iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Cfa-020793

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAEX03001585

Gene Name

AMFR

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCAFG00000009169.3	ENSCAFT00000014581.3	ENSCAFP00000013489.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	5.80e-09	36.6	256	294
UBD/Alpha-Helix/CUE	2.40e-11	43.6	371	412

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           CaiC+++++   + lpCgH+fh +Cl  w        +  +CP+Cr
   Q: 256  CAICWDSMQA-ARKLPCGHLFHNSCLRSW------LEQDTSCPTCR 294
           ********99.******************......9*********8 PP

UBD/Alpha-Helix/CUE

   S: 1    dletaleqLkeiFPnldysviqvvLeantgsleaavnnLLegs 43
           +l+ +++q++e+FP+++y ++ ++L ++t s+e +++n+Leg 
   Q: 371  QLNAMAHQIQEMFPQVPYHLVLQDL-QLTRSVEITTDNILEGR 412
           5889*********************.***************95 PP

Organism

Canis familiaris

Protein Sequence
(Fasta)

VLVNTACCVL MLVAKLIQCI VFGPLRVSER QHLKDKFWNF IFYKFIFIFG VLNVQTVEEV 60
VMWCLWFAGL VFLHLMVQLC KDRFEYVSFQ PTTPMSSHGR VLSLLIAMLL SCCGLAVVCC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTCTAGTAA ATACTGCATG CTGTGTTTTG ATGCTGGTGG CTAAGCTAAT CCAGTGTATT 60
GTGTTTGGCC CTCTTCGAGT GAGTGAGAGG CAGGTAAGTC CAAGGCTAAG CCTGATTTTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR003892--CUE
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51140--CUE
PS50089--ZF_RING_2

Pfam

PF02845--CUE
PF13639--zf-RING_2

SMART

SM00546--CUE
SM00184--RING

Gene Ontology

GO:0036513--C:Derlin-1 retrotranslocation complex
GO:0005794--C:Golgi apparatus
GO:0030176--C:integral component of endoplasmic reticulum membrane
GO:0048471--C:perinuclear region of cytoplasm
GO:0004872--F:receptor activity
GO:1904264--F:ubiquitin protein ligase activity involved in ERAD pathway
GO:1990381--F:ubiquitin-specific protease binding
GO:0034450--F:ubiquitin-ubiquitin ligase activity
GO:0008270--F:zinc ion binding
GO:0030968--P:endoplasmic reticulum unfolded protein response
GO:0032092--P:positive regulation of protein binding
GO:0051865--P:protein autoubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0051259--P:protein oligomerization
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0030433--P:ubiquitin-dependent ERAD pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001300	Ailuropoda melanoleuca	95.35	0.00e+00	1040.00
IUUC-Apl-003404	Anas platyrhynchos	87.68	0.00e+00	932.00
IUUC-Aca-004559	Anolis carolinensis	84.15	0.00e+00	872.00
IUUC-Ame-011640	Astyanax mexicanus	74.54	0.00e+00	763.00
IUUC-Bta-012980	Bos taurus	95.54	0.00e+00	1056.00
IUUC-Cel-018598	Caenorhabditis elegans	24.41	2.00e-30	127.00
IUUC-Cja-019577	Callithrix jacchus	94.64	0.00e+00	1048.00
IUUC-Cpo-022387	Cavia porcellus	95.00	0.00e+00	1014.00
IUUC-Csa-023168	Chlorocebus sabaeus	94.82	0.00e+00	1050.00
IUUC-Cho-024433	Choloepus hoffmanni	96.22	0.00e+00	858.00
IUUC-Cin-025215	Ciona intestinalis	48.28	2.00e-141	495.00
IUUC-Csv-026133	Ciona savignyi	48.76	3.00e-130	459.00
IUUC-Dre-027594	Danio rerio	71.66	0.00e+00	721.00
IUUC-Dno-029407	Dasypus novemcinctus	95.71	0.00e+00	1023.00
IUUC-Dor-030961	Dipodomys ordii	95.36	0.00e+00	1042.00
IUUC-Ete-032962	Echinops telfairi	86.61	0.00e+00	865.00
IUUC-Eca-033683	Equus caballus	94.30	0.00e+00	1017.00
IUUC-Eeu-034515	Erinaceus europaeus	97.78	9.00e-79	287.00
IUUC-Fca-035398	Felis catus	97.65	0.00e+00	1012.00
IUUC-Fal-036758	Ficedula albicollis	81.71	0.00e+00	875.00
IUUC-Gmo-039014	Gadus morhua	73.18	0.00e+00	711.00
IUUC-Gga-040575	Gallus gallus	87.86	0.00e+00	967.00
IUUC-Gac-041414	Gasterosteus aculeatus	72.88	0.00e+00	691.00
IUUC-Hsa-046272	Homo sapiens	94.64	0.00e+00	1047.00
IUUC-Itr-047956	Ictidomys tridecemlineatus	95.54	0.00e+00	1020.00
IUUC-Lch-050491	Latimeria chalumnae	80.65	0.00e+00	819.00
IUUC-Loc-052758	Lepisosteus oculatus	77.25	0.00e+00	775.00
IUUC-Laf-053452	Loxodonta africana	95.36	0.00e+00	1022.00
IUUC-Mcc-055820	Macaca mulatta	94.91	0.00e+00	1031.00
IUUC-Meu-056726	Macropus eugenii	87.50	0.00e+00	766.00
IUUC-Mga-059937	Meleagris gallopavo	87.86	0.00e+00	935.00
IUUC-Mmr-060730	Microcebus murinus	94.82	0.00e+00	1011.00
IUUC-Mdo-062771	Monodelphis domestica	91.48	0.00e+00	997.00
IUUC-Mmu-064219	Mus musculus	94.63	0.00e+00	1037.00
IUUC-Mpu-066796	Mustela putorius furo	98.18	0.00e+00	1066.00
IUUC-Mlu-068189	Myotis lucifugus	93.93	0.00e+00	1001.00
IUUC-Nle-069239	Nomascus leucogenys	94.82	0.00e+00	1050.00
IUUC-Opr-070702	Ochotona princeps	87.05	2.00e-140	492.00
IUUC-Ont-072033	Oreochromis niloticus	74.81	0.00e+00	754.00
IUUC-Oan-073717	Ornithorhynchus anatinus	85.33	0.00e+00	872.00
IUUC-Ocu-074145	Oryctolagus cuniculus	92.50	0.00e+00	1024.00
IUUC-Ogl-077929	Oryza glaberrima	53.49	9.00e-12	63.20
IUUC-Ola-087152	Oryzias latipes	72.16	0.00e+00	724.00
IUUC-Oga-088486	Otolemur garnettii	95.36	0.00e+00	1016.00
IUUC-Oar-089310	Ovis aries	96.07	0.00e+00	1061.00
IUUC-Ptr-090649	Pan troglodytes	94.64	0.00e+00	1048.00
IUUC-Pan-091692	Papio anubis	90.18	0.00e+00	985.00
IUUC-Psi-093064	Pelodiscus sinensis	94.22	0.00e+00	772.00
IUUC-Pma-094763	Petromyzon marinus	77.05	2.00e-96	344.00
IUUC-Ppa-095969	Physcomitrella patens	28.49	5.00e-35	142.00
IUUC-Pfo-096810	Poecilia formosa	73.65	0.00e+00	730.00
IUUC-Pab-097859	Pongo abelii	94.55	0.00e+00	1030.00
IUUC-Pop-099576	Populus trichocarpa	26.18	8.00e-27	115.00
IUUC-Pca-100344	Procavia capensis	93.77	0.00e+00	982.00
IUUC-Pva-103114	Pteropus vampyrus	67.68	0.00e+00	653.00
IUUC-Rno-105880	Rattus norvegicus	92.76	0.00e+00	1011.00
IUUC-Sha-107015	Sarcophilus harrisii	93.92	0.00e+00	980.00
IUUC-Sar-113397	Sorex araneus	97.30	0.00e+00	760.00
IUUC-Ssc-115988	Sus scrofa	91.72	2.00e-146	511.00
IUUC-Tgu-116717	Taeniopygia guttata	89.48	0.00e+00	911.00
IUUC-Tru-117805	Takifugu rubripes	71.53	0.00e+00	751.00
IUUC-Tsy-119442	Tarsius syrichta	89.11	0.00e+00	947.00
IUUC-Tni-119777	Tetraodon nigroviridis	71.59	2.00e-170	592.00
IUUC-Tbe-127322	Tupaia belangeri	67.77	1.00e-113	404.00
IUUC-Ttr-128181	Tursiops truncatus	95.18	0.00e+00	1055.00
IUUC-Vpa-130483	Vicugna pacos	85.24	0.00e+00	661.00
IUUC-Xtr-132614	Xenopus tropicalis	81.27	0.00e+00	772.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence