iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	TRANSFAC	RAID2
Protein-protein Interaction
IID
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	76.03	0.00e+00	653.00	IUUC-Hsa-045735

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Rattus norvegicus

Functional Description
(View)

Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Functionally coupled with the E2 ubiquitin-protein ligases UB2D1, UB2D2 and UB2D3. Regulator of EGFR mediated signal transduction; upon EGF activation, ubiquitinates EGFR. Inhibits EGF stimulated MAPK1 activation. Promotes ubiquitination of SRC phosphorylated at 'Tyr-419', has the highest ubiquitin ligase activity among CBL family proteins. In collaboration with CD2AP may act as regulatory checkpoint for Ret signaling by modulating the rate of RET degradation after ligand activation; CD2AP converts it from an inhibitor to a promoter of RET degradation; the function limits the potency of GDNF on neuronal survival.

Protein Sequence
(Fasta)

MAAATAPQGW QWGEPRALGR AVKLLQRLEE QCRDLRLFVG PPSLRDLLPR TAQLLREVAK 60
ARSDKTRGDP EGPGGAGDFL VIYLTNLEAK GRQVAELLPH RGKKDANQDV FPEGSRFRRQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCCCAGGCCA CCCGAGCGAC CCATGGCTGC GGCTACAGCC CCGCAAGGGT GGCAGTGGGG 60
AGAGCCACGC GCGCTTGGCC GGGCGGTAAA GTTGCTCCAG CGCCTGGAAG AGCAATGCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0106--Calcium
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0729--SH3-binding
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR024162--Adaptor_Cbl
IPR014741--Adaptor_Cbl_EF_hand-like
IPR003153--Adaptor_Cbl_N_hlx
IPR014742--Adaptor_Cbl_SH2-like
IPR024159--Cbl_PTB
IPR011992--EF-hand-dom_pair
IPR000980--SH2
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS51506--CBL_PTB
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF02262--Cbl_N
PF02761--Cbl_N2
PF02762--Cbl_N3

SMART

SM00184--RING

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0045121--C:membrane raft
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0005509--F:calcium ion binding
GO:0030971--F:receptor tyrosine kinase binding
GO:0017124--F:SH3 domain binding
GO:0004871--F:signal transducer activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0007175--P:negative regulation of epidermal growth factor-activated receptor activity
GO:0043407--P:negative regulation of MAP kinase activity
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0006508--P:proteolysis

KEGG

rno:292699

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002286	Ailuropoda melanoleuca	71.00	5.00e-173	600.00
IUUC-Bta-012705	Bos taurus	72.34	9.00e-179	619.00
IUUC-Cja-019179	Callithrix jacchus	76.04	0.00e+00	655.00
IUUC-Cfa-020593	Canis familiaris	69.15	8.00e-171	593.00
IUUC-Cpo-021289	Cavia porcellus	74.34	2.00e-171	595.00
IUUC-Csa-023966	Chlorocebus sabaeus	68.40	1.00e-173	602.00
IUUC-Dor-030246	Dipodomys ordii	76.39	4.00e-126	444.00
IUUC-Eca-033921	Equus caballus	64.11	8.00e-135	473.00
IUUC-Fca-035747	Felis catus	58.65	7.00e-149	520.00
IUUC-Ggo-044622	Gorilla gorilla	78.86	1.00e-148	518.00
IUUC-Hsa-045735	Homo sapiens	76.27	0.00e+00	650.00
IUUC-Itr-049001	Ictidomys tridecemlineatus	76.48	1.00e-165	576.00
IUUC-Laf-053983	Loxodonta africana	69.66	0.00e+00	629.00
IUUC-Mmr-061310	Microcebus murinus	69.83	3.00e-172	598.00
IUUC-Mmu-064155	Mus musculus	86.72	0.00e+00	832.00
IUUC-Mpu-066655	Mustela putorius furo	75.90	7.00e-178	616.00
IUUC-Mlu-067929	Myotis lucifugus	75.57	6.00e-139	486.00
IUUC-Nle-070065	Nomascus leucogenys	64.52	5.00e-146	510.00
IUUC-Ocu-074049	Oryctolagus cuniculus	75.69	2.00e-128	451.00
IUUC-Oga-087952	Otolemur garnettii	76.03	0.00e+00	669.00
IUUC-Oar-089382	Ovis aries	70.14	3.00e-177	614.00
IUUC-Pan-092075	Papio anubis	75.00	3.00e-174	604.00
IUUC-Pab-098100	Pongo abelii	67.51	3.00e-158	551.00
IUUC-Pca-100830	Procavia capensis	74.31	3.00e-103	368.00
IUUC-Pva-102714	Pteropus vampyrus	71.43	7.00e-158	550.00
IUUC-Sha-107138	Sarcophilus harrisii	66.99	2.00e-124	439.00
IUUC-Ssc-116424	Sus scrofa	71.71	0.00e+00	653.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence