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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046450
UUCD1 version UUC-HoS-00620
Ensembl Protein ID ENSP00000367872.3
UniProt Accession P62873; B1AJZ7; P04697; P04901; Q1RMY8; GBB1_HUMAN
Genbank Protein ID CAA28207.1; AAM15918.1; AAP35969.1; CAG33065.1; CAI20029.1; CAI20029.1; CAI95654.1; CAI95654.1; EAW56147.1; AAH04186.1; AAH05888.1; AAH08991.1; AAI14619.1; AAA63265.1
Protein Name Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; Transducin beta chain 1
Genbank Nucleotide ID X04526; AF501882; BT007305; CR456784; AL031282; AL109917; AL109917; AL031282; CH471183; BC004186; BC005888; BC008991; BC114618; M36430
Gene Name GNB1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000078369.17 ENST00000378609.8 ENSP00000367872.3
ENSG00000078369.17 ENST00000439272.6 ENSP00000399741.2
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
miRWalkTargetScanRepTarmiRNAMap
SomamiRmiRcodeRAID2LncRNADisease
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Variation
ClinVarGWASdbGWAS CentralOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDUniProtBioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 3.70e-42 142.1 224 260
UBD/Beta-Prp 1.30e-54 187.1 136 340
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvl 35
           gH++++++++f ++ + +++GsdD t++++Dlr +  
   Q: 224  GHESDINAICFfPNgNAFATGSDDATCRLFDLRADQE 260
           8*********99777*****************98865 PP
   

   UBD/Beta-Prp
   S: 45   lrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsgh 136
            r+l gh++  ++++f +d   +vt+s D t  +wd++tg+++ t++gh+ +v+sls+ p++  +vsG  d  +++wd+++g c + t++gh
   Q: 136  SRELAGHTGYLSCCRFLDDN-QIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQ-TFTGH 225
           5899***************7.7****************************************************************.***** PP
   S: 137  dgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtl.tgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvks 227
           ++ +n +++ p+gn +++Gs+D t+rl+dl+ ++ l t    +    ++s+sf+++g+ l++g +d   ++wd  + +    l gh++ v++
   Q: 226  ESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYsHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSC 317
           *********************************999999434455789******************************************** PP
   S: 228  vrfspnderlvsgssDgsiriWd 250
           + +++++  +++gs D  ++iW+
   Q: 318  LGVTDDGMAVATGSWDSFLKIWN 340
           **********************8 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     G proteins are composed of 3 units, alpha, beta and gamma. Interacts with ARHGEF18 and RASD2 (PubMed:14512443, PubMed:19255495). The heterodimer formed by GNB1 and GNG2 interacts with ARHGEF5 (PubMed:19713215).
 G proteins are composed of 3 units, alpha, beta and gamma. Interacts with ARHGEF18 and RASD2 (PubMed:14512443, PubMed:19255495). The heterodimer formed by GNB1 and GNG2 interacts with ARHGEF5 (PubMed:19713215).
Protein Sequence
(Fasta)
MSELDQLRQE AEQLKNQIRD ARKACADATL SQITNNIDPV GRIQMRTRRT LRGHLAKIYA 60
MHWGTDSRLL VSASQDGKLI IWDSYTTNKV HAIPLRSSWV MTCAYAPSGN YVACGGLDNI 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046450|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GAGCGCGTGG GGTTTTCCGA GGCTGCGGGC AGGGGCCCGC CGCGCCCATC CCGATGGCTG 60
GAGGCGTCTG AGGGGCGGAC GGAGGCGGCG GCGGCGGCGG CGGGAGCGGG AGCGGGCGGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046450|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0225--Disease mutation
KW-0991--Mental retardation
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0807--Transducer
KW-0853--WD repeat
Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR020472--G-protein_beta_WD-40_rep
IPR001632--Gprotein_B
IPR016346--Guanine_nucleotide-bd_bsu
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
PRINTS

PR00319--GPROTEINB
PR00320--GPROTEINBRPT
SMART

SM00320--WD40
Gene Ontology

GO:0044297--C:cell body
GO:0005829--C:cytosol
GO:0030425--C:dendrite
GO:0070062--C:extracellular exosome
GO:1903561--C:extracellular vesicle
GO:0005834--C:heterotrimeric G-protein complex
GO:0005622--C:intracellular
GO:0005765--C:lysosomal membrane
GO:0016020--C:membrane
GO:0043209--C:myelin sheath
GO:0097381--C:photoreceptor disc membrane
GO:0001917--C:photoreceptor inner segment
GO:0042622--C:photoreceptor outer segment membrane
GO:0005886--C:plasma membrane
GO:0047391--F:alkylglycerophosphoethanolamine phosphodiesterase activity
GO:0003924--F:GTPase activity
GO:0051020--F:GTPase binding
GO:0032403--F:protein complex binding
GO:0004871--F:signal transducer activity
GO:0007191--P:adenylate cyclase-activating dopamine receptor signaling pathway
GO:0010659--P:cardiac muscle cell apoptotic process
GO:0008283--P:cell proliferation
GO:0071870--P:cellular response to catecholamine stimulus
GO:0071377--P:cellular response to glucagon stimulus
GO:0071456--P:cellular response to hypoxia
GO:0071380--P:cellular response to prostaglandin E stimulus
GO:0007213--P:G-protein coupled acetylcholine receptor signaling pathway
GO:0007200--P:phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0030168--P:platelet activation
GO:0007204--P:positive regulation of cytosolic calcium ion concentration
GO:0006457--P:protein folding
GO:0070208--P:protein heterotrimerization
GO:0007265--P:Ras protein signal transduction
GO:0060041--P:retina development in camera-type eye
GO:0016056--P:rhodopsin mediated signaling pathway
GO:0050909--P:sensory perception of taste
GO:0007165--P:signal transduction
GO:0007223--P:Wnt signaling pathway, calcium modulating pathway
KEGG hsa:2782
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001337 Ailuropoda melanoleuca 100.00 0.00e+00 670.00
IUUC-Apl-003811 Anas platyrhynchos 97.94 0.00e+00 657.00
IUUC-Acl-008154 Aspergillus clavatus 68.55 5.00e-138 484.00
IUUC-Afl-008568 Aspergillus flavus 68.82 6.00e-140 490.00
IUUC-Afu-008789 Aspergillus fumigatus 68.55 5.00e-138 484.00
IUUC-Ani-009213 Aspergillus nidulans 69.12 3.00e-139 488.00
IUUC-Ang-009836 Aspergillus niger 68.82 5.00e-140 490.00
IUUC-Aor-010165 Aspergillus oryzae 68.82 6.00e-140 490.00
IUUC-Ame-011092 Astyanax mexicanus 98.24 0.00e+00 694.00
IUUC-Bta-012709 Bos taurus 100.00 0.00e+00 670.00
IUUC-Cja-019782 Callithrix jacchus 100.00 0.00e+00 670.00
IUUC-Cfa-020111 Canis familiaris 100.00 0.00e+00 670.00
IUUC-Cpo-022494 Cavia porcellus 100.00 0.00e+00 670.00
IUUC-Csa-023672 Chlorocebus sabaeus 100.00 0.00e+00 670.00
IUUC-Cne-026811 Cryptococcus neoformans 67.57 3.00e-138 484.00
IUUC-Dre-028478 Danio rerio 98.82 0.00e+00 696.00
IUUC-Eca-033359 Equus caballus 99.71 0.00e+00 669.00
IUUC-Fal-037004 Ficedula albicollis 97.94 0.00e+00 657.00
IUUC-Gmo-039709 Gadus morhua 98.53 0.00e+00 694.00
IUUC-Gga-041163 Gallus gallus 97.55 0.00e+00 629.00
IUUC-Gac-041386 Gasterosteus aculeatus 97.94 0.00e+00 669.00
IUUC-Gma-043322 Glycine max 45.23 9.00e-87 313.00
IUUC-Ggo-045261 Gorilla gorilla 99.69 0.00e+00 630.00
IUUC-Itr-049064 Ictidomys tridecemlineatus 100.00 0.00e+00 670.00
IUUC-Lch-049422 Latimeria chalumnae 97.65 0.00e+00 657.00
IUUC-Loc-052939 Lepisosteus oculatus 97.94 0.00e+00 671.00
IUUC-Lma-052985 Leptosphaeria maculans 67.96 2.00e-136 478.00
IUUC-Laf-054222 Loxodonta africana 100.00 0.00e+00 670.00
IUUC-Mcc-054970 Macaca mulatta 100.00 0.00e+00 670.00
IUUC-Mvi-060482 Microbotryum violaceum 72.29 2.00e-149 521.00
IUUC-Mmr-061302 Microcebus murinus 99.71 0.00e+00 669.00
IUUC-Mdo-062044 Monodelphis domestica 99.41 0.00e+00 665.00
IUUC-Mmu-063323 Mus musculus 100.00 0.00e+00 670.00
IUUC-Mlu-067309 Myotis lucifugus 100.00 0.00e+00 670.00
IUUC-Nfi-068332 Neosartorya fischeri 68.55 2.00e-137 482.00
IUUC-Nle-069791 Nomascus leucogenys 100.00 0.00e+00 670.00
IUUC-Ont-071280 Oreochromis niloticus 98.24 0.00e+00 693.00
IUUC-Oan-072780 Ornithorhynchus anatinus 98.82 0.00e+00 664.00
IUUC-Ocu-073769 Oryctolagus cuniculus 100.00 0.00e+00 670.00
IUUC-Ola-087490 Oryzias latipes 97.24 0.00e+00 639.00
IUUC-Oga-087961 Otolemur garnettii 100.00 0.00e+00 670.00
IUUC-Pan-092079 Papio anubis 100.00 0.00e+00 670.00
IUUC-Psi-093225 Pelodiscus sinensis 97.94 0.00e+00 657.00
IUUC-Pno-095135 Phaeosphaeria nodorum 67.96 3.00e-136 478.00
IUUC-Pfo-097028 Poecilia formosa 97.35 0.00e+00 669.00
IUUC-Pab-098658 Pongo abelii 100.00 0.00e+00 670.00
IUUC-Pca-100313 Procavia capensis 99.41 0.00e+00 659.00
IUUC-Pva-102636 Pteropus vampyrus 99.71 0.00e+00 668.00
IUUC-Pgr-103321 Puccinia graminis 73.19 4.00e-150 523.00
IUUC-Ptt-103728 Puccinia triticina 73.19 4.00e-150 523.00
IUUC-Pyt-104426 Pyrenophora triticirepentis 62.83 5.00e-124 437.00
IUUC-Rno-105112 Rattus norvegicus 100.00 0.00e+00 670.00
IUUC-Sha-106856 Sarcophilus harrisii 99.41 0.00e+00 665.00
IUUC-Sre-115035 Sporisorium reilianum 69.97 2.00e-140 491.00
IUUC-Tru-117793 Takifugu rubripes 97.94 0.00e+00 672.00
IUUC-Tni-120495 Tetraodon nigroviridis 97.35 0.00e+00 664.00
IUUC-Tme-126886 Tuber melanosporum 70.36 3.00e-136 478.00
IUUC-Uma-129589 Ustilago maydis 70.27 6.00e-141 493.00
Created Date 25-Jun-2017

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