iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Cfa-020983

Ensembl Protein ID

ENSCAFP00000026084.3

UniProt Accession

E2RMF7; E2RMF7_CANLF

Genbank Protein ID

ENSCAFP00000026084

Protein Name

Tyrosine-protein kinase

Genbank Nucleotide ID

AAEX03026717

Gene Name

BTK

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCAFG00000017669.3	ENSCAFT00000028042.3	ENSCAFP00000026084.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.90e-13	50.4	216	273

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           ++kv +lydy++ n ++L+l+kG+  +++  ee +  W+++ ++ +g++G +P+n+v+++e
   Q: 216  LKKVVALYDYMPMNANDLQLRKGEEYFIL--EESNLPWWRA-RDKNGQEGYIPSNYVTEAE 273
           689*************************9..9999******.6***************987 PP

Organism

Canis familiaris

Protein Sequence
(Fasta)

MAAVILESIF LKRSQQKKKT SPLNFKKRLF LLTMHKLSYY EYDFERGRRG SKKGSIDVEK 60
ITCVETVVPE KNPPPERQIP RRGEESSEME QISIIERFPY PFQVVYDEGP LYVFSPTEEL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGGTAGTTT GGGACAGCAG CAGGGAACCA AATACCATGC TACTGAGAAG AAAAAAAAAG 60
ACATTGGTTT AAGTCAGGAA ACAAAAAAAG GGAACTGAGT GGCTGTGAAA GGGTGGGGTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom
IPR001562--Znf_Btk_motif

PROSITE

PS50003--PH_DOMAIN
PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3
PS51113--ZF_BTK

Pfam

PF00779--BTK
PF00169--PH
PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00402--TECBTKDOMAIN
PR00109--TYRKINASE

SMART

SM00107--BTK
SM00233--PH
SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0031410--C:cytoplasmic vesicle
GO:0005829--C:cytosol
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0045121--C:membrane raft
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0005547--F:phosphatidylinositol-3,4,5-trisphosphate binding
GO:0005102--F:receptor binding
GO:0002344--P:B cell affinity maturation
GO:0030154--P:cell differentiation
GO:0048469--P:cell maturation
GO:0098761--P:cellular response to interleukin-7
GO:0007249--P:I-kappaB kinase/NF-kappaB signaling
GO:0045087--P:innate immune response
GO:0030889--P:negative regulation of B cell proliferation
GO:0001818--P:negative regulation of cytokine production
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0042127--P:regulation of cell proliferation
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

cfa:492019

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001365	Ailuropoda melanoleuca	99.24	0.00e+00	1315.00
IUUC-Apl-003907	Anas platyrhynchos	86.87	0.00e+00	1157.00
IUUC-Aca-004978	Anolis carolinensis	77.00	0.00e+00	1065.00
IUUC-Ame-010694	Astyanax mexicanus	57.18	5.00e-153	534.00
IUUC-Bta-012467	Bos taurus	98.33	0.00e+00	1304.00
IUUC-Cja-018841	Callithrix jacchus	98.03	0.00e+00	1301.00
IUUC-Cpo-021307	Cavia porcellus	98.94	0.00e+00	1312.00
IUUC-Csa-023508	Chlorocebus sabaeus	98.79	0.00e+00	976.00
IUUC-Dre-028544	Danio rerio	58.21	6.00e-149	520.00
IUUC-Dno-029828	Dasypus novemcinctus	96.97	0.00e+00	1278.00
IUUC-Dor-030102	Dipodomys ordii	90.85	0.00e+00	1084.00
IUUC-Ete-032981	Echinops telfairi	89.53	0.00e+00	1165.00
IUUC-Eca-033594	Equus caballus	99.09	0.00e+00	1311.00
IUUC-Eeu-035281	Erinaceus europaeus	93.55	0.00e+00	1029.00
IUUC-Fca-035495	Felis catus	98.63	0.00e+00	1264.00
IUUC-Fal-036719	Ficedula albicollis	86.49	0.00e+00	1184.00
IUUC-Gga-041193	Gallus gallus	86.19	0.00e+00	1156.00
IUUC-Gac-042383	Gasterosteus aculeatus	46.76	1.00e-128	453.00
IUUC-Hsa-045931	Homo sapiens	98.94	0.00e+00	1281.00
IUUC-Itr-048061	Ictidomys tridecemlineatus	98.63	0.00e+00	1306.00
IUUC-Lch-049868	Latimeria chalumnae	75.92	0.00e+00	995.00
IUUC-Loc-052730	Lepisosteus oculatus	58.20	1.00e-164	573.00
IUUC-Laf-053516	Loxodonta africana	98.18	0.00e+00	1328.00
IUUC-Mcc-054795	Macaca mulatta	98.94	0.00e+00	1282.00
IUUC-Meu-056157	Macropus eugenii	84.83	0.00e+00	1098.00
IUUC-Mga-059529	Meleagris gallopavo	86.18	0.00e+00	987.00
IUUC-Mmr-060824	Microcebus murinus	93.93	0.00e+00	1198.00
IUUC-Mdo-063036	Monodelphis domestica	94.99	0.00e+00	1259.00
IUUC-Mmu-064047	Mus musculus	98.33	0.00e+00	1308.00
IUUC-Mpu-066810	Mustela putorius furo	98.94	0.00e+00	1313.00
IUUC-Mlu-067671	Myotis lucifugus	97.59	0.00e+00	1297.00
IUUC-Nle-069108	Nomascus leucogenys	98.94	0.00e+00	1281.00
IUUC-Opr-070505	Ochotona princeps	78.64	0.00e+00	692.00
IUUC-Ont-072585	Oreochromis niloticus	58.37	5.00e-161	560.00
IUUC-Oan-073495	Ornithorhynchus anatinus	92.87	0.00e+00	1267.00
IUUC-Ocu-074416	Oryctolagus cuniculus	98.48	0.00e+00	1305.00
IUUC-Ola-086938	Oryzias latipes	59.30	3.00e-157	548.00
IUUC-Oga-088995	Otolemur garnettii	97.28	0.00e+00	1264.00
IUUC-Oar-089632	Ovis aries	97.27	0.00e+00	1280.00
IUUC-Ptr-090941	Pan troglodytes	98.94	0.00e+00	1281.00
IUUC-Pan-091900	Papio anubis	95.90	0.00e+00	1231.00
IUUC-Psi-093048	Pelodiscus sinensis	85.93	0.00e+00	1129.00
IUUC-Pfo-096955	Poecilia formosa	60.28	1.00e-164	572.00
IUUC-Pab-097587	Pongo abelii	98.79	0.00e+00	1281.00
IUUC-Pca-100374	Procavia capensis	89.26	2.00e-149	522.00
IUUC-Pva-102583	Pteropus vampyrus	98.33	0.00e+00	1280.00
IUUC-Rno-104868	Rattus norvegicus	93.66	0.00e+00	1224.00
IUUC-Sha-106744	Sarcophilus harrisii	93.63	0.00e+00	1277.00
IUUC-Sar-113041	Sorex araneus	98.13	0.00e+00	1127.00
IUUC-Ssc-115294	Sus scrofa	98.63	0.00e+00	1308.00
IUUC-Tgu-116458	Taeniopygia guttata	53.39	0.00e+00	721.00
IUUC-Tsy-118945	Tarsius syrichta	97.18	0.00e+00	865.00
IUUC-Ttr-128769	Tursiops truncatus	88.77	0.00e+00	1166.00
IUUC-Vpa-130517	Vicugna pacos	93.11	0.00e+00	733.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence