iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Apl-003981

Ensembl Protein ID

ENSAPLP00000007314.1

UniProt Accession

U3IJ92; U3IJ92_ANAPL

Genbank Protein ID

ENSAPLP00000007314

Protein Name

Ribosome biogenesis protein WDR12; WD repeat-containing protein 12

Genbank Nucleotide ID

ADON01053230

Gene Name

WDR12

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAPLG00000007646.1	ENSAPLT00000007974.1	ENSAPLP00000007314.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.10e-44	146.8	297	332
UBD/Beta-Prp	1.30e-44	152.3	202	368

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd..tllvsGsdDgtikvWDlrtgv 34
           Ht++vt++++ ++  + l+sGs D+ +k+WD+r+++
   Q: 297  HTGWVTSVKWsPTheHQLISGSLDNIVKLWDTRSCK 332
           **********9444577**************99876 PP

UBD/Beta-Prp

   S: 83   tgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkl 171
           t++++ tl+gh++ + s+ +s   + + s+s+d ti++wd etg   + tl+g++ v n+v+++  ++ l+sGs+Dr +rlWd ++++ 
   Q: 202  TRTPLATLSGHTEAISSVLWSD-AEEICSASWDHTIKLWDAETGGLKS-TLTGNK-VFNSVSYSTLCRRLASGSTDRHIRLWDPRSKDG 287
           577899***************9.99**********************9.***987.99**************************66654 PP
   S: 172  lrtl...tgghtdsvyslsfdsng.kelvsgsldgtvklwdlq.tgecvrtlnghtdnvksvrfspnderlvsgssDgsiriW 249
              l   t+ ht+ v+s++++++   +l+sgsld+ vklwd +  +  ++ l +h+d v++v+ + ++ +l+sg++D+ ++++
   Q: 288  SLVLlslTS-HTGWVTSVKWSPTHeHQLISGSLDNIVKLWDTRsCKAPLYDLAAHEDKVLCVDWT-ETGLLLSGGADNKLYCY 368
           333334387.************99788****************54566****************9.999**********9997 PP

Organism

Anas platyrhynchos

Functional Description
(View)

Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.

Protein Sequence
(Fasta)

SADHKYVEFD FLINGQFLRM PLVTHMEMEN ISTEEVVEIE YVEKYMAPQP EECIFHDDWI 60
SSVQATEEWI LTGCYDQTAR IWSLEGKSIM TIAGHTEVVK DVAWVKQDSL SCLLLSASMD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCAGCTGACC ACAAGTATGT GGAATTTGAC TTCCTTATCA ATGGCCAGTT CTTGCGTATG 60
CCGCTGGTCA CACACATGGA GATGGAAAAT ATCTCCACGG TAAGTCATGC TCACTTTCTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0690--Ribosome biogenesis
KW-0698--rRNA processing
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR028599--WDR12/Ytm1

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005654--C:nucleoplasm
GO:0070545--C:PeBoW complex
GO:0030687--C:preribosome, large subunit precursor
GO:0043021--F:ribonucleoprotein complex binding
GO:0008283--P:cell proliferation
GO:0000466--P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000463--P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0007219--P:Notch signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000532	Aegilops tauschii	34.31	9.00e-55	207.00
IUUC-Aml-001997	Ailuropoda melanoleuca	87.50	2.00e-173	601.00
IUUC-Atr-002544	Amborella trichopoda	33.33	2.00e-49	189.00
IUUC-Aca-004370	Anolis carolinensis	86.51	0.00e+00	627.00
IUUC-Aly-006455	Arabidopsis lyrata	35.07	1.00e-52	199.00
IUUC-Ath-006669	Arabidopsis thaliana	35.07	3.00e-52	198.00
IUUC-Ago-007864	Ashbya gossypii	30.05	9.00e-32	130.00
IUUC-Acl-008177	Aspergillus clavatus	30.60	2.00e-33	136.00
IUUC-Afl-008617	Aspergillus flavus	29.56	6.00e-33	134.00
IUUC-Afu-008752	Aspergillus fumigatus	29.04	4.00e-31	129.00
IUUC-Ani-009136	Aspergillus nidulans	29.40	2.00e-32	133.00
IUUC-Ang-009701	Aspergillus niger	28.77	3.00e-31	129.00
IUUC-Aor-009884	Aspergillus oryzae	29.04	3.00e-32	132.00
IUUC-Ate-010472	Aspergillus terreus	30.71	7.00e-21	94.40
IUUC-Ame-011432	Astyanax mexicanus	80.69	2.00e-172	598.00
IUUC-Bgr-012218	Blumeria graminis	28.37	8.00e-33	134.00
IUUC-Bta-012829	Bos taurus	86.97	5.00e-173	600.00
IUUC-Bci-013953	Botrytis cinerea	30.11	2.00e-34	139.00
IUUC-Bdi-014351	Brachypodium distachyon	35.28	1.00e-49	190.00
IUUC-Bol-016514	Brassica oleracea	35.52	5.00e-50	191.00
IUUC-Bra-016988	Brassica rapa	35.52	7.00e-50	191.00
IUUC-Cel-018569	Caenorhabditis elegans	33.06	1.00e-41	163.00
IUUC-Cja-019468	Callithrix jacchus	86.70	3.00e-167	580.00
IUUC-Cfa-020471	Canis familiaris	85.90	4.00e-170	590.00
IUUC-Cpo-022260	Cavia porcellus	86.44	6.00e-168	583.00
IUUC-Cre-022614	Chlamydomonas reinhardtii	30.03	1.00e-31	130.00
IUUC-Csa-023989	Chlorocebus sabaeus	86.70	2.00e-168	584.00
IUUC-Cho-024426	Choloepus hoffmanni	85.71	5.00e-140	490.00
IUUC-Cin-025789	Ciona intestinalis	45.19	2.00e-85	309.00
IUUC-Cne-027063	Cryptococcus neoformans	26.33	7.00e-14	71.60
IUUC-Dre-027907	Danio rerio	80.47	1.00e-173	602.00
IUUC-Dno-029225	Dasypus novemcinctus	87.23	1.00e-172	598.00
IUUC-Dor-031082	Dipodomys ordii	70.21	2.00e-123	435.00
IUUC-Dse-031308	Dothistroma septosporum	29.29	7.00e-33	134.00
IUUC-Dme-032189	Drosophila melanogaster	43.09	6.00e-84	303.00
IUUC-Ete-032247	Echinops telfairi	80.32	1.00e-155	541.00
IUUC-Eca-034285	Equus caballus	86.70	2.00e-172	598.00
IUUC-Eeu-035322	Erinaceus europaeus	78.35	2.00e-144	504.00
IUUC-Fca-036114	Felis catus	86.70	3.00e-172	597.00
IUUC-Fal-036891	Ficedula albicollis	97.46	0.00e+00	642.00
IUUC-Fox-037965	Fusarium oxysporum	26.38	4.00e-31	129.00
IUUC-Fso-038244	Fusarium solani	26.38	4.00e-31	129.00
IUUC-Gmo-039040	Gadus morhua	77.66	8.00e-168	582.00
IUUC-Gga-040610	Gallus gallus	97.88	0.00e+00	700.00
IUUC-Gac-042117	Gasterosteus aculeatus	76.52	1.00e-161	561.00
IUUC-Gma-043146	Glycine max	36.56	2.00e-56	212.00
IUUC-Ggo-045179	Gorilla gorilla	86.44	2.00e-165	574.00
IUUC-Hsa-046114	Homo sapiens	87.23	3.00e-167	580.00
IUUC-Hvu-047331	Hordeum vulgare	34.04	4.00e-52	198.00
IUUC-Itr-048275	Ictidomys tridecemlineatus	87.50	4.00e-174	603.00
IUUC-Kpa-049304	Komagataella pastoris	30.75	2.00e-40	159.00
IUUC-Lch-050655	Latimeria chalumnae	75.93	4.00e-119	420.00
IUUC-Lpe-051675	Leersia perrieri	35.64	8.00e-54	204.00
IUUC-Loc-052868	Lepisosteus oculatus	82.76	1.00e-173	602.00
IUUC-Lma-053258	Leptosphaeria maculans	28.06	1.00e-30	129.00
IUUC-Laf-053993	Loxodonta africana	86.97	3.00e-172	597.00
IUUC-Mcc-055128	Macaca mulatta	73.46	1.00e-133	468.00
IUUC-Meu-056501	Macropus eugenii	81.90	2.00e-144	504.00
IUUC-Mor-057114	Magnaporthe oryzae	25.95	5.00e-26	111.00
IUUC-Mtr-058367	Medicago truncatula	36.83	3.00e-52	198.00
IUUC-Mla-059107	Melampsora laricipopulina	27.54	3.00e-23	102.00
IUUC-Mga-059745	Meleagris gallopavo	96.58	0.00e+00	691.00
IUUC-Mvi-060362	Microbotryum violaceum	29.48	2.00e-26	113.00
IUUC-Mdo-062257	Monodelphis domestica	82.04	4.00e-173	600.00
IUUC-Mmu-063546	Mus musculus	86.70	1.00e-172	598.00
IUUC-Mac-065540	Musa acuminata	32.72	7.00e-50	191.00
IUUC-Mpu-066284	Mustela putorius furo	86.97	5.00e-173	600.00
IUUC-Mlu-067241	Myotis lucifugus	86.17	3.00e-172	597.00
IUUC-Nfi-068260	Neosartorya fischeri	29.04	7.00e-32	131.00
IUUC-Ncr-068719	Neurospora crassa	26.11	2.00e-25	109.00
IUUC-Nle-068981	Nomascus leucogenys	86.44	1.00e-166	579.00
IUUC-Opr-071218	Ochotona princeps	78.63	2.00e-151	528.00
IUUC-Ont-071646	Oreochromis niloticus	77.39	7.00e-166	576.00
IUUC-Oan-073453	Ornithorhynchus anatinus	88.83	0.00e+00	644.00
IUUC-Ocu-074008	Oryctolagus cuniculus	86.97	7.00e-173	599.00
IUUC-Oba-075712	Oryza barthii	29.57	4.00e-37	148.00
IUUC-Obr-076721	Oryza brachyantha	34.57	8.00e-54	204.00
IUUC-Ogl-077229	Oryza glaberrima	34.13	1.00e-53	203.00
IUUC-Ogu-078977	Oryza glumaepatula	29.57	2.00e-37	149.00
IUUC-Oin-079683	Oryza indica	34.13	8.00e-54	204.00
IUUC-Olo-080291	Oryza longistaminata	28.37	2.00e-24	105.00
IUUC-Ome-081834	Oryza meridionalis	34.67	5.00e-55	208.00
IUUC-Oni-082507	Oryza nivara	32.35	2.00e-48	186.00
IUUC-Opu-083396	Oryza punctata	34.13	1.00e-53	203.00
IUUC-Oru-085220	Oryza rufipogon	32.35	4.00e-48	185.00
IUUC-Osa-085767	Oryza sativa	34.13	8.00e-54	204.00
IUUC-Ola-087420	Oryzias latipes	76.98	1.00e-166	578.00
IUUC-Olu-087740	Ostreococcus lucimarinus	29.52	4.00e-33	135.00
IUUC-Oga-088264	Otolemur garnettii	85.37	7.00e-171	592.00
IUUC-Oar-089335	Ovis aries	86.17	2.00e-171	595.00
IUUC-Ptr-091320	Pan troglodytes	87.23	3.00e-167	580.00
IUUC-Pan-092833	Papio anubis	86.70	3.00e-168	583.00
IUUC-Psi-093504	Pelodiscus sinensis	90.43	0.00e+00	650.00
IUUC-Pma-094189	Petromyzon marinus	68.16	3.00e-146	511.00
IUUC-Pno-094929	Phaeosphaeria nodorum	26.68	4.00e-32	132.00
IUUC-Ppa-095429	Physcomitrella patens	34.22	3.00e-55	208.00
IUUC-Pfo-096337	Poecilia formosa	76.46	3.00e-167	580.00
IUUC-Pab-097571	Pongo abelii	87.23	4.00e-167	580.00
IUUC-Pop-099977	Populus trichocarpa	36.16	7.00e-56	211.00
IUUC-Pca-100394	Procavia capensis	81.38	2.00e-158	551.00
IUUC-Ppe-101848	Prunus persica	38.08	2.00e-57	216.00
IUUC-Pva-102921	Pteropus vampyrus	87.00	1.00e-79	290.00
IUUC-Pgr-103637	Puccinia graminis	29.15	5.00e-29	121.00
IUUC-Ptt-103781	Puccinia triticina	29.12	7.00e-29	121.00
IUUC-Pte-104135	Pyrenophora teres	26.96	4.00e-33	137.00
IUUC-Pyt-104609	Pyrenophora triticirepentis	26.65	2.00e-31	129.00
IUUC-Rno-105114	Rattus norvegicus	85.11	1.00e-171	595.00
IUUC-Sce-106401	Saccharomyces cerevisiae	29.88	2.00e-34	139.00
IUUC-Sha-107122	Sarcophilus harrisii	82.97	1.00e-164	572.00
IUUC-Sja-107766	Schizosaccharomyces japonicus	30.85	4.00e-38	152.00
IUUC-Spo-108134	Schizosaccharomyces pombe	29.84	1.00e-31	130.00
IUUC-Ssl-108398	Sclerotinia sclerotiorum	30.08	6.00e-36	144.00
IUUC-Smo-108720	Selaginella moellendorffii	32.43	9.00e-47	180.00
IUUC-Sit-110311	Setaria italica	34.66	6.00e-54	204.00
IUUC-Sly-111023	Solanum lycopersicum	32.92	6.00e-49	187.00
IUUC-Stu-112778	Solanum tuberosum	35.87	2.00e-54	206.00
IUUC-Sar-113596	Sorex araneus	77.66	4.00e-149	520.00
IUUC-Sbi-114193	Sorghum bicolor	34.67	4.00e-53	201.00
IUUC-Ssc-116066	Sus scrofa	86.44	2.00e-171	594.00
IUUC-Tgu-117048	Taeniopygia guttata	96.57	0.00e+00	691.00
IUUC-Tsy-119573	Tarsius syrichta	53.19	1.00e-93	335.00
IUUC-Tni-119820	Tetraodon nigroviridis	75.73	3.00e-164	570.00
IUUC-Tca-121605	Theobroma cacao	36.31	4.00e-54	204.00
IUUC-Tre-121947	Trichoderma reesei	27.34	4.00e-31	128.00
IUUC-Tvi-122481	Trichoderma virens	27.82	5.00e-33	135.00
IUUC-Tae-125861	Triticum aestivum	34.57	4.00e-55	208.00
IUUC-Tur-126586	Triticum urartu	34.04	4.00e-54	204.00
IUUC-Tme-126900	Tuber melanosporum	31.40	2.00e-39	155.00
IUUC-Tbe-127736	Tupaia belangeri	62.96	7.00e-107	380.00
IUUC-Ttr-129041	Tursiops truncatus	73.94	7.00e-145	506.00
IUUC-Vpa-130260	Vicugna pacos	86.70	1.00e-172	598.00
IUUC-Vvi-131009	Vitis vinifera	35.81	2.00e-53	202.00
IUUC-Xtr-132083	Xenopus tropicalis	79.68	8.00e-169	586.00
IUUC-Xma-133094	Xiphophorus maculatus	75.93	5.00e-166	577.00
IUUC-Yli-134531	Yarrowia lipolytica	25.90	9.00e-19	87.80
IUUC-Zma-135509	Zea mays	34.13	4.00e-51	195.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence