iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Psi-093079

Ensembl Protein ID

ENSPSIP00000006919.1

UniProt Accession

K7FFV9; K7FFV9_PELSI

Genbank Protein ID

ENSPSIP00000006919

Protein Name

E3 ubiquitin-protein ligase

Genbank Nucleotide ID

AGCU01038992

Gene Name

SIAH2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPSIG00000006388.1	ENSPSIT00000006958.1	ENSPSIP00000006919.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	99.24	6.00e-158	553.00	IUUC-Hsa-046179
E3 activity/RING/RING	98.86	1.00e-156	549.00	IUUC-Mmu-063206
E3 activity/RING/RING	99.24	1.00e-157	551.00	IUUC-Rno-105477

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Pelodiscus sinensis

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

Protein Sequence
(Fasta)

GGGGGPVSPQ HHELTSLFEC PVCFDYVLPP ILQCQAGHLV CNQCRQKLSC CPTCRGSLTP 60
SIRNLAMEKV ASAVLFPCKY ATTGCSLTLH HTEKPEHEDI CEYRPYSCPC PGASCKWQGS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCGGCGGCG GCGGGCCGGT CTCGCCTCAG CACCACGAGC TGACCTCGTT GTTCGAGTGT 60
CCCGTCTGCT TCGACTATGT GCTGCCCCCG ATCCTGCAGT GCCAGGCCGG GCATCTGGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR018121--7-in-absentia-prot_TRAF-dom
IPR001370--BIR_rpt
IPR004162--SINA-like
IPR008974--TRAF-like
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR013010--Znf_SIAH

PROSITE

PS50089--ZF_RING_2
PS51081--ZF_SIAH

Pfam

PF03145--Sina

Gene Ontology

GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007275--P:multicellular organism development
GO:0090090--P:negative regulation of canonical Wnt signaling pathway
GO:0043154--P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:2001237--P:negative regulation of extrinsic apoptotic signaling pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001409	Ailuropoda melanoleuca	99.61	9.00e-155	539.00
IUUC-Ame-011678	Astyanax mexicanus	92.09	3.00e-141	494.00
IUUC-Bta-012750	Bos taurus	99.22	7.00e-153	532.00
IUUC-Cja-019800	Callithrix jacchus	99.61	4.00e-153	533.00
IUUC-Cfa-020505	Canis familiaris	99.22	2.00e-152	531.00
IUUC-Cpo-021394	Cavia porcellus	98.84	3.00e-153	533.00
IUUC-Csa-023374	Chlorocebus sabaeus	99.61	4.00e-153	533.00
IUUC-Cho-024933	Choloepus hoffmanni	99.61	4.00e-153	533.00
IUUC-Dre-027711	Danio rerio	91.70	6.00e-141	493.00
IUUC-Dno-029260	Dasypus novemcinctus	93.94	3.00e-148	517.00
IUUC-Dor-030489	Dipodomys ordii	96.22	2.00e-107	380.00
IUUC-Ete-032946	Echinops telfairi	98.84	3.00e-155	540.00
IUUC-Eca-033546	Equus caballus	98.11	5.00e-157	546.00
IUUC-Eeu-034861	Erinaceus europaeus	95.75	1.00e-148	518.00
IUUC-Fal-037160	Ficedula albicollis	88.45	1.00e-132	465.00
IUUC-Gmo-039091	Gadus morhua	89.72	4.00e-139	486.00
IUUC-Gga-040252	Gallus gallus	98.05	1.00e-151	528.00
IUUC-Gac-041673	Gasterosteus aculeatus	89.72	2.00e-139	488.00
IUUC-Ggo-044618	Gorilla gorilla	99.61	4.00e-153	533.00
IUUC-Hsa-046179	Homo sapiens	99.61	4.00e-153	533.00
IUUC-Itr-048976	Ictidomys tridecemlineatus	98.06	1.00e-152	531.00
IUUC-Lch-049496	Latimeria chalumnae	95.04	5.00e-151	526.00
IUUC-Loc-052107	Lepisosteus oculatus	92.80	3.00e-141	494.00
IUUC-Laf-054257	Loxodonta africana	98.47	7.00e-154	535.00
IUUC-Mcc-055023	Macaca mulatta	99.61	4.00e-153	533.00
IUUC-Meu-055922	Macropus eugenii	97.65	2.00e-149	520.00
IUUC-Mga-060070	Meleagris gallopavo	94.72	3.00e-149	520.00
IUUC-Mmr-061494	Microcebus murinus	99.61	4.00e-153	533.00
IUUC-Mdo-061971	Monodelphis domestica	99.22	2.00e-152	531.00
IUUC-Mmu-063206	Mus musculus	99.61	1.00e-152	531.00
IUUC-Mpu-066597	Mustela putorius furo	99.61	4.00e-153	533.00
IUUC-Mlu-067199	Myotis lucifugus	99.22	1.00e-152	531.00
IUUC-Nle-069342	Nomascus leucogenys	99.61	4.00e-153	533.00
IUUC-Opr-070341	Ochotona princeps	56.86	4.00e-50	191.00
IUUC-Ont-071906	Oreochromis niloticus	90.12	2.00e-140	491.00
IUUC-Oan-073701	Ornithorhynchus anatinus	53.85	7.00e-50	190.00
IUUC-Ocu-073950	Oryctolagus cuniculus	99.23	4.00e-155	540.00
IUUC-Oga-089154	Otolemur garnettii	99.61	4.00e-153	533.00
IUUC-Oar-089446	Ovis aries	98.08	4.00e-155	539.00
IUUC-Ptr-091088	Pan troglodytes	99.61	4.00e-153	533.00
IUUC-Pfo-097007	Poecilia formosa	85.38	6.00e-133	466.00
IUUC-Pab-098092	Pongo abelii	99.61	4.00e-153	533.00
IUUC-Pca-100328	Procavia capensis	96.47	9.00e-148	515.00
IUUC-Pva-102368	Pteropus vampyrus	100.00	5.00e-64	237.00
IUUC-Rno-105477	Rattus norvegicus	99.61	1.00e-152	531.00
IUUC-Sha-107630	Sarcophilus harrisii	99.62	1.00e-158	551.00
IUUC-Ssc-116441	Sus scrofa	99.22	8.00e-153	532.00
IUUC-Tru-118004	Takifugu rubripes	87.35	1.00e-134	472.00
IUUC-Tsy-119548	Tarsius syrichta	89.47	2.00e-67	248.00
IUUC-Tni-120846	Tetraodon nigroviridis	88.93	4.00e-137	480.00
IUUC-Vpa-130799	Vicugna pacos	99.42	5.00e-103	365.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence