iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Sha-107138

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEFK01121646

Gene Name

CBLC

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSHAG00000004198.1	ENSSHAT00000004831.1	ENSSHAP00000004783.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	1.40e-06	28.9	234	273

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iC e+ kd +++ pCgH+ +  Cl+ w     ++s+  +CP Cr
   Q: 234  CKICAERNKD-TRLKPCGHLLCYPCLEGW-----QKSPGHTCPFCR 273
           99********.******************.....7889999****8 PP

Organism

Sarcophilus harrisii

Protein Sequence
(Fasta)

RRQLTKLALI FSHMHTELRA LFPDGHYCGH SYQLSKPQAQ DFWRTACGTR CVVPWEEFKK 60
LLSSCHPVKP GPMAQALKST IDLTVSGHVS VFEFDVFTRL FQPWASLLKN WTLLAVTHPG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAACCTCAGT GCGCTGGGGC AAACTCAGAC CCTCGAGTCA CAGAGAATGC CGGCTTGTGT 60
GAGGGCGGGA GTTTGGGCTC CACTCTCCGA ACGCCCCATC CCAGATGCAT TGTTCAGGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR024162--Adaptor_Cbl
IPR014741--Adaptor_Cbl_EF_hand-like
IPR003153--Adaptor_Cbl_N_hlx
IPR014742--Adaptor_Cbl_SH2-like
IPR024159--Cbl_PTB
IPR011992--EF-hand-dom_pair
IPR000980--SH2
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS51506--CBL_PTB
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF02262--Cbl_N
PF02761--Cbl_N2
PF02762--Cbl_N3

SMART

SM00184--RING

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0005509--F:calcium ion binding
GO:0004871--F:signal transducer activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0007166--P:cell surface receptor signaling pathway
GO:0007175--P:negative regulation of epidermal growth factor-activated receptor activity
GO:0043407--P:negative regulation of MAP kinase activity
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002286	Ailuropoda melanoleuca	59.67	3.00e-123	435.00
IUUC-Bta-012705	Bos taurus	65.11	3.00e-124	438.00
IUUC-Cfa-020593	Canis familiaris	68.31	2.00e-119	422.00
IUUC-Cpo-021289	Cavia porcellus	65.42	2.00e-116	412.00
IUUC-Csa-023966	Chlorocebus sabaeus	67.00	4.00e-121	427.00
IUUC-Fca-035747	Felis catus	65.85	3.00e-116	411.00
IUUC-Ggo-044622	Gorilla gorilla	67.65	3.00e-123	434.00
IUUC-Hsa-045735	Homo sapiens	66.67	9.00e-122	430.00
IUUC-Itr-049001	Ictidomys tridecemlineatus	63.99	1.00e-123	436.00
IUUC-Mmr-061310	Microcebus murinus	67.44	1.00e-122	432.00
IUUC-Mmu-064155	Mus musculus	70.07	9.00e-122	430.00
IUUC-Mpu-066655	Mustela putorius furo	69.47	5.00e-120	424.00
IUUC-Mlu-067929	Myotis lucifugus	70.23	1.00e-111	395.00
IUUC-Oga-087952	Otolemur garnettii	71.28	4.00e-124	437.00
IUUC-Oar-089382	Ovis aries	68.99	5.00e-120	424.00
IUUC-Pan-092075	Papio anubis	67.99	1.00e-122	432.00
IUUC-Rno-105348	Rattus norvegicus	65.24	2.00e-124	438.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence