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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045743
UUCD1 version UUC-HoS-01254
Ensembl Protein ID ENSP00000311949.6
UniProt Accession Q58WW2; A2A295; B4DNB8; Q7L8I0; Q8IXH3; Q8TB19; DCAF6_HUMAN
Genbank Protein ID AAX09330.1; ABG76793.1; AAO15301.1; BAG60180.1; CAI20078.1; CAI20078.1; CAI20078.1; CAI20078.1; CAI22478.1; CAI22478.1; CAI22478.1; CAI22478.1; CAI22481.1; CAI22481.1; CAI22481.1; CAI22481.1; CAI22625.1; CAI22625.1; CAI22625.1; CAI22625.1; CAM28213.1; CAM28213.1; CAM28213.1; CAM28213.1; CAM28292.1; CAM28292.1; CAM28292.1; CAM28292.1; CAM28293.1; CAM28293.1; CAM28293.1; CAM28293.1; CAM28303.1; CAM28303.1; CAM28303.1; CAM28303.1; EAW90809.1; AAH25262.2; CAB66672.2
Protein Name DDB1- and CUL4-associated factor 6; Androgen receptor complex-associated protein; IQ motif and WD repeat-containing protein 1; Nuclear receptor interaction protein
Genbank Nucleotide ID AY766164; DQ768089; AF116725; AK297847; Z97876; AL031287; AL033531; AL033532; AL033531; AL031287; AL033532; Z97876; AL031287; AL033531; AL033532; Z97876; AL033532; AL031287; AL033531; Z97876; Z97876; AL031287; AL033531; AL033532; AL033531; AL031287; AL033532; Z97876; AL031287; AL033531; AL033532; Z97876; AL033532; AL031287; AL033531; Z97876; CH471067; BC025262; AL136738
Gene Name DCAF6; IQWD1; MSTP055
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000143164.15 ENST00000367843.7 ENSP00000356817.3
ENSG00000143164.15 ENST00000470721.5 ENSP00000432304.1
ENSG00000143164.15 ENST00000312263.10 ENSP00000311949.6
ENSG00000143164.15 ENST00000367840.3 ENSP00000356814.3
ENSG00000143164.15 ENST00000432587.6 ENSP00000396238.2
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
RepTarmiRNAMapSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
ClinVarGWAS CentralOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtBioGRID
mUbiSiDa
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/DCX/DWD WD_repeat 17588513
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 3.40e-16 60.3 92 120
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf....sdtllvsGsdDgti 25
           gH + +++ +f    +d+ +vs+s+Dg+i
   Q: 92   GHRANIFSAKFlpctNDKQIVSCSGDGVI 120
           8************9777**********98 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Ligand-dependent coactivator of nuclear receptors. Enhance transcriptional activity of the nuclear receptors NR3C1 and AR. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
 Ligand-dependent coactivator of nuclear receptors. Enhance transcriptional activity of the nuclear receptors NR3C1 and AR. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
Protein Sequence
(Fasta)
MSRGGSYPHL LWDVRKRSLG LEDPSRLRSR YLGRREFIQR LKLEATLNVH DGCVNTICWN 60
DTGEYILSGS DDTKLVISNP YSRKVLTTIR SGHRANIFSA KFLPCTNDKQ IVSCSGDGVI 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045743|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ACTTTATCGA GGAGCCGGTG GTAGGTGGCC CGCAGGCCTC GGGCACCGGC GGCCGACATC 60
GCCGCCGAGG GATCGTTGGC AGCCGGGTGG GAGCGTGGCT GTGTTCTCGT CCCTGGCTGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045743|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat
Interpro

IPR000048--IQ_motif_EF-hand-BS
IPR002469--Peptidase_S9B_N
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
PROSITE

PS50096--IQ
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0080008--C:Cul4-RING E3 ubiquitin ligase complex
GO:0005829--C:cytosol
GO:0005925--C:focal adhesion
GO:0005634--C:nucleus
GO:0030374--F:ligand-dependent nuclear receptor transcription coactivator activity
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0016567--P:protein ubiquitination
KEGG hsa:55827
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001399 Ailuropoda melanoleuca 93.91 0.00e+00 869.00
IUUC-Apl-003181 Anas platyrhynchos 80.21 0.00e+00 1206.00
IUUC-Aca-004953 Anolis carolinensis 85.58 0.00e+00 677.00
IUUC-Acl-008211 Aspergillus clavatus 27.64 4.00e-27 117.00
IUUC-Afu-008828 Aspergillus fumigatus 28.05 7.00e-28 119.00
IUUC-Ate-010555 Aspergillus terreus 25.85 3.00e-25 111.00
IUUC-Ame-011314 Astyanax mexicanus 85.59 0.00e+00 665.00
IUUC-Bta-013552 Bos taurus 90.23 0.00e+00 1481.00
IUUC-Cja-019015 Callithrix jacchus 98.91 0.00e+00 869.00
IUUC-Cfa-021249 Canis familiaris 96.30 0.00e+00 834.00
IUUC-Cpo-021903 Cavia porcellus 94.13 0.00e+00 862.00
IUUC-Csa-023744 Chlorocebus sabaeus 99.13 0.00e+00 870.00
IUUC-Cho-024527 Choloepus hoffmanni 80.36 5.00e-178 618.00
IUUC-Dre-028040 Danio rerio 86.16 0.00e+00 667.00
IUUC-Dno-029777 Dasypus novemcinctus 96.74 0.00e+00 848.00
IUUC-Dor-030879 Dipodomys ordii 86.96 0.00e+00 798.00
IUUC-Ete-032607 Echinops telfairi 68.59 4.00e-140 492.00
IUUC-Eca-033396 Equus caballus 94.08 0.00e+00 1403.00
IUUC-Eeu-034944 Erinaceus europaeus 70.74 6.00e-147 515.00
IUUC-Fca-036020 Felis catus 89.11 0.00e+00 1455.00
IUUC-Fal-037527 Ficedula albicollis 74.19 0.00e+00 1141.00
IUUC-Gmo-039347 Gadus morhua 83.19 0.00e+00 638.00
IUUC-Gga-040564 Gallus gallus 77.88 0.00e+00 1213.00
IUUC-Gac-042029 Gasterosteus aculeatus 84.46 0.00e+00 649.00
IUUC-Ggo-045634 Gorilla gorilla 98.81 0.00e+00 714.00
IUUC-Itr-048064 Ictidomys tridecemlineatus 92.51 0.00e+00 1430.00
IUUC-Lch-050457 Latimeria chalumnae 81.64 0.00e+00 700.00
IUUC-Loc-052880 Lepisosteus oculatus 87.22 0.00e+00 667.00
IUUC-Lma-053032 Leptosphaeria maculans 29.74 1.00e-27 119.00
IUUC-Laf-053836 Loxodonta africana 90.38 0.00e+00 1143.00
IUUC-Mcc-055749 Macaca mulatta 99.13 0.00e+00 868.00
IUUC-Mga-059293 Meleagris gallopavo 75.78 0.00e+00 1115.00
IUUC-Mmr-060923 Microcebus murinus 97.61 0.00e+00 870.00
IUUC-Mdo-063056 Monodelphis domestica 83.33 0.00e+00 1304.00
IUUC-Mmu-063121 Mus musculus 86.21 0.00e+00 1456.00
IUUC-Mpu-066035 Mustela putorius furo 91.69 0.00e+00 766.00
IUUC-Mlu-067903 Myotis lucifugus 88.91 0.00e+00 1402.00
IUUC-Nfi-068606 Neosartorya fischeri 27.76 2.00e-27 118.00
IUUC-Nle-069415 Nomascus leucogenys 99.53 0.00e+00 826.00
IUUC-Opr-070809 Ochotona princeps 78.53 5.00e-141 495.00
IUUC-Ont-071470 Oreochromis niloticus 84.46 0.00e+00 649.00
IUUC-Oan-072748 Ornithorhynchus anatinus 89.85 1.00e-131 462.00
IUUC-Ocu-073865 Oryctolagus cuniculus 91.08 0.00e+00 1390.00
IUUC-Ola-086755 Oryzias latipes 83.33 0.00e+00 644.00
IUUC-Oga-088309 Otolemur garnettii 79.13 0.00e+00 700.00
IUUC-Oar-090264 Ovis aries 96.30 0.00e+00 864.00
IUUC-Ptr-090603 Pan troglodytes 99.57 0.00e+00 873.00
IUUC-Pan-092480 Papio anubis 97.14 0.00e+00 1562.00
IUUC-Psi-092973 Pelodiscus sinensis 80.95 0.00e+00 957.00
IUUC-Pfo-096506 Poecilia formosa 83.90 0.00e+00 644.00
IUUC-Pab-097581 Pongo abelii 91.14 0.00e+00 1425.00
IUUC-Pca-100155 Procavia capensis 88.67 0.00e+00 748.00
IUUC-Pva-103022 Pteropus vampyrus 97.18 0.00e+00 704.00
IUUC-Pte-104187 Pyrenophora teres 30.00 2.00e-28 121.00
IUUC-Pyt-104546 Pyrenophora triticirepentis 29.35 3.00e-27 117.00
IUUC-Rno-105851 Rattus norvegicus 92.83 0.00e+00 863.00
IUUC-Sha-106790 Sarcophilus harrisii 80.25 0.00e+00 1283.00
IUUC-Sja-107779 Schizosaccharomyces japonicus 32.59 8.00e-35 142.00
IUUC-Spo-108129 Schizosaccharomyces pombe 31.86 2.00e-33 138.00
IUUC-Ssc-115801 Sus scrofa 83.45 5.00e-121 427.00
IUUC-Tgu-116760 Taeniopygia guttata 79.10 0.00e+00 1154.00
IUUC-Tru-118422 Takifugu rubripes 84.18 0.00e+00 644.00
IUUC-Tni-120340 Tetraodon nigroviridis 84.57 0.00e+00 641.00
IUUC-Tbe-127997 Tupaia belangeri 74.71 6.00e-166 578.00
IUUC-Ttr-129311 Tursiops truncatus 87.85 0.00e+00 744.00
IUUC-Vpa-130145 Vicugna pacos 96.02 0.00e+00 783.00
IUUC-Xtr-132496 Xenopus tropicalis 63.21 0.00e+00 982.00
IUUC-Xma-133610 Xiphophorus maculatus 84.75 0.00e+00 647.00
Created Date 25-Jun-2017

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