iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Cin-025753

Ensembl Protein ID

ENSCINP00000030514.1

UniProt Accession

H2XLI2; H2XLI2_CIOIN

Genbank Protein ID

ENSCINP00000030514

Protein Name

Lissencephaly-1 homolog

Genbank Nucleotide ID

EAAA01000807

Gene Name

LOC100180225

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCING00000021752.1	ENSCINT00000033927.1	ENSCINP00000030514.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.20e-52	172.0	191	229
UBD/Beta-Prp	2.60e-88	295.8	105	411

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
           gH   v++++f +d +++vs+s+D+tik+W+l tg ++k
   Q: 191  GHDHNVSSVSFmPDgDHIVSASRDKTIKLWELATGYCIK 229
           899*********999*******************99887 PP

UBD/Beta-Prp

   S: 5    lkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkgh 93
           l+gh  ++it v f+p +s+++++ +d+tikvwd++tg++ r+l+gh+++v++++f+p+gk+l+++s D  +k+wd+  ++c+ tl+gh
   Q: 105  LSGH-RNPITRVIFHPVYSVVLSAAEDSTIKVWDYETGDFERTLKGHTDAVQDISFDPTGKVLASCSADLSVKIWDFVEFECTKTLTGH 192
           5555.569999****************************************************************************** PP
   S: 94   edsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtds 182
           +++v s+sf+p+gd++vs+s+d+ti++w+l tg+c++ t+ gh+++v++v+ + dg+ll+s+s+D+tvr+W  +t ++  +l++ h++ 
   Q: 193  DHNVSSVSFMPDGDHIVSASRDKTIKLWELATGYCIK-TFLGHKEWVRMVRPNMDGSLLASCSNDQTVRVWLTATTECKMELRE-HDHV 279
           *************************************.*********************************************9.**** PP
   S: 183  vyslsfdsng....................kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdl 251
           v++ls+ +++                    +++vsgs+d+t+k+wd++tg+c+ tl+gh+++++   f+p++++l+++s+D+++r+Wd+
   Q: 280  VECLSWAPESaaanicaaagievrkgekvgPFIVSGSRDKTLKIWDVSTGQCLFTLIGHDSWIRAAMFHPRGKFLITASDDKTLRVWDI 368
           ***************************************************************************************** PP
   S: 252  rsgdllktlqlhnssvisvavlsfgdnvlvlgsedskvniwklk 295
           +++ + ktl+ h++ v+  +v + + +++++gs d  v++w+++
   Q: 369  KNKRCHKTLAAHEHFVTDLDV-HKSAPYIITGSVDLLVKVWECR 411
           *********************.99*****************985 PP

Organism

Ciona intestinalis

Functional Description
(View)

Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes.

Protein Sequence
(Fasta)

MVLSTRQRDE LNLAISEYLR ANGYSKALDA FKEEADLVRN PEQPDKKYEG LMEKKWTSVV 60
RLQRKVMDLE AKLNELQKET RDGLTPHNKK DPSEWIPRPP ERCALSGHRN PITRVIFHPV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTTAAAATG ACGAAATACA GTTGTTTAGG ATTTTAGTTT ATCTTTTTAA ATAAAAAGGT 60
ACCGCCAAAT AACTAGAGTT CAAAGTATAT GTTTATCTAT ATGTAACTGG TTTAGTTATT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0493--Microtubule
KW-0498--Mitosis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR017252--Dynein_regulator_LIS1
IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08513--LisH
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00667--LisH
SM00320--WD40

Gene Ontology

GO:1904115--C:axon cytoplasm
GO:0005938--C:cell cortex
GO:0005813--C:centrosome
GO:0000776--C:kinetochore
GO:0005874--C:microtubule
GO:0005875--C:microtubule associated complex
GO:0008017--F:microtubule binding
GO:0051301--P:cell division
GO:0000132--P:establishment of mitotic spindle orientation
GO:0007281--P:germ cell development
GO:0031023--P:microtubule organizing center organization
GO:0007067--P:mitotic nuclear division
GO:0022008--P:neurogenesis
GO:0007097--P:nuclear migration
GO:2000574--P:regulation of microtubule motor activity
GO:0008090--P:retrograde axonal transport
GO:0047496--P:vesicle transport along microtubule

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001589	Ailuropoda melanoleuca	70.50	7.00e-178	614.00
IUUC-Apl-004024	Anas platyrhynchos	71.05	0.00e+00	634.00
IUUC-Aca-004564	Anolis carolinensis	70.56	0.00e+00	625.00
IUUC-Ago-007862	Ashbya gossypii	26.19	1.00e-33	135.00
IUUC-Acl-008360	Aspergillus clavatus	44.94	1.00e-97	348.00
IUUC-Afl-008502	Aspergillus flavus	45.31	9.00e-91	325.00
IUUC-Afu-008848	Aspergillus fumigatus	44.69	2.00e-98	351.00
IUUC-Ani-009173	Aspergillus nidulans	39.90	4.00e-83	300.00
IUUC-Ang-009873	Aspergillus niger	41.62	2.00e-86	311.00
IUUC-Aor-009973	Aspergillus oryzae	43.18	4.00e-87	313.00
IUUC-Ate-010523	Aspergillus terreus	38.43	1.00e-83	301.00
IUUC-Ame-011154	Astyanax mexicanus	71.78	0.00e+00	639.00
IUUC-Bgr-011972	Blumeria graminis	45.48	1.00e-98	351.00
IUUC-Bta-013106	Bos taurus	71.05	0.00e+00	634.00
IUUC-Bci-013615	Botrytis cinerea	43.72	1.00e-92	332.00
IUUC-Cel-018459	Caenorhabditis elegans	53.51	8.00e-137	478.00
IUUC-Cja-018755	Callithrix jacchus	68.86	2.00e-178	617.00
IUUC-Cfa-020749	Canis familiaris	71.05	0.00e+00	634.00
IUUC-Cpo-022371	Cavia porcellus	71.05	0.00e+00	634.00
IUUC-Cre-022578	Chlamydomonas reinhardtii	34.81	3.00e-52	197.00
IUUC-Csa-023524	Chlorocebus sabaeus	71.01	9.00e-156	541.00
IUUC-Cho-024764	Choloepus hoffmanni	64.32	4.00e-146	509.00
IUUC-Csv-025817	Ciona savignyi	91.00	0.00e+00	766.00
IUUC-Cgl-026529	Colletotrichum gloeosporioides	45.69	6.00e-92	329.00
IUUC-Cne-027087	Cryptococcus neoformans	50.26	2.00e-105	374.00
IUUC-Dre-028314	Danio rerio	70.32	0.00e+00	629.00
IUUC-Dno-029050	Dasypus novemcinctus	70.80	0.00e+00	634.00
IUUC-Dor-030222	Dipodomys ordii	65.45	9.00e-165	571.00
IUUC-Dse-031164	Dothistroma septosporum	44.53	5.00e-96	343.00
IUUC-Dme-031745	Drosophila melanogaster	63.11	2.00e-156	543.00
IUUC-Ete-032508	Echinops telfairi	73.29	4.00e-129	453.00
IUUC-Eca-034288	Equus caballus	70.50	2.00e-177	613.00
IUUC-Eeu-034984	Erinaceus europaeus	65.45	2.00e-164	570.00
IUUC-Fca-036498	Felis catus	71.05	0.00e+00	634.00
IUUC-Fal-036920	Ficedula albicollis	71.05	0.00e+00	634.00
IUUC-Fox-037996	Fusarium oxysporum	45.80	2.00e-100	357.00
IUUC-Fso-038160	Fusarium solani	44.87	2.00e-97	347.00
IUUC-Gmo-038983	Gadus morhua	71.05	0.00e+00	632.00
IUUC-Ggr-040051	Gaeumannomyces graminis	46.56	6.00e-95	339.00
IUUC-Gga-040623	Gallus gallus	71.05	0.00e+00	634.00
IUUC-Gac-041613	Gasterosteus aculeatus	70.80	0.00e+00	634.00
IUUC-Ggo-045410	Gorilla gorilla	63.25	3.00e-153	533.00
IUUC-Hsa-046358	Homo sapiens	71.05	0.00e+00	634.00
IUUC-Itr-047890	Ictidomys tridecemlineatus	71.05	0.00e+00	634.00
IUUC-Kpa-049351	Komagataella pastoris	27.80	2.00e-41	162.00
IUUC-Lch-049936	Latimeria chalumnae	70.56	0.00e+00	632.00
IUUC-Loc-052476	Lepisosteus oculatus	70.50	1.00e-177	613.00
IUUC-Lma-053170	Leptosphaeria maculans	47.52	4.00e-95	340.00
IUUC-Laf-053713	Loxodonta africana	69.51	4.00e-179	619.00
IUUC-Mcc-054628	Macaca mulatta	70.56	0.00e+00	631.00
IUUC-Meu-055927	Macropus eugenii	62.09	7.00e-104	368.00
IUUC-Mor-056962	Magnaporthe oryzae	46.08	8.00e-95	339.00
IUUC-Mpo-057583	Magnaporthe poae	47.27	2.00e-93	335.00
IUUC-Mla-058819	Melampsora laricipopulina	48.65	5.00e-111	393.00
IUUC-Mga-059945	Meleagris gallopavo	70.80	0.00e+00	633.00
IUUC-Mvi-060403	Microbotryum violaceum	53.85	8.00e-125	439.00
IUUC-Mmr-061289	Microcebus murinus	70.50	6.00e-178	615.00
IUUC-Mdo-061912	Monodelphis domestica	70.56	0.00e+00	630.00
IUUC-Mmu-063253	Mus musculus	71.05	0.00e+00	634.00
IUUC-Mpu-066638	Mustela putorius furo	71.05	0.00e+00	634.00
IUUC-Mlu-067267	Myotis lucifugus	69.68	1.00e-179	620.00
IUUC-Nfi-068571	Neosartorya fischeri	42.57	4.00e-90	323.00
IUUC-Ncr-068895	Neurospora crassa	48.66	6.00e-100	356.00
IUUC-Nle-069087	Nomascus leucogenys	71.43	4.00e-148	516.00
IUUC-Opr-070579	Ochotona princeps	70.80	0.00e+00	634.00
IUUC-Ont-072432	Oreochromis niloticus	71.78	0.00e+00	637.00
IUUC-Oan-073072	Ornithorhynchus anatinus	71.05	0.00e+00	634.00
IUUC-Ocu-074180	Oryctolagus cuniculus	70.80	0.00e+00	634.00
IUUC-Ola-086772	Oryzias latipes	71.53	0.00e+00	637.00
IUUC-Oga-088219	Otolemur garnettii	69.44	2.00e-178	617.00
IUUC-Oar-090394	Ovis aries	71.05	0.00e+00	634.00
IUUC-Ptr-091517	Pan troglodytes	71.05	0.00e+00	634.00
IUUC-Pan-092421	Papio anubis	70.56	0.00e+00	631.00
IUUC-Psi-093370	Pelodiscus sinensis	70.56	0.00e+00	631.00
IUUC-Pma-094319	Petromyzon marinus	71.63	1.00e-154	537.00
IUUC-Pno-094815	Phaeosphaeria nodorum	47.12	7.00e-99	352.00
IUUC-Pfo-097089	Poecilia formosa	71.78	0.00e+00	640.00
IUUC-Pab-098421	Pongo abelii	71.05	0.00e+00	634.00
IUUC-Pca-100120	Procavia capensis	52.10	2.00e-117	414.00
IUUC-Pva-102960	Pteropus vampyrus	70.80	0.00e+00	630.00
IUUC-Pgr-103538	Puccinia graminis	45.88	3.00e-108	384.00
IUUC-Ptt-103990	Puccinia triticina	39.85	5.00e-40	157.00
IUUC-Pte-104261	Pyrenophora teres	47.71	7.00e-100	355.00
IUUC-Pyt-104780	Pyrenophora triticirepentis	47.95	3.00e-100	357.00
IUUC-Rno-105123	Rattus norvegicus	71.05	0.00e+00	634.00
IUUC-Sce-106208	Saccharomyces cerevisiae	29.18	3.00e-35	141.00
IUUC-Sha-107010	Sarcophilus harrisii	70.32	0.00e+00	628.00
IUUC-Sja-107899	Schizosaccharomyces japonicus	32.75	1.00e-59	222.00
IUUC-Ssl-108571	Sclerotinia sclerotiorum	44.02	3.00e-93	333.00
IUUC-Sar-113309	Sorex araneus	69.75	5.00e-175	605.00
IUUC-Sre-115003	Sporisorium reilianum	47.26	4.00e-116	409.00
IUUC-Ssc-116148	Sus scrofa	71.05	0.00e+00	634.00
IUUC-Tgu-117299	Taeniopygia guttata	71.05	0.00e+00	634.00
IUUC-Tru-117721	Takifugu rubripes	71.05	0.00e+00	635.00
IUUC-Tsy-119493	Tarsius syrichta	70.56	0.00e+00	628.00
IUUC-Tni-120355	Tetraodon nigroviridis	71.29	2.00e-180	623.00
IUUC-Tre-121977	Trichoderma reesei	39.87	8.00e-92	329.00
IUUC-Tvi-122661	Trichoderma virens	41.38	1.00e-91	328.00
IUUC-Tme-127031	Tuber melanosporum	46.87	4.00e-98	350.00
IUUC-Tbe-127492	Tupaia belangeri	61.92	2.00e-89	321.00
IUUC-Ttr-128929	Tursiops truncatus	71.05	0.00e+00	633.00
IUUC-Uma-129347	Ustilago maydis	46.12	7.00e-115	405.00
IUUC-Vda-129837	Verticillium dahliae	45.56	4.00e-95	340.00
IUUC-Vpa-130532	Vicugna pacos	60.21	3.00e-137	479.00
IUUC-Xtr-131985	Xenopus tropicalis	70.07	0.00e+00	630.00
IUUC-Xma-133314	Xiphophorus maculatus	72.02	0.00e+00	641.00
IUUC-Yli-134403	Yarrowia lipolytica	39.11	5.00e-71	260.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence