iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Laf-053528

UUCD1 version

UUC-LoA-00387

Ensembl Protein ID

ENSLAFP00000009416.2

UniProt Accession

G3T760; G3T760_LOXAF

Protein Name

Uncharacterized protein

Gene Name

WSB2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000011263.2	ENSLAFT00000011263.2	ENSLAFP00000009416.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	8.80e-15	54.7	358	405
E3 adaptor/Cullin RING/DCX/DWD	1.30e-31	107.6	153	186
UBD/Beta-Prp	1.50e-45	156.0	127	281

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 1    lsklwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyed 51
           ++++w++++   SL+hLCR+a r++l+++++    +LP+Pk++k++L y++
   Q: 358  HVQFWTAPRVLSSLKHLCRKALRSFLTTYQV---LALPIPKKMKEFLTYRT 405
           689****************************...***************86 PP

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf..sd.tllvsGsdDgtikvWDlr 31
           gH+d v++l+f  s+  +lvs+s+D+t+++WDl 
   Q: 153  GHQDVVRDLSFtpSGsLILVSASRDKTLRIWDLN 186
           8***********6556779*************85 PP

UBD/Beta-Prp

   S: 66   ilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsg.dklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllv 153
           il+tg +D+ ik+w+++tg  +  l+gh+d v++lsf psg   lvs+s+d+t+r+wdl++  +  ++lsgh ++v c +++pd+++l 
   Q: 127  ILATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGsLILVSASRDKTLRIWDLNKHGKQIQVLSGHLQWVYCCSISPDCSMLC 215
           899************************************9967789************987666666********************** PP
   S: 154  sGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlng 220
           s++  + v lW++++ +l+r+l+g h++sv s +f++++  lv++s+d+ v++wd  tge +r+l+ 
   Q: 216  SAAGEKSVFLWSMRSYTLIRKLEG-HQSSVVSCDFSPDSALLVTASYDTNVIMWDPYTGERLRSLHH 281
           **********************99.******************************999999998875 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

MLSPAPEEPL LLAELKPGRP HQFDWKSSCE TWSVAFSPDG SWFAWSQGHC IVKLIPWPLE 60
EQFIPKGFEA KSRSSKNDPK GRGSPKEKTL DCGQIVWGLA FSPWPSPPSR RLWARHHPQV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCTGTCTC CTGCCCCAGA GGAACCGCTG CTGCTGGCCG AGCTCAAACC CGGGCGCCCC 60
CACCAGTTTG ATTGGAAGTC GAGCTGTGAG ACTTGGAGCG TCGCCTTCTC GCCTGATGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR020472--G-protein_beta_WD-40_rep
IPR001496--SOCS_box
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50225--SOCS
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF07525--SOCS_box
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00253--SOCS
SM00969--SOCS_box
SM00320--WD40

Gene Ontology

GO:0005622--C:intracellular
GO:0035556--P:intracellular signal transduction
GO:0016567--P:protein ubiquitination

KEGG

lav:100672844

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002221	Ailuropoda melanoleuca	97.54	0.00e+00	816.00
IUUC-Apl-004107	Anas platyrhynchos	69.03	3.00e-131	461.00
IUUC-Aca-004354	Anolis carolinensis	73.38	6.00e-168	583.00
IUUC-Bta-012627	Bos taurus	98.03	0.00e+00	773.00
IUUC-Cja-018897	Callithrix jacchus	96.40	0.00e+00	775.00
IUUC-Cfa-020122	Canis familiaris	97.78	0.00e+00	816.00
IUUC-Cpo-022540	Cavia porcellus	97.29	0.00e+00	787.00
IUUC-Csa-023719	Chlorocebus sabaeus	97.94	0.00e+00	787.00
IUUC-Cho-024367	Choloepus hoffmanni	96.98	2.00e-171	594.00
IUUC-Dno-029021	Dasypus novemcinctus	98.28	0.00e+00	793.00
IUUC-Dor-030321	Dipodomys ordii	97.42	0.00e+00	783.00
IUUC-Ete-032955	Echinops telfairi	98.50	0.00e+00	785.00
IUUC-Eca-033485	Equus caballus	98.47	0.00e+00	765.00
IUUC-Fca-035389	Felis catus	97.94	0.00e+00	788.00
IUUC-Fal-037184	Ficedula albicollis	84.45	2.00e-142	497.00
IUUC-Gga-041014	Gallus gallus	77.00	1.00e-176	612.00
IUUC-Ggo-045585	Gorilla gorilla	98.21	0.00e+00	795.00
IUUC-Hsa-046344	Homo sapiens	98.28	0.00e+00	796.00
IUUC-Itr-049085	Ictidomys tridecemlineatus	98.20	0.00e+00	790.00
IUUC-Lch-050131	Latimeria chalumnae	69.76	4.00e-168	583.00
IUUC-Loc-052807	Lepisosteus oculatus	54.39	1.00e-117	416.00
IUUC-Mcc-055665	Macaca mulatta	98.28	0.00e+00	796.00
IUUC-Meu-056054	Macropus eugenii	88.38	0.00e+00	698.00
IUUC-Mga-059326	Meleagris gallopavo	77.44	0.00e+00	628.00
IUUC-Mmr-060815	Microcebus murinus	95.81	0.00e+00	778.00
IUUC-Mdo-062000	Monodelphis domestica	91.32	0.00e+00	751.00
IUUC-Mmu-063927	Mus musculus	96.92	0.00e+00	783.00
IUUC-Mpu-065726	Mustela putorius furo	96.14	0.00e+00	772.00
IUUC-Mlu-067527	Myotis lucifugus	97.14	4.00e-119	419.00
IUUC-Nle-069680	Nomascus leucogenys	97.70	0.00e+00	788.00
IUUC-Opr-070356	Ochotona princeps	97.99	0.00e+00	804.00
IUUC-Oan-073647	Ornithorhynchus anatinus	83.21	3.00e-135	474.00
IUUC-Ocu-073973	Oryctolagus cuniculus	97.54	0.00e+00	786.00
IUUC-Oga-088797	Otolemur garnettii	97.79	0.00e+00	786.00
IUUC-Oar-089187	Ovis aries	97.95	0.00e+00	771.00
IUUC-Ptr-091317	Pan troglodytes	98.21	0.00e+00	795.00
IUUC-Pan-092694	Papio anubis	90.39	0.00e+00	680.00
IUUC-Psi-093392	Pelodiscus sinensis	80.15	0.00e+00	642.00
IUUC-Pab-098145	Pongo abelii	97.94	0.00e+00	787.00
IUUC-Pca-100454	Procavia capensis	89.97	0.00e+00	725.00
IUUC-Pva-102986	Pteropus vampyrus	89.97	0.00e+00	726.00
IUUC-Rno-104931	Rattus norvegicus	95.36	0.00e+00	766.00
IUUC-Sha-106476	Sarcophilus harrisii	92.52	0.00e+00	749.00
IUUC-Ssc-115643	Sus scrofa	98.45	0.00e+00	787.00
IUUC-Tgu-117522	Taeniopygia guttata	64.13	1.00e-136	479.00
IUUC-Tsy-119301	Tarsius syrichta	98.25	0.00e+00	809.00
IUUC-Ttr-128683	Tursiops truncatus	98.45	0.00e+00	788.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence