iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ssc-115722

Ensembl Protein ID

ENSSSCP00000021556.1

UniProt Accession

I3LBY4; I3LBY4_PIG

Protein Name

Uncharacterized protein

Gene Name

SOCS3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSSCG00000029772.1	ENSSSCT00000030554.1	ENSSSCP00000021556.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	88.37	4.00e-64	240.00	IUUC-Hsa-046909

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Sus scrofa

Protein Sequence
(Fasta)

GEANLLLSAE PAGTFLIRDS SDQRHFFTLS VKTQSGTKNL RIQCEGGSFS LXPRFDCVLK 60
LVHHYMPPSG APSFSSPPTE XSEVPEQPPA QPLPGGPPRR AYYIYSGGEK IPLVLSRPLS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCGAGGCGA ACCTGCTGCT TAGCGCCGAG CCCGCGGGCA CCTTCCTCAT CCGCGACAGC 60
TCGGACCAGC GACACTTCTT CACGCTCAGC GTCAAGACCC AGTCGGGGAC CAAGAACCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000980--SH2
IPR028414--SOCS3
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF07525--SOCS_box

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005737--C:cytoplasm
GO:0004860--F:protein kinase inhibitor activity
GO:0060670--P:branching involved in labyrinthine layer morphogenesis
GO:0019221--P:cytokine-mediated signaling pathway
GO:0007259--P:JAK-STAT cascade
GO:0043066--P:negative regulation of apoptotic process
GO:0050728--P:negative regulation of inflammatory response
GO:0046627--P:negative regulation of insulin receptor signaling pathway
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0006469--P:negative regulation of protein kinase activity
GO:0042512--P:negative regulation of tyrosine phosphorylation of Stat1 protein
GO:0042518--P:negative regulation of tyrosine phosphorylation of Stat3 protein
GO:0060674--P:placenta blood vessel development
GO:0045597--P:positive regulation of cell differentiation
GO:0060708--P:spongiotrophoblast differentiation
GO:0060707--P:trophoblast giant cell differentiation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001529	Ailuropoda melanoleuca	82.56	4.00e-67	247.00
IUUC-Apl-003607	Anas platyrhynchos	73.68	2.00e-57	214.00
IUUC-Aca-005063	Anolis carolinensis	73.41	8.00e-67	245.00
IUUC-Ame-010859	Astyanax mexicanus	54.71	2.00e-46	178.00
IUUC-Bta-012817	Bos taurus	82.39	2.00e-71	261.00
IUUC-Cja-019605	Callithrix jacchus	86.63	4.00e-72	263.00
IUUC-Cfa-021231	Canis familiaris	83.72	4.00e-67	247.00
IUUC-Cpo-022003	Cavia porcellus	83.43	8.00e-67	246.00
IUUC-Csa-023511	Chlorocebus sabaeus	86.05	1.00e-70	258.00
IUUC-Dre-028536	Danio rerio	57.65	1.00e-48	185.00
IUUC-Dno-029003	Dasypus novemcinctus	81.29	1.00e-69	255.00
IUUC-Eca-034205	Equus caballus	77.40	8.00e-61	225.00
IUUC-Fca-036317	Felis catus	83.14	9.00e-70	255.00
IUUC-Gmo-038777	Gadus morhua	59.46	5.00e-19	86.30
IUUC-Gga-041258	Gallus gallus	74.27	2.00e-58	218.00
IUUC-Gac-041837	Gasterosteus aculeatus	55.29	1.00e-45	175.00
IUUC-Ggo-045620	Gorilla gorilla	86.05	1.00e-70	258.00
IUUC-Hsa-046909	Homo sapiens	86.05	1.00e-70	258.00
IUUC-Itr-048023	Ictidomys tridecemlineatus	81.77	9.00e-72	262.00
IUUC-Lch-049510	Latimeria chalumnae	64.33	2.00e-56	211.00
IUUC-Loc-052863	Lepisosteus oculatus	60.00	6.00e-52	196.00
IUUC-Laf-054136	Loxodonta africana	82.86	3.00e-68	250.00
IUUC-Mcc-055383	Macaca mulatta	86.05	1.00e-70	258.00
IUUC-Meu-056153	Macropus eugenii	79.19	9.00e-71	259.00
IUUC-Mmr-061185	Microcebus murinus	80.35	5.00e-67	246.00
IUUC-Mdo-061819	Monodelphis domestica	81.98	6.00e-73	266.00
IUUC-Mmu-064231	Mus musculus	88.95	3.00e-77	280.00
IUUC-Mpu-066691	Mustela putorius furo	84.30	4.00e-67	247.00
IUUC-Mlu-067673	Myotis lucifugus	83.82	8.00e-77	279.00
IUUC-Ont-072406	Oreochromis niloticus	51.18	4.00e-41	160.00
IUUC-Oan-073249	Ornithorhynchus anatinus	68.42	7.00e-60	223.00
IUUC-Ocu-074935	Oryctolagus cuniculus	86.96	3.00e-31	125.00
IUUC-Ola-087373	Oryzias latipes	44.12	4.00e-32	130.00
IUUC-Oga-088041	Otolemur garnettii	87.72	6.00e-70	256.00
IUUC-Oar-089646	Ovis aries	81.25	1.00e-63	235.00
IUUC-Ptr-091502	Pan troglodytes	86.05	1.00e-70	258.00
IUUC-Pan-091934	Papio anubis	86.05	1.00e-70	258.00
IUUC-Pfo-096412	Poecilia formosa	41.76	8.00e-31	126.00
IUUC-Pab-098554	Pongo abelii	86.05	1.00e-70	258.00
IUUC-Rno-105874	Rattus norvegicus	89.53	8.00e-78	282.00
IUUC-Sha-107151	Sarcophilus harrisii	79.43	3.00e-70	257.00
IUUC-Tgu-117151	Taeniopygia guttata	76.30	8.00e-59	219.00
IUUC-Tru-118428	Takifugu rubripes	51.18	3.00e-43	167.00
IUUC-Tni-120590	Tetraodon nigroviridis	52.35	5.00e-43	166.00
IUUC-Ttr-129065	Tursiops truncatus	84.66	4.00e-70	257.00
IUUC-Xtr-132167	Xenopus tropicalis	57.06	3.00e-49	187.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence