iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fso-038232

Ensembl Protein ID

NechaP32729

UniProt Accession

P78717; UBC2_NECHA

Genbank Protein ID

AAB47850.1

Protein Name

Ubiquitin-conjugating enzyme E2 2; E2 ubiquitin-conjugating enzyme 2; Radiation sensitivity protein 6; Ubiquitin carrier protein UBC2; Ubiquitin-protein ligase UBC2

Genbank Nucleotide ID

U86521

Gene Name

P78717; UBC2; RAD6

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
NechaG32729	NechaT32729	NechaP32729

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	1.10e-52	177.2	8	143

Active Site

Position(s)	Description	Evidence
88	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388, ECO:0000255\|PROSITE-ProRule:PRU10133}

Domain Profile

E2/UBC

   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilkeeekWspalsv 98
           Rl++++k++++dpp+g+sa+pv + ++++w+++i+Gp+dtp+e+g+F+l ++f+e+YP kPP+vkf++++fhPnvy++G++Cl+il+  ++Wsp+++v
   Q: 8    RLMRDFKRMQTDPPAGVSASPVPD-NVMTWNAVIIGPADTPFEDGTFRLVMQFEEQYPNKPPQVKFISEMFHPNVYATGELCLDILQ--NRWSPTYDV 102
           9***********************.9************************************************************9..********* PP
   S: 99   esvllsiqsllaepnpesplneeaaellkknreeykkkvre 139
           + vl+siqsll++pn+ sp+n+ea++l+k+nr+ey k+vre
   Q: 103  AAVLTSIQSLLNDPNTGSPANVEASNLYKDNRKEYTKRVRE 143
           **************************************985 PP

Organism

Fusarium solani

Functional Description
(View)

Catalyzes the covalent attachment of ubiquitin to other proteins. Plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation. Also involved in postreplication repair of UV-damaged DNA, in N-end rule-dependent protein degradation and in sporulation.

Protein Sequence
(Fasta)

MSTAARRRLM RDFKRMQTDP PAGVSASPVP DNVMTWNAVI IGPADTPFED GTFRLVMQFE 60
EQYPNKPPQV KFISEMFHPN VYATGELCLD ILQNRWSPTY DVAAVLTSIQ SLLNDPNTGS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCTACAG CTGCGCGCCG CCGCTTGATG CGAGACTTCA AGGTATGGCA TCCGGGGGAA 60
TAGCCAACAT ATAATGTTAA CAACAGCTGC AGCGCATGCA AACCGACCCT CCCGCCGGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0156--Chromatin regulator
KW-0963--Cytoplasm
KW-0227--DNA damage
KW-0234--DNA repair
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0749--Sporulation
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0016740--F:transferase activity
GO:0016569--P:covalent chromatin modification
GO:0006281--P:DNA repair
GO:0016567--P:protein ubiquitination
GO:0006355--P:regulation of transcription, DNA-templated
GO:0030435--P:sporulation resulting in formation of a cellular spore
GO:0006351--P:transcription, DNA-templated

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001001	Aegilops tauschii	65.10	6.00e-61	224.00
IUUC-Aml-002120	Ailuropoda melanoleuca	68.87	2.00e-64	236.00
IUUC-Atr-002862	Amborella trichopoda	67.11	4.00e-62	228.00
IUUC-Apl-004063	Anas platyrhynchos	61.49	5.00e-54	201.00
IUUC-Aca-005001	Anolis carolinensis	68.21	2.00e-64	235.00
IUUC-Aly-006336	Arabidopsis lyrata	66.44	3.00e-55	205.00
IUUC-Ath-007547	Arabidopsis thaliana	66.44	3.00e-55	205.00
IUUC-Ago-007745	Ashbya gossypii	78.00	2.00e-72	262.00
IUUC-Acl-008139	Aspergillus clavatus	93.38	2.00e-83	299.00
IUUC-Afl-008551	Aspergillus flavus	94.04	6.00e-84	300.00
IUUC-Afu-008980	Aspergillus fumigatus	94.04	6.00e-84	300.00
IUUC-Ang-009554	Aspergillus niger	94.04	6.00e-84	300.00
IUUC-Aor-010242	Aspergillus oryzae	94.04	6.00e-84	300.00
IUUC-Ate-010390	Aspergillus terreus	94.04	6.00e-84	300.00
IUUC-Ame-010743	Astyanax mexicanus	69.54	1.00e-64	236.00
IUUC-Bgr-012039	Blumeria graminis	94.12	3.00e-75	271.00
IUUC-Bta-012840	Bos taurus	68.87	2.00e-64	236.00
IUUC-Bci-013919	Botrytis cinerea	96.03	4.00e-85	304.00
IUUC-Bdi-015010	Brachypodium distachyon	67.11	9.00e-62	226.00
IUUC-Bol-016245	Brassica oleracea	66.44	8.00e-62	227.00
IUUC-Bra-018026	Brassica rapa	66.44	8.00e-62	227.00
IUUC-Cel-018244	Caenorhabditis elegans	69.80	5.00e-65	238.00
IUUC-Cja-019737	Callithrix jacchus	68.87	2.00e-64	236.00
IUUC-Cfa-020244	Canis familiaris	68.87	2.00e-64	236.00
IUUC-Cpo-021323	Cavia porcellus	69.54	1.00e-64	236.00
IUUC-Cre-022822	Chlamydomonas reinhardtii	68.22	1.00e-52	197.00
IUUC-Csa-023430	Chlorocebus sabaeus	68.87	2.00e-64	236.00
IUUC-Cho-024773	Choloepus hoffmanni	54.30	1.00e-44	170.00
IUUC-Cin-025537	Ciona intestinalis	68.46	6.00e-54	201.00
IUUC-Csv-025846	Ciona savignyi	68.46	2.00e-57	212.00
IUUC-Cgl-026381	Colletotrichum gloeosporioides	98.68	1.00e-87	312.00
IUUC-Cne-026864	Cryptococcus neoformans	71.81	3.00e-66	242.00
IUUC-Cme-027284	Cyanidioschyzon merolae	63.33	2.00e-50	190.00
IUUC-Dre-028358	Danio rerio	68.87	2.00e-64	236.00
IUUC-Dno-029661	Dasypus novemcinctus	68.87	2.00e-64	236.00
IUUC-Dor-030452	Dipodomys ordii	66.18	5.00e-56	207.00
IUUC-Dse-031487	Dothistroma septosporum	94.04	2.00e-84	302.00
IUUC-Dme-031863	Drosophila melanogaster	70.20	2.00e-64	235.00
IUUC-Ete-032595	Echinops telfairi	66.89	7.00e-63	230.00
IUUC-Eca-033377	Equus caballus	68.87	2.00e-64	236.00
IUUC-Eeu-035191	Erinaceus europaeus	54.90	3.00e-44	169.00
IUUC-Fca-036336	Felis catus	68.87	2.00e-64	236.00
IUUC-Fal-037474	Ficedula albicollis	67.80	2.00e-49	185.00
IUUC-Fox-037808	Fusarium oxysporum	99.34	3.00e-88	315.00
IUUC-Gmo-038517	Gadus morhua	68.87	2.00e-64	236.00
IUUC-Ggr-039875	Gaeumannomyces graminis	97.33	1.00e-85	306.00
IUUC-Gga-040494	Gallus gallus	68.87	2.00e-64	236.00
IUUC-Gac-042471	Gasterosteus aculeatus	68.87	7.00e-65	237.00
IUUC-Gma-043865	Glycine max	67.11	2.00e-62	229.00
IUUC-Ggo-044896	Gorilla gorilla	68.87	2.00e-64	236.00
IUUC-Hsa-046239	Homo sapiens	68.87	2.00e-64	236.00
IUUC-Hvu-047054	Hordeum vulgare	65.10	6.00e-61	224.00
IUUC-Itr-048960	Ictidomys tridecemlineatus	68.87	2.00e-64	236.00
IUUC-Kpa-049225	Komagataella pastoris	82.55	2.00e-75	272.00
IUUC-Lch-049964	Latimeria chalumnae	68.87	2.00e-64	236.00
IUUC-Lpe-050826	Leersia perrieri	67.11	7.00e-62	227.00
IUUC-Loc-051962	Lepisosteus oculatus	70.20	3.00e-65	238.00
IUUC-Laf-053380	Loxodonta africana	68.87	2.00e-64	236.00
IUUC-Mcc-054819	Macaca mulatta	68.87	1.00e-64	236.00
IUUC-Meu-056231	Macropus eugenii	68.87	2.00e-64	236.00
IUUC-Mor-057087	Magnaporthe oryzae	95.56	5.00e-76	274.00
IUUC-Mpo-057498	Magnaporthe poae	97.33	6.00e-86	308.00
IUUC-Mtr-058612	Medicago truncatula	67.11	2.00e-54	202.00
IUUC-Mla-058876	Melampsora laricipopulina	75.50	1.00e-64	236.00
IUUC-Mga-059863	Meleagris gallopavo	65.47	1.00e-56	210.00
IUUC-Mvi-060330	Microbotryum violaceum	74.83	8.00e-62	227.00
IUUC-Mmr-060630	Microcebus murinus	68.87	2.00e-64	236.00
IUUC-Mdo-062676	Monodelphis domestica	68.87	2.00e-64	236.00
IUUC-Mmu-063491	Mus musculus	68.87	2.00e-64	236.00
IUUC-Mac-064774	Musa acuminata	67.11	7.00e-62	227.00
IUUC-Mpu-065803	Mustela putorius furo	68.87	2.00e-64	236.00
IUUC-Mlu-067147	Myotis lucifugus	68.87	2.00e-64	236.00
IUUC-Nfi-068580	Neosartorya fischeri	94.04	6.00e-84	300.00
IUUC-Ncr-068913	Neurospora crassa	98.01	7.00e-87	310.00
IUUC-Nle-070105	Nomascus leucogenys	68.87	2.00e-64	236.00
IUUC-Opr-070935	Ochotona princeps	68.87	2.00e-64	236.00
IUUC-Ont-071335	Oreochromis niloticus	68.87	7.00e-65	237.00
IUUC-Oan-072706	Ornithorhynchus anatinus	63.70	2.00e-57	213.00
IUUC-Ocu-074130	Oryctolagus cuniculus	68.87	2.00e-64	236.00
IUUC-Oba-075896	Oryza barthii	67.11	7.00e-62	227.00
IUUC-Obr-076770	Oryza brachyantha	67.79	3.00e-62	228.00
IUUC-Ogl-077117	Oryza glaberrima	67.11	7.00e-62	227.00
IUUC-Ogu-078939	Oryza glumaepatula	67.11	7.00e-62	227.00
IUUC-Oin-079769	Oryza indica	67.11	7.00e-62	227.00
IUUC-Olo-081018	Oryza longistaminata	56.36	5.00e-52	195.00
IUUC-Ome-081285	Oryza meridionalis	67.11	5.00e-62	227.00
IUUC-Oni-082537	Oryza nivara	67.11	7.00e-62	227.00
IUUC-Opu-083310	Oryza punctata	67.11	5.00e-62	227.00
IUUC-Oru-084754	Oryza rufipogon	67.11	7.00e-62	227.00
IUUC-Osa-086290	Oryza sativa	67.11	7.00e-62	227.00
IUUC-Ola-087160	Oryzias latipes	68.87	7.00e-65	237.00
IUUC-Olu-087830	Ostreococcus lucimarinus	65.77	1.00e-53	199.00
IUUC-Oga-088836	Otolemur garnettii	68.87	2.00e-64	236.00
IUUC-Oar-090141	Ovis aries	68.87	2.00e-64	236.00
IUUC-Ptr-091453	Pan troglodytes	68.87	2.00e-64	236.00
IUUC-Pan-092511	Papio anubis	68.87	2.00e-64	236.00
IUUC-Psi-094094	Pelodiscus sinensis	68.87	2.00e-64	236.00
IUUC-Pma-094376	Petromyzon marinus	68.87	4.00e-64	234.00
IUUC-Pno-094935	Phaeosphaeria nodorum	93.38	3.00e-83	298.00
IUUC-Ppa-095689	Physcomitrella patens	69.29	3.00e-53	198.00
IUUC-Pfo-096656	Poecilia formosa	68.21	2.00e-64	235.00
IUUC-Pab-098121	Pongo abelii	68.87	2.00e-64	236.00
IUUC-Pop-099517	Populus trichocarpa	67.11	4.00e-62	228.00
IUUC-Pca-100906	Procavia capensis	63.58	8.00e-58	213.00
IUUC-Ppe-101594	Prunus persica	67.11	4.00e-62	228.00
IUUC-Pva-102380	Pteropus vampyrus	68.21	2.00e-62	228.00
IUUC-Pgr-103611	Puccinia graminis	75.50	7.00e-65	237.00
IUUC-Ptt-103971	Puccinia triticina	77.97	3.00e-49	184.00
IUUC-Pte-104378	Pyrenophora teres	92.72	2.00e-83	298.00
IUUC-Pyt-104757	Pyrenophora triticirepentis	92.72	2.00e-83	298.00
IUUC-Rno-105772	Rattus norvegicus	68.87	1.00e-64	237.00
IUUC-Sce-106283	Saccharomyces cerevisiae	78.00	2.00e-72	262.00
IUUC-Sha-107650	Sarcophilus harrisii	68.21	3.00e-63	231.00
IUUC-Sja-107790	Schizosaccharomyces japonicus	82.67	5.00e-67	244.00
IUUC-Spo-108073	Schizosaccharomyces pombe	82.67	4.00e-67	244.00
IUUC-Ssl-108432	Sclerotinia sclerotiorum	96.03	4.00e-85	304.00
IUUC-Smo-109512	Selaginella moellendorffii	67.79	2.00e-62	229.00
IUUC-Sit-110731	Setaria italica	67.11	5.00e-62	227.00
IUUC-Sly-111506	Solanum lycopersicum	67.11	3.00e-62	228.00
IUUC-Stu-112080	Solanum tuberosum	67.11	3.00e-62	228.00
IUUC-Sar-113429	Sorex araneus	68.87	2.00e-64	236.00
IUUC-Sbi-114289	Sorghum bicolor	67.11	5.00e-62	227.00
IUUC-Sre-115106	Sporisorium reilianum	72.85	5.00e-62	228.00
IUUC-Ssc-116265	Sus scrofa	68.87	2.00e-64	236.00
IUUC-Tgu-117383	Taeniopygia guttata	68.87	2.00e-64	236.00
IUUC-Tru-118576	Takifugu rubripes	68.21	7.00e-64	234.00
IUUC-Tsy-119000	Tarsius syrichta	68.87	2.00e-64	236.00
IUUC-Tni-119745	Tetraodon nigroviridis	68.21	4.00e-64	234.00
IUUC-Tca-121827	Theobroma cacao	67.79	2.00e-62	228.00
IUUC-Tre-122002	Trichoderma reesei	98.01	9.00e-88	313.00
IUUC-Tvi-122331	Trichoderma virens	98.01	9.00e-88	313.00
IUUC-Tae-124461	Triticum aestivum	66.44	2.00e-61	227.00
IUUC-Tur-126866	Triticum urartu	65.77	2.00e-61	225.00
IUUC-Tme-127148	Tuber melanosporum	92.00	1.00e-82	296.00
IUUC-Tbe-127921	Tupaia belangeri	66.89	4.00e-60	221.00
IUUC-Ttr-129121	Tursiops truncatus	68.87	2.00e-64	236.00
IUUC-Uma-129561	Ustilago maydis	72.85	4.00e-62	228.00
IUUC-Vda-129711	Verticillium dahliae	98.68	1.00e-87	312.00
IUUC-Vpa-130570	Vicugna pacos	61.03	2.00e-50	189.00
IUUC-Vvi-131108	Vitis vinifera	67.11	2.00e-62	229.00
IUUC-Xtr-132301	Xenopus tropicalis	68.87	2.00e-64	236.00
IUUC-Xma-133667	Xiphophorus maculatus	68.87	7.00e-65	237.00
IUUC-Yli-134660	Yarrowia lipolytica	83.44	8.00e-77	276.00
IUUC-Zma-135584	Zea mays	65.77	2.00e-61	225.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence