iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ptr-091295

UUCD1 version

UUC-PaT-00999

Ensembl Protein ID

ENSPTRP00000027533.5

UniProt Accession

G2HEI6; G2HEI6_PANTR

Genbank Protein ID

BAK62144.1; JAA10921.1; JAA14487.1; JAA31313.1; JAA43703.1

Protein Name

Ubiquitin-conjugating enzyme E2-25 kDa; Ubiquitin-conjugating enzyme E2K

Genbank Nucleotide ID

AACZ03034261; GABC01000417; GABF01007658; GABD01001787; GABE01001036

Gene Name

UBE2K

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000015998.5	ENSPTRT00000029839.5	ENSPTRP00000027533.5

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	3.40e-46	156.4	8	146
UBD/Alpha-Helix/UBA	4.50e-11	42.5	161	199
UBD/UBC-like/UBD_UBC	5.50e-73	243.6	8	149

Active Site

Position(s)	Description	Evidence
92	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00388}

Domain Profile

E2/UBC

   S: 1    Rlkkelkel...ekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyen.GkvClsi 85
           R+k+e+ke+   e++++++i++++vde ++te++ +i Gp+dtpYegg ++lei++pe+YPf+PPkv+f+tki+hPn+++  G++Cl+i
   Q: 8    RIKREFKEVlksEETSKNQIKVDLVDE-NFTELRGEIAGPPDTPYEGGRYQLEIKIPETYPFNPPKVRFITKIWHPNISSVtGAICLDI 95
           7888888873335556699********.9***************************************************99******* PP
   S: 86   lkeeekWspalsvesvllsiqsllaepnpesplneeaaellkknreeykkkvr 138
           lk  ++W +a+++++vlls+q+lla ++p++p+++ +a+++k+n+e++k+++r
   Q: 96   LK--DQWAAAMTLRTVLLSLQALLAAAEPDDPQDAVVANQYKQNPEMFKQTAR 146
           *9..**********************************************986 PP

UBD/Alpha-Helix/UBA

   S: 2    ededkleqlveMGFdreealqaLraannnleaAveyLld 40
           e++ k+e+l++MGFdr++++ aL + ++++e A+e+Ll+
   Q: 161  EYTKKIENLCAMGFDRNAVIVALSSKSWDVETATELLLS 199
           6789*********************************97 PP

UBD/UBC-like/UBD_UBC

   S: 1    rikkelkdllrdeea...qisadlvdddlfelratiagppdspyeggvffltiklptdypfkppkvafitkiyhpnins.ngsicldil 85
           rik+e+k++l++ee+   qi++dlvd++++elr++iagppd+pyegg+++l+ik+p++ypf+ppkv+fitki+hpni+s +g+icldil
   Q: 8    RIKREFKEVLKSEETsknQIKVDLVDENFTELRGEIAGPPDTPYEGGRYQLEIKIPETYPFNPPKVRFITKIWHPNISSvTGAICLDIL 96
           8*************9999*********************************************************************** PP
   S: 86   rsqwsaaltlskvllslcslladaepddplvaeiariyktdkekykriarewt 138
           ++qw+aa+tl++vllsl++lla+aepddp++a++a++yk+++e++k++ar+w+
   Q: 97   KDQWAAAMTLRTVLLSLQALLAAAEPDDPQDAVVANQYKQNPEMFKQTARLWA 149
           ****************************************************7 PP

Organism

Pan troglodytes

Protein Sequence
(Fasta)

MANIAVQRIK REFKEVLKSE ETSKNQIKVD LVDENFTELR GEIAGPPDTP YEGGRYQLEI 60
KIPETYPFNP PKVRFITKIW HPNISSVTGA ICLDILKDQW AAAMTLRTVL LSLQALLAAA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACGCGAGCTC GTGGCTCGGG CGTACGGGGG GCTACAACGG GAGCGGCTGC GCCGCCCGGC 60
CGGGTCAACG TCGTGCGCAT GCGCCGACCC GGCGCCATTT TGGTGGCCGG GCGCGGAGGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR015940--UBA
IPR009060--UBA-like
IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS50030--UBA
PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00627--UBA
PF00179--UQ_con

SMART

SM00165--UBA

Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0032433--C:filopodium tip
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0034450--F:ubiquitin-ubiquitin ligase activity
GO:0035458--P:cellular response to interferon-beta
GO:0010994--P:free ubiquitin chain polymerization
GO:0010800--P:positive regulation of peptidyl-threonine phosphorylation
GO:0060340--P:positive regulation of type I interferon-mediated signaling pathway
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070936--P:protein K48-linked ubiquitination
GO:0000209--P:protein polyubiquitination
GO:0032434--P:regulation of proteasomal ubiquitin-dependent protein catabolic process

KEGG

ptr:461178

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000621	Aegilops tauschii	51.55	4.00e-28	117.00
IUUC-Aml-001286	Ailuropoda melanoleuca	100.00	5.00e-110	389.00
IUUC-Atr-003063	Amborella trichopoda	47.94	1.00e-39	155.00
IUUC-Apl-004122	Anas platyrhynchos	91.50	9.00e-97	345.00
IUUC-Aca-004565	Anolis carolinensis	94.74	3.00e-99	353.00
IUUC-Aly-006390	Arabidopsis lyrata	47.72	4.00e-44	170.00
IUUC-Ath-006637	Arabidopsis thaliana	46.86	2.00e-41	161.00
IUUC-Ago-007714	Ashbya gossypii	44.62	6.00e-38	150.00
IUUC-Acl-008189	Aspergillus clavatus	49.68	7.00e-28	117.00
IUUC-Afl-008489	Aspergillus flavus	41.40	3.00e-28	118.00
IUUC-Afu-008850	Aspergillus fumigatus	40.65	1.00e-28	119.00
IUUC-Ani-009361	Aspergillus nidulans	50.68	1.00e-26	113.00
IUUC-Ang-009548	Aspergillus niger	48.39	2.00e-26	112.00
IUUC-Aor-010105	Aspergillus oryzae	41.40	3.00e-28	118.00
IUUC-Ate-010389	Aspergillus terreus	40.55	8.00e-28	116.00
IUUC-Ame-011454	Astyanax mexicanus	97.00	2.00e-107	380.00
IUUC-Bgr-012255	Blumeria graminis	48.41	8.00e-34	136.00
IUUC-Bta-012992	Bos taurus	100.00	5.00e-110	389.00
IUUC-Bci-013806	Botrytis cinerea	40.09	3.00e-36	144.00
IUUC-Bdi-015024	Brachypodium distachyon	48.22	1.00e-40	159.00
IUUC-Bol-015985	Brassica oleracea	48.22	1.00e-44	172.00
IUUC-Bra-016805	Brassica rapa	48.22	6.00e-45	173.00
IUUC-Cel-018353	Caenorhabditis elegans	52.26	1.00e-56	212.00
IUUC-Cja-019051	Callithrix jacchus	99.50	4.00e-109	386.00
IUUC-Cfa-020016	Canis familiaris	100.00	5.00e-110	389.00
IUUC-Cpo-022026	Cavia porcellus	100.00	5.00e-110	389.00
IUUC-Cre-022987	Chlamydomonas reinhardtii	48.98	6.00e-42	163.00
IUUC-Csa-023059	Chlorocebus sabaeus	100.00	5.00e-110	389.00
IUUC-Cho-024276	Choloepus hoffmanni	96.60	1.00e-73	268.00
IUUC-Cin-025598	Ciona intestinalis	60.71	4.00e-56	210.00
IUUC-Csv-025831	Ciona savignyi	62.24	2.00e-54	205.00
IUUC-Cgl-026449	Colletotrichum gloeosporioides	44.51	2.00e-34	138.00
IUUC-Cne-027068	Cryptococcus neoformans	41.38	4.00e-41	160.00
IUUC-Dre-028139	Danio rerio	97.00	2.00e-107	381.00
IUUC-Dno-029169	Dasypus novemcinctus	93.50	3.00e-102	363.00
IUUC-Dor-030382	Dipodomys ordii	86.00	2.00e-88	318.00
IUUC-Dse-031335	Dothistroma septosporum	50.96	6.00e-37	147.00
IUUC-Dme-032003	Drosophila melanogaster	68.34	2.00e-71	261.00
IUUC-Ete-032868	Echinops telfairi	91.00	2.00e-88	317.00
IUUC-Eca-033428	Equus caballus	100.00	5.00e-110	389.00
IUUC-Eeu-035103	Erinaceus europaeus	73.44	3.00e-49	186.00
IUUC-Fca-035366	Felis catus	100.00	5.00e-110	389.00
IUUC-Fal-037016	Ficedula albicollis	100.00	5.00e-110	389.00
IUUC-Fox-037969	Fusarium oxysporum	42.62	3.00e-34	137.00
IUUC-Fso-038296	Fusarium solani	44.26	4.00e-36	144.00
IUUC-Gmo-039135	Gadus morhua	96.00	5.00e-106	376.00
IUUC-Ggr-039768	Gaeumannomyces graminis	46.25	8.00e-26	110.00
IUUC-Gga-041018	Gallus gallus	99.50	9.00e-110	388.00
IUUC-Gac-041503	Gasterosteus aculeatus	96.50	6.00e-107	379.00
IUUC-Gma-042779	Glycine max	50.26	3.00e-43	167.00
IUUC-Ggo-045032	Gorilla gorilla	100.00	5.00e-110	389.00
IUUC-Hsa-046490	Homo sapiens	100.00	5.00e-110	389.00
IUUC-Itr-048373	Ictidomys tridecemlineatus	100.00	5.00e-110	389.00
IUUC-Kpa-049297	Komagataella pastoris	49.02	6.00e-34	137.00
IUUC-Lch-050588	Latimeria chalumnae	68.25	5.00e-76	276.00
IUUC-Lpe-051070	Leersia perrieri	48.22	1.00e-32	132.00
IUUC-Loc-052549	Lepisosteus oculatus	97.50	7.00e-108	382.00
IUUC-Lma-052949	Leptosphaeria maculans	49.36	6.00e-37	147.00
IUUC-Laf-053688	Loxodonta africana	92.16	3.00e-100	357.00
IUUC-Mcc-055606	Macaca mulatta	100.00	5.00e-110	389.00
IUUC-Mor-056946	Magnaporthe oryzae	37.44	6.00e-23	100.00
IUUC-Mpo-057441	Magnaporthe poae	49.04	7.00e-26	110.00
IUUC-Mtr-058002	Medicago truncatula	49.74	7.00e-43	166.00
IUUC-Mla-059007	Melampsora laricipopulina	43.52	1.00e-37	149.00
IUUC-Mga-059254	Meleagris gallopavo	98.89	1.00e-97	348.00
IUUC-Mvi-060346	Microbotryum violaceum	41.50	1.00e-33	135.00
IUUC-Mmr-061211	Microcebus murinus	100.00	5.00e-110	389.00
IUUC-Mdo-062458	Monodelphis domestica	99.00	1.00e-107	381.00
IUUC-Mmu-063648	Mus musculus	100.00	5.00e-110	389.00
IUUC-Mac-065447	Musa acuminata	48.22	4.00e-41	160.00
IUUC-Mpu-066407	Mustela putorius furo	100.00	2.00e-109	387.00
IUUC-Mlu-067682	Myotis lucifugus	92.93	3.00e-100	357.00
IUUC-Nfi-068517	Neosartorya fischeri	40.65	9.00e-29	120.00
IUUC-Ncr-068749	Neurospora crassa	48.08	2.00e-38	152.00
IUUC-Nle-069712	Nomascus leucogenys	98.89	1.00e-97	348.00
IUUC-Opr-070651	Ochotona princeps	100.00	5.00e-110	389.00
IUUC-Ont-071595	Oreochromis niloticus	96.50	6.00e-107	379.00
IUUC-Oan-073058	Ornithorhynchus anatinus	100.00	7.00e-79	285.00
IUUC-Ocu-074939	Oryctolagus cuniculus	100.00	5.00e-110	389.00
IUUC-Oba-075530	Oryza barthii	48.99	7.00e-32	129.00
IUUC-Obr-076838	Oryza brachyantha	48.48	3.00e-31	127.00
IUUC-Ogl-077606	Oryza glaberrima	48.99	7.00e-32	129.00
IUUC-Ogu-078238	Oryza glumaepatula	48.99	7.00e-32	129.00
IUUC-Oin-079643	Oryza indica	48.99	2.00e-31	128.00
IUUC-Ome-081274	Oryza meridionalis	48.99	7.00e-32	129.00
IUUC-Oni-082651	Oryza nivara	48.99	7.00e-32	129.00
IUUC-Opu-083933	Oryza punctata	48.99	1.00e-31	129.00
IUUC-Oru-085054	Oryza rufipogon	48.99	1.00e-31	129.00
IUUC-Osa-085716	Oryza sativa	48.99	2.00e-31	128.00
IUUC-Ola-087043	Oryzias latipes	96.50	6.00e-107	379.00
IUUC-Olu-087846	Ostreococcus lucimarinus	46.63	7.00e-42	162.00
IUUC-Oga-088897	Otolemur garnettii	93.94	2.00e-100	357.00
IUUC-Oar-089673	Ovis aries	92.93	1.00e-100	358.00
IUUC-Pan-092034	Papio anubis	100.00	1.00e-97	348.00
IUUC-Psi-093498	Pelodiscus sinensis	100.00	5.00e-110	389.00
IUUC-Pma-094115	Petromyzon marinus	82.91	1.00e-89	322.00
IUUC-Pno-095102	Phaeosphaeria nodorum	40.76	7.00e-38	150.00
IUUC-Ppa-095326	Physcomitrella patens	46.19	6.00e-40	156.00
IUUC-Pfo-096940	Poecilia formosa	96.50	5.00e-107	379.00
IUUC-Pab-098279	Pongo abelii	100.00	5.00e-110	389.00
IUUC-Pop-099543	Populus trichocarpa	49.24	2.00e-44	171.00
IUUC-Pca-100782	Procavia capensis	99.50	5.00e-108	382.00
IUUC-Ppe-101789	Prunus persica	47.94	4.00e-37	147.00
IUUC-Pva-102147	Pteropus vampyrus	71.02	5.00e-58	216.00
IUUC-Pgr-103643	Puccinia graminis	45.06	9.00e-38	150.00
IUUC-Ptt-103772	Puccinia triticina	47.95	2.00e-36	145.00
IUUC-Pte-104370	Pyrenophora teres	49.36	1.00e-36	146.00
IUUC-Pyt-104592	Pyrenophora triticirepentis	40.74	1.00e-36	146.00
IUUC-Rno-104984	Rattus norvegicus	100.00	5.00e-110	389.00
IUUC-Sce-106394	Saccharomyces cerevisiae	43.01	3.00e-35	141.00
IUUC-Sha-106624	Sarcophilus harrisii	93.50	5.00e-104	369.00
IUUC-Ssl-108609	Sclerotinia sclerotiorum	42.86	1.00e-40	159.00
IUUC-Smo-109656	Selaginella moellendorffii	48.47	3.00e-40	157.00
IUUC-Sit-110639	Setaria italica	47.98	1.00e-39	155.00
IUUC-Sly-110978	Solanum lycopersicum	48.22	6.00e-44	169.00
IUUC-Stu-112088	Solanum tuberosum	48.22	3.00e-44	171.00
IUUC-Sar-113285	Sorex araneus	84.36	3.00e-76	277.00
IUUC-Sbi-113986	Sorghum bicolor	47.98	3.00e-39	154.00
IUUC-Sre-115046	Sporisorium reilianum	46.71	8.00e-37	146.00
IUUC-Ssc-116314	Sus scrofa	100.00	5.00e-110	389.00
IUUC-Tgu-117427	Taeniopygia guttata	99.44	6.00e-98	349.00
IUUC-Tru-118196	Takifugu rubripes	84.44	4.00e-102	363.00
IUUC-Tsy-119208	Tarsius syrichta	97.98	1.00e-106	378.00
IUUC-Tni-119667	Tetraodon nigroviridis	97.00	2.00e-107	380.00
IUUC-Tca-121446	Theobroma cacao	49.75	3.00e-45	174.00
IUUC-Tre-122053	Trichoderma reesei	38.12	1.00e-31	129.00
IUUC-Tvi-122533	Trichoderma virens	36.00	4.00e-31	127.00
IUUC-Tae-124726	Triticum aestivum	48.73	2.00e-33	135.00
IUUC-Tme-127024	Tuber melanosporum	49.38	4.00e-39	154.00
IUUC-Tbe-127752	Tupaia belangeri	96.50	5.00e-105	372.00
IUUC-Ttr-128287	Tursiops truncatus	100.00	8.00e-98	348.00
IUUC-Uma-129512	Ustilago maydis	39.22	3.00e-36	144.00
IUUC-Vda-129947	Verticillium dahliae	37.20	2.00e-31	128.00
IUUC-Vpa-130481	Vicugna pacos	100.00	5.00e-108	382.00
IUUC-Vvi-131429	Vitis vinifera	46.19	3.00e-41	160.00
IUUC-Xtr-132710	Xenopus tropicalis	83.17	2.00e-95	341.00
IUUC-Xma-134308	Xiphophorus maculatus	96.00	1.00e-106	378.00
IUUC-Yli-134523	Yarrowia lipolytica	44.00	5.00e-34	137.00
IUUC-Zma-135733	Zea mays	47.14	1.00e-37	149.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence