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Basic Information Integrated Annotations

Tag Content
iUUCD ID IUUC-Rno-104980
Ensembl Protein ID ENSRNOP00000054923.2
UniProt Accession Q5BJP3; UFM1_RAT
Genbank Protein ID AAH91395.1
Protein Name Ubiquitin-fold modifier 1
Genbank Nucleotide ID BC091395
Gene Name Ufm1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000038176.3 ENSRNOT00000058116.3 ENSRNOP00000054923.2
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
TRANSFACRAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
CPLMPhosphositePlus
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
ULD/UDP/UBQ/UBQ_Other 98.82 7.00e-44 172.00 IUUC-Hsa-046891
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Rattus norvegicus
Functional Description
(View)

Functional Description



     Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to substrate proteins as a monomer or a lysine-linked polymer. The so-called ufmylation, requires the UFM1-activating E1 enzyme UBA5, the UFM1-conjugating E2 enzyme UFC1, and the UFM1-ligase E3 enzyme UFL1. This post-translational modification on lysine residues of proteins may play a crucial role in a number of cellular processes. TRIP4 ufmylation may for instance play a role in nuclear receptors-mediated transcription. Other substrates may include DDRGK1 with which it may play a role in the cellular response to endoplasmic reticulum stress.
Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to substrate proteins as a monomer or a lysine-linked polymer. The so-called ufmylation, requires the UFM1-activating E1 enzyme UBA5, the UFM1-conjugating E2 enzyme UFC1, and the UFM1-ligase E3 enzyme UFL1. This post-translational modification on lysine residues of proteins may play a crucial role in a number of cellular processes. TRIP4 ufmylation may for instance play a role in nuclear receptors-mediated transcription. Other substrates may include DDRGK1 with which it may play a role in the cellular response to endoplasmic reticulum stress.
Protein Sequence
(Fasta)
MSKVSFKITL TSDPRLPYKV LSVPESTPFT AVLKFAAEEF KVPAATSAII TNDGIGINPA 60
QTAGNVFLKH GSELRLIPRD RVGSC 85
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Protein Fasta Sequence



>IUUC-Rno-104980|ULD,UBQ_Other|Rattus norvegicus
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Nucleotide Sequence
(Fasta)
GTGGGCCGCG AAGGACCCCA CTGCCTGCCA TCAAGGAAGC TAGGCGGGCG GCTGTTCGCG 60
GTTTGAGTAC CAGGCGGTTC CACCATGTAA GTGTCAGTCC CCGCGTCCCG GCCTTGACTC 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Rno-104980|ULD,UBQ_Other|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway

Interpro

IPR029071--Ubiquitin-rel_dom
IPR005375--UFM1

Pfam

PF03671--Ufm1

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005783--C:endoplasmic reticulum
GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0043066--P:negative regulation of apoptotic process
GO:1990592--P:protein K69-linked ufmylation
GO:0071569--P:protein ufmylation
GO:0033146--P:regulation of intracellular estrogen receptor signaling pathway
GO:0034976--P:response to endoplasmic reticulum stress

KEGG rno:365797
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002340 Ailuropoda melanoleuca 98.81 1.00e-44 170.00
IUUC-Atr-002692 Amborella trichopoda 84.34 3.00e-38 149.00
IUUC-Apl-003216 Anas platyrhynchos 94.05 1.00e-42 163.00
IUUC-Aca-004340 Anolis carolinensis 96.34 5.00e-42 161.00
IUUC-Aly-005396 Arabidopsis lyrata 84.52 3.00e-38 149.00
IUUC-Ath-007254 Arabidopsis thaliana 84.52 3.00e-38 149.00
IUUC-Bdi-014766 Brachypodium distachyon 84.15 1.00e-37 147.00
IUUC-Bol-015854 Brassica oleracea 84.52 4.00e-38 148.00
IUUC-Bra-017056 Brassica rapa 84.52 4.00e-38 148.00
IUUC-Cel-018224 Caenorhabditis elegans 91.46 7.00e-41 157.00
IUUC-Cja-019654 Callithrix jacchus 98.81 1.00e-44 170.00
IUUC-Cfa-020773 Canis familiaris 98.81 2.00e-44 169.00
IUUC-Cre-022911 Chlamydomonas reinhardtii 83.13 2.00e-38 149.00
IUUC-Csa-023159 Chlorocebus sabaeus 98.81 2.00e-44 169.00
IUUC-Cin-025175 Ciona intestinalis 90.36 3.00e-40 155.00
IUUC-Csv-025838 Ciona savignyi 86.75 1.00e-38 150.00
IUUC-Dre-028404 Danio rerio 97.59 2.00e-43 166.00
IUUC-Dno-029917 Dasypus novemcinctus 96.34 2.00e-42 163.00
IUUC-Dme-031742 Drosophila melanogaster 89.16 8.00e-40 154.00
IUUC-Eca-034203 Equus caballus 97.65 8.00e-45 171.00
IUUC-Fca-035910 Felis catus 98.81 2.00e-44 169.00
IUUC-Fal-036934 Ficedula albicollis 95.24 6.00e-43 164.00
IUUC-Gga-040278 Gallus gallus 94.12 2.00e-43 166.00
IUUC-Gma-043236 Glycine max 85.37 3.00e-38 149.00
IUUC-Hsa-046891 Homo sapiens 98.82 2.00e-45 172.00
IUUC-Hvu-047577 Hordeum vulgare 83.13 8.00e-38 147.00
IUUC-Itr-048991 Ictidomys tridecemlineatus 97.62 3.00e-44 169.00
IUUC-Lpe-051293 Leersia perrieri 84.34 8.00e-38 147.00
IUUC-Loc-051783 Lepisosteus oculatus 96.34 3.00e-42 162.00
IUUC-Meu-056072 Macropus eugenii 96.92 5.00e-33 131.00
IUUC-Mtr-058403 Medicago truncatula 84.34 3.00e-38 149.00
IUUC-Mga-059440 Meleagris gallopavo 95.56 5.00e-21 92.00
IUUC-Mmr-061477 Microcebus murinus 89.61 3.00e-36 142.00
IUUC-Mdo-062878 Monodelphis domestica 97.62 7.00e-44 167.00
IUUC-Mmu-063120 Mus musculus 98.82 2.00e-45 172.00
IUUC-Mac-065340 Musa acuminata 85.37 2.00e-38 149.00
IUUC-Mpu-066256 Mustela putorius furo 98.82 2.00e-45 172.00
IUUC-Mlu-067449 Myotis lucifugus 98.82 2.00e-45 172.00
IUUC-Nle-069109 Nomascus leucogenys 98.81 2.00e-44 169.00
IUUC-Opr-070387 Ochotona princeps 76.56 8.00e-23 97.80
IUUC-Ocu-074677 Oryctolagus cuniculus 98.81 3.00e-44 169.00
IUUC-Oba-075987 Oryza barthii 84.34 9.00e-38 147.00
IUUC-Obr-076359 Oryza brachyantha 84.34 9.00e-38 147.00
IUUC-Ogl-077776 Oryza glaberrima 84.34 9.00e-38 147.00
IUUC-Ogu-078176 Oryza glumaepatula 84.34 9.00e-38 147.00
IUUC-Oin-079729 Oryza indica 84.34 9.00e-38 147.00
IUUC-Ome-082009 Oryza meridionalis 84.34 9.00e-38 147.00
IUUC-Oni-082503 Oryza nivara 84.34 9.00e-38 147.00
IUUC-Opu-084099 Oryza punctata 84.34 8.00e-38 147.00
IUUC-Oru-084912 Oryza rufipogon 84.34 9.00e-38 147.00
IUUC-Osa-085481 Oryza sativa 84.34 9.00e-38 147.00
IUUC-Ola-086978 Oryzias latipes 97.56 8.00e-43 164.00
IUUC-Oga-088728 Otolemur garnettii 98.46 2.00e-33 132.00
IUUC-Ptr-091085 Pan troglodytes 98.81 2.00e-44 169.00
IUUC-Pan-092802 Papio anubis 98.81 2.00e-44 169.00
IUUC-Psi-093487 Pelodiscus sinensis 96.43 3.00e-43 166.00
IUUC-Ppa-095524 Physcomitrella patens 86.42 6.00e-38 147.00
IUUC-Pfo-097061 Poecilia formosa 96.39 3.00e-43 165.00
IUUC-Pab-098717 Pongo abelii 96.47 1.00e-42 163.00
IUUC-Ppe-101618 Prunus persica 84.15 8.00e-38 147.00
IUUC-Smo-109095 Selaginella moellendorffii 83.95 7.00e-38 148.00
IUUC-Sit-110509 Setaria italica 84.34 1.00e-37 147.00
IUUC-Sly-110926 Solanum lycopersicum 85.37 3.00e-38 149.00
IUUC-Stu-112759 Solanum tuberosum 85.37 3.00e-38 149.00
IUUC-Sbi-114543 Sorghum bicolor 83.13 1.00e-37 147.00
IUUC-Ssc-116296 Sus scrofa 98.46 2.00e-33 132.00
IUUC-Tgu-117443 Taeniopygia guttata 96.39 7.00e-43 164.00
IUUC-Tru-117917 Takifugu rubripes 94.12 1.00e-41 160.00
IUUC-Tca-121412 Theobroma cacao 85.37 3.00e-38 149.00
IUUC-Tae-123384 Triticum aestivum 84.15 1.00e-37 147.00
IUUC-Vpa-130061 Vicugna pacos 98.46 2.00e-33 132.00
IUUC-Vvi-131618 Vitis vinifera 85.37 3.00e-38 149.00
IUUC-Xtr-132556 Xenopus tropicalis 95.24 2.00e-43 166.00
IUUC-Xma-133325 Xiphophorus maculatus 95.12 7.00e-42 160.00
Created Date 25-Jun-2017

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