iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.20e-78	265.0	36	613

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 48   ellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde..aeekk 134
           +++++l+ l+++lw+++ +     e+++a++k+ ++f+g++q+Da Efl +lld+++e+l+ +++ + +e+   + s+ s++  ++  +
   Q: 36   RVTEQLAALVRALWTREYTPQLSAEFKNAVSKYGSQFQGNSQHDALEFLLWLLDRVHEDLEGSTHGQGSEQLPPEASKISEDlrSSAAP 124
           5789********************************************************88666666666555555555555578888 PP
   S: 135  kkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke...................................... 185
           ++ ++s+++  Fq q++s+++c++c ++s++++pfl +slp+p ++++ ++                                      
   Q: 125  PSLGPSFVQSHFQAQYRSSLTCPHCLKQSNTFDPFLCVSLPIPLRQTRFLSvtlvfpsksqrflrvglavpilstvaalrkmvaeeggv 213
           99999*****************************************98888************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 214  paeevilvelypngfqrsffdeedlntiaegdnvyafqvpplpgpgtlaahppglsvsprlavrdsqrfsvplhsenrvlilfcnlvgs 302
           ***************************************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 303  gqqasrnnlfpwifrfgppfliredrtiswaqlqqcilskvrclmrnevsaqdlgtlfsirvvglslacsylspqdsrplchwavdral 391
           ***************************************************************************************** PP
   S: 186  ....................................................slqdcLesftkeeelegenkyycekckkkqeaekklk 222
                                                               +l++c++s+tkee+l ++++++c++c+ +q+ + kl+
   Q: 392  hlrrpggpphvklavewdssvterlfgslqeervqdadsvwrqqqahqqpscTLDECFQSYTKEEQLAQDDAWKCPHCQVLQQGVVKLS 480
           ***************************************************************************************** PP
   S: 223  lkklPevLilhLkRfsfseeqksrekinkkvefple.Ldlspfctspeekqke....................kkkYeLiavvvHsGsl 290
           l++lP++Li+hLkRf   + +++r+k+++ v+fpl+ L+++p+++++++++k                     +  Y+L+av++H+Gsl
   Q: 481  LWTLPDILIIHLKRF--CQVGERRNKLSTLVKFPLSgLNMAPHVARRSTNSKAgpgpwsswkqpiclpttyplDFLYDLYAVCNHHGSL 567
           ***************..88899************************99998889*********************************** PP
   S: 291  ssGHYvayvkn.ekgkWllfdDskVtevkeeevleetgstaYvlfYkrr 338
           ++GHY+ay++n  +g+W+ +dDs+V++++e+ev++   + aY+lfY++r
   Q: 568  QGGHYTAYCRNsLDGQWYSYDDSTVEPLREDEVNT---RGAYILFYQKR 613
           ***********55788*******************...********985 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MAMEKGALLA PRARHQPLLA AQGQIVLWDL NPRYLRVTEQ LAALVRALWT REYTPQLSAE 60
FKNAVSKYGS QFQGNSQHDA LEFLLWLLDR VHEDLEGSTH GQGSEQLPPE ASKISEDLRS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCGATGG AGAAGGGGGC TTTGCTTGCG CCCCGGGCCC GGCACCAGCC TCTTCTGGCA 60
GCCCAGGGCC AGATCGTCCT TTGGGATCTC AACCCCAGAT ATCTTCGGGT GACGGGGCGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

rno:100147704

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001922	Ailuropoda melanoleuca	71.67	0.00e+00	1254.00
IUUC-Aca-004436	Anolis carolinensis	50.74	0.00e+00	764.00
IUUC-Ame-011153	Astyanax mexicanus	48.01	0.00e+00	804.00
IUUC-Bta-013560	Bos taurus	72.94	0.00e+00	1405.00
IUUC-Cja-018737	Callithrix jacchus	77.02	0.00e+00	1441.00
IUUC-Cfa-020347	Canis familiaris	71.85	0.00e+00	1305.00
IUUC-Csa-023656	Chlorocebus sabaeus	77.92	0.00e+00	1451.00
IUUC-Cho-024864	Choloepus hoffmanni	66.26	0.00e+00	800.00
IUUC-Dre-028066	Danio rerio	56.35	0.00e+00	795.00
IUUC-Dno-028855	Dasypus novemcinctus	66.08	0.00e+00	1191.00
IUUC-Dor-030475	Dipodomys ordii	87.31	0.00e+00	746.00
IUUC-Eca-034147	Equus caballus	79.86	0.00e+00	1250.00
IUUC-Eeu-034703	Erinaceus europaeus	70.39	1.00e-137	484.00
IUUC-Fca-036550	Felis catus	68.40	0.00e+00	1160.00
IUUC-Gac-042087	Gasterosteus aculeatus	48.35	0.00e+00	772.00
IUUC-Ggo-045171	Gorilla gorilla	78.42	0.00e+00	1456.00
IUUC-Hsa-045961	Homo sapiens	78.42	0.00e+00	1457.00
IUUC-Itr-048673	Ictidomys tridecemlineatus	73.71	0.00e+00	686.00
IUUC-Loc-052852	Lepisosteus oculatus	59.64	0.00e+00	841.00
IUUC-Laf-054033	Loxodonta africana	73.82	0.00e+00	1339.00
IUUC-Mcc-055431	Macaca mulatta	77.82	0.00e+00	1455.00
IUUC-Mmr-061035	Microcebus murinus	78.42	0.00e+00	1450.00
IUUC-Mdo-062172	Monodelphis domestica	64.11	0.00e+00	862.00
IUUC-Mmu-063966	Mus musculus	92.38	0.00e+00	1786.00
IUUC-Mpu-066307	Mustela putorius furo	71.88	0.00e+00	1303.00
IUUC-Nle-070172	Nomascus leucogenys	78.32	0.00e+00	1456.00
IUUC-Opr-070499	Ochotona princeps	84.18	0.00e+00	993.00
IUUC-Ont-071920	Oreochromis niloticus	60.26	0.00e+00	799.00
IUUC-Ocu-074014	Oryctolagus cuniculus	81.79	0.00e+00	1190.00
IUUC-Ola-086360	Oryzias latipes	59.37	0.00e+00	811.00
IUUC-Oga-088202	Otolemur garnettii	75.35	0.00e+00	1400.00
IUUC-Oar-089819	Ovis aries	74.12	0.00e+00	1408.00
IUUC-Ptr-091076	Pan troglodytes	77.44	0.00e+00	1454.00
IUUC-Pan-092248	Papio anubis	77.62	0.00e+00	1439.00
IUUC-Pfo-096332	Poecilia formosa	57.20	0.00e+00	764.00
IUUC-Pab-098453	Pongo abelii	78.26	0.00e+00	1455.00
IUUC-Pca-100290	Procavia capensis	57.69	0.00e+00	664.00
IUUC-Pva-102317	Pteropus vampyrus	66.37	0.00e+00	1184.00
IUUC-Sha-106558	Sarcophilus harrisii	55.95	0.00e+00	1018.00
IUUC-Sar-113105	Sorex araneus	58.33	0.00e+00	983.00
IUUC-Ssc-115312	Sus scrofa	74.16	0.00e+00	1375.00
IUUC-Tru-117995	Takifugu rubripes	58.83	0.00e+00	785.00
IUUC-Tsy-119325	Tarsius syrichta	71.54	0.00e+00	714.00
IUUC-Tni-120517	Tetraodon nigroviridis	56.67	0.00e+00	791.00
IUUC-Tbe-127439	Tupaia belangeri	64.16	7.00e-123	435.00
IUUC-Ttr-128829	Tursiops truncatus	66.21	0.00e+00	1182.00
IUUC-Vpa-130306	Vicugna pacos	71.59	3.00e-139	489.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence