iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mtr-057731

Ensembl Protein ID

KEH42950

UniProt Accession

A0A072VY12; A0A072VY12_MEDTR

Genbank Protein ID

KEH42950.1

Protein Name

Ubiquitin carboxyl-terminal hydrolase

Genbank Nucleotide ID

CM001217

Gene Name

MTR_1g078300

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
MTR_1g078300	KEH42950	KEH42950

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/UCH	5.20e-77	260.9	2	325

Active Site

Position(s)	Description	Evidence
82	Nucleophile	{ECO:0000256\|PIRSR:PIRSR038120-1}
157	Proton donor	{ECO:0000256\|PIRSR:PIRSR038120-1}

Domain Profile

DUB/UCH

   S: 7    ewleLesdPglftllvedfgvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktiffakqvigNsCatyAllsv 107
           +w+++esdPg+ft+l+++  vk++ qveelysLdp+ l+++ +pv+gl++lFk+ + ++ +r           v +d   ++ffa qvi+N+Cat+A+ls 
   Q: 2    SWCTIESDPGVFTELIQQMQVKGV-QVEELYSLDPDALNSL-RPVYGLIFLFKWRPGEKDER----------AVIKDPNPNLFFASQVINNACATQAILSI 90
           7***********************.****************.**************999999..........33467789********************* PP
   S: 108  llncedklldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqytkeafhfvsyvningrlyeldglkpfPldlgkk.. 206
           lln  d+  d+G++l +lke+tk + pe k+la++n++ ++++hns+ar+e++  +e+++++   ++++++hf+sy +++g lyeldglk+ P+ lg++  
   Q: 91   LLNSPDV--DIGPELTKLKEFTKNFPPELKGLAINNSDPIRAAHNSFARPEPFVPEEQKAAT---KDDDVYHFISYLPVDGVLYELDGLKEGPISLGQCag 186
           ******9..********************************************988877555...59*******************************976 PP
   S: 207  .keteelkdklkvvraflerikllesdeirfnllaivadrrviktlrlnvlkid......................keLlkLlkdieseeekieaqlddek 284
            + + e+ + ++ v+   eri+ ++++eirfnllaiv++r+ ++t  l+ l+                          L + l+++++ +e   +++  e+
   Q: 187  gQGDMEWLKMVQPVI--QERIERYSQNEIRFNLLAIVKNRKEVYTSELKELQKRrerilqqlsaskaerlvdnsssDVLNNSLSEVNAGIEAATEKILLEE 285
           667889999999999..****************************99986666679******************9866778999***************** PP
   S: 285  ekrkkfkiddirRtenydeficifikdlaregilrklvee 324
           ek kk+  ++irR++ny  f++ f+k la++++l+ l e+
   Q: 286  EKFKKWRTENIRRKHNYIPFLFNFLKLLAEKKQLKPLIEK 325
           ***********************************99987 PP

Organism

Medicago truncatula

Protein Sequence
(Fasta)

MSWCTIESDP GVFTELIQQM QVKGVQVEEL YSLDPDALNS LRPVYGLIFL FKWRPGEKDE 60
RAVIKDPNPN LFFASQVINN ACATQAILSI LLNSPDVDIG PELTKLKEFT KNFPPELKGL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTTTAAAAT ATTCATAATG TATTTGAGAG TTTTAGTCTA AAGTATAAAC CCTCGAGGGA 60
GAAGATAATA GAATTACAGT GAGTGCAGAG TCACAGAGAA ATCAGAGGCA GAAAAACCCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH
IPR017390--Ubiquitinyl_hydrolase_UCH37

Pfam

PF01088--Peptidase_C12

PRINTS

PR00707--UBCTHYDRLASE

Gene Ontology

GO:0005622--C:intracellular
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000936	Aegilops tauschii	74.32	4.00e-145	506.00
IUUC-Aml-001866	Ailuropoda melanoleuca	50.61	2.00e-89	321.00
IUUC-Atr-002966	Amborella trichopoda	79.04	2.00e-149	521.00
IUUC-Apl-003306	Anas platyrhynchos	44.85	2.00e-82	298.00
IUUC-Aca-004763	Anolis carolinensis	49.69	3.00e-88	317.00
IUUC-Aly-005581	Arabidopsis lyrata	79.04	5.00e-143	499.00
IUUC-Ath-007283	Arabidopsis thaliana	79.94	9.00e-147	511.00
IUUC-Ago-007999	Ashbya gossypii	36.26	4.00e-32	131.00
IUUC-Acl-008231	Aspergillus clavatus	51.90	4.00e-62	230.00
IUUC-Afl-008557	Aspergillus flavus	48.46	1.00e-60	225.00
IUUC-Afu-008988	Aspergillus fumigatus	52.52	2.00e-61	228.00
IUUC-Ani-009420	Aspergillus nidulans	40.12	1.00e-60	226.00
IUUC-Ang-009859	Aspergillus niger	49.79	5.00e-59	220.00
IUUC-Aor-010145	Aspergillus oryzae	48.46	1.00e-60	225.00
IUUC-Ate-010347	Aspergillus terreus	47.84	1.00e-59	223.00
IUUC-Ame-010791	Astyanax mexicanus	51.04	9.00e-92	329.00
IUUC-Bgr-012298	Blumeria graminis	41.34	9.00e-59	219.00
IUUC-Bta-013251	Bos taurus	50.92	1.00e-89	322.00
IUUC-Bci-013786	Botrytis cinerea	41.14	3.00e-63	234.00
IUUC-Bdi-014132	Brachypodium distachyon	74.77	1.00e-140	491.00
IUUC-Bol-015611	Brassica oleracea	76.95	2.00e-145	507.00
IUUC-Bra-017769	Brassica rapa	76.95	7.00e-145	505.00
IUUC-Cel-018604	Caenorhabditis elegans	41.95	8.00e-69	253.00
IUUC-Cja-019768	Callithrix jacchus	46.61	5.00e-83	300.00
IUUC-Cfa-020207	Canis familiaris	50.61	2.00e-89	321.00
IUUC-Cpo-021925	Cavia porcellus	49.08	4.00e-83	300.00
IUUC-Cre-022919	Chlamydomonas reinhardtii	50.61	8.00e-84	302.00
IUUC-Csa-023958	Chlorocebus sabaeus	50.61	4.00e-89	320.00
IUUC-Cho-024928	Choloepus hoffmanni	56.76	2.00e-19	89.00
IUUC-Cin-025771	Ciona intestinalis	41.76	7.00e-69	253.00
IUUC-Csv-026149	Ciona savignyi	43.95	4.00e-73	267.00
IUUC-Cgl-026424	Colletotrichum gloeosporioides	38.01	3.00e-50	191.00
IUUC-Cne-026955	Cryptococcus neoformans	32.29	1.00e-45	176.00
IUUC-Cme-027104	Cyanidioschyzon merolae	31.75	2.00e-46	178.00
IUUC-Dre-027409	Danio rerio	50.45	7.00e-91	326.00
IUUC-Dno-028921	Dasypus novemcinctus	50.61	3.00e-89	320.00
IUUC-Dor-030891	Dipodomys ordii	45.20	6.00e-37	148.00
IUUC-Dse-031170	Dothistroma septosporum	39.37	1.00e-61	229.00
IUUC-Dme-031677	Drosophila melanogaster	45.02	4.00e-80	290.00
IUUC-Ete-032646	Echinops telfairi	44.34	2.00e-44	173.00
IUUC-Eca-033776	Equus caballus	49.51	1.00e-80	291.00
IUUC-Eeu-035305	Erinaceus europaeus	46.15	9.00e-41	159.00
IUUC-Fca-035846	Felis catus	46.74	8.00e-85	306.00
IUUC-Fal-037597	Ficedula albicollis	48.21	2.00e-77	281.00
IUUC-Fox-037670	Fusarium oxysporum	49.58	1.00e-54	206.00
IUUC-Fso-038243	Fusarium solani	50.00	8.00e-55	206.00
IUUC-Gmo-038499	Gadus morhua	46.93	9.00e-81	292.00
IUUC-Ggr-039975	Gaeumannomyces graminis	47.18	9.00e-56	209.00
IUUC-Gga-040904	Gallus gallus	49.55	4.00e-92	330.00
IUUC-Gac-042058	Gasterosteus aculeatus	49.69	2.00e-88	318.00
IUUC-Gma-043030	Glycine max	92.22	1.00e-179	621.00
IUUC-Ggo-044699	Gorilla gorilla	47.48	5.00e-77	280.00
IUUC-Hsa-046227	Homo sapiens	50.31	7.00e-89	319.00
IUUC-Hvu-047359	Hordeum vulgare	74.32	1.00e-143	501.00
IUUC-Itr-048989	Ictidomys tridecemlineatus	45.94	6.00e-84	303.00
IUUC-Lch-049829	Latimeria chalumnae	50.31	5.00e-89	320.00
IUUC-Lpe-050899	Leersia perrieri	76.85	4.00e-136	476.00
IUUC-Loc-052264	Lepisosteus oculatus	49.24	4.00e-87	314.00
IUUC-Lma-053110	Leptosphaeria maculans	53.07	6.00e-56	210.00
IUUC-Laf-053639	Loxodonta africana	50.61	2.00e-89	321.00
IUUC-Mcc-055506	Macaca mulatta	50.61	4.00e-89	320.00
IUUC-Meu-056267	Macropus eugenii	44.27	2.00e-51	196.00
IUUC-Mor-057001	Magnaporthe oryzae	48.93	3.00e-59	221.00
IUUC-Mpo-057608	Magnaporthe poae	47.06	1.00e-38	152.00
IUUC-Mla-059016	Melampsora laricipopulina	44.06	1.00e-43	168.00
IUUC-Mga-060178	Meleagris gallopavo	48.43	5.00e-83	300.00
IUUC-Mvi-060353	Microbotryum violaceum	39.16	4.00e-57	214.00
IUUC-Mmr-060738	Microcebus murinus	50.61	4.00e-89	320.00
IUUC-Mdo-062266	Monodelphis domestica	52.88	8.00e-63	232.00
IUUC-Mmu-063619	Mus musculus	50.31	5.00e-89	320.00
IUUC-Mac-065301	Musa acuminata	80.61	7.00e-158	548.00
IUUC-Mpu-066058	Mustela putorius furo	50.00	6.00e-89	320.00
IUUC-Mlu-067292	Myotis lucifugus	50.61	1.00e-88	319.00
IUUC-Nfi-068275	Neosartorya fischeri	50.38	2.00e-62	232.00
IUUC-Ncr-068713	Neurospora crassa	39.29	5.00e-60	223.00
IUUC-Nle-069013	Nomascus leucogenys	50.61	1.00e-89	322.00
IUUC-Opr-070628	Ochotona princeps	44.03	4.00e-78	284.00
IUUC-Ont-072688	Oreochromis niloticus	48.93	4.00e-87	313.00
IUUC-Oan-073004	Ornithorhynchus anatinus	48.81	4.00e-66	243.00
IUUC-Ocu-074303	Oryctolagus cuniculus	50.92	2.00e-88	319.00
IUUC-Oba-075002	Oryza barthii	75.08	2.00e-142	497.00
IUUC-Obr-076392	Oryza brachyantha	75.31	4.00e-138	483.00
IUUC-Ogl-077271	Oryza glaberrima	75.08	2.00e-142	497.00
IUUC-Ogu-078493	Oryza glumaepatula	75.38	2.00e-143	501.00
IUUC-Oin-080084	Oryza indica	75.38	2.00e-143	501.00
IUUC-Olo-080803	Oryza longistaminata	75.08	4.00e-143	499.00
IUUC-Ome-081146	Oryza meridionalis	74.77	5.00e-142	496.00
IUUC-Oni-082146	Oryza nivara	75.38	2.00e-143	501.00
IUUC-Opu-083633	Oryza punctata	75.31	1.00e-137	481.00
IUUC-Oru-084789	Oryza rufipogon	75.38	2.00e-143	501.00
IUUC-Osa-086196	Oryza sativa	75.38	2.00e-143	501.00
IUUC-Ola-087126	Oryzias latipes	48.47	2.00e-86	311.00
IUUC-Olu-087665	Ostreococcus lucimarinus	46.91	2.00e-74	271.00
IUUC-Oga-089140	Otolemur garnettii	46.74	2.00e-84	305.00
IUUC-Oar-090296	Ovis aries	50.15	4.00e-88	317.00
IUUC-Ptr-090566	Pan troglodytes	50.31	7.00e-89	319.00
IUUC-Pan-092052	Papio anubis	50.61	4.00e-89	320.00
IUUC-Psi-093723	Pelodiscus sinensis	49.84	2.00e-80	291.00
IUUC-Pma-094568	Petromyzon marinus	51.14	4.00e-64	237.00
IUUC-Pno-095120	Phaeosphaeria nodorum	52.40	7.00e-57	213.00
IUUC-Ppa-095761	Physcomitrella patens	70.47	2.00e-138	484.00
IUUC-Pfo-096210	Poecilia formosa	50.31	3.00e-88	317.00
IUUC-Pab-098463	Pongo abelii	50.92	4.00e-89	320.00
IUUC-Pop-099423	Populus trichocarpa	86.23	1.00e-168	584.00
IUUC-Pca-100108	Procavia capensis	53.53	2.00e-72	265.00
IUUC-Ppe-101176	Prunus persica	87.72	2.00e-169	587.00
IUUC-Pva-102629	Pteropus vampyrus	54.39	2.00e-73	268.00
IUUC-Pgr-103419	Puccinia graminis	45.30	3.00e-54	204.00
IUUC-Pte-104207	Pyrenophora teres	55.42	3.00e-41	160.00
IUUC-Pyt-104471	Pyrenophora triticirepentis	52.84	5.00e-61	227.00
IUUC-Rno-105579	Rattus norvegicus	44.74	3.00e-76	278.00
IUUC-Sha-106894	Sarcophilus harrisii	49.31	9.00e-76	276.00
IUUC-Sja-107732	Schizosaccharomyces japonicus	42.95	3.00e-65	241.00
IUUC-Spo-108371	Schizosaccharomyces pombe	42.35	7.00e-71	259.00
IUUC-Ssl-108467	Sclerotinia sclerotiorum	39.46	1.00e-49	189.00
IUUC-Smo-109396	Selaginella moellendorffii	73.72	8.00e-137	479.00
IUUC-Sit-110630	Setaria italica	75.68	2.00e-145	507.00
IUUC-Sly-110972	Solanum lycopersicum	86.67	4.00e-164	569.00
IUUC-Stu-112185	Solanum tuberosum	87.43	7.00e-177	612.00
IUUC-Sar-113294	Sorex araneus	44.89	2.00e-77	282.00
IUUC-Sbi-113951	Sorghum bicolor	75.68	7.00e-145	505.00
IUUC-Ssc-115501	Sus scrofa	48.58	3.00e-82	297.00
IUUC-Tgu-117152	Taeniopygia guttata	48.21	2.00e-77	281.00
IUUC-Tru-118388	Takifugu rubripes	49.08	2.00e-88	318.00
IUUC-Tsy-119109	Tarsius syrichta	50.31	6.00e-89	320.00
IUUC-Tni-120048	Tetraodon nigroviridis	49.08	2.00e-88	318.00
IUUC-Tca-121750	Theobroma cacao	87.46	3.00e-177	613.00
IUUC-Tre-122130	Trichoderma reesei	47.04	3.00e-58	218.00
IUUC-Tvi-122284	Trichoderma virens	43.15	5.00e-55	207.00
IUUC-Tae-124082	Triticum aestivum	75.38	2.00e-144	504.00
IUUC-Tur-126366	Triticum urartu	67.08	1.00e-111	395.00
IUUC-Tme-127187	Tuber melanosporum	42.01	7.00e-70	256.00
IUUC-Tbe-127619	Tupaia belangeri	44.30	4.00e-62	230.00
IUUC-Ttr-128867	Tursiops truncatus	47.37	2.00e-61	228.00
IUUC-Vda-129912	Verticillium dahliae	37.86	6.00e-56	210.00
IUUC-Vpa-130552	Vicugna pacos	54.59	2.00e-63	235.00
IUUC-Vvi-130881	Vitis vinifera	87.13	5.00e-170	589.00
IUUC-Xtr-131934	Xenopus tropicalis	48.96	8.00e-92	329.00
IUUC-Xma-133312	Xiphophorus maculatus	50.31	4.00e-88	317.00
IUUC-Yli-134487	Yarrowia lipolytica	34.90	2.00e-56	211.00
IUUC-Zma-135639	Zea mays	64.86	3.00e-130	457.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence