           +l+ h+  v++v++   +d+++v+g+e++ v +w++++n++
   Q: 362  SLSAHQLGVSAVQM---DDWKIVSGGEEGLVSVWDYRMNQK 399
           ******99999999...********************9875 PP

Organism

Oryctolagus cuniculus

Protein Sequence
(Fasta)

MDDVPFFDVQ LPYELAINIF QYLGRKELGR CAQVSKTWKV IAEDEVLWYR LCQQEGHLLE 60
SSISDYSCWK LVFQECRARE HMLRTNWKNR KGAVSELEPV PDAVLCDVHS HDGVVVAGYT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AACGAAATGG ATGATGTGCC CTTCTTCGAT GTCCAGCTGC CTTATGAATT GGCCATCAAC 60
ATATTTCAGT ATCTGGGCAG GAAAGAACTA GGACGGTGTG CGCAGGTAAG CTATGGTTAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR001810--F-box_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50181--FBOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12937--F-box-like

SMART

SM00256--FBOX
SM00320--WD40

Gene Ontology

GO:1990393--C:3M complex
GO:0031467--C:Cul7-RING ubiquitin ligase complex
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0048471--C:perinuclear region of cytoplasm
GO:0019005--C:SCF ubiquitin ligase complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008283--P:cell proliferation
GO:0007030--P:Golgi organization
GO:0060716--P:labyrinthine layer blood vessel development
GO:0050775--P:positive regulation of dendrite morphogenesis
GO:0060712--P:spongiotrophoblast layer development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001274	Ailuropoda melanoleuca	90.72	0.00e+00	931.00
IUUC-Apl-003239	Anas platyrhynchos	65.30	0.00e+00	684.00
IUUC-Aca-004756	Anolis carolinensis	61.50	2.00e-136	478.00
IUUC-Ame-011198	Astyanax mexicanus	54.07	4.00e-51	194.00
IUUC-Bta-012430	Bos taurus	56.29	4.00e-142	498.00
IUUC-Cja-019131	Callithrix jacchus	82.89	0.00e+00	824.00
IUUC-Cfa-021022	Canis familiaris	90.72	0.00e+00	932.00
IUUC-Cpo-021898	Cavia porcellus	90.52	0.00e+00	927.00
IUUC-Csa-023452	Chlorocebus sabaeus	85.36	0.00e+00	860.00
IUUC-Cho-024759	Choloepus hoffmanni	78.14	0.00e+00	770.00
IUUC-Dre-028123	Danio rerio	50.51	8.00e-143	500.00
IUUC-Dno-029045	Dasypus novemcinctus	91.59	0.00e+00	866.00
IUUC-Dor-030433	Dipodomys ordii	90.46	0.00e+00	779.00
IUUC-Ete-032465	Echinops telfairi	89.63	0.00e+00	775.00
IUUC-Eca-034134	Equus caballus	90.52	0.00e+00	930.00
IUUC-Eeu-035047	Erinaceus europaeus	79.39	0.00e+00	803.00
IUUC-Fca-036574	Felis catus	89.90	0.00e+00	917.00
IUUC-Fal-037665	Ficedula albicollis	62.42	5.00e-178	617.00
IUUC-Gmo-039137	Gadus morhua	45.53	1.00e-59	223.00
IUUC-Gga-040711	Gallus gallus	64.89	0.00e+00	670.00
IUUC-Gac-041675	Gasterosteus aculeatus	54.89	4.00e-54	203.00
IUUC-Ggo-045331	Gorilla gorilla	84.95	0.00e+00	856.00
IUUC-Hsa-046240	Homo sapiens	85.57	0.00e+00	865.00
IUUC-Itr-048412	Ictidomys tridecemlineatus	91.55	0.00e+00	913.00
IUUC-Loc-052631	Lepisosteus oculatus	55.33	3.00e-164	572.00
IUUC-Laf-054127	Loxodonta africana	79.71	9.00e-60	221.00
IUUC-Mcc-055083	Macaca mulatta	85.36	0.00e+00	865.00
IUUC-Mga-060113	Meleagris gallopavo	64.68	0.00e+00	670.00
IUUC-Mmr-061780	Microcebus murinus	90.74	0.00e+00	927.00
IUUC-Mdo-063066	Monodelphis domestica	67.70	0.00e+00	704.00
IUUC-Mmu-063524	Mus musculus	85.98	0.00e+00	853.00
IUUC-Mpu-066913	Mustela putorius furo	90.52	0.00e+00	923.00
IUUC-Mlu-067924	Myotis lucifugus	88.19	0.00e+00	885.00
IUUC-Nle-069558	Nomascus leucogenys	85.16	0.00e+00	821.00
IUUC-Opr-070506	Ochotona princeps	92.86	0.00e+00	950.00
IUUC-Ont-071514	Oreochromis niloticus	48.98	3.00e-138	485.00
IUUC-Ola-087416	Oryzias latipes	49.08	1.00e-136	479.00
IUUC-Oga-088643	Otolemur garnettii	91.34	0.00e+00	937.00
IUUC-Oar-090172	Ovis aries	90.93	0.00e+00	926.00
IUUC-Ptr-090870	Pan troglodytes	85.77	0.00e+00	866.00
IUUC-Pan-092017	Papio anubis	84.95	0.00e+00	855.00
IUUC-Psi-093794	Pelodiscus sinensis	66.12	0.00e+00	674.00
IUUC-Pfo-096192	Poecilia formosa	51.22	3.00e-143	501.00
IUUC-Pab-097882	Pongo abelii	84.95	0.00e+00	852.00
IUUC-Pca-100902	Procavia capensis	88.98	1.00e-129	456.00
IUUC-Pva-103139	Pteropus vampyrus	90.52	0.00e+00	930.00
IUUC-Rno-105798	Rattus norvegicus	85.57	0.00e+00	871.00
IUUC-Sha-106576	Sarcophilus harrisii	68.05	0.00e+00	699.00
IUUC-Ssc-115923	Sus scrofa	81.52	0.00e+00	835.00
IUUC-Tgu-116667	Taeniopygia guttata	57.99	2.00e-119	422.00
IUUC-Tru-118323	Takifugu rubripes	47.65	6.00e-134	471.00
IUUC-Tsy-118818	Tarsius syrichta	77.11	2.00e-107	382.00
IUUC-Tni-120438	Tetraodon nigroviridis	47.24	1.00e-126	446.00
IUUC-Tbe-127784	Tupaia belangeri	94.66	2.00e-113	402.00
IUUC-Ttr-128288	Tursiops truncatus	80.21	0.00e+00	800.00
IUUC-Vpa-130307	Vicugna pacos	85.75	0.00e+00	789.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence