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Tag Content
iUUCD ID IUUC-Tme-127031
Ensembl Protein ID CAZ81993
UniProt Accession D5GBI7; LIS1_TUBMM
Genbank Protein ID CAZ81993.1
Protein Name Nuclear distribution protein PAC1; Lissencephaly-1 homolog; nudF homolog
Genbank Nucleotide ID FN430097
Gene Name PAC1; LIS1; GSTUM_00005652001
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
GSTUM_00005652001 CAZ81993 CAZ81993
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 2.50e-50 164.9 352 386
UBD/Beta-Prp 2.40e-68 229.1 116 451
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtg 33
    gH +++++laf + ++l+s sdD+ti++WDl+++
   Q: 352 GHDNWIRALAFhPAgKYLLSVSDDKTIRCWDLTQD 386
    8**********9666*****************987 PP
   


   UBD/Beta-Prp

   S: 7    ghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgk..ilvtgseDrtikvwdls.tgkcvhtlkghedsvlslsfsp 104
    ++h + i++v+f+p s+la+gs+d tik+wd++ g l r+++gh+++v +++f + +lv++s+D tik+wd++ +k ++tl+gh++sv +++f p
   Q: 116 TSHRNSINSVAFHPIFSVLASGSDDTTIKIWDWELGELERTVKGHTKAVLDLDFGGPKAgvLLVSCSSDLTIKLWDPNnEYKNIRTLTGHDHSVSAVRFIP 216
    578899************************************************8776678**************998679******************** PP
   S: 105 ..sgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsng........... 192
    g++lvs+s+d+t+rvw++ tg+c++ t sgh+++++ v+ + dg+ l s++ D+t rlWd +t++ t+ g h++ v++ f + +
   Q: 217 saAGEYLVSASRDKTLRVWEVATGYCVK-TISGHSDWIRDVEPSHDGRWLLSAGGDQTTRLWDASTAEHKATFLG-HEHVVNCCVFAPPSsyphlatiagl 315
    8778************************.*********************************************9.*********9888889999999999 PP
   S: 193 ..........kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrs.gdllktlqlhn.................. 264
    +++++gs+d+t+klwd +g+ ++tl gh+++++ ++f+p +++l+s+s+D++ir+Wdl++ g ++kt+ +
   Q: 316 kkpppatsssEFIATGSRDKTIKLWDA-RGTLLKTLVGHDNWIRALAFHPAGKYLLSVSDDKTIRCWDLTQdGRCVKTVDEAHshfatclrwapapakeqt 415
    9999999999****************9.7889************************************865279******999889999999999998888 PP
   S: 265 .............ssvisvavlsfgdnvlvlgsedskvniwk 293
    ++vi v + v+++gs+d +v++++
   Q: 416 ngeaktngipkagEKVINVRC------VIATGSADMNVRVFA 451
    888888888888888888888......8899999*9999986 PP
   

Organism Tuber melanosporum
Functional Description
(View)

Functional Description



     Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs.
Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs.
Protein Sequence
(Fasta)
MSTPVNYLIP RQKDELHKAI LAYFSASGLS NTGAALREEL GVGDEFLDQN TMKKYEGVLE 60
KKWTGVLRLQ KKIMELESRL SSLQSELDSA TPTSLTRRNV DPSSWLPRAP AKHVLTSHRN 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Tme-127031|E3,WD_repeat;UBD,Beta-Prp|Tuber melanosporum
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CACCCCGAAA GGAAATCCTC CAATAGTTCT ACCCATCAAG ATATTGCAGA ACTTTCTTCG 60
CTGGTCTCCC TCTGGCCCTT CCTCTAAACC CGAAAGGCGA GAAGGGACAG GACCCCACCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Tme-127031|E3,WD_repeat;UBD,Beta-Prp|Tuber melanosporum
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0493--Microtubule
KW-0498--Mitosis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR017252--Dynein_regulator_LIS1
IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005874--C:microtubule
GO:0000922--C:spindle pole
GO:0051301--P:cell division
GO:0007067--P:mitotic nuclear division
GO:0006810--P:transport

KEGG tml:GSTUM_00005652001
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001589 Ailuropoda melanoleuca 47.97 9.00e-106 374.00
IUUC-Apl-004024 Anas platyrhynchos 49.38 2.00e-109 386.00
IUUC-Aca-004564 Anolis carolinensis 48.89 6.00e-107 379.00
IUUC-Ago-007862 Ashbya gossypii 27.82 7.00e-39 152.00
IUUC-Acl-008360 Aspergillus clavatus 65.52 5.00e-176 608.00
IUUC-Afl-008502 Aspergillus flavus 60.63 2.00e-159 553.00
IUUC-Afu-008848 Aspergillus fumigatus 67.38 0.00e+00 656.00
IUUC-Ani-009173 Aspergillus nidulans 60.45 1.00e-161 560.00
IUUC-Ang-009873 Aspergillus niger 58.47 2.00e-157 546.00
IUUC-Aor-009973 Aspergillus oryzae 57.93 1.00e-151 527.00
IUUC-Ate-010523 Aspergillus terreus 61.17 3.00e-166 576.00
IUUC-Ame-010969 Astyanax mexicanus 48.64 2.00e-110 390.00
IUUC-Bgr-011972 Blumeria graminis 67.03 0.00e+00 653.00
IUUC-Bta-013106 Bos taurus 48.39 2.00e-109 387.00
IUUC-Bci-013615 Botrytis cinerea 66.45 0.00e+00 650.00
IUUC-Bra-017265 Brassica rapa 33.06 4.00e-29 122.00
IUUC-Cel-018459 Caenorhabditis elegans 44.72 6.00e-98 348.00
IUUC-Cja-018755 Callithrix jacchus 47.41 4.00e-106 376.00
IUUC-Cfa-020749 Canis familiaris 48.39 2.00e-109 387.00
IUUC-Cpo-022371 Cavia porcellus 48.39 2.00e-109 387.00
IUUC-Csa-023524 Chlorocebus sabaeus 50.15 2.00e-93 333.00
IUUC-Cho-024764 Choloepus hoffmanni 46.02 4.00e-90 322.00
IUUC-Cin-025753 Ciona intestinalis 48.37 4.00e-101 359.00
IUUC-Csv-025817 Ciona savignyi 46.62 3.00e-104 369.00
IUUC-Cgl-026529 Colletotrichum gloeosporioides 68.34 0.00e+00 632.00
IUUC-Cne-027087 Cryptococcus neoformans 53.09 3.00e-119 419.00
IUUC-Dre-028314 Danio rerio 48.89 3.00e-109 386.00
IUUC-Dno-029050 Dasypus novemcinctus 48.39 2.00e-109 386.00
IUUC-Dor-030222 Dipodomys ordii 44.58 3.00e-99 353.00
IUUC-Dse-031164 Dothistroma septosporum 61.35 8.00e-170 587.00
IUUC-Dme-031745 Drosophila melanogaster 46.90 2.00e-97 347.00
IUUC-Ete-032508 Echinops telfairi 51.13 5.00e-74 269.00
IUUC-Eca-034288 Equus caballus 47.46 1.00e-104 370.00
IUUC-Eeu-034984 Erinaceus europaeus 44.33 4.00e-98 349.00
IUUC-Fca-036498 Felis catus 48.39 2.00e-109 387.00
IUUC-Fal-036920 Ficedula albicollis 49.38 2.00e-109 386.00
IUUC-Fox-037996 Fusarium oxysporum 65.21 0.00e+00 624.00
IUUC-Fso-038160 Fusarium solani 63.52 1.00e-173 600.00
IUUC-Gmo-038983 Gadus morhua 47.55 1.00e-108 384.00
IUUC-Ggr-040051 Gaeumannomyces graminis 64.13 1.00e-174 603.00
IUUC-Gga-040623 Gallus gallus 49.38 2.00e-109 386.00
IUUC-Gac-041613 Gasterosteus aculeatus 47.52 2.00e-108 383.00
IUUC-Ggo-045410 Gorilla gorilla 44.53 1.00e-88 318.00
IUUC-Hsa-046358 Homo sapiens 49.38 2.00e-109 387.00
IUUC-Hvu-047729 Hordeum vulgare 30.58 1.00e-29 122.00
IUUC-Itr-047890 Ictidomys tridecemlineatus 48.39 2.00e-109 387.00
IUUC-Kpa-049351 Komagataella pastoris 29.77 7.00e-47 179.00
IUUC-Lch-049936 Latimeria chalumnae 48.14 9.00e-110 388.00
IUUC-Loc-052476 Lepisosteus oculatus 47.72 7.00e-105 371.00
IUUC-Lma-053170 Leptosphaeria maculans 67.90 0.00e+00 628.00
IUUC-Laf-053713 Loxodonta africana 48.10 1.00e-106 377.00
IUUC-Mcc-054628 Macaca mulatta 48.64 1.00e-109 387.00
IUUC-Meu-055927 Macropus eugenii 42.15 4.00e-54 202.00
IUUC-Mor-056962 Magnaporthe oryzae 63.68 3.00e-179 619.00
IUUC-Mpo-057583 Magnaporthe poae 65.00 1.00e-168 584.00
IUUC-Mla-058819 Melampsora laricipopulina 49.67 7.00e-117 412.00
IUUC-Mga-059945 Meleagris gallopavo 49.14 5.00e-109 385.00
IUUC-Mvi-060403 Microbotryum violaceum 54.05 1.00e-137 480.00
IUUC-Mmr-061289 Microcebus murinus 47.97 1.00e-105 374.00
IUUC-Mdo-061912 Monodelphis domestica 47.99 2.00e-108 384.00
IUUC-Mmu-063253 Mus musculus 48.39 2.00e-109 387.00
IUUC-Mpu-066638 Mustela putorius furo 48.39 2.00e-109 387.00
IUUC-Mlu-067267 Myotis lucifugus 47.50 6.00e-107 378.00
IUUC-Nfi-068571 Neosartorya fischeri 62.31 4.00e-169 585.00
IUUC-Ncr-068895 Neurospora crassa 66.45 3.00e-174 602.00
IUUC-Nle-069087 Nomascus leucogenys 47.14 1.00e-90 324.00
IUUC-Opr-070579 Ochotona princeps 48.39 2.00e-109 386.00
IUUC-Ont-072432 Oreochromis niloticus 48.17 1.00e-108 384.00
IUUC-Oan-073072 Ornithorhynchus anatinus 48.39 2.00e-109 387.00
IUUC-Ocu-074180 Oryctolagus cuniculus 48.39 2.00e-109 386.00
IUUC-Oba-075448 Oryza barthii 30.58 1.00e-29 122.00
IUUC-Obr-076138 Oryza brachyantha 31.06 6.00e-30 124.00
IUUC-Oin-079811 Oryza indica 31.70 2.00e-29 122.00
IUUC-Olo-080245 Oryza longistaminata 31.70 3.00e-29 122.00
IUUC-Oni-082640 Oryza nivara 30.58 1.00e-29 122.00
IUUC-Oru-084609 Oryza rufipogon 30.58 1.00e-29 122.00
IUUC-Ola-086815 Oryzias latipes 47.39 8.00e-109 385.00
IUUC-Oga-088219 Otolemur garnettii 47.29 2.00e-106 377.00
IUUC-Oar-090394 Ovis aries 48.39 2.00e-109 387.00
IUUC-Ptr-091517 Pan troglodytes 48.39 2.00e-109 387.00
IUUC-Pan-092421 Papio anubis 48.64 1.00e-109 387.00
IUUC-Psi-093370 Pelodiscus sinensis 49.38 5.00e-109 385.00
IUUC-Pma-094319 Petromyzon marinus 48.36 7.00e-91 325.00
IUUC-Pno-094815 Phaeosphaeria nodorum 69.57 0.00e+00 649.00
IUUC-Pfo-097089 Poecilia formosa 49.01 3.00e-110 389.00
IUUC-Pab-098421 Pongo abelii 48.39 2.00e-109 387.00
IUUC-Pca-100120 Procavia capensis 39.13 4.00e-64 236.00
IUUC-Pva-102960 Pteropus vampyrus 48.14 4.00e-108 382.00
IUUC-Pgr-103538 Puccinia graminis 49.03 6.00e-120 422.00
IUUC-Ptt-103990 Puccinia triticina 42.64 2.00e-43 168.00
IUUC-Pte-104261 Pyrenophora teres 69.00 0.00e+00 644.00
IUUC-Pyt-104780 Pyrenophora triticirepentis 69.21 0.00e+00 645.00
IUUC-Rno-105123 Rattus norvegicus 48.39 2.00e-109 387.00
IUUC-Sce-106208 Saccharomyces cerevisiae 25.70 3.00e-39 154.00
IUUC-Sha-107010 Sarcophilus harrisii 48.14 2.00e-108 383.00
IUUC-Sja-107899 Schizosaccharomyces japonicus 35.14 1.00e-71 261.00
IUUC-Ssl-108571 Sclerotinia sclerotiorum 68.71 1.00e-180 624.00
IUUC-Sar-113309 Sorex araneus 47.21 3.00e-103 366.00
IUUC-Sre-115003 Sporisorium reilianum 52.22 6.00e-133 465.00
IUUC-Ssc-116148 Sus scrofa 48.39 2.00e-109 387.00
IUUC-Tgu-117299 Taeniopygia guttata 49.38 3.00e-109 386.00
IUUC-Tru-117721 Takifugu rubripes 47.77 4.00e-108 382.00
IUUC-Tsy-119493 Tarsius syrichta 47.89 5.00e-107 379.00
IUUC-Tni-120355 Tetraodon nigroviridis 47.52 2.00e-107 380.00
IUUC-Tre-121977 Trichoderma reesei 59.57 3.00e-162 562.00
IUUC-Tvi-122661 Trichoderma virens 61.12 1.00e-162 564.00
IUUC-Tur-126181 Triticum urartu 31.66 2.00e-29 122.00
IUUC-Tbe-127492 Tupaia belangeri 42.26 4.00e-50 189.00
IUUC-Ttr-128929 Tursiops truncatus 48.39 3.00e-109 386.00
IUUC-Uma-129347 Ustilago maydis 51.66 8.00e-130 454.00
IUUC-Vda-129837 Verticillium dahliae 65.29 3.00e-171 592.00
IUUC-Vpa-130532 Vicugna pacos 41.06 3.00e-87 313.00
IUUC-Xtr-131985 Xenopus tropicalis 48.64 4.00e-110 389.00
IUUC-Xma-133314 Xiphophorus maculatus 48.66 2.00e-110 390.00
IUUC-Yli-134403 Yarrowia lipolytica 43.16 3.00e-99 353.00
Created Date 25-Jun-2017

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