iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Xtr-131815

Ensembl Protein ID

ENSXETP00000015581.3

UniProt Accession

A4QND0; UBL4A_XENTR

Genbank Protein ID

AAI35439.1

Protein Name

Ubiquitin-like protein 4A

Genbank Nucleotide ID

BC135438

Gene Name

ubl4a

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000007175.3	ENSXETT00000015581.3	ENSXETP00000015581.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
ULD/UDP/UBQ/UBQ_PIM	6.10e-20	71.1	1	74

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UDP/UBQ/UBQ_PIM

   S: 1    mkltvktlkgkefelevseddtveelKekiakesgvppeqqkLIyaGkiLkDdttLselgikdgsvvhlvvkks 74
           m+ltvk+lkgke +++vse dtv ++K +++++ +vp++qq+L++ Gk L D+ +L  + i  gs + l+vk +
   Q: 1    MQLTVKALKGKEANIQVSEGDTVLAVKRLVEEKLKVPVSQQRLLFRGKALADEHCLAHYSIGPGSRLNLMVKEQ 74
           99*********************************************************************975 PP

Organism

Xenopus tropicalis

Functional Description
(View)

As part of a cytosolic protein quality control complex, the bag6/bat3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates to their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The bag6/bat3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Similarly, the bag6/bat3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum. The bag6/bat3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome.

Protein Sequence
(Fasta)

MQLTVKALKG KEANIQVSEG DTVLAVKRLV EEKLKVPVSQ QRLLFRGKAL ADEHCLAHYS 60
IGPGSRLNLM VKEQVAPEGH SGGNTAWKSL SVILRKHFSP TDAERVLEYV QKDYERSLSL 120

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Nucleotide Sequence
(Fasta)

CCTGGCTGGA GTCAGAGATG CAGCTGACGG TGAAAGCATT GAAAGGAAAG GAAGCCAATA 60
TCCAGGTGAC TAGTGATAGC CCGGTGCTGT GTGCGGATAG GTTGGAAGCG ATATACACTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0813--Transport

Interpro

IPR019956--Ubiquitin
IPR029071--Ubiquitin-rel_dom
IPR019954--Ubiquitin_CS
IPR000626--Ubiquitin_dom

PROSITE

PS00299--UBIQUITIN_1
PS50053--UBIQUITIN_2

Pfam

PF00240--ubiquitin

PRINTS

PR00348--UBIQUITIN

SMART

SM00213--UBQ

Gene Ontology

GO:0071818--C:BAT3 complex
GO:0005829--C:cytosol
GO:0071816--P:tail-anchored membrane protein insertion into ER membrane
GO:0006810--P:transport

KEGG

xtr:100125140

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001829	Ailuropoda melanoleuca	52.11	1.00e-30	125.00
IUUC-Aca-005306	Anolis carolinensis	59.62	1.00e-47	181.00
IUUC-Ame-010823	Astyanax mexicanus	49.70	9.00e-38	149.00
IUUC-Bta-013094	Bos taurus	52.47	6.00e-37	146.00
IUUC-Cja-018762	Callithrix jacchus	53.62	2.00e-30	124.00
IUUC-Cfa-020432	Canis familiaris	50.96	4.00e-36	143.00
IUUC-Cpo-021312	Cavia porcellus	53.85	6.00e-36	142.00
IUUC-Csa-023983	Chlorocebus sabaeus	54.19	4.00e-37	146.00
IUUC-Dre-028189	Danio rerio	53.16	3.00e-42	163.00
IUUC-Dno-029710	Dasypus novemcinctus	36.30	3.00e-18	84.00
IUUC-Dor-030848	Dipodomys ordii	56.12	2.00e-36	144.00
IUUC-Dme-031909	Drosophila melanogaster	36.76	4.00e-19	86.70
IUUC-Ete-032719	Echinops telfairi	51.06	3.00e-28	117.00
IUUC-Eca-033402	Equus caballus	54.23	2.00e-35	140.00
IUUC-Eeu-034802	Erinaceus europaeus	50.00	8.00e-16	74.70
IUUC-Fca-035600	Felis catus	50.96	4.00e-36	143.00
IUUC-Gmo-038655	Gadus morhua	51.85	2.00e-40	157.00
IUUC-Gga-040933	Gallus gallus	42.55	3.00e-25	107.00
IUUC-Gac-041809	Gasterosteus aculeatus	47.02	3.00e-36	144.00
IUUC-Ggo-044574	Gorilla gorilla	54.68	7.00e-31	126.00
IUUC-Hsa-046633	Homo sapiens	54.19	3.00e-37	147.00
IUUC-Itr-048284	Ictidomys tridecemlineatus	54.19	2.00e-37	147.00
IUUC-Loc-051925	Lepisosteus oculatus	56.76	4.00e-45	173.00
IUUC-Laf-053420	Loxodonta africana	49.69	1.00e-38	152.00
IUUC-Mcc-055841	Macaca mulatta	56.12	2.00e-34	138.00
IUUC-Meu-056392	Macropus eugenii	41.91	8.00e-23	99.00
IUUC-Mmr-061224	Microcebus murinus	55.24	3.00e-33	133.00
IUUC-Mdo-062067	Monodelphis domestica	55.41	4.00e-32	130.00
IUUC-Mmu-063667	Mus musculus	53.55	1.00e-37	148.00
IUUC-Mpu-066384	Mustela putorius furo	50.34	3.00e-29	120.00
IUUC-Mlu-067611	Myotis lucifugus	52.87	9.00e-36	142.00
IUUC-Nle-069564	Nomascus leucogenys	43.64	1.00e-18	85.10
IUUC-Opr-070425	Ochotona princeps	58.14	4.00e-36	142.00
IUUC-Oan-073168	Ornithorhynchus anatinus	49.52	1.00e-22	99.00
IUUC-Ocu-074452	Oryctolagus cuniculus	57.42	4.00e-41	159.00
IUUC-Ola-086473	Oryzias latipes	52.56	3.00e-40	156.00
IUUC-Oga-088650	Otolemur garnettii	54.19	5.00e-37	146.00
IUUC-Oar-089593	Ovis aries	52.08	3.00e-28	117.00
IUUC-Ptr-090659	Pan troglodytes	54.68	9.00e-31	125.00
IUUC-Pan-092760	Papio anubis	55.48	9.00e-41	159.00
IUUC-Psi-092996	Pelodiscus sinensis	59.43	8.00e-30	121.00
IUUC-Pfo-096839	Poecilia formosa	51.59	2.00e-38	151.00
IUUC-Pab-098410	Pongo abelii	52.86	1.00e-30	125.00
IUUC-Pca-100665	Procavia capensis	43.90	2.00e-11	60.80
IUUC-Rno-104898	Rattus norvegicus	53.55	2.00e-37	147.00
IUUC-Sha-107088	Sarcophilus harrisii	51.41	1.00e-25	108.00
IUUC-Ssc-116266	Sus scrofa	51.59	7.00e-36	143.00
IUUC-Tru-117619	Takifugu rubripes	50.35	3.00e-35	140.00
IUUC-Ttr-128314	Tursiops truncatus	38.97	5.00e-22	96.70

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence