iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ocu-074222

Ensembl Protein ID

ENSOCUP00000021074.2

UniProt Accession

P63150; P50409; Q00007; 2ABA_RABIT

Genbank Protein ID

AAA18497.1

Protein Name

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform; PP2A subunit B isoform B55-alpha; PP2A subunit B isoform PR55-alpha; PP2A subunit B isoform R2-alpha; PP2A subunit B isoform alpha

Genbank Nucleotide ID

U09356

Gene Name

PPP2R2A

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOCUG00000027088.2	ENSOCUT00000030174.2	ENSOCUP00000021074.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	7.00e-12	45.2	227	257

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 4    dsvtclaf..sd.tllvsGsdDgtikvWDlr 31
           + +t+ +f  ++ +++v +s  gti+++D+r
   Q: 227  EVITAAEFhpNScNTFVYSSSKGTIRLCDMR 257
           5689999**744799999999********87 PP

Organism

Oryctolagus cuniculus

Functional Description
(View)

PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules (By similarity). Found in a complex with at least ARL2, PPP2CB, PPP2R1A, PPP2R2A, PPP2R5E and TBCD (By similarity). Interacts with TP53 (By similarity). Interacts with IER5 (By similarity).

Protein Sequence
(Fasta)

MAGAGGGNDI QWCFSQVKGA VDDDVAEADI ISTVEFNHSG ELLATGDKGG RVVIFQQEQE 60
NKIQSHSRGE YNVYSTFQSH EPEFDYLKSL EIEEKINKIR WLPQKNAAQF LLSTNDKTIK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCAGGTA AAGGAGAAAT CCCCCTCGCC CACTGATCCG GCGATGCTTC CCTCCTCCTC 60
CTTCCATCAC CCCCTAGCGA CCGCTCGTGC CTCTCGCGGA GCCCCGGGGC TCCCCCCGGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR000009--PP2A_PR55
IPR018067--PP2A_PR55_CS
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS01024--PR55_1
PS01025--PR55_2

PRINTS

PR00600--PP2APR55

SMART

SM00320--WD40

Gene Ontology

GO:0000159--C:protein phosphatase type 2A complex
GO:0019888--F:protein phosphatase regulator activity
GO:0004722--F:protein serine/threonine phosphatase activity
GO:0006470--P:protein dephosphorylation
GO:0043278--P:response to morphine

KEGG

ocu:100328616

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001197	Ailuropoda melanoleuca	100.00	0.00e+00	888.00
IUUC-Atr-002517	Amborella trichopoda	50.00	3.00e-127	448.00
IUUC-Apl-004226	Anas platyrhynchos	98.88	0.00e+00	881.00
IUUC-Aca-005147	Anolis carolinensis	99.11	0.00e+00	880.00
IUUC-Acl-008202	Aspergillus clavatus	55.15	4.00e-131	461.00
IUUC-Afl-008646	Aspergillus flavus	56.03	2.00e-133	469.00
IUUC-Afu-009027	Aspergillus fumigatus	55.79	8.00e-133	466.00
IUUC-Ani-009191	Aspergillus nidulans	55.46	7.00e-134	470.00
IUUC-Ang-009769	Aspergillus niger	56.10	1.00e-135	476.00
IUUC-Aor-010030	Aspergillus oryzae	55.82	6.00e-132	464.00
IUUC-Ate-010549	Aspergillus terreus	55.39	7.00e-132	464.00
IUUC-Ame-011776	Astyanax mexicanus	92.63	0.00e+00	826.00
IUUC-Bta-012702	Bos taurus	100.00	0.00e+00	885.00
IUUC-Bci-013801	Botrytis cinerea	54.15	2.00e-137	482.00
IUUC-Bdi-014767	Brachypodium distachyon	50.52	8.00e-126	443.00
IUUC-Bol-015921	Brassica oleracea	50.71	1.00e-135	476.00
IUUC-Bra-017400	Brassica rapa	50.71	3.00e-135	475.00
IUUC-Cel-018618	Caenorhabditis elegans	65.33	2.00e-173	601.00
IUUC-Cja-019036	Callithrix jacchus	100.00	0.00e+00	884.00
IUUC-Cfa-021248	Canis familiaris	100.00	0.00e+00	884.00
IUUC-Cpo-022172	Cavia porcellus	100.00	0.00e+00	884.00
IUUC-Cre-022876	Chlamydomonas reinhardtii	52.21	9.00e-133	466.00
IUUC-Csa-023864	Chlorocebus sabaeus	100.00	0.00e+00	889.00
IUUC-Cin-025380	Ciona intestinalis	77.30	0.00e+00	706.00
IUUC-Csv-026097	Ciona savignyi	75.74	0.00e+00	696.00
IUUC-Cgl-026750	Colletotrichum gloeosporioides	53.96	1.00e-132	466.00
IUUC-Dre-027406	Danio rerio	92.00	0.00e+00	818.00
IUUC-Dno-028876	Dasypus novemcinctus	89.32	0.00e+00	810.00
IUUC-Dor-030390	Dipodomys ordii	85.24	0.00e+00	724.00
IUUC-Dse-031305	Dothistroma septosporum	54.13	4.00e-134	471.00
IUUC-Dme-032131	Drosophila melanogaster	80.18	0.00e+00	724.00
IUUC-Eca-033584	Equus caballus	100.00	0.00e+00	853.00
IUUC-Fca-035565	Felis catus	95.73	0.00e+00	837.00
IUUC-Fal-036821	Ficedula albicollis	98.43	0.00e+00	874.00
IUUC-Fox-037988	Fusarium oxysporum	54.99	7.00e-133	467.00
IUUC-Fso-038460	Fusarium solani	54.07	4.00e-134	471.00
IUUC-Gmo-038834	Gadus morhua	92.17	0.00e+00	811.00
IUUC-Ggr-039883	Gaeumannomyces graminis	53.65	3.00e-134	471.00
IUUC-Gga-041009	Gallus gallus	99.32	0.00e+00	878.00
IUUC-Gac-042418	Gasterosteus aculeatus	88.81	0.00e+00	815.00
IUUC-Gma-044088	Glycine max	50.59	8.00e-130	457.00
IUUC-Ggo-044599	Gorilla gorilla	100.00	0.00e+00	884.00
IUUC-Hsa-046718	Homo sapiens	100.00	0.00e+00	884.00
IUUC-Itr-048651	Ictidomys tridecemlineatus	100.00	0.00e+00	889.00
IUUC-Kpa-049100	Komagataella pastoris	52.19	6.00e-133	467.00
IUUC-Lch-050528	Latimeria chalumnae	96.21	0.00e+00	827.00
IUUC-Loc-052663	Lepisosteus oculatus	88.75	0.00e+00	828.00
IUUC-Laf-053403	Loxodonta africana	99.78	0.00e+00	887.00
IUUC-Mcc-055776	Macaca mulatta	100.00	0.00e+00	880.00
IUUC-Meu-056756	Macropus eugenii	83.33	0.00e+00	698.00
IUUC-Mor-057270	Magnaporthe oryzae	53.33	7.00e-133	467.00
IUUC-Mpo-057327	Magnaporthe poae	54.41	5.00e-135	474.00
IUUC-Mtr-058561	Medicago truncatula	49.50	7.00e-126	444.00
IUUC-Mla-059127	Melampsora laricipopulina	56.85	1.00e-147	516.00
IUUC-Mga-059946	Meleagris gallopavo	98.88	0.00e+00	881.00
IUUC-Mvi-060503	Microbotryum violaceum	60.61	2.00e-107	382.00
IUUC-Mmr-061468	Microcebus murinus	89.55	0.00e+00	813.00
IUUC-Mdo-062340	Monodelphis domestica	99.11	0.00e+00	882.00
IUUC-Mmu-064151	Mus musculus	100.00	0.00e+00	889.00
IUUC-Mac-065244	Musa acuminata	50.51	1.00e-126	446.00
IUUC-Mpu-066190	Mustela putorius furo	100.00	0.00e+00	888.00
IUUC-Mlu-068197	Myotis lucifugus	99.76	0.00e+00	850.00
IUUC-Nfi-068532	Neosartorya fischeri	55.79	5.00e-133	467.00
IUUC-Ncr-068905	Neurospora crassa	53.96	1.00e-135	476.00
IUUC-Nle-069966	Nomascus leucogenys	97.98	0.00e+00	853.00
IUUC-Ont-071603	Oreochromis niloticus	91.29	0.00e+00	810.00
IUUC-Oan-073540	Ornithorhynchus anatinus	97.65	1.00e-168	584.00
IUUC-Obr-076686	Oryza brachyantha	51.87	9.00e-135	473.00
IUUC-Opu-083739	Oryza punctata	51.72	4.00e-135	474.00
IUUC-Oru-084892	Oryza rufipogon	51.31	2.00e-134	472.00
IUUC-Ola-087128	Oryzias latipes	89.82	0.00e+00	790.00
IUUC-Olu-087882	Ostreococcus lucimarinus	50.41	5.00e-128	451.00
IUUC-Oga-089168	Otolemur garnettii	99.78	0.00e+00	887.00
IUUC-Oar-089815	Ovis aries	99.55	0.00e+00	885.00
IUUC-Ptr-091110	Pan troglodytes	100.00	0.00e+00	884.00
IUUC-Pan-092884	Papio anubis	100.00	0.00e+00	889.00
IUUC-Psi-093292	Pelodiscus sinensis	90.41	0.00e+00	818.00
IUUC-Pno-094992	Phaeosphaeria nodorum	54.32	2.00e-134	472.00
IUUC-Ppa-095378	Physcomitrella patens	50.30	6.00e-132	464.00
IUUC-Pfo-097312	Poecilia formosa	90.56	0.00e+00	832.00
IUUC-Pab-098146	Pongo abelii	100.00	0.00e+00	889.00
IUUC-Pca-100882	Procavia capensis	99.60	1.00e-140	493.00
IUUC-Pva-102176	Pteropus vampyrus	92.39	0.00e+00	829.00
IUUC-Ptt-103844	Puccinia triticina	56.82	1.00e-142	499.00
IUUC-Pte-104403	Pyrenophora teres	54.26	2.00e-134	471.00
IUUC-Pyt-104776	Pyrenophora triticirepentis	54.13	6.00e-134	470.00
IUUC-Rno-105484	Rattus norvegicus	99.78	0.00e+00	889.00
IUUC-Sha-107382	Sarcophilus harrisii	99.52	0.00e+00	850.00
IUUC-Spo-108186	Schizosaccharomyces pombe	55.31	7.00e-133	467.00
IUUC-Smo-109273	Selaginella moellendorffii	52.09	1.00e-134	473.00
IUUC-Sly-111422	Solanum lycopersicum	51.51	8.00e-130	457.00
IUUC-Sbi-114402	Sorghum bicolor	50.90	8.00e-132	463.00
IUUC-Ssc-115355	Sus scrofa	100.00	0.00e+00	889.00
IUUC-Tgu-116737	Taeniopygia guttata	98.66	0.00e+00	879.00
IUUC-Tru-118130	Takifugu rubripes	91.22	0.00e+00	805.00
IUUC-Tsy-119206	Tarsius syrichta	96.85	0.00e+00	838.00
IUUC-Tni-120009	Tetraodon nigroviridis	91.22	0.00e+00	805.00
IUUC-Tca-121708	Theobroma cacao	50.00	3.00e-129	455.00
IUUC-Tre-122188	Trichoderma reesei	54.78	4.00e-132	464.00
IUUC-Tvi-122271	Trichoderma virens	54.53	3.00e-133	468.00
IUUC-Tbe-127340	Tupaia belangeri	85.48	0.00e+00	726.00
IUUC-Ttr-128725	Tursiops truncatus	99.78	0.00e+00	881.00
IUUC-Vda-130007	Verticillium dahliae	53.96	2.00e-133	469.00
IUUC-Vpa-130425	Vicugna pacos	95.95	0.00e+00	862.00
IUUC-Vvi-130930	Vitis vinifera	51.51	1.00e-128	452.00
IUUC-Xtr-131852	Xenopus tropicalis	94.03	0.00e+00	868.00
IUUC-Xma-133921	Xiphophorus maculatus	90.77	0.00e+00	837.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence