iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Xtr-132410

Ensembl Protein ID

ENSXETP00000016051.3

UniProt Accession

F6XSC8; F6XSC8_XENTR

Genbank Protein ID

ENSXETP00000016051

Protein Name

Vav guanine nucleotide exchange factor 1

Genbank Nucleotide ID

AAMC01098847

Gene Name

vav1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000007366.3	ENSXETT00000016051.3	ENSXETP00000016051.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	7.40e-20	70.8	792	842

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 7    qvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFve 60
           ++ yd+ a +  eL+lk+Gdv++++  ++  +gW+kg  e  gk G fP+n+ve
   Q: 792  RARYDFCARDRTELSLKEGDVIRIL-SKKGQNGWWKG--EVYGKVGWFPANYVE 842
           578**********************.888889*****..9************98 PP

Organism

Xenopus tropicalis

Protein Sequence
(Fasta)

MELWRHCARW LIQCRVLPPN HRVTLDTAQV CDLAQALRDG VLLCQLLNNL MPNAVNLSEI 60
NLRPQMSQFL CLKNIRTFLS TCSEKFKMRR ADLFEAFDLF DVRDFGKVID TLSILSWTSV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAGCTGT GGAGGCACTG TGCTCGCTGG TTGATCCAAT GCCGGGTACT TCCTCCAAAT 60
CACCGTGTGA CTCTGGACAC TGCCCAGGTT TGTGACCTCG CTCAGGCACT TCGGGATGGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0862--Zinc

Interpro

IPR022613--CAMSAP_CH
IPR001715--CH-domain
IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR002219--PE/DAG-bd
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR000980--SH2
IPR011511--SH3_2
IPR001452--SH3_domain
IPR028530--Vav

PROSITE

PS50021--CH
PS00741--DH_1
PS50010--DH_2
PS50003--PH_DOMAIN
PS50001--SH2
PS50002--SH3
PS00479--ZF_DAG_PE_1
PS50081--ZF_DAG_PE_2

Pfam

PF00130--C1_1
PF11971--CAMSAP_CH
PF00169--PH
PF00621--RhoGEF
PF00017--SH2
PF00018--SH3_1
PF07653--SH3_2

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00109--C1
SM00033--CH
SM00233--PH
SM00325--RhoGEF
SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005622--C:intracellular
GO:0046872--F:metal ion binding
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0035023--P:regulation of Rho protein signal transduction
GO:0007264--P:small GTPase mediated signal transduction

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Cja-020009	Callithrix jacchus	72.50	0.00e+00	1205.00
IUUC-Cfa-020768	Canis familiaris	71.80	0.00e+00	1189.00
IUUC-Dno-029602	Dasypus novemcinctus	71.68	0.00e+00	1191.00
IUUC-Eca-033682	Equus caballus	71.92	0.00e+00	1192.00
IUUC-Fca-035629	Felis catus	71.24	0.00e+00	1214.00
IUUC-Gmo-039693	Gadus morhua	58.12	0.00e+00	914.00
IUUC-Gac-041567	Gasterosteus aculeatus	64.29	0.00e+00	987.00
IUUC-Hsa-045886	Homo sapiens	72.27	0.00e+00	1200.00
IUUC-Itr-048730	Ictidomys tridecemlineatus	68.82	0.00e+00	1142.00
IUUC-Loc-051761	Lepisosteus oculatus	66.31	0.00e+00	1113.00
IUUC-Laf-054537	Loxodonta africana	71.92	0.00e+00	1228.00
IUUC-Mcc-054726	Macaca mulatta	72.50	0.00e+00	1204.00
IUUC-Mmr-060980	Microcebus murinus	70.39	0.00e+00	1174.00
IUUC-Mdo-061926	Monodelphis domestica	69.88	0.00e+00	1051.00
IUUC-Mmu-063942	Mus musculus	71.21	0.00e+00	1194.00
IUUC-Mpu-066000	Mustela putorius furo	71.80	0.00e+00	1186.00
IUUC-Mlu-067818	Myotis lucifugus	70.49	0.00e+00	1176.00
IUUC-Ont-072213	Oreochromis niloticus	64.22	0.00e+00	1043.00
IUUC-Ola-087345	Oryzias latipes	63.15	0.00e+00	1001.00
IUUC-Oga-089104	Otolemur garnettii	71.80	0.00e+00	1197.00
IUUC-Oar-089459	Ovis aries	72.35	0.00e+00	1205.00
IUUC-Ptr-090766	Pan troglodytes	71.39	0.00e+00	1100.00
IUUC-Pan-091994	Papio anubis	71.60	0.00e+00	1183.00
IUUC-Psi-093595	Pelodiscus sinensis	70.13	0.00e+00	1121.00
IUUC-Pfo-097210	Poecilia formosa	63.79	0.00e+00	1004.00
IUUC-Pab-098630	Pongo abelii	72.34	0.00e+00	1170.00
IUUC-Pva-102406	Pteropus vampyrus	70.98	0.00e+00	1149.00
IUUC-Pte-104123	Pyrenophora teres	46.94	2.00e-10	61.60
IUUC-Pyt-104567	Pyrenophora triticirepentis	46.94	2.00e-10	61.60
IUUC-Rno-105763	Rattus norvegicus	68.98	0.00e+00	1145.00
IUUC-Sha-106683	Sarcophilus harrisii	70.66	0.00e+00	1200.00
IUUC-Ssc-115338	Sus scrofa	71.43	0.00e+00	1109.00
IUUC-Tru-118199	Takifugu rubripes	63.25	0.00e+00	966.00
IUUC-Tni-120548	Tetraodon nigroviridis	63.90	0.00e+00	1000.00
IUUC-Tbe-127995	Tupaia belangeri	55.72	2.00e-113	403.00
IUUC-Vpa-130066	Vicugna pacos	80.00	8.00e-39	155.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence