iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oga-088198

Ensembl Protein ID

ENSOGAP00000006554.2

UniProt Accession

H0WW30; H0WW30_OTOGA

Genbank Protein ID

ENSOGAP00000006554

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAQR03130801

Gene Name

CBL

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOGAG00000007319.2	ENSOGAT00000007323.2	ENSOGAP00000006554.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	1.70e-07	31.6	380	419

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iC e  kd +++ pCgH+++++Cl  w    + +s  + CP Cr
   Q: 380  CKICAENDKD-VKIEPCGHLMCTSCLTSW----Q-ESEGQGCPFCR 419
           99********.******************....5.555555****8 PP

Organism

Otolemur garnettii

Protein Sequence
(Fasta)

MAGNVKKSSG AGGGGGSGGS GSGGLIGLMK DAFQPHHHHH HLSPHPPGTV DKKMVEKCWK 60
LMDKVVRLCQ NPKLALKNSP PYILDLLPDT YQHLRTILSR YEGKMETLGE NEYFRVFMEN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCCGGCA ACGTGAAAAA GAGCTCTGGG GCCGGGGGCG GTGGCGGCTC CGGGGGCTCG 60
GGCTCTGGAG GCCTGATCGG GCTCATGAAG GACGCCTTCC AGCCGCACCA CCACCACCAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR024162--Adaptor_Cbl
IPR014741--Adaptor_Cbl_EF_hand-like
IPR003153--Adaptor_Cbl_N_hlx
IPR014742--Adaptor_Cbl_SH2-like
IPR024159--Cbl_PTB
IPR011992--EF-hand-dom_pair
IPR000980--SH2
IPR015940--UBA
IPR009060--UBA-like
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS51506--CBL_PTB
PS50030--UBA
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF02262--Cbl_N
PF02761--Cbl_N2
PF02762--Cbl_N3
PF00627--UBA

SMART

SM00184--RING
SM00165--UBA

Gene Ontology

GO:0005829--C:cytosol
GO:0016600--C:flotillin complex
GO:0005634--C:nucleus
GO:0005509--F:calcium ion binding
GO:0004871--F:signal transducer activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007166--P:cell surface receptor signaling pathway
GO:0043066--P:negative regulation of apoptotic process
GO:0042059--P:negative regulation of epidermal growth factor receptor signaling pathway
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0048260--P:positive regulation of receptor-mediated endocytosis
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002357	Ailuropoda melanoleuca	79.77	0.00e+00	1224.00
IUUC-Apl-004041	Anas platyrhynchos	75.46	0.00e+00	1174.00
IUUC-Aca-004899	Anolis carolinensis	73.76	0.00e+00	1087.00
IUUC-Bta-012759	Bos taurus	79.91	0.00e+00	1268.00
IUUC-Cja-019207	Callithrix jacchus	82.28	0.00e+00	1326.00
IUUC-Cfa-020897	Canis familiaris	81.82	0.00e+00	1299.00
IUUC-Cpo-021453	Cavia porcellus	79.98	0.00e+00	1264.00
IUUC-Csa-023136	Chlorocebus sabaeus	83.22	0.00e+00	1325.00
IUUC-Cho-024282	Choloepus hoffmanni	72.84	0.00e+00	1039.00
IUUC-Cin-025574	Ciona intestinalis	71.54	1.00e-176	612.00
IUUC-Csv-025938	Ciona savignyi	69.87	9.00e-172	596.00
IUUC-Dre-027644	Danio rerio	89.68	0.00e+00	823.00
IUUC-Dno-030025	Dasypus novemcinctus	80.07	0.00e+00	1250.00
IUUC-Dme-032213	Drosophila melanogaster	74.81	0.00e+00	640.00
IUUC-Eca-033900	Equus caballus	81.37	0.00e+00	1254.00
IUUC-Eeu-035142	Erinaceus europaeus	79.46	0.00e+00	869.00
IUUC-Fca-035455	Felis catus	80.11	0.00e+00	1258.00
IUUC-Fal-037182	Ficedula albicollis	95.77	0.00e+00	876.00
IUUC-Gmo-038698	Gadus morhua	90.11	0.00e+00	814.00
IUUC-Gga-040438	Gallus gallus	74.42	0.00e+00	1204.00
IUUC-Gac-042166	Gasterosteus aculeatus	71.12	0.00e+00	869.00
IUUC-Ggo-045618	Gorilla gorilla	83.32	0.00e+00	1343.00
IUUC-Hsa-046177	Homo sapiens	83.42	0.00e+00	1330.00
IUUC-Itr-048795	Ictidomys tridecemlineatus	89.38	0.00e+00	925.00
IUUC-Lch-050095	Latimeria chalumnae	78.92	0.00e+00	970.00
IUUC-Loc-052570	Lepisosteus oculatus	92.74	0.00e+00	811.00
IUUC-Laf-054008	Loxodonta africana	80.33	0.00e+00	1280.00
IUUC-Mcc-054676	Macaca mulatta	83.12	0.00e+00	1321.00
IUUC-Mga-059239	Meleagris gallopavo	74.25	0.00e+00	1207.00
IUUC-Mmr-060907	Microcebus murinus	81.44	0.00e+00	1292.00
IUUC-Mdo-062595	Monodelphis domestica	77.39	0.00e+00	1194.00
IUUC-Mmu-063725	Mus musculus	81.08	0.00e+00	1328.00
IUUC-Mpu-066771	Mustela putorius furo	80.41	0.00e+00	1287.00
IUUC-Mlu-067206	Myotis lucifugus	74.13	0.00e+00	1051.00
IUUC-Nle-069285	Nomascus leucogenys	81.26	0.00e+00	1231.00
IUUC-Opr-071026	Ochotona princeps	80.91	0.00e+00	1255.00
IUUC-Ont-071954	Oreochromis niloticus	73.52	0.00e+00	907.00
IUUC-Ocu-074657	Oryctolagus cuniculus	80.26	0.00e+00	1234.00
IUUC-Ola-087165	Oryzias latipes	71.27	0.00e+00	933.00
IUUC-Oar-090258	Ovis aries	79.63	0.00e+00	1206.00
IUUC-Ptr-090710	Pan troglodytes	83.42	0.00e+00	1330.00
IUUC-Pan-092785	Papio anubis	83.12	0.00e+00	1322.00
IUUC-Pfo-096990	Poecilia formosa	90.11	0.00e+00	811.00
IUUC-Pab-098526	Pongo abelii	83.95	0.00e+00	1333.00
IUUC-Pva-102352	Pteropus vampyrus	97.07	0.00e+00	892.00
IUUC-Rno-105876	Rattus norvegicus	79.40	0.00e+00	1292.00
IUUC-Sha-107588	Sarcophilus harrisii	75.16	0.00e+00	1027.00
IUUC-Sar-112959	Sorex araneus	77.58	0.00e+00	1198.00
IUUC-Ssc-115261	Sus scrofa	81.98	0.00e+00	1277.00
IUUC-Tgu-116580	Taeniopygia guttata	72.48	0.00e+00	1147.00
IUUC-Tru-118731	Takifugu rubripes	73.16	0.00e+00	902.00
IUUC-Tsy-118982	Tarsius syrichta	70.34	0.00e+00	822.00
IUUC-Tni-120725	Tetraodon nigroviridis	63.59	0.00e+00	984.00
IUUC-Tbe-128018	Tupaia belangeri	89.03	0.00e+00	1071.00
IUUC-Ttr-128927	Tursiops truncatus	81.88	0.00e+00	1315.00
IUUC-Vpa-130369	Vicugna pacos	80.68	0.00e+00	1204.00
IUUC-Xtr-132474	Xenopus tropicalis	67.22	0.00e+00	1053.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence