iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tni-120015

UUCD1 version

UUC-TeN-01151

Ensembl Protein ID

ENSTNIP00000022216.1

UniProt Accession

H3DNW7; H3DNW7_TETNG

Protein Name

Ubiquitin carboxyl-terminal hydrolase 16; Deubiquitinating enzyme 16; Ubiquitin thioesterase 16; Ubiquitin-specific-processing protease 16

Gene Name

usp16; USP16

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTNIG00000019025.1	ENSTNIT00000022455.1	ENSTNIP00000022216.1
ENSTNIG00000019025.1	ENSTNIT00000001143.1	ENSTNIP00000004072.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	4.00e-87	292.7	201	818

Active Site

Position(s)	Description	Evidence
210	Nucleophile	ECO:0000256\|HAMAP-Rule:MF_03062}
761	Proton acceptor	ECO:0000256\|HAMAP-Rule:MF_03062}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle........kkkeklneenp...........kepkgellkslqklfeelwkskkkavsp 70
           +Gl+NlgNtC++N+v+Q Ls+++ lr++l+          k+       +            +++g+l+ ++ +l++e+ +skk++v+p
   Q: 201  KGLSNLGNTCFFNAVIQNLSQTQLLRQNLNVvikdtslsIKP-------DaclnldplevqLDKSGPLTLAMCQLLNEMRDSKKGVVTP 282
           5****************************9986656555333.......1344444477779999************************ PP
   S: 71   rellkalkkeaeefsgyeqqDaqEflaflldqleeelkk.....eknkpkeeeeeedkselsde......aeekkkkknkslisdlFqg 148
           ++l+++++k+a +f+g++qqD+qE+l++lld+++ e  k            e+ +e+k+ +++e      +e++k    k++++ +F+g
   Q: 283  QQLFTQVCKKAARFKGFQQQDSQELLRYLLDAVRAEEIKrvslgI-----REAVKESKKITDEEqlkkslKEYEKSGLPKNIVDSVFGG 366
           *********************************988866355541.....444333333333332333347777777788********* PP
   S: 149  qlksqikclecdnvssreepfldlslpvpgkeetkke.................................................... 185
           +l+s+i+c++c++vs+ +e fldlslpv+++  +kk+                                                    
   Q: 367  ELTSTIMCQQCKTVSVVTEMFLDLSLPVSDEAYRKKNlkkgpntcglthsdrkspalvneddnavpgskyqqkkakkqakkqakhqkrq 455
           ********************************998889*************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 456  qklegrvtlealsppnhpessqtvsaadlndeenqdnersreasmseenqisvseadregsdthqamkdqdedslvdedtptpsvnpfa 544
           ***************************************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 545  ilaedqhtkpvasddngkgdvcdeaennlvieiekvtlddafledpdasehppeaedeqkesreytvvnqdpklafhtlrtrtvpegqe 633
           ***************************************************************************************** PP
   S: 186  .slqdcLesftkeeelegenkyycekckkkqe.................aekklklkklPevLilhLkRfsfseeqksrekinkkvefp 256
            s+++cL  ft+ e+l+++n + c +c+++q                  a k++ +++lP+vL+lhLkRf  ++++ s  k+n++v+fp
   Q: 634  cSVHSCLFRFTEVETLTQNNSLLCVTCTQQQPkkdkglfalgsknvytdALKQMLISSLPPVLTLHLKRF--QQNGFSICKVNRHVQFP 720
           ****************************888899999999999999999*********************..88999999********* PP
   S: 257  leLdlspfctspeekqke...kkkYeLiavvvHsGslssGHYvayvkn................ekgkWllfdDskVtevkeeevleet 326
           l Ldl+pfc  +++++++   +  Y+L+++v HsG+++sGHY+ayvk                  +g+W++++D++V++v+e++v++  
   Q: 721  LILDLAPFCGVKCKNVADgepQALYSLYGIVEHSGTMRSGHYTAYVKVrpegpklasngqdvepPRGSWYHISDTSVQPVSESKVQS-- 807
           ***********999988788899*************************99999998877777766888*******************.. PP
   S: 327  gstaYvlfYkrr 338
            ++aY+lfY+r+
   Q: 808  -CQAYLLFYERM 818
           .*********96 PP

Organism

Tetraodon nigroviridis

Functional Description
(View)

Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.

Protein Sequence
(Fasta)

MGKKRGKDKN SREEEDADVI GPSCRHIKKG TDQTLLKKLS GNSNWTSCQD CRNEEKKEGT 60
STCMQQGCGE EQETPGLWMC LKCGHSGCGR NSEKQHAIQH YETPHSDPHC LVISLDSWSV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGGAAGA AACGAGGCAA GGACAAGAAC TCAAGGGAAG AAGAGGACGC GGACGTAATA 60
GGTAATCATA GAAAAACGCG TTTTTATATG ATCATCAGTC ATCTGGAATG ATGGCAACGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0010--Activator
KW-0131--Cell cycle
KW-0132--Cell division
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0498--Mitosis
KW-0539--Nucleus
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR030849--UBP16
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0005634--C:nucleus
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0003713--F:transcription coactivator activity
GO:0008270--F:zinc ion binding
GO:0051301--P:cell division
GO:0016578--P:histone deubiquitination
GO:0007067--P:mitotic nuclear division
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0051289--P:protein homotetramerization
GO:0051726--P:regulation of cell cycle
GO:0006351--P:transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000997	Aegilops tauschii	34.01	1.00e-24	108.00
IUUC-Aml-001931	Ailuropoda melanoleuca	51.72	5.00e-113	402.00
IUUC-Atr-003015	Amborella trichopoda	28.64	3.00e-33	137.00
IUUC-Apl-004145	Anas platyrhynchos	53.85	2.00e-103	370.00
IUUC-Aca-004314	Anolis carolinensis	44.77	7.00e-170	590.00
IUUC-Aly-006422	Arabidopsis lyrata	28.88	7.00e-27	116.00
IUUC-Ath-006732	Arabidopsis thaliana	28.86	1.00e-30	128.00
IUUC-Ame-011659	Astyanax mexicanus	52.90	5.00e-125	441.00
IUUC-Bta-013362	Bos taurus	45.96	3.00e-175	608.00
IUUC-Bdi-014624	Brachypodium distachyon	35.42	6.00e-25	109.00
IUUC-Bol-015853	Brassica oleracea	42.96	2.00e-26	114.00
IUUC-Bra-016751	Brassica rapa	29.05	3.00e-26	114.00
IUUC-Cja-019177	Callithrix jacchus	47.05	0.00e+00	631.00
IUUC-Cfa-020051	Canis familiaris	51.36	3.00e-113	402.00
IUUC-Cpo-021886	Cavia porcellus	43.06	1.00e-163	569.00
IUUC-Csa-024103	Chlorocebus sabaeus	46.98	0.00e+00	634.00
IUUC-Cho-024315	Choloepus hoffmanni	45.16	2.00e-44	174.00
IUUC-Cin-025775	Ciona intestinalis	48.94	1.00e-38	151.00
IUUC-Csv-026075	Ciona savignyi	46.60	2.00e-48	187.00
IUUC-Dre-028388	Danio rerio	53.17	0.00e+00	753.00
IUUC-Dno-029409	Dasypus novemcinctus	45.40	2.00e-178	619.00
IUUC-Ete-032807	Echinops telfairi	46.95	1.00e-90	327.00
IUUC-Eca-033479	Equus caballus	45.78	1.00e-178	619.00
IUUC-Eeu-034835	Erinaceus europaeus	47.46	5.00e-67	248.00
IUUC-Fca-036320	Felis catus	46.15	1.00e-178	620.00
IUUC-Gmo-039480	Gadus morhua	57.74	1.00e-132	466.00
IUUC-Gga-040527	Gallus gallus	52.66	1.00e-106	380.00
IUUC-Gac-042343	Gasterosteus aculeatus	64.40	0.00e+00	933.00
IUUC-Gma-044402	Glycine max	29.07	6.00e-33	135.00
IUUC-Ggo-045598	Gorilla gorilla	46.96	0.00e+00	628.00
IUUC-Hsa-046598	Homo sapiens	47.54	0.00e+00	630.00
IUUC-Hvu-047146	Hordeum vulgare	34.87	4.00e-25	110.00
IUUC-Itr-047951	Ictidomys tridecemlineatus	45.98	1.00e-179	623.00
IUUC-Lch-050536	Latimeria chalumnae	49.76	4.00e-101	362.00
IUUC-Lpe-050703	Leersia perrieri	35.90	5.00e-26	113.00
IUUC-Loc-051814	Lepisosteus oculatus	58.81	3.00e-138	485.00
IUUC-Laf-053732	Loxodonta africana	45.57	3.00e-177	615.00
IUUC-Mcc-054661	Macaca mulatta	47.10	0.00e+00	634.00
IUUC-Meu-055967	Macropus eugenii	48.62	2.00e-94	340.00
IUUC-Mtr-057945	Medicago truncatula	30.72	6.00e-32	132.00
IUUC-Mga-059551	Meleagris gallopavo	52.72	2.00e-109	390.00
IUUC-Mmr-061747	Microcebus murinus	46.48	7.00e-178	617.00
IUUC-Mdo-062220	Monodelphis domestica	52.50	2.00e-113	403.00
IUUC-Mmu-063582	Mus musculus	50.00	5.00e-106	378.00
IUUC-Mac-064941	Musa acuminata	29.16	5.00e-33	136.00
IUUC-Mpu-066339	Mustela putorius furo	46.42	8.00e-177	613.00
IUUC-Mlu-067248	Myotis lucifugus	51.07	1.00e-109	390.00
IUUC-Nle-069252	Nomascus leucogenys	47.10	0.00e+00	632.00
IUUC-Opr-070969	Ochotona princeps	45.81	4.00e-175	608.00
IUUC-Ont-071786	Oreochromis niloticus	63.17	0.00e+00	956.00
IUUC-Ocu-074704	Oryctolagus cuniculus	45.49	2.00e-174	606.00
IUUC-Oba-075094	Oryza barthii	28.27	1.00e-25	112.00
IUUC-Obr-076743	Oryza brachyantha	35.38	1.00e-25	112.00
IUUC-Ogl-077739	Oryza glaberrima	28.27	8.00e-26	112.00
IUUC-Ogu-078851	Oryza glumaepatula	28.57	3.00e-26	114.00
IUUC-Oin-079402	Oryza indica	28.57	3.00e-26	114.00
IUUC-Olo-080431	Oryza longistaminata	28.57	3.00e-26	114.00
IUUC-Ome-081580	Oryza meridionalis	28.57	3.00e-26	114.00
IUUC-Oni-082644	Oryza nivara	28.57	3.00e-26	114.00
IUUC-Opu-083452	Oryza punctata	28.62	5.00e-26	113.00
IUUC-Oru-084546	Oryza rufipogon	28.57	3.00e-26	114.00
IUUC-Osa-085858	Oryza sativa	28.57	3.00e-26	114.00
IUUC-Ola-086795	Oryzias latipes	58.51	0.00e+00	822.00
IUUC-Oga-088713	Otolemur garnettii	45.42	1.00e-177	616.00
IUUC-Oar-089887	Ovis aries	46.43	2.00e-175	609.00
IUUC-Ptr-091670	Pan troglodytes	47.22	0.00e+00	631.00
IUUC-Pan-092293	Papio anubis	47.10	0.00e+00	634.00
IUUC-Psi-093101	Pelodiscus sinensis	51.24	3.00e-109	389.00
IUUC-Ppa-095622	Physcomitrella patens	28.12	3.00e-30	127.00
IUUC-Pfo-097202	Poecilia formosa	58.75	0.00e+00	945.00
IUUC-Pab-098539	Pongo abelii	36.55	1.00e-136	480.00
IUUC-Pop-099588	Populus trichocarpa	28.24	1.00e-33	138.00
IUUC-Pca-101069	Procavia capensis	41.01	2.00e-66	246.00
IUUC-Ppe-101794	Prunus persica	30.21	3.00e-33	137.00
IUUC-Sha-106889	Sarcophilus harrisii	52.75	9.00e-111	394.00
IUUC-Sit-110283	Setaria italica	28.92	1.00e-25	111.00
IUUC-Sly-111491	Solanum lycopersicum	28.91	3.00e-35	143.00
IUUC-Stu-112820	Solanum tuberosum	29.09	6.00e-39	156.00
IUUC-Sar-113530	Sorex araneus	52.45	9.00e-113	400.00
IUUC-Sbi-113785	Sorghum bicolor	39.72	8.00e-23	102.00
IUUC-Ssc-116091	Sus scrofa	45.57	7.00e-177	613.00
IUUC-Tgu-117478	Taeniopygia guttata	48.31	3.00e-101	362.00
IUUC-Tru-118640	Takifugu rubripes	77.06	0.00e+00	1179.00
IUUC-Tsy-119042	Tarsius syrichta	39.06	4.00e-99	355.00
IUUC-Tca-121701	Theobroma cacao	29.57	5.00e-35	143.00
IUUC-Tae-125351	Triticum aestivum	34.36	5.00e-23	103.00
IUUC-Tur-126788	Triticum urartu	33.85	4.00e-23	103.00
IUUC-Tbe-127309	Tupaia belangeri	45.92	2.00e-71	263.00
IUUC-Ttr-128271	Tursiops truncatus	46.24	9.00e-173	600.00
IUUC-Vpa-130674	Vicugna pacos	46.22	4.00e-162	565.00
IUUC-Xtr-131869	Xenopus tropicalis	42.35	4.00e-168	585.00
IUUC-Xma-134195	Xiphophorus maculatus	60.38	0.00e+00	920.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence