iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000017186.3	ENSMMUT00000024165.3	ENSMMUP00000022610.3
ENSMMUG00000017186.3	ENSMMUT00000071177.1	ENSMMUP00000054796.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.20e-34	117.1	181	218
UBD/Beta-Prp	6.40e-52	177.7	280	541

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvll 36
           gH +sv+c+ f  + +++ +GsdD+ +k+W +++g+ll
   Q: 181  GHLSSVYCVTFdRTgRRIFTGSDDCLVKIWATDDGRLL 218
           8**********955599*****************9987 PP

UBD/Beta-Prp

   S: 19   spdksllatgsrdgtikvwdvttgkl.....lrsl.sgheaevtavk..fspdgkilvtgseDrtikvw..dlstgkcvhtlkghedsv 97
           s +k++l ++++dgti  w ++ g+l      +++ +   ++v+ ++  fs  g +l+tgs+D++i+v+     +++ ++ l+ h+d+v
   Q: 280  SGSKRYLSSTGADGTICFWLWDAGTLkinprPAKFtERPRPGVQMICssFSAGGMFLATGSTDHIIRVYffGSGQPEKISELEFHTDKV 368
           67899***********999999999988988555547777888765522777888**************777779999*********** PP
   S: 98   lslsfspsgdklvsGshdrtirvwdletgqclee................tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgk 170
            s++fs +++++vsGs+d t+r+w+ + +++ +                  +++++  v++v+++  +n ++++ ++ t+++W++ tg+
   Q: 369  DSIQFSNTSNRFVSGSRDGTARIWQFKRREWKSIlldmatrpagqnlqgiEDKITKMKVTMVAWDRHDNTVITAVNNMTLKVWNSYTGQ 457
           ********************************99***************888899999******************************* PP
   S: 171  llrtltgghtdsvysls...fdsngkelvsgsldgtvklwdlqtgecvrtlnght.....dnvksvrfspnderlvsgssDgsiriW 249
           l++ l g h+d v  l+   fd+  + l s+++dg v++wdl +g  +r++ +         v + + sp++++++++ s+g + i+
   Q: 458  LIHVLMG-HEDEVFVLEphpFDP--RVLFSAGHDGNVIVWDLARGVKIRSYFNMIegqghGAVFDCKCSPDGQHFACTDSHGHLLIF 541
           ******9.*********999999..89******************999998875544445566667777999999999999988887 PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MSCERKGLSE LRSELYFLIA RFLEDGPCQQ AAQVRSRGVL SPQLLPRRTD WTGKEHPRTY 60
QNLVKYYRHL APDHLLQICH RLGPLLEQEI PQSVPGVQTL LGAGRQSLLR TNKSCKHVVW 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCTTGTG AGAGGAAAGG CCTCTCGGAG CTGCGATCGG GTAAGTCGGG GGGCTGCCGG 60
GGCCGCTGGC ACCGGGCGAT TCCGCCCGCG GTCCCCCGCC CCCCGCCGCC CGGCCGCTCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0103--Bromodomain
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR001487--Bromodomain
IPR018359--Bromodomain_CS
IPR028738--PHIP
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00633--BROMODOMAIN_1
PS50014--BROMODOMAIN_2
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00439--Bromodomain
PF00400--WD40

PRINTS

PR00503--BROMODOMAIN

SMART

SM00297--BROMO
SM00320--WD40

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0007010--P:cytoskeleton organization
GO:0008286--P:insulin receptor signaling pathway
GO:2001237--P:negative regulation of extrinsic apoptotic signaling pathway
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0008360--P:regulation of cell shape
GO:0006357--P:regulation of transcription from RNA polymerase II promoter

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002299	Ailuropoda melanoleuca	96.47	0.00e+00	3213.00
IUUC-Atr-002600	Amborella trichopoda	31.69	4.00e-70	261.00
IUUC-Apl-003700	Anas platyrhynchos	86.66	0.00e+00	2869.00
IUUC-Aca-004474	Anolis carolinensis	82.26	0.00e+00	2819.00
IUUC-Bta-013125	Bos taurus	95.74	0.00e+00	3117.00
IUUC-Cja-018868	Callithrix jacchus	95.88	0.00e+00	3363.00
IUUC-Cfa-021179	Canis familiaris	95.88	0.00e+00	3175.00
IUUC-Cpo-022077	Cavia porcellus	91.55	0.00e+00	3082.00
IUUC-Csa-023618	Chlorocebus sabaeus	99.34	0.00e+00	3427.00
IUUC-Cho-024794	Choloepus hoffmanni	90.32	0.00e+00	872.00
IUUC-Dre-028029	Danio rerio	79.75	0.00e+00	1338.00
IUUC-Dno-030048	Dasypus novemcinctus	95.90	0.00e+00	3234.00
IUUC-Dor-030195	Dipodomys ordii	84.76	0.00e+00	1465.00
IUUC-Ete-032748	Echinops telfairi	83.44	0.00e+00	1157.00
IUUC-Eca-034274	Equus caballus	97.16	0.00e+00	3175.00
IUUC-Eeu-034688	Erinaceus europaeus	85.19	0.00e+00	1418.00
IUUC-Fca-035451	Felis catus	95.80	0.00e+00	3058.00
IUUC-Fal-037465	Ficedula albicollis	85.18	0.00e+00	2875.00
IUUC-Gmo-039451	Gadus morhua	68.58	0.00e+00	722.00
IUUC-Gga-040798	Gallus gallus	86.11	0.00e+00	2954.00
IUUC-Hsa-046757	Homo sapiens	98.74	0.00e+00	3381.00
IUUC-Hvu-047706	Hordeum vulgare	31.84	1.00e-37	150.00
IUUC-Itr-048843	Ictidomys tridecemlineatus	94.46	0.00e+00	1190.00
IUUC-Lch-050646	Latimeria chalumnae	78.29	0.00e+00	2751.00
IUUC-Laf-054140	Loxodonta africana	96.02	0.00e+00	3208.00
IUUC-Mmr-060837	Microcebus murinus	97.69	0.00e+00	1670.00
IUUC-Mdo-061903	Monodelphis domestica	94.68	0.00e+00	1712.00
IUUC-Mmu-063772	Mus musculus	94.51	0.00e+00	3257.00
IUUC-Mpu-066359	Mustela putorius furo	96.48	0.00e+00	2954.00
IUUC-Mlu-067928	Myotis lucifugus	95.02	0.00e+00	3227.00
IUUC-Nle-070094	Nomascus leucogenys	97.69	0.00e+00	3330.00
IUUC-Opr-070971	Ochotona princeps	74.84	0.00e+00	959.00
IUUC-Ont-072221	Oreochromis niloticus	75.71	0.00e+00	1316.00
IUUC-Oan-073185	Ornithorhynchus anatinus	87.68	0.00e+00	2895.00
IUUC-Ocu-074033	Oryctolagus cuniculus	95.00	0.00e+00	2876.00
IUUC-Ogl-077493	Oryza glaberrima	25.07	1.00e-33	139.00
IUUC-Ogu-078641	Oryza glumaepatula	24.28	2.00e-29	125.00
IUUC-Oin-079669	Oryza indica	31.13	4.00e-52	199.00
IUUC-Olo-080755	Oryza longistaminata	31.65	4.00e-54	207.00
IUUC-Oni-082991	Oryza nivara	27.78	2.00e-39	159.00
IUUC-Oga-088578	Otolemur garnettii	96.53	0.00e+00	3165.00
IUUC-Oar-090247	Ovis aries	96.08	0.00e+00	3120.00
IUUC-Ptr-091266	Pan troglodytes	98.71	0.00e+00	3286.00
IUUC-Pan-092734	Papio anubis	99.40	0.00e+00	3426.00
IUUC-Pfo-096191	Poecilia formosa	72.20	0.00e+00	2046.00
IUUC-Pab-098402	Pongo abelii	98.68	0.00e+00	3377.00
IUUC-Pca-101128	Procavia capensis	83.81	0.00e+00	2857.00
IUUC-Pva-103058	Pteropus vampyrus	95.34	0.00e+00	1580.00
IUUC-Rno-106013	Rattus norvegicus	93.58	0.00e+00	3136.00
IUUC-Sha-107496	Sarcophilus harrisii	91.38	0.00e+00	3097.00
IUUC-Sar-113520	Sorex araneus	91.02	0.00e+00	1539.00
IUUC-Sbi-114195	Sorghum bicolor	29.92	2.00e-58	220.00
IUUC-Ssc-115461	Sus scrofa	92.70	0.00e+00	3147.00
IUUC-Tgu-116821	Taeniopygia guttata	85.64	0.00e+00	2917.00
IUUC-Tsy-119132	Tarsius syrichta	85.10	0.00e+00	2590.00
IUUC-Tbe-127479	Tupaia belangeri	93.43	0.00e+00	1467.00
IUUC-Ttr-128427	Tursiops truncatus	90.89	0.00e+00	3056.00
IUUC-Vpa-130160	Vicugna pacos	93.37	0.00e+00	3047.00
IUUC-Xtr-132717	Xenopus tropicalis	74.35	0.00e+00	2559.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence