iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ggo-045402

UUCD1 version

UUC-GoG-01101

Ensembl Protein ID

ENSGGOP00000016948.1

UniProt Accession

G3RMD4; G3RMD4_GORGO

Protein Name

Ubiquitinyl hydrolase 1

Gene Name

USP45

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGGOG00000000091.2	ENSGGOT00000024286.1	ENSGGOP00000016948.1
ENSGGOG00000000091.2	ENSGGOT00000000091.2	ENSGGOP00000000089.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.40e-86	290.4	191	813

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrellle..kkkeklneenp..............kepkgellkslqklfeelwkskkkavsprell 74
           G++NlgNtC++N+v+Q L+++  l++l++e  +  ++++ +                 ++ g+l+++l  +++++ +++k+  sp+ l+
   Q: 191  GITNLGNTCFFNAVMQNLAQTYTLTDLMNEikE--SSTKLK-IfpssdsqldplvveLSRPGPLTSALFLFLHSMKETEKGPLSPKVLF 276
           9*****************************542..333222.23445566666777777777*************************** PP
   S: 75   kalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde......aeekkkkknkslisdlFqgqlksqikcl 157
           ++l+++a++f+ ++qqD+qE+l++lld++++e +k+ + ++ +++++ ++++ d+      + + k+  + ++i+++F g+l+s+++c+
   Q: 277  NQLCQKAPRFKDFQQQDSQELLHYLLDAVRTEETKRIQASILKAFNNPTTKTADDetrkkvKAYGKEGVKMNFIDRIFIGELTSTVMCE 365
           *********************************99888888888888877777773443335555555555****************** PP
   S: 158  ecdnvssreepfldlslpvpgkeetkke............................................................. 185
           ec+n+s+ ++pf+d+slp+ +++ +k++                                                             
   Q: 366  ECANISTVKDPFIDISLPIIEERVSKPLlwgrmnkyrslretdhdrysgnvtienihqpraakkhssskdksqlihdrkcirklssget 454
           ***********************99888************************************************************* PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 455  vtyqknenlemngdslmfaslmnsesrlnesptddsekeashsesnvdadsepsesesaskqtglfrsssgsgvhpdgplyplsagell 543
           ***************************************************************************************** PP
   S: 186  ...........................................................................slqdcLesftkeee 199
                                                                                      s+q+cL +ft+ e 
   Q: 544  ytketdsgdkemaeaiselrlsstvtgdqdfdrenqplnisnnlcflegkhlrshspqnafqtlsqsyittskecSIQSCLYQFTSMEL 632
           ***************************************************************************************** PP
   S: 200  legenkyycekckkkqe....................aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctsp 268
           l g+nk+ ce+c+k+++                    a+k+l ++ +P vLilhLkRf  ++++ s +k+n++v+fpl+Ldl+pfc+ +
   Q: 633  LMGNNKLLCENCTKNKQkyqeetsfavekkvegvytnARKQLLISAVPAVLILHLKRF--HQAGLSLRKVNRHVDFPLMLDLAPFCSAT 719
           *************888889999999999999999999*********************..9999************************8 PP
   S: 269  eekqke..kkkYeLiavvvHsGslssGHYvayvkn..........................ekgkWllfdDskVtevkeeevleetgst 329
           +++ ++  k+ Y L+++v HsGs+++GHY+ayvk                           + g+W++++D++V++v+e++ l+   ++
   Q: 720  CKNASVgdKVLYGLYGIVEHSGSMREGHYTAYVKVrtpsrklsehnakkknvpglkaadseSAGQWVHVSDTYVQVVPESRALS---AQ 805
           8887667799*************************999999999999999999999888877888*******************...** PP
   S: 330  aYvlfYkr 337
           aY+lfY+r
   Q: 806  AYLLFYER 813
           ******98 PP

Organism

Gorilla gorilla

Protein Sequence
(Fasta)

MRVKDPTKAL PGKAKRSKRP TVPHDEDSSD DIAVGLTCQH VSHAISVNHV KRAIAENLWS 60
VCSECLKERR FYDGQLVLTS DIWLCLKCGF QGCGKNSESQ HSLKHFKSSR TEPHCIIINL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATCCCTTCAG TAAATAACAG ATGCGGGTGA AAGATCCAAC TAAAGCTTTA CCTGGGAAAG 60
CCAAAAGAAG TAAAAGGCCT ACTGTACCTC ATGATGAAGA CTCTTCGGAT GATATTGCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0006281--P:DNA repair
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002331	Ailuropoda melanoleuca	73.67	0.00e+00	1091.00
IUUC-Apl-003512	Anas platyrhynchos	66.99	0.00e+00	1038.00
IUUC-Aca-004284	Anolis carolinensis	61.05	0.00e+00	938.00
IUUC-Ame-010735	Astyanax mexicanus	63.98	8.00e-85	307.00
IUUC-Bta-012880	Bos taurus	81.71	0.00e+00	1259.00
IUUC-Cja-019144	Callithrix jacchus	92.77	0.00e+00	1501.00
IUUC-Cfa-020971	Canis familiaris	82.63	0.00e+00	721.00
IUUC-Cpo-022497	Cavia porcellus	69.15	0.00e+00	1073.00
IUUC-Csa-023910	Chlorocebus sabaeus	94.17	0.00e+00	1442.00
IUUC-Cho-024358	Choloepus hoffmanni	61.90	6.00e-110	390.00
IUUC-Dre-028106	Danio rerio	60.92	6.00e-149	521.00
IUUC-Dno-029456	Dasypus novemcinctus	76.57	0.00e+00	701.00
IUUC-Dor-030438	Dipodomys ordii	63.81	0.00e+00	929.00
IUUC-Dme-031870	Drosophila melanogaster	46.43	3.00e-35	144.00
IUUC-Ete-032736	Echinops telfairi	64.51	0.00e+00	927.00
IUUC-Eca-034211	Equus caballus	83.05	0.00e+00	1330.00
IUUC-Eeu-034797	Erinaceus europaeus	81.01	3.00e-85	309.00
IUUC-Fca-035947	Felis catus	77.92	0.00e+00	1142.00
IUUC-Fal-037199	Ficedula albicollis	66.94	0.00e+00	917.00
IUUC-Gmo-039228	Gadus morhua	61.01	1.00e-139	490.00
IUUC-Gga-040823	Gallus gallus	63.14	4.00e-162	564.00
IUUC-Gac-042406	Gasterosteus aculeatus	59.52	1.00e-135	477.00
IUUC-Hsa-046430	Homo sapiens	98.90	0.00e+00	1623.00
IUUC-Itr-048855	Ictidomys tridecemlineatus	81.50	0.00e+00	746.00
IUUC-Lch-049547	Latimeria chalumnae	57.58	0.00e+00	888.00
IUUC-Loc-052842	Lepisosteus oculatus	57.95	0.00e+00	875.00
IUUC-Laf-053988	Loxodonta africana	83.31	0.00e+00	1338.00
IUUC-Mcc-055491	Macaca mulatta	89.34	0.00e+00	1439.00
IUUC-Meu-056256	Macropus eugenii	64.02	4.00e-173	601.00
IUUC-Mtr-057945	Medicago truncatula	31.58	1.00e-33	139.00
IUUC-Mla-059026	Melampsora laricipopulina	31.22	8.00e-17	82.00
IUUC-Mga-059833	Meleagris gallopavo	59.67	2.00e-164	572.00
IUUC-Mmr-060952	Microcebus murinus	85.09	0.00e+00	1330.00
IUUC-Mdo-062642	Monodelphis domestica	70.05	0.00e+00	1070.00
IUUC-Mmu-063945	Mus musculus	77.56	0.00e+00	1207.00
IUUC-Mpu-065944	Mustela putorius furo	75.46	0.00e+00	1152.00
IUUC-Mlu-067049	Myotis lucifugus	81.61	0.00e+00	1256.00
IUUC-Nle-069828	Nomascus leucogenys	96.70	0.00e+00	1573.00
IUUC-Opr-070672	Ochotona princeps	70.73	1.00e-142	500.00
IUUC-Ont-072121	Oreochromis niloticus	59.02	6.00e-134	471.00
IUUC-Oan-073656	Ornithorhynchus anatinus	64.61	0.00e+00	1023.00
IUUC-Ocu-074323	Oryctolagus cuniculus	80.59	0.00e+00	1241.00
IUUC-Ola-087238	Oryzias latipes	59.18	3.00e-145	509.00
IUUC-Oga-088379	Otolemur garnettii	77.39	0.00e+00	1214.00
IUUC-Oar-089718	Ovis aries	82.00	0.00e+00	1256.00
IUUC-Ptr-091358	Pan troglodytes	99.14	0.00e+00	1625.00
IUUC-Pan-092023	Papio anubis	94.98	0.00e+00	1538.00
IUUC-Psi-093256	Pelodiscus sinensis	64.77	0.00e+00	968.00
IUUC-Pfo-097285	Poecilia formosa	51.95	1.00e-119	424.00
IUUC-Pab-098539	Pongo abelii	98.41	0.00e+00	1602.00
IUUC-Pca-100610	Procavia capensis	67.95	0.00e+00	920.00
IUUC-Pva-102985	Pteropus vampyrus	89.73	0.00e+00	690.00
IUUC-Rno-105538	Rattus norvegicus	77.36	0.00e+00	1212.00
IUUC-Sha-107022	Sarcophilus harrisii	72.39	5.00e-178	617.00
IUUC-Sja-107712	Schizosaccharomyces japonicus	27.35	1.00e-20	94.70
IUUC-Spo-108149	Schizosaccharomyces pombe	30.99	6.00e-21	96.30
IUUC-Sar-113637	Sorex araneus	70.21	0.00e+00	1050.00
IUUC-Ssc-115870	Sus scrofa	81.81	0.00e+00	1305.00
IUUC-Tgu-116907	Taeniopygia guttata	67.40	0.00e+00	1046.00
IUUC-Tru-117835	Takifugu rubripes	51.96	1.00e-109	390.00
IUUC-Tsy-118869	Tarsius syrichta	78.46	0.00e+00	1214.00
IUUC-Tbe-128041	Tupaia belangeri	65.69	0.00e+00	943.00
IUUC-Ttr-128901	Tursiops truncatus	80.68	0.00e+00	1264.00
IUUC-Vpa-130331	Vicugna pacos	82.97	0.00e+00	1185.00
IUUC-Xtr-131794	Xenopus tropicalis	65.15	1.00e-145	510.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence