iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Loc-052599

Ensembl Protein ID

ENSLOCP00000004656.1

UniProt Accession

W5M8E8; W5M8E8_LEPOC

Genbank Protein ID

ENSLOCP00000004656

Protein Name

tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4; WD repeat-containing protein 4

Genbank Nucleotide ID

AHAT01033676

Gene Name

wdr4; WDR4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLOCG00000003903.1	ENSLOCT00000004664.1	ENSLOCP00000004656.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.80e-07	31.4	185	225

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.....sdtllvsGsdDgtikvWDlrtgvllks 38
           gH++ v++l f     +   l+sGs+Dgt+++W++  g+ l+s
   Q: 185  GHKEFVSSL-FvlpyqP-YWLLSGSGDGTLRLWEFEFGKELQS 225
           688888998.8885433.669**************99998886 PP

Organism

Lepisosteus oculatus

Functional Description
(View)

Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.

Protein Sequence
(Fasta)

MALLEVRKEY LVVSSGSKFI AVKTEEIREP FVYDCTKAEN KPEESGNKGD EVGAEEKGSD 60
RILAMAFSAS GEYFALTDDS KRLVLFRTKP VWECLSTRWV VRRCTSLTMT KAEDQILVAD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGTAATGATG ACGCGATAAA CGAGCGACAA TTCCTATCTT ACTCCACGTG AGGAAGACAT 60
GGCCCTGCTG GAAGTACGCA AAGAATATCT AGTTGTAAGC AGTGGAAGTA AATTTATTGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0819--tRNA processing
KW-0853--WD repeat

Interpro

IPR028884--Trm82
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0005634--C:nucleus
GO:0036265--P:RNA (guanine-N7)-methylation
GO:0030488--P:tRNA methylation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000556	Aegilops tauschii	27.97	2.00e-13	69.70
IUUC-Atr-002431	Amborella trichopoda	34.21	1.00e-11	61.60
IUUC-Apl-003975	Anas platyrhynchos	54.62	2.00e-108	385.00
IUUC-Aca-005170	Anolis carolinensis	53.12	2.00e-102	366.00
IUUC-Aly-005769	Arabidopsis lyrata	30.64	2.00e-28	120.00
IUUC-Ath-006733	Arabidopsis thaliana	30.33	2.00e-27	116.00
IUUC-Acl-008151	Aspergillus clavatus	29.79	4.00e-18	85.90
IUUC-Afl-008518	Aspergillus flavus	31.18	1.00e-16	80.50
IUUC-Afu-009102	Aspergillus fumigatus	30.08	3.00e-16	80.10
IUUC-Ani-009442	Aspergillus nidulans	27.62	8.00e-16	78.60
IUUC-Aor-010133	Aspergillus oryzae	31.00	2.00e-19	90.50
IUUC-Ate-010465	Aspergillus terreus	28.40	3.00e-17	83.20
IUUC-Ame-010613	Astyanax mexicanus	55.64	2.00e-124	439.00
IUUC-Bgr-012067	Blumeria graminis	28.71	1.00e-18	87.40
IUUC-Bta-012788	Bos taurus	48.77	7.00e-104	370.00
IUUC-Bdi-014458	Brachypodium distachyon	31.58	4.00e-18	85.90
IUUC-Bol-016398	Brassica oleracea	33.33	4.00e-28	119.00
IUUC-Bra-017059	Brassica rapa	30.26	5.00e-25	108.00
IUUC-Cpo-021963	Cavia porcellus	50.13	1.00e-97	350.00
IUUC-Csa-024148	Chlorocebus sabaeus	51.60	5.00e-94	337.00
IUUC-Cne-026834	Cryptococcus neoformans	37.43	5.00e-22	99.40
IUUC-Dre-028427	Danio rerio	58.09	7.00e-133	466.00
IUUC-Dno-028881	Dasypus novemcinctus	46.84	4.00e-91	328.00
IUUC-Dor-030522	Dipodomys ordii	51.28	7.00e-107	380.00
IUUC-Dme-032136	Drosophila melanogaster	39.58	7.00e-29	121.00
IUUC-Fca-035833	Felis catus	52.57	2.00e-104	372.00
IUUC-Fal-037497	Ficedula albicollis	55.49	3.00e-113	401.00
IUUC-Gga-040547	Gallus gallus	54.40	4.00e-113	401.00
IUUC-Gac-041761	Gasterosteus aculeatus	50.27	2.00e-106	378.00
IUUC-Gma-043722	Glycine max	31.58	2.00e-25	110.00
IUUC-Ggo-045340	Gorilla gorilla	51.60	1.00e-100	359.00
IUUC-Hsa-046403	Homo sapiens	52.57	2.00e-100	359.00
IUUC-Hvu-047643	Hordeum vulgare	33.33	8.00e-23	101.00
IUUC-Itr-048103	Ictidomys tridecemlineatus	52.83	1.00e-108	386.00
IUUC-Kpa-049283	Komagataella pastoris	37.59	2.00e-19	90.50
IUUC-Lch-050682	Latimeria chalumnae	54.07	3.00e-120	425.00
IUUC-Lpe-050712	Leersia perrieri	35.86	9.00e-29	121.00
IUUC-Laf-054390	Loxodonta africana	53.37	4.00e-110	391.00
IUUC-Mcc-054747	Macaca mulatta	52.30	4.00e-98	351.00
IUUC-Mtr-058600	Medicago truncatula	35.37	4.00e-29	122.00
IUUC-Mla-059129	Melampsora laricipopulina	27.13	9.00e-14	70.90
IUUC-Mga-059876	Meleagris gallopavo	54.67	8.00e-116	409.00
IUUC-Mvi-060359	Microbotryum violaceum	32.74	8.00e-17	82.00
IUUC-Mmr-061518	Microcebus murinus	50.61	2.00e-101	362.00
IUUC-Mac-065625	Musa acuminata	30.91	2.00e-25	109.00
IUUC-Nfi-068402	Neosartorya fischeri	28.93	6.00e-15	75.50
IUUC-Nle-069914	Nomascus leucogenys	51.22	6.00e-94	337.00
IUUC-Ont-071555	Oreochromis niloticus	51.21	4.00e-107	381.00
IUUC-Oan-072951	Ornithorhynchus anatinus	54.18	1.00e-110	392.00
IUUC-Ocu-074679	Oryctolagus cuniculus	50.68	3.00e-98	351.00
IUUC-Oba-075355	Oryza barthii	27.43	3.00e-15	76.60
IUUC-Obr-076769	Oryza brachyantha	35.15	1.00e-29	124.00
IUUC-Ogl-077168	Oryza glaberrima	33.47	3.00e-28	119.00
IUUC-Ogu-078275	Oryza glumaepatula	28.27	2.00e-15	77.40
IUUC-Oin-079207	Oryza indica	33.47	3.00e-28	119.00
IUUC-Oni-082437	Oryza nivara	27.43	1.00e-14	74.70
IUUC-Opu-084031	Oryza punctata	34.73	5.00e-29	122.00
IUUC-Oru-084380	Oryza rufipogon	27.43	7.00e-15	75.10
IUUC-Osa-085327	Oryza sativa	33.47	6.00e-28	118.00
IUUC-Ola-086716	Oryzias latipes	50.39	3.00e-103	368.00
IUUC-Olu-087708	Ostreococcus lucimarinus	29.06	4.00e-18	85.50
IUUC-Oar-090239	Ovis aries	51.37	2.00e-103	369.00
IUUC-Ptr-090851	Pan troglodytes	51.84	4.00e-101	361.00
IUUC-Pan-092558	Papio anubis	51.83	4.00e-93	335.00
IUUC-Psi-093792	Pelodiscus sinensis	53.87	5.00e-114	404.00
IUUC-Ppa-095757	Physcomitrella patens	33.33	2.00e-27	117.00
IUUC-Pfo-096465	Poecilia formosa	50.77	8.00e-115	406.00
IUUC-Pab-097722	Pongo abelii	51.84	6.00e-106	377.00
IUUC-Pop-098979	Populus trichocarpa	32.51	6.00e-23	101.00
IUUC-Pca-100753	Procavia capensis	50.40	2.00e-70	259.00
IUUC-Ppe-101515	Prunus persica	32.77	8.00e-26	111.00
IUUC-Sja-107780	Schizosaccharomyces japonicus	27.78	2.00e-13	70.10
IUUC-Spo-108251	Schizosaccharomyces pombe	29.55	1.00e-15	77.40
IUUC-Smo-108938	Selaginella moellendorffii	33.33	2.00e-24	107.00
IUUC-Sit-110020	Setaria italica	34.39	6.00e-28	118.00
IUUC-Sly-111543	Solanum lycopersicum	35.71	6.00e-30	125.00
IUUC-Stu-111925	Solanum tuberosum	35.71	3.00e-29	122.00
IUUC-Sbi-114061	Sorghum bicolor	33.73	3.00e-29	122.00
IUUC-Tgu-117321	Taeniopygia guttata	55.29	8.00e-106	376.00
IUUC-Tru-118454	Takifugu rubripes	49.73	6.00e-103	367.00
IUUC-Tni-119894	Tetraodon nigroviridis	48.15	1.00e-91	329.00
IUUC-Tca-121746	Theobroma cacao	32.70	3.00e-25	109.00
IUUC-Tae-124459	Triticum aestivum	33.76	3.00e-24	106.00
IUUC-Tur-126254	Triticum urartu	28.76	2.00e-15	76.30
IUUC-Tbe-127683	Tupaia belangeri	58.24	7.00e-27	114.00
IUUC-Ttr-129056	Tursiops truncatus	49.11	8.00e-96	343.00
IUUC-Vvi-131428	Vitis vinifera	31.75	5.00e-26	112.00
IUUC-Xma-133605	Xiphophorus maculatus	50.52	8.00e-113	400.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence