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Basic Information Integrated Annotations

Tag Content
iUUCD ID IUUC-Hsa-046819
UUCD1 version UUC-HoS-01263
Ensembl Protein ID ENSP00000444856.2
UniProt Accession Q13617; B3KT95; B7Z6K8; D3DRY6; G3V1S2; O00200; Q5T2B6; Q9UNF9; CUL2_HUMAN
Genbank Protein ID AAC51190.1; AAD23581.1; BAG53007.1; BAH13294.1; CAI13163.1; EAW85924.1; EAW85925.1; EAW85926.1; EAW85927.1; EAW85928.1; AAH09591.1; AAI10902.1; AAC50545.1
Protein Name Cullin-2
Genbank Nucleotide ID U83410; AF126404; AK095217; AK300491; AL392046; CH471072; CH471072; CH471072; CH471072; CH471072; BC009591; BC110901; U58088
Gene Name CUL2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000108094.14 ENST00000374746.5 ENSP00000363878.1
ENSG00000108094.14 ENST00000374754.8 ENSP00000363886.4
ENSG00000108094.14 ENST00000421317.4 ENSP00000414095.2
ENSG00000108094.14 ENST00000537177.5 ENSP00000444856.2
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
miRWalkRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/Cullin Cullin_N_terminal 9122164; 9447969; 12149480
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/Cullin 8.10e-213 710.2 30 657
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/Cullin

   S: 2    lreavkkilrqesv.kkeyeelytavynlclsk...vgaklYkklkevleefikqvkkkveesedeqlLktynreWekfreqlkvlrkifay 89
    l +++k++++ e+v +++++++++++y+lc+++ +g++lY+++k +le+++++++k+v es +eq+L +y+r+We++++++++++++++y
   Q: 30 LLTTIKAVVMLEYVeRATWNDRFSDIYALCVAYpepLGERLYTETKIFLENHVRHLHKRVLES-EEQVLVMYHRYWEEYSKGADYMDCLYRY 120
    6689***********************************************************.566************************* PP
   S: 90 ldrtyvkk.................skkvsevrkLaldlwrkeivedikkrllelllklieaeRkgeavdrrllsgvveslveLslnk.... 160
    l+++++kk ++ ++e+ +Lald+wrk +ve++++ l+++ll+ i+++R ge ++++++gv++s+v+++++k
   Q: 121 LNTQFIKKnklteadlqygyggvdmNEPLMEIGELALDMWRKLMVEPLQAILIRMLLREIKNDRGGEDPNQKVIHGVINSFVHVEQYKkkfp 212
    ********999999998888888877778********************************************************9999*** PP
   S: 161 laiykesFEakfleatqefykaesaeflqenevdeYlkkvearlneeeeraaryleestetkLlevvekeliakhlesllaelvallrdkkt 252
    l++y+e FE++fl++t e+yk+e++++lqe+++++Y++kv rl++ee r+++yl++s++tk++++++++++a+hl++l+ae+++++r++k+
   Q: 213 LKFYQEIFESPFLTETGEYYKQEASNLLQESNCSQYMEKVLGRLKDEEIRCRKYLHPSSYTKVIHECQQRMVADHLQFLHAECHNIIRQEKK 304
    ******************************************************************************************** PP
   S: 253 edlsrmykLlsrvlngleellkeleshikeqgkaaltaeekekdpkkyVerllelknklqklvseaFnndakFlkaldkafetfvnknsvlk 344
    +d+++my Ll+ v++gl ++++el++hi+++g++a+++ ++e++p+ +Ve++le++ k+ +l+++++n d++F++aldka++++vn ++ ++
   Q: 305 NDMANMYVLLRAVSTGLPHMIQELQNHIHDEGLRATSNLTQENMPTLFVESVLEVHGKFVQLINTVLNGDQHFMSALDKALTSVVNYREPKS 396
    ******************************************************************************************** PP
   S: 345 aakspEllAryiDqlLrksskglteeeleaqldkvllvfkyisekdvFekyYkkhLakRLlsgksasseaEesviekLkeecgaeftskLer 436
    ++k+pEllA+y+D+lL+ks+kg+te+e+e++l+++++vfkyi++kdvF+k+Y+++LakRL++g+s+s+++Ee++i+kLk++cg+eftskL+r
   Q: 397 VCKAPELLAKYCDNLLKKSAKGMTENEVEDRLTSFITVFKYIDDKDVFQKFYARMLAKRLIHGLSMSMDSEEAMINKLKQACGYEFTSKLHR 488
    ******************************************************************************************** PP
   S: 437 MfqdlkvSedlnrqFk..eekenteesesvelsvlvLsagaWpta.setekvsLPaelektiekfeefYlekhsgRkLqWqhtlgraelkae 525
    M++d++vS dln++F+ ++++t ++ +++++++vL+agaWp + + +++++P+elek++++fe fY++++sgRkL+W+h+l+++e+k++
   Q: 489 MYTDMSVSADLNNKFNnfIKNQDTVIDLGISFQIYVLQAGAWPLTqAPSSTFAIPQELEKSVQMFELFYSQHFSGRKLTWLHYLCTGEVKMN 580
    ****************8889***********************99666689***************************************** PP
   S: 526 lkkgkyelqVstfQmavLLafnnsekvsveelkkatelpeeeLrrtlqsLvsskkqvlkkepeskeieeedlfsvNqef 604
    + ++y +V+t+QmavLLafnnse+vs++el+++t+++e+eL++t++sL+++k ++++++e+++i++e++fs+N++f
   Q: 581 YLGKPYVAMVTTYQMAVLLAFNNSETVSYKELQDSTQMNEKELTKTIKSLLDVK--MINHDSEKEDIDAESSFSLNMNF 657
    *999*************************************************9..*********************99 PP
   

Organism Homo sapiens
Functional Description
(View)

Functional Description



     Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (PubMed:27565346). May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF).
Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (PubMed:27565346). May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF).
Protein Sequence
(Fasta)
MVPGKEFQHY TCTMSLKPRV VDFDETWNKL LTTIKAVVML EYVERATWND RFSDIYALCV 60
AYPEPLGERL YTETKIFLEN HVRHLHKRVL ESEEQVLVMY HRYWEEYSKG ADYMDCLYRY 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Hsa-046819|E3,Cullin|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATTGCTTTCC GGGTGGCGGG GGGGATTTGG CAGCAGCGGA AGAAGGAGAC CGGAGGGTGT 60
GTGTTGGGCA AAGCCGGAGG CAGAGGAGGA CGATTGTTTT ACGGATCCCG TGATCGGCCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Hsa-046819|E3,Cullin|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0945--Host-virus interaction
KW-1017--Isopeptide bond
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway

Interpro

IPR016157--Cullin_CS
IPR016158--Cullin_homology
IPR001373--Cullin_N
IPR019559--Cullin_neddylation_domain
IPR016159--Cullin_repeat-like_dom
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS01256--CULLIN_1
PS50069--CULLIN_2

Pfam

PF00888--Cullin
PF10557--Cullin_Nedd8

SMART

SM00182--CULLIN
SM00884--Cullin_Nedd8

Gene Ontology

GO:0031462--C:Cul2-RING ubiquitin ligase complex
GO:0005829--C:cytosol
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0030891--C:VCB complex
GO:0031625--F:ubiquitin protein ligase binding
GO:0007050--P:cell cycle arrest
GO:0000082--P:G1/S transition of mitotic cell cycle
GO:0097193--P:intrinsic apoptotic signaling pathway
GO:0008285--P:negative regulation of cell proliferation
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0061418--P:regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0016032--P:viral process

KEGG hsa:8453
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001969 Ailuropoda melanoleuca 99.73 0.00e+00 1564.00
IUUC-Apl-004067 Anas platyrhynchos 96.79 0.00e+00 1493.00
IUUC-Aca-004534 Anolis carolinensis 92.66 0.00e+00 1451.00
IUUC-Ame-011695 Astyanax mexicanus 93.15 0.00e+00 1451.00
IUUC-Bta-013074 Bos taurus 99.60 0.00e+00 1556.00
IUUC-Cel-018431 Caenorhabditis elegans 43.23 2.00e-177 615.00
IUUC-Cja-019371 Callithrix jacchus 99.74 0.00e+00 1578.00
IUUC-Cfa-020508 Canis familiaris 99.46 0.00e+00 1553.00
IUUC-Cpo-021851 Cavia porcellus 97.99 0.00e+00 1508.00
IUUC-Csa-023583 Chlorocebus sabaeus 100.00 0.00e+00 1570.00
IUUC-Cho-024308 Choloepus hoffmanni 91.71 0.00e+00 676.00
IUUC-Cin-025350 Ciona intestinalis 46.74 0.00e+00 708.00
IUUC-Csv-026096 Ciona savignyi 41.65 0.00e+00 642.00
IUUC-Dre-028828 Danio rerio 92.21 0.00e+00 1430.00
IUUC-Dno-029709 Dasypus novemcinctus 98.79 0.00e+00 1545.00
IUUC-Dor-030319 Dipodomys ordii 84.06 0.00e+00 948.00
IUUC-Dme-031938 Drosophila melanogaster 50.39 0.00e+00 741.00
IUUC-Ete-032756 Echinops telfairi 82.95 0.00e+00 1248.00
IUUC-Eca-034019 Equus caballus 99.33 0.00e+00 1556.00
IUUC-Eeu-034914 Erinaceus europaeus 93.88 0.00e+00 1041.00
IUUC-Fca-035926 Felis catus 99.60 0.00e+00 1554.00
IUUC-Fal-037627 Ficedula albicollis 96.51 0.00e+00 1487.00
IUUC-Gmo-038728 Gadus morhua 92.10 0.00e+00 1431.00
IUUC-Gga-040820 Gallus gallus 93.41 0.00e+00 1480.00
IUUC-Gac-041293 Gasterosteus aculeatus 91.44 0.00e+00 1432.00
IUUC-Ggo-045235 Gorilla gorilla 97.20 0.00e+00 1492.00
IUUC-Itr-048063 Ictidomys tridecemlineatus 99.50 0.00e+00 842.00
IUUC-Lch-049443 Latimeria chalumnae 94.63 0.00e+00 1464.00
IUUC-Loc-052798 Lepisosteus oculatus 93.09 0.00e+00 1452.00
IUUC-Laf-053379 Loxodonta africana 99.06 0.00e+00 1551.00
IUUC-Mcc-055702 Macaca mulatta 100.00 0.00e+00 1575.00
IUUC-Meu-056223 Macropus eugenii 71.28 0.00e+00 967.00
IUUC-Mga-060034 Meleagris gallopavo 96.39 0.00e+00 1488.00
IUUC-Mmr-061090 Microcebus murinus 98.79 0.00e+00 1547.00
IUUC-Mdo-062530 Monodelphis domestica 96.51 0.00e+00 1488.00
IUUC-Mmu-063857 Mus musculus 97.32 0.00e+00 1473.00
IUUC-Mpu-065915 Mustela putorius furo 99.73 0.00e+00 1557.00
IUUC-Mlu-068049 Myotis lucifugus 99.60 0.00e+00 1564.00
IUUC-Nle-069102 Nomascus leucogenys 97.17 0.00e+00 1132.00
IUUC-Opr-071197 Ochotona princeps 86.86 0.00e+00 1259.00
IUUC-Ont-071902 Oreochromis niloticus 92.21 0.00e+00 1439.00
IUUC-Oan-073307 Ornithorhynchus anatinus 92.39 0.00e+00 1468.00
IUUC-Ocu-074703 Oryctolagus cuniculus 98.66 0.00e+00 1545.00
IUUC-Ola-086789 Oryzias latipes 92.38 0.00e+00 1444.00
IUUC-Oga-088480 Otolemur garnettii 99.06 0.00e+00 1550.00
IUUC-Oar-089899 Ovis aries 99.73 0.00e+00 1564.00
IUUC-Ptr-090965 Pan troglodytes 99.87 0.00e+00 1558.00
IUUC-Pan-092920 Papio anubis 95.72 0.00e+00 1454.00
IUUC-Psi-093122 Pelodiscus sinensis 96.24 0.00e+00 1480.00
IUUC-Pma-094656 Petromyzon marinus 77.88 0.00e+00 1222.00
IUUC-Pfo-096342 Poecilia formosa 92.08 0.00e+00 1438.00
IUUC-Pab-097544 Pongo abelii 100.00 0.00e+00 1560.00
IUUC-Pca-100564 Procavia capensis 98.05 0.00e+00 788.00
IUUC-Pva-102179 Pteropus vampyrus 88.65 0.00e+00 681.00
IUUC-Rno-105439 Rattus norvegicus 97.58 0.00e+00 1477.00
IUUC-Sha-106654 Sarcophilus harrisii 96.39 0.00e+00 1491.00
IUUC-Sar-113138 Sorex araneus 94.09 0.00e+00 1426.00
IUUC-Ssc-115543 Sus scrofa 99.80 0.00e+00 1061.00
IUUC-Tgu-117095 Taeniopygia guttata 96.25 0.00e+00 1485.00
IUUC-Tru-118593 Takifugu rubripes 81.53 0.00e+00 1372.00
IUUC-Tsy-119621 Tarsius syrichta 95.27 0.00e+00 956.00
IUUC-Tni-119697 Tetraodon nigroviridis 91.82 0.00e+00 1431.00
IUUC-Tbe-127831 Tupaia belangeri 90.95 0.00e+00 1224.00
IUUC-Ttr-129108 Tursiops truncatus 99.73 0.00e+00 1557.00
IUUC-Vpa-130414 Vicugna pacos 89.23 0.00e+00 724.00
IUUC-Xtr-132054 Xenopus tropicalis 92.36 0.00e+00 1423.00
Created Date 25-Jun-2017

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