iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Nle-069013

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin carboxyl-terminal hydrolase

Genbank Nucleotide ID

ADFV01022859

Gene Name

UCHL5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSNLEG00000018047.2	ENSNLET00000023033.2	ENSNLEP00000021925.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/UCH	3.70e-101	338.9	68	387

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/UCH

   S: 1    mnsqvkewleLesdPglftllvedfgvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktif 89
           m++++ ew+ +esdPg+ft+l++ fg+++  qvee++sL+pen++++ +pv+gl++lFk+++ +e +          +vv+++ ++tif
   Q: 68   MTGNAGEWCLMESDPGVFTELIKGFGCRGA-QVEEIWSLEPENFEKL-KPVHGLIFLFKWQPGEEPAG---------SVVQDSRLDTIF 145
           788999************************.****************.********************.........899********* PP
   S: 90   fakqvigNsCatyAllsvllncedklldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqytkeaf 178
           fakqvi+N+Cat+A++svllnc+++ ++lG+tls++ke+++++++ +k+lal+n++ ++++hns+ar+++++ +++++++    +++af
   Q: 146  FAKQVINNACATQAIVSVLLNCTHQDVHLGETLSEFKEFSQSFDAAMKGLALSNSDSIRQVHNSFARQQMFEFDTKTSAK----EEDAF 230
           *****************************************************************************888....79*** PP
   S: 179  hfvsyvningrlyeldglkpfPldlgkkketeelkdklkvvraflerikllesdeirfnllaivadrrviktlrlnvlkid........ 259
           hfvsyv++ngrlyeldgl++ P+dlg+ ++++++ ++++ v+   +ri++++++eirfnl+aiv+dr++i+++++  l+ +        
   Q: 231  HFVSYVPVNGRLYELDGLREGPIDLGA-CNQDDWISAVRPVI--EKRIQKYSEGEIRFNLMAIVSDRKMIYEQKIAELQRQlaeepmdt 316
           **************************9.78999*********..******************************976655566777776 PP
   S: 260  keLlkLlkdieseeekieaqlddekekrkkfkiddirRtenydeficifikdlaregilrklveetisevrefg 333
            +  ++l++i+se++k+++ +++e++k k++ki++irR++ny  fi++++k+la++++l  lve+    + +++
   Q: 317  DQGNSMLSAIQSEVAKNQMLIEEEVQKLKRYKIENIRRKHNYLPFIMELLKTLAEHQQLIPLVEKA---KEKQN 387
           44569**********************************************************993...33344 PP

Organism

Nomascus leucogenys

Protein Sequence
(Fasta)

MSLGWLERPP ALRRAAGDGA RRLSGSRRGD VWLTSSAAVL LRSVAGGSWC GGQPRARGGS 60
GRCVAGAMTG NAGEWCLMES DPGVFTELIK GFGCRGAQVE EIWSLEPENF EKLKPVHGLI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCTCTAG GGTGGCTAGA GCGTCCTCCC GCGCTCCGTC GCGCTGCAGG TGACGGCGCC 60
CGGAGGCTGT CGGGAAGTAG GCGGGGTGAC GTGTGGTTGA CGAGCTCGGC GGCGGTTTTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH
IPR033837--UCH37

Pfam

PF01088--Peptidase_C12

PRINTS

PR00707--UBCTHYDRLASE

Gene Ontology

GO:0005829--C:cytosol
GO:0031011--C:Ino80 complex
GO:0005739--C:mitochondrion
GO:0005654--C:nucleoplasm
GO:0004866--F:endopeptidase inhibitor activity
GO:0003723--F:RNA binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination
GO:0061136--P:regulation of proteasomal protein catabolic process
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000936	Aegilops tauschii	48.01	1.00e-84	306.00
IUUC-Aml-001866	Ailuropoda melanoleuca	98.72	0.00e+00	640.00
IUUC-Atr-002966	Amborella trichopoda	45.31	1.00e-81	296.00
IUUC-Apl-003306	Anas platyrhynchos	84.92	1.00e-173	602.00
IUUC-Aca-004763	Anolis carolinensis	94.21	5.00e-176	609.00
IUUC-Aly-005581	Arabidopsis lyrata	48.33	2.00e-80	292.00
IUUC-Ath-007283	Arabidopsis thaliana	48.94	7.00e-84	303.00
IUUC-Ago-007999	Ashbya gossypii	33.44	1.00e-33	136.00
IUUC-Acl-008231	Aspergillus clavatus	43.33	1.00e-52	200.00
IUUC-Afl-008557	Aspergillus flavus	38.24	1.00e-54	206.00
IUUC-Afu-008988	Aspergillus fumigatus	44.81	8.00e-55	207.00
IUUC-Ani-009420	Aspergillus nidulans	38.36	9.00e-53	200.00
IUUC-Ang-009859	Aspergillus niger	40.82	2.00e-49	189.00
IUUC-Aor-010145	Aspergillus oryzae	38.24	1.00e-54	206.00
IUUC-Ate-010347	Aspergillus terreus	41.96	1.00e-53	202.00
IUUC-Ame-010791	Astyanax mexicanus	89.06	2.00e-178	617.00
IUUC-Bgr-012298	Blumeria graminis	37.95	2.00e-49	188.00
IUUC-Bta-013251	Bos taurus	98.40	0.00e+00	642.00
IUUC-Bci-013786	Botrytis cinerea	38.17	1.00e-57	216.00
IUUC-Bdi-014132	Brachypodium distachyon	49.85	7.00e-83	300.00
IUUC-Bol-015611	Brassica oleracea	49.09	6.00e-84	303.00
IUUC-Bra-017769	Brassica rapa	49.09	1.00e-83	303.00
IUUC-Cel-018604	Caenorhabditis elegans	47.28	7.00e-82	296.00
IUUC-Cja-019768	Callithrix jacchus	90.93	0.00e+00	647.00
IUUC-Cfa-020207	Canis familiaris	98.72	0.00e+00	640.00
IUUC-Cpo-021925	Cavia porcellus	94.57	2.00e-176	610.00
IUUC-Cre-022919	Chlamydomonas reinhardtii	45.24	2.00e-73	269.00
IUUC-Csa-023958	Chlorocebus sabaeus	98.68	0.00e+00	701.00
IUUC-Cho-024928	Choloepus hoffmanni	100.00	1.00e-42	166.00
IUUC-Cin-025771	Ciona intestinalis	53.87	4.00e-99	354.00
IUUC-Csv-026149	Ciona savignyi	58.04	9.00e-102	363.00
IUUC-Cgl-026424	Colletotrichum gloeosporioides	38.38	4.00e-51	194.00
IUUC-Cne-026955	Cryptococcus neoformans	38.25	5.00e-55	207.00
IUUC-Cme-027104	Cyanidioschyzon merolae	33.15	3.00e-48	185.00
IUUC-Dre-027409	Danio rerio	88.15	3.00e-175	607.00
IUUC-Dno-028921	Dasypus novemcinctus	98.08	0.00e+00	637.00
IUUC-Dor-030891	Dipodomys ordii	44.58	4.00e-34	139.00
IUUC-Dse-031170	Dothistroma septosporum	40.38	3.00e-58	218.00
IUUC-Dme-031677	Drosophila melanogaster	60.24	6.00e-116	410.00
IUUC-Ete-032707	Echinops telfairi	67.48	1.00e-119	422.00
IUUC-Eca-033776	Equus caballus	98.26	9.00e-169	585.00
IUUC-Eeu-035305	Erinaceus europaeus	78.57	4.00e-87	314.00
IUUC-Fca-035846	Felis catus	90.34	0.00e+00	639.00
IUUC-Fal-037597	Ficedula albicollis	92.36	1.00e-156	545.00
IUUC-Fox-037670	Fusarium oxysporum	43.61	1.00e-55	209.00
IUUC-Fso-038243	Fusarium solani	43.56	5.00e-55	207.00
IUUC-Gmo-038499	Gadus morhua	83.39	1.00e-158	552.00
IUUC-Ggr-039975	Gaeumannomyces graminis	41.06	4.00e-48	184.00
IUUC-Gga-040904	Gallus gallus	93.58	0.00e+00	634.00
IUUC-Gac-042058	Gasterosteus aculeatus	88.18	6.00e-168	583.00
IUUC-Gma-043030	Glycine max	48.66	2.00e-86	312.00
IUUC-Ggo-044699	Gorilla gorilla	93.49	3.00e-169	587.00
IUUC-Hsa-046227	Homo sapiens	99.36	0.00e+00	644.00
IUUC-Hvu-047359	Hordeum vulgare	47.43	9.00e-84	303.00
IUUC-Itr-048989	Ictidomys tridecemlineatus	89.04	0.00e+00	640.00
IUUC-Lch-049829	Latimeria chalumnae	91.37	9.00e-172	595.00
IUUC-Lpe-050899	Leersia perrieri	49.53	2.00e-79	289.00
IUUC-Loc-052264	Lepisosteus oculatus	89.49	8.00e-170	589.00
IUUC-Lma-053110	Leptosphaeria maculans	36.00	6.00e-49	187.00
IUUC-Laf-053639	Loxodonta africana	98.72	0.00e+00	640.00
IUUC-Mcc-055506	Macaca mulatta	98.42	0.00e+00	697.00
IUUC-Meu-056267	Macropus eugenii	41.90	4.00e-46	179.00
IUUC-Mor-057001	Magnaporthe oryzae	45.38	9.00e-55	206.00
IUUC-Mpo-057608	Magnaporthe poae	41.18	7.00e-33	133.00
IUUC-Mtr-057731	Medicago truncatula	48.66	1.00e-85	309.00
IUUC-Mla-059016	Melampsora laricipopulina	43.28	1.00e-43	169.00
IUUC-Mga-060178	Meleagris gallopavo	94.08	2.00e-170	590.00
IUUC-Mvi-060353	Microbotryum violaceum	38.32	5.00e-54	204.00
IUUC-Mmr-060738	Microcebus murinus	98.72	0.00e+00	641.00
IUUC-Mdo-062266	Monodelphis domestica	97.06	6.00e-119	419.00
IUUC-Mmu-063619	Mus musculus	96.17	0.00e+00	627.00
IUUC-Mac-065301	Musa acuminata	50.32	1.00e-88	319.00
IUUC-Mpu-066058	Mustela putorius furo	98.40	0.00e+00	639.00
IUUC-Mlu-067292	Myotis lucifugus	97.12	0.00e+00	625.00
IUUC-Nfi-068275	Neosartorya fischeri	39.10	8.00e-56	210.00
IUUC-Ncr-068713	Neurospora crassa	39.05	2.00e-57	215.00
IUUC-Opr-070628	Ochotona princeps	85.10	1.00e-170	592.00
IUUC-Ont-072688	Oreochromis niloticus	88.89	2.00e-168	584.00
IUUC-Oan-073004	Ornithorhynchus anatinus	95.88	2.00e-138	484.00
IUUC-Ocu-074303	Oryctolagus cuniculus	92.48	0.00e+00	664.00
IUUC-Oba-075002	Oryza barthii	50.15	1.00e-82	299.00
IUUC-Obr-076392	Oryza brachyantha	49.84	2.00e-80	292.00
IUUC-Ogl-077271	Oryza glaberrima	50.15	1.00e-82	299.00
IUUC-Ogu-078493	Oryza glumaepatula	50.15	4.00e-83	301.00
IUUC-Oin-080084	Oryza indica	50.15	4.00e-83	301.00
IUUC-Olo-080803	Oryza longistaminata	49.85	8.00e-83	300.00
IUUC-Ome-081146	Oryza meridionalis	48.92	1.00e-81	296.00
IUUC-Oni-082146	Oryza nivara	50.15	4.00e-83	301.00
IUUC-Opu-083633	Oryza punctata	49.53	1.00e-79	289.00
IUUC-Oru-084789	Oryza rufipogon	50.15	4.00e-83	301.00
IUUC-Osa-086196	Oryza sativa	50.15	4.00e-83	301.00
IUUC-Ola-087126	Oryzias latipes	89.14	4.00e-165	573.00
IUUC-Olu-087665	Ostreococcus lucimarinus	42.16	1.00e-68	252.00
IUUC-Oga-089140	Otolemur garnettii	90.88	0.00e+00	627.00
IUUC-Oar-090296	Ovis aries	97.44	0.00e+00	632.00
IUUC-Ptr-090566	Pan troglodytes	99.36	0.00e+00	644.00
IUUC-Pan-092052	Papio anubis	98.68	0.00e+00	700.00
IUUC-Psi-093723	Pelodiscus sinensis	94.10	4.00e-162	563.00
IUUC-Pma-094568	Petromyzon marinus	61.67	5.00e-105	374.00
IUUC-Pno-095120	Phaeosphaeria nodorum	45.65	5.00e-50	191.00
IUUC-Ppa-095761	Physcomitrella patens	47.37	9.00e-84	303.00
IUUC-Pfo-096210	Poecilia formosa	88.50	5.00e-169	586.00
IUUC-Pab-098463	Pongo abelii	98.68	0.00e+00	717.00
IUUC-Pop-099423	Populus trichocarpa	49.26	4.00e-85	308.00
IUUC-Pca-100108	Procavia capensis	96.39	2.00e-142	498.00
IUUC-Ppe-101176	Prunus persica	50.60	1.00e-85	309.00
IUUC-Pva-102629	Pteropus vampyrus	94.85	2.00e-151	528.00
IUUC-Pgr-103419	Puccinia graminis	40.55	1.00e-56	213.00
IUUC-Pte-104207	Pyrenophora teres	44.97	7.00e-33	132.00
IUUC-Pyt-104471	Pyrenophora triticirepentis	39.80	1.00e-56	213.00
IUUC-Rno-105579	Rattus norvegicus	86.96	3.00e-164	570.00
IUUC-Sha-106894	Sarcophilus harrisii	92.75	2.00e-152	531.00
IUUC-Sja-107732	Schizosaccharomyces japonicus	39.00	5.00e-59	221.00
IUUC-Spo-108371	Schizosaccharomyces pombe	42.33	2.00e-59	222.00
IUUC-Ssl-108467	Sclerotinia sclerotiorum	39.19	2.00e-47	182.00
IUUC-Smo-109396	Selaginella moellendorffii	51.69	3.00e-88	318.00
IUUC-Sit-110630	Setaria italica	49.70	4.00e-86	311.00
IUUC-Sly-110972	Solanum lycopersicum	50.48	5.00e-81	293.00
IUUC-Stu-112185	Solanum tuberosum	50.90	4.00e-89	320.00
IUUC-Sar-113294	Sorex araneus	80.77	1.00e-163	568.00
IUUC-Sbi-113951	Sorghum bicolor	50.31	8.00e-87	313.00
IUUC-Ssc-115501	Sus scrofa	96.97	2.00e-171	594.00
IUUC-Tgu-117152	Taeniopygia guttata	92.36	1.00e-156	545.00
IUUC-Tru-118388	Takifugu rubripes	87.86	6.00e-168	583.00
IUUC-Tsy-119109	Tarsius syrichta	98.77	0.00e+00	664.00
IUUC-Tni-120048	Tetraodon nigroviridis	87.86	1.00e-168	585.00
IUUC-Tca-121750	Theobroma cacao	50.00	7.00e-89	320.00
IUUC-Tre-122130	Trichoderma reesei	38.80	1.00e-54	206.00
IUUC-Tvi-122284	Trichoderma virens	39.67	3.00e-52	198.00
IUUC-Tae-124082	Triticum aestivum	47.43	2.00e-83	301.00
IUUC-Tur-126366	Triticum urartu	43.65	2.00e-67	249.00
IUUC-Tme-127187	Tuber melanosporum	40.40	7.00e-58	217.00
IUUC-Tbe-127619	Tupaia belangeri	89.55	9.00e-143	499.00
IUUC-Ttr-128867	Tursiops truncatus	87.35	6.00e-123	433.00
IUUC-Vda-129912	Verticillium dahliae	36.95	4.00e-52	198.00
IUUC-Vpa-130552	Vicugna pacos	99.04	7.00e-125	440.00
IUUC-Vvi-130881	Vitis vinifera	51.20	8.00e-85	306.00
IUUC-Xtr-131934	Xenopus tropicalis	84.80	8.00e-171	592.00
IUUC-Xma-133312	Xiphophorus maculatus	88.50	7.00e-169	585.00
IUUC-Yli-134487	Yarrowia lipolytica	39.91	6.00e-49	187.00
IUUC-Zma-135462	Zea mays	44.00	1.00e-72	266.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence