iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box	F-box	11864566; 23528706

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/SCF/F-box	0.02	15.3	8	52
E3 adaptor/Cullin RING/DCX/DWD	1.20e-10	41.6	101	134

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/SCF/F-box

   S: 102  lldrlpeeilveilklldkee.llraarvcrrwqelasqkalwkt 145
            l +lp e+l + +++l++++ + ++ +vcrr++++ +++++w++
   Q: 8    ELISLPSELLCHLFTYLPQRQlITEIPLVCRRFNTILNDDKFWSR 52
           56789************88886899*********99999***986 PP

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf...sd.tllvsGsdDgtikvWDl 30
           gH++ v ++ +   ++  + +sGs+D ti++W++
   Q: 101  GHSATVDSVMLfenNNkQFCLSGSRDRTIRLWSI 134
           8*******9955*7667889************95 PP

Organism

Caenorhabditis elegans

Protein Sequence
(Fasta)

MTNAQPTELI SLPSELLCHL FTYLPQRQLI TEIPLVCRRF NTILNDDKFW SRRIRTEQKV 60
RLPDCELKHP EYEPKKSFYA MHRQRDRWRA WETQTVITAP GHSATVDSVM LFENNNKQFC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CATCCTTATG ACAAATGCTC AACCAACGGA GCTCATATCC CTTCCTTCGG AGCTCCTTTG 60
CCATCTTTTC ACCTATTTAC CACAACGACA ATTGATCACA GAAATTCCAC TGGTATGCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR001810--F-box_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50181--FBOX
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12937--F-box-like
PF00400--WD40

SMART

SM00256--FBOX
SM00320--WD40

Gene Ontology

GO:0043204--C:perikaryon
GO:0098793--C:presynapse
GO:0015870--P:acetylcholine transport
GO:0050976--P:detection of mechanical stimulus involved in sensory perception of touch
GO:0050961--P:detection of temperature stimulus involved in sensory perception
GO:0007638--P:mechanosensory behavior
GO:0048666--P:neuron development
GO:1905789--P:positive regulation of detection of mechanical stimulus involved in sensory perception of touch
GO:0097151--P:positive regulation of inhibitory postsynaptic potential
GO:1905792--P:positive regulation of mechanosensory behavior
GO:0045933--P:positive regulation of muscle contraction
GO:0032230--P:positive regulation of synaptic transmission, GABAergic
GO:1902805--P:positive regulation of synaptic vesicle transport
GO:0016080--P:synaptic vesicle targeting
GO:0040040--P:thermosensory behavior

KEGG

cel:CELE_T01E8.4

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001913	Ailuropoda melanoleuca	26.48	4.00e-30	124.00
IUUC-Aca-004823	Anolis carolinensis	25.96	5.00e-25	107.00
IUUC-Bta-012687	Bos taurus	26.50	2.00e-29	122.00
IUUC-Cja-018873	Callithrix jacchus	25.81	5.00e-25	107.00
IUUC-Cfa-020350	Canis familiaris	26.65	1.00e-29	122.00
IUUC-Cpo-021990	Cavia porcellus	25.22	1.00e-29	122.00
IUUC-Csa-023590	Chlorocebus sabaeus	27.74	1.00e-24	106.00
IUUC-Dre-028778	Danio rerio	28.89	4.00e-14	71.20
IUUC-Dor-030840	Dipodomys ordii	24.21	4.00e-16	77.80
IUUC-Eca-034232	Equus caballus	26.69	3.00e-24	104.00
IUUC-Fca-036533	Felis catus	26.88	6.00e-29	120.00
IUUC-Gmo-038675	Gadus morhua	25.70	8.00e-18	83.20
IUUC-Gac-041443	Gasterosteus aculeatus	25.50	2.00e-19	89.00
IUUC-Ggo-044439	Gorilla gorilla	25.22	4.00e-20	91.30
IUUC-Hsa-046835	Homo sapiens	25.22	1.00e-17	83.20
IUUC-Itr-048482	Ictidomys tridecemlineatus	25.81	3.00e-30	124.00
IUUC-Lch-049736	Latimeria chalumnae	25.47	1.00e-15	76.60
IUUC-Laf-054045	Loxodonta africana	26.98	6.00e-20	90.10
IUUC-Mcc-054869	Macaca mulatta	27.74	2.00e-24	105.00
IUUC-Meu-056621	Macropus eugenii	25.90	5.00e-23	100.00
IUUC-Mmr-061740	Microcebus murinus	26.57	5.00e-26	110.00
IUUC-Mdo-062012	Monodelphis domestica	24.64	2.00e-24	105.00
IUUC-Mmu-063107	Mus musculus	25.62	3.00e-30	124.00
IUUC-Mpu-065889	Mustela putorius furo	27.64	3.00e-29	121.00
IUUC-Mlu-067453	Myotis lucifugus	28.61	9.00e-33	133.00
IUUC-Nle-070132	Nomascus leucogenys	28.43	1.00e-24	106.00
IUUC-Opr-070719	Ochotona princeps	22.39	1.00e-14	73.20
IUUC-Ont-072613	Oreochromis niloticus	25.48	4.00e-21	94.40
IUUC-Ocu-074377	Oryctolagus cuniculus	24.07	7.00e-13	67.00
IUUC-Ola-087040	Oryzias latipes	26.64	3.00e-15	74.70
IUUC-Oga-089018	Otolemur garnettii	26.43	1.00e-28	119.00
IUUC-Oar-089327	Ovis aries	26.18	7.00e-29	120.00
IUUC-Ptr-090748	Pan troglodytes	28.43	9.00e-25	106.00
IUUC-Pan-091879	Papio anubis	30.18	1.00e-15	75.50
IUUC-Psi-093031	Pelodiscus sinensis	27.67	8.00e-28	116.00
IUUC-Pfo-096738	Poecilia formosa	34.08	2.00e-18	85.90
IUUC-Pab-097958	Pongo abelii	27.62	2.00e-20	92.00
IUUC-Pca-101049	Procavia capensis	20.23	8.00e-14	70.50
IUUC-Pva-102123	Pteropus vampyrus	25.86	2.00e-26	112.00
IUUC-Rno-105239	Rattus norvegicus	26.25	1.00e-30	125.00
IUUC-Sha-107531	Sarcophilus harrisii	26.24	2.00e-20	92.00
IUUC-Sar-113257	Sorex araneus	25.82	2.00e-23	102.00
IUUC-Ssc-115236	Sus scrofa	26.40	3.00e-27	115.00
IUUC-Tru-117762	Takifugu rubripes	25.27	4.00e-19	87.80
IUUC-Tni-120085	Tetraodon nigroviridis	23.24	7.00e-15	73.60
IUUC-Ttr-128831	Tursiops truncatus	25.55	9.00e-21	93.60
IUUC-Xtr-132712	Xenopus tropicalis	29.13	4.00e-20	90.90

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence