iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oga-089104

Ensembl Protein ID

ENSOGAP00000001818.2

UniProt Accession

H0WJW9; H0WJW9_OTOGA

Genbank Protein ID

ENSOGAP00000001818

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAQR03141083

Gene Name

VAV1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOGAG00000002034.2	ENSOGAT00000002039.2	ENSOGAP00000001818.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.40e-20	73.0	788	839

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 7    qvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
           ++ yd+ a +  eL+lk+Gd+++++ +++  +gW++g  e  g+ G fP+n+ve+
   Q: 788  KARYDFCARDRSELSLKEGDIIKIL-NKKGQQGWWRG--EIYGRIGWFPSNYVEE 839
           788**********************.89999******..9*************86 PP

Organism

Otolemur garnettii

Protein Sequence
(Fasta)

MELWRQCTHW LIQCRVLPPS HRVTWEGAQV CELAQALRDG VLLCQLLNNL LPHAVNLREV 60
NLRPQMSQFL CLKNIRTFLS TCCEKFGLKR SELFEAFDLF DVQDFGKVIY TLSALSWTPI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGGGCGGGT GGGCGGTGGA GGCCACGTCG GTGCACAGGC CGGCCGGGGC AGGCAGCAGC 60
CATGGAGCTG TGGCGCCAGT GCACCCACTG GCTGATCCAG TGCCGTGTGC TGCCACCCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0862--Zinc

Interpro

IPR022613--CAMSAP_CH
IPR001715--CH-domain
IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR002219--PE/DAG-bd
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR000980--SH2
IPR001452--SH3_domain
IPR003096--SM22_calponin
IPR028530--Vav

PROSITE

PS50021--CH
PS00741--DH_1
PS50010--DH_2
PS50003--PH_DOMAIN
PS50001--SH2
PS50002--SH3
PS00479--ZF_DAG_PE_1
PS50081--ZF_DAG_PE_2

Pfam

PF00130--C1_1
PF11971--CAMSAP_CH
PF00169--PH
PF00621--RhoGEF
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00888--SM22CALPONIN

SMART

SM00109--C1
SM00033--CH
SM00233--PH
SM00325--RhoGEF
SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005911--C:cell-cell junction
GO:0005622--C:intracellular
GO:0046872--F:metal ion binding
GO:0030676--F:Rac guanyl-nucleotide exchange factor activity
GO:0007186--P:G-protein coupled receptor signaling pathway
GO:0006955--P:immune response
GO:0007229--P:integrin-mediated signaling pathway
GO:0030593--P:neutrophil chemotaxis
GO:0006909--P:phagocytosis
GO:0045785--P:positive regulation of cell adhesion
GO:0045954--P:positive regulation of natural killer cell mediated cytotoxicity
GO:0072593--P:reactive oxygen species metabolic process
GO:0008361--P:regulation of cell size
GO:0035023--P:regulation of Rho protein signal transduction
GO:0007264--P:small GTPase mediated signal transduction
GO:0030217--P:T cell differentiation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001362	Ailuropoda melanoleuca	57.90	0.00e+00	926.00
IUUC-Apl-003734	Anas platyrhynchos	57.73	0.00e+00	851.00
IUUC-Aca-004477	Anolis carolinensis	57.76	0.00e+00	926.00
IUUC-Ame-011279	Astyanax mexicanus	53.18	0.00e+00	836.00
IUUC-Bta-013049	Bos taurus	81.98	0.00e+00	1227.00
IUUC-Cja-020009	Callithrix jacchus	95.38	0.00e+00	1623.00
IUUC-Cfa-020768	Canis familiaris	96.45	0.00e+00	1617.00
IUUC-Cpo-021966	Cavia porcellus	55.45	0.00e+00	776.00
IUUC-Csa-023892	Chlorocebus sabaeus	56.43	0.00e+00	838.00
IUUC-Cin-025115	Ciona intestinalis	38.09	1.00e-137	483.00
IUUC-Csv-025995	Ciona savignyi	37.18	9.00e-143	500.00
IUUC-Dre-028199	Danio rerio	53.46	0.00e+00	858.00
IUUC-Dno-029602	Dasypus novemcinctus	94.79	0.00e+00	1612.00
IUUC-Eca-033682	Equus caballus	95.86	0.00e+00	1622.00
IUUC-Fca-035629	Felis catus	95.74	0.00e+00	1650.00
IUUC-Fal-036802	Ficedula albicollis	57.08	0.00e+00	931.00
IUUC-Gmo-039693	Gadus morhua	60.05	0.00e+00	960.00
IUUC-Gga-040884	Gallus gallus	58.99	0.00e+00	936.00
IUUC-Gac-041567	Gasterosteus aculeatus	66.16	0.00e+00	1032.00
IUUC-Ggo-044460	Gorilla gorilla	54.77	0.00e+00	777.00
IUUC-Hsa-045886	Homo sapiens	95.86	0.00e+00	1634.00
IUUC-Itr-048730	Ictidomys tridecemlineatus	90.78	0.00e+00	1516.00
IUUC-Loc-051761	Lepisosteus oculatus	71.93	0.00e+00	1191.00
IUUC-Laf-054537	Loxodonta africana	95.50	0.00e+00	1622.00
IUUC-Mcc-054726	Macaca mulatta	95.50	0.00e+00	1631.00
IUUC-Meu-056680	Macropus eugenii	53.72	0.00e+00	856.00
IUUC-Mga-060013	Meleagris gallopavo	59.08	0.00e+00	957.00
IUUC-Mmr-060980	Microcebus murinus	95.36	0.00e+00	1630.00
IUUC-Mdo-061926	Monodelphis domestica	86.90	0.00e+00	1341.00
IUUC-Mmu-063942	Mus musculus	93.96	0.00e+00	1602.00
IUUC-Mpu-066000	Mustela putorius furo	96.57	0.00e+00	1623.00
IUUC-Mlu-067818	Myotis lucifugus	93.31	0.00e+00	1550.00
IUUC-Nle-069863	Nomascus leucogenys	54.93	0.00e+00	888.00
IUUC-Opr-070372	Ochotona princeps	50.93	4.00e-170	592.00
IUUC-Ont-072213	Oreochromis niloticus	66.98	0.00e+00	1100.00
IUUC-Ocu-074830	Oryctolagus cuniculus	79.62	0.00e+00	1199.00
IUUC-Ola-087345	Oryzias latipes	64.08	0.00e+00	1040.00
IUUC-Oar-089459	Ovis aries	95.38	0.00e+00	1607.00
IUUC-Ptr-090766	Pan troglodytes	95.75	0.00e+00	1514.00
IUUC-Pan-091994	Papio anubis	94.68	0.00e+00	1609.00
IUUC-Psi-093595	Pelodiscus sinensis	78.73	0.00e+00	1276.00
IUUC-Pfo-097210	Poecilia formosa	66.39	0.00e+00	1070.00
IUUC-Pab-098630	Pongo abelii	95.90	0.00e+00	1597.00
IUUC-Pva-102406	Pteropus vampyrus	94.56	0.00e+00	1565.00
IUUC-Pte-104123	Pyrenophora teres	48.33	1.00e-10	62.80
IUUC-Pyt-104567	Pyrenophora triticirepentis	53.06	2.00e-10	61.60
IUUC-Rno-105763	Rattus norvegicus	90.65	0.00e+00	1529.00
IUUC-Sha-106683	Sarcophilus harrisii	87.12	0.00e+00	1511.00
IUUC-Sly-111123	Solanum lycopersicum	50.00	2.00e-10	59.30
IUUC-Stu-112434	Solanum tuberosum	50.00	2.00e-10	59.70
IUUC-Sar-113457	Sorex araneus	79.73	0.00e+00	911.00
IUUC-Ssc-115338	Sus scrofa	96.27	0.00e+00	1515.00
IUUC-Tgu-116595	Taeniopygia guttata	58.13	0.00e+00	922.00
IUUC-Tru-118199	Takifugu rubripes	64.03	0.00e+00	996.00
IUUC-Tsy-119429	Tarsius syrichta	53.07	0.00e+00	764.00
IUUC-Tni-120548	Tetraodon nigroviridis	64.52	0.00e+00	1024.00
IUUC-Tbe-127235	Tupaia belangeri	69.80	5.00e-137	481.00
IUUC-Ttr-128281	Tursiops truncatus	57.08	0.00e+00	909.00
IUUC-Vpa-130066	Vicugna pacos	68.42	6.00e-73	268.00
IUUC-Xtr-132410	Xenopus tropicalis	71.80	0.00e+00	1238.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence