iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ssc-116091

Ensembl Protein ID

ENSSSCP00000025243.1

UniProt Accession

I3LMC2; I3LMC2_PIG

Genbank Protein ID

ENSSSCP00000025243

Protein Name

Ubiquitin carboxyl-terminal hydrolase 16; Deubiquitinating enzyme 16; Ubiquitin thioesterase 16; Ubiquitin-specific-processing protease 16

Genbank Nucleotide ID

FP236679

Gene Name

USP16

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSSCG00000027594.1	ENSSSCT00000029188.1	ENSSSCP00000025243.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.30e-91	307.6	198	825

Active Site

Position(s)	Description	Evidence
207	Nucleophile	ECO:0000256\|HAMAP-Rule:MF_03062}
761	Proton acceptor	ECO:0000256\|HAMAP-Rule:MF_03062}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle..........kkkeklneenp............kepkgellkslqklfeelwkskkka 67
           +Gl+NlgNtC++N+v+Q Ls++p lrell+e          +         p             ep g+l+ ++ ++++e++++kk+ 
   Q: 198  KGLSNLGNTCFFNAVMQNLSQTPVLRELLKEvkmsgtivkiE---------PpdlaltepleinLEPPGPLTLAMSQFLNEMQETKKGI 277
           5******************************86555555540.........24555555555658899********************* PP
   S: 68   vsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlk 151
           v+prel+++++k+a++f+gy+qqD+qE+l++lld+++ e +++ +k + +++++++++l++e     ++++kkk+ +s+++++F+g+l+
   Q: 278  VTPRELFSQVCKKAVRFKGYQQQDSQELLRYLLDGMRAEEHQRVSKGILKAFGNSTEKLDEElknkvKDYEKKKSVPSFVDRIFGGELT 366
           *************************************************************99999999******************** PP
   S: 152  sqikclecdnvssreepfldlslpvpgkeetkke....................................................... 185
           s+i+c ec++vs  +e+fldlslpv ++++ kk+                                                       
   Q: 367  STIMCDECRTVSLVHESFLDLSLPVLDDQSGKKSindknlkktmededkdceeekdndsyikerndipsgtskhlqkkakkqakkqaky 455
           *****************************99999******************************************************* PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 456  qrrqqkiqgkvlhlndvcavdhpedneceveastsevdvksshtsqeevmhkeccekdlnghektvesvtdnqksteegdmkivnldnd 544
           ***************************************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 545  levlassptectgnlngaylkagsngevdissgfknlnlnaalepdeinieilnddltpgakvyevvnedpetafctlanreafntdec 633
           ***************************************************************************************** PP
   S: 186  slqdcLesftkeeelegenkyycekckkkqe..................aekklklkklPevLilhLkRfsfseeqksrekinkkvefp 256
           s+q+cL +ft++e+l+++nk+ ce c+++q                   a+k++ ++  P+vL+lhLkRf  ++++ + +k+nk+++fp
   Q: 634  SIQHCLYQFTRNEKLRDANKLLCEVCTRRQYsgpkanikegerkhvytnAKKQMLISLAPPVLTLHLKRF--QQAGFNLRKVNKHIKFP 720
           ***************************7777888888888888888888*********************..9999************* PP
   S: 257  leLdlspfctspeekqke...kkkYeLiavvvHsGslssGHYvayvkn........................ekgkWllfdDskVtevk 318
           + Ldl+pfct ++++++e   ++ Y+L++vv HsG+++sGHY+ay+k                         +kg+W++++D++V++v+
   Q: 721  EILDLAPFCTLKCKNVAEentRVLYSLYGVVEHSGTMRSGHYTAYAKArtanshlsdlvlhgdipqdfemesTKGQWFHISDTHVQAVP 809
           ***********9999887777999************************9999999999999999999999888999************* PP
   S: 319  eeevleetgstaYvlfYkr 337
            ++vl+   s+aY+lfY+r
   Q: 810  TTKVLN---SQAYLLFYER 825
           ******...********98 PP

Organism

Sus scrofa

Functional Description
(View)

Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.

Protein Sequence
(Fasta)

MGKKRTKGKT VPIDDSSESL EPTCRHIRKG LEQGNLKKAL VNVEWNICQD CKTDNKVKDK 60
SEEETENPSV WLCLKCGHQG CGRDSQEQHA LKHYMTPRSE PHCLVLSLDN WSVWCYLCDD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGGGGCCAAA GCCACTTCCC ATGATGCTGC GTACCGGAAG TTGTTGCTTT CTAGGGGTCA 60
CGCTGGCTTC GGCTCTGTCG CTCTCAATTC GTCACCAGGA GGAAGACGCA GCTGGTTGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0010--Activator
KW-0131--Cell cycle
KW-0132--Cell division
KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0498--Mitosis
KW-0539--Nucleus
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR030849--UBP16
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0005634--C:nucleus
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0003713--F:transcription coactivator activity
GO:0008270--F:zinc ion binding
GO:0051301--P:cell division
GO:0006974--P:cellular response to DNA damage stimulus
GO:0070537--P:histone H2A K63-linked deubiquitination
GO:0007067--P:mitotic nuclear division
GO:0035522--P:monoubiquitinated histone H2A deubiquitination
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0045901--P:positive regulation of translational elongation
GO:0051289--P:protein homotetramerization
GO:0051726--P:regulation of cell cycle
GO:0006351--P:transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000997	Aegilops tauschii	29.34	7.00e-29	122.00
IUUC-Aml-001931	Ailuropoda melanoleuca	91.10	0.00e+00	1395.00
IUUC-Atr-003015	Amborella trichopoda	31.89	7.00e-36	145.00
IUUC-Apl-004145	Anas platyrhynchos	63.38	0.00e+00	900.00
IUUC-Aca-004314	Anolis carolinensis	59.58	0.00e+00	883.00
IUUC-Aly-006422	Arabidopsis lyrata	29.04	4.00e-29	123.00
IUUC-Ath-006732	Arabidopsis thaliana	31.30	5.00e-34	139.00
IUUC-Ame-011659	Astyanax mexicanus	49.09	1.00e-111	397.00
IUUC-Bta-013362	Bos taurus	92.06	0.00e+00	1418.00
IUUC-Bdi-014624	Brachypodium distachyon	30.09	2.00e-28	120.00
IUUC-Bol-015941	Brassica oleracea	29.79	1.00e-32	135.00
IUUC-Bra-016751	Brassica rapa	29.15	2.00e-30	127.00
IUUC-Cja-019177	Callithrix jacchus	91.34	0.00e+00	1435.00
IUUC-Cfa-020051	Canis familiaris	91.58	0.00e+00	1416.00
IUUC-Cpo-021886	Cavia porcellus	80.53	0.00e+00	1278.00
IUUC-Csa-024103	Chlorocebus sabaeus	91.22	0.00e+00	1438.00
IUUC-Cho-024315	Choloepus hoffmanni	78.47	2.00e-129	456.00
IUUC-Cin-025775	Ciona intestinalis	51.06	2.00e-40	157.00
IUUC-Csv-026075	Ciona savignyi	52.13	3.00e-58	219.00
IUUC-Cme-027348	Cyanidioschyzon merolae	38.51	4.00e-20	92.80
IUUC-Dno-029409	Dasypus novemcinctus	88.45	0.00e+00	1390.00
IUUC-Dor-030443	Dipodomys ordii	79.28	0.00e+00	650.00
IUUC-Ete-032807	Echinops telfairi	85.04	0.00e+00	691.00
IUUC-Eca-033479	Equus caballus	91.82	0.00e+00	1443.00
IUUC-Eeu-034835	Erinaceus europaeus	83.45	0.00e+00	656.00
IUUC-Fca-036320	Felis catus	92.42	0.00e+00	1460.00
IUUC-Fal-037029	Ficedula albicollis	61.09	0.00e+00	848.00
IUUC-Gmo-039480	Gadus morhua	52.72	6.00e-116	411.00
IUUC-Gga-040527	Gallus gallus	63.66	0.00e+00	923.00
IUUC-Gac-042343	Gasterosteus aculeatus	50.69	6.00e-115	408.00
IUUC-Gma-044402	Glycine max	28.17	2.00e-32	134.00
IUUC-Ggo-045598	Gorilla gorilla	90.73	0.00e+00	1426.00
IUUC-Hsa-046598	Homo sapiens	90.61	0.00e+00	1418.00
IUUC-Hvu-047146	Hordeum vulgare	36.41	2.00e-27	118.00
IUUC-Itr-047951	Ictidomys tridecemlineatus	89.89	0.00e+00	1412.00
IUUC-Lch-050536	Latimeria chalumnae	56.66	5.00e-129	455.00
IUUC-Lpe-050703	Leersia perrieri	28.44	4.00e-28	120.00
IUUC-Loc-051814	Lepisosteus oculatus	56.48	3.00e-126	445.00
IUUC-Laf-053732	Loxodonta africana	86.88	0.00e+00	1397.00
IUUC-Mcc-054661	Macaca mulatta	91.58	0.00e+00	1441.00
IUUC-Meu-055967	Macropus eugenii	73.08	6.00e-156	544.00
IUUC-Mtr-057945	Medicago truncatula	31.23	2.00e-33	137.00
IUUC-Mga-059551	Meleagris gallopavo	63.43	0.00e+00	929.00
IUUC-Mmr-061747	Microcebus murinus	91.49	0.00e+00	1401.00
IUUC-Mdo-062220	Monodelphis domestica	68.95	0.00e+00	1055.00
IUUC-Mmu-063582	Mus musculus	81.25	0.00e+00	1244.00
IUUC-Mpu-066339	Mustela putorius furo	91.10	0.00e+00	1440.00
IUUC-Mlu-067511	Myotis lucifugus	86.40	0.00e+00	1336.00
IUUC-Nle-069252	Nomascus leucogenys	91.34	0.00e+00	1438.00
IUUC-Opr-070969	Ochotona princeps	86.03	0.00e+00	1295.00
IUUC-Ont-071786	Oreochromis niloticus	51.31	1.00e-117	417.00
IUUC-Ocu-074704	Oryctolagus cuniculus	90.65	0.00e+00	1396.00
IUUC-Oba-075094	Oryza barthii	29.00	6.00e-30	126.00
IUUC-Obr-076743	Oryza brachyantha	30.89	4.00e-30	126.00
IUUC-Ogl-077739	Oryza glaberrima	29.00	4.00e-30	126.00
IUUC-Ogu-078851	Oryza glumaepatula	29.00	6.00e-30	126.00
IUUC-Oin-079402	Oryza indica	29.00	6.00e-30	126.00
IUUC-Olo-080431	Oryza longistaminata	29.00	5.00e-30	126.00
IUUC-Ome-081580	Oryza meridionalis	29.00	8.00e-30	125.00
IUUC-Oni-082644	Oryza nivara	29.00	6.00e-30	126.00
IUUC-Opu-083452	Oryza punctata	29.66	1.00e-29	125.00
IUUC-Oru-084546	Oryza rufipogon	29.00	6.00e-30	126.00
IUUC-Osa-085858	Oryza sativa	29.00	6.00e-30	126.00
IUUC-Ola-086795	Oryzias latipes	48.89	4.00e-114	405.00
IUUC-Oga-088713	Otolemur garnettii	89.41	0.00e+00	1401.00
IUUC-Oar-089887	Ovis aries	92.66	0.00e+00	1430.00
IUUC-Ptr-091670	Pan troglodytes	91.10	0.00e+00	1432.00
IUUC-Pan-092293	Papio anubis	91.58	0.00e+00	1441.00
IUUC-Psi-093101	Pelodiscus sinensis	66.03	0.00e+00	923.00
IUUC-Ppa-095825	Physcomitrella patens	30.15	2.00e-33	137.00
IUUC-Pfo-097202	Poecilia formosa	49.67	4.00e-118	418.00
IUUC-Pab-098773	Pongo abelii	90.71	0.00e+00	1112.00
IUUC-Pop-099136	Populus trichocarpa	29.38	1.00e-39	158.00
IUUC-Pca-101069	Procavia capensis	70.62	0.00e+00	851.00
IUUC-Ppe-101794	Prunus persica	29.97	5.00e-36	146.00
IUUC-Pva-103092	Pteropus vampyrus	86.13	0.00e+00	662.00
IUUC-Rno-105237	Rattus norvegicus	81.87	0.00e+00	1254.00
IUUC-Sha-106889	Sarcophilus harrisii	72.80	0.00e+00	1110.00
IUUC-Sit-110283	Setaria italica	32.38	1.00e-29	125.00
IUUC-Sly-111487	Solanum lycopersicum	29.52	6.00e-38	152.00
IUUC-Stu-112820	Solanum tuberosum	29.05	1.00e-37	151.00
IUUC-Sar-113530	Sorex araneus	82.45	0.00e+00	1297.00
IUUC-Sbi-113785	Sorghum bicolor	35.48	2.00e-25	111.00
IUUC-Tgu-117478	Taeniopygia guttata	59.98	0.00e+00	877.00
IUUC-Tru-118640	Takifugu rubripes	52.67	8.00e-120	424.00
IUUC-Tsy-119042	Tarsius syrichta	76.60	0.00e+00	880.00
IUUC-Tni-120015	Tetraodon nigroviridis	45.57	4.00e-179	621.00
IUUC-Tca-121701	Theobroma cacao	28.39	9.00e-38	152.00
IUUC-Tae-125351	Triticum aestivum	29.61	6.00e-27	116.00
IUUC-Tur-126788	Triticum urartu	28.70	2.00e-26	114.00
IUUC-Tbe-127309	Tupaia belangeri	73.09	0.00e+00	1082.00
IUUC-Ttr-128271	Tursiops truncatus	92.78	0.00e+00	1454.00
IUUC-Vpa-130674	Vicugna pacos	91.93	0.00e+00	1327.00
IUUC-Xtr-131869	Xenopus tropicalis	52.28	0.00e+00	791.00
IUUC-Xma-134195	Xiphophorus maculatus	44.51	0.00e+00	644.00
IUUC-Zma-135157	Zea mays	31.50	7.00e-27	115.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence